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ESICM LIVES 2016: part two : Milan, Italy. 1–5 October 2016

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Association of Vitamin D Receptor Gene Polymorphisms and Hypovitaminosis D with Reduced Bone Mineral Density in Survivors of Childhood Leukemia: A Study in Algerian Patients.

Survivors of childhood leukemia are at increased risk of long-term skeletal complications, including reduced bone mineral density (BMD). Vitamin D deficiency and genetic variations in the vitamin D receptor (VDR) gene are important factors influencing bone health, yet their combined effects remain insufficiently studied, particularly in North African populations. This case-control study included 130 survivors of childhood acute lymphoblastic leukemia (ALL) in remission (age range: 5-26 years) and 110 age- and sex-matched healthy controls recruited from Beni Messous Hospital. BMD was assessed a

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… Morales La Madrid A. Ilbawi A. Childhood cancer survival in low- and middle-income countries and the Global South: Emerging evidence and critical gaps from a scoping review of observational studies EJC Paediatr. Oncol. 2025 6 100422 10.1016/j.ejcped.2025.100422 PMC12682699 41368027 8. Wei Z. Du Z. …

Antibiotic de-escalation patterns and outcomes in critically ill patients with suspected pneumonia as informed by bronchoalveolar lavage results.

PurposeAntibiotic stewardship in critically ill pneumonia patients is crucial yet challenging, partly due to the limitations of noninvasive diagnostic tests. This study reports an antibiotic de-escalation pattern informed by bronchoalveolar lavage (BAL) results, incorporating quantitative cultures and multiplex PCR rapid diagnostic tests.MethodsWe analyzed data from SCRIPT, a single-center prospective cohort study of mechanically ventilated patients who underwent a BAL for suspected pneumonia. We used the Narrow Antibiotic Therapy (NAT) score to quantify day-by-day antibiotic prescription patt

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… Grant RA, Morales-Nebreda L, Markov NS et al. (2021) Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia. Nature 590(7847):635–641. 10.1038/s41586-020-03148-w 21. …

Prevalence of Atrial Fibrillation and Intervention Therapy in Cardiac Amyloidosis.

Atrial fibrillation (AF) is a common and serious arrhythmia that frequently complicates cardiac amyloidosis (CA), a rare condition characterized by amyloid deposits in the heart. The coexistence of AF in CA patients significantly increases the risk of heart failure, stroke, and other life-threatening complications; however, the therapeutic approach to managing AF in CA patients remains underexplored. Thus, this review discusses the features of AF in CA patients, recent research on the development of effective treatment options, and strategies for future therapies. A comprehensive review of the

Понимание иранскими пациентами, страдающими множественным склерозом, источников поддержки, необходимых для корректировки: качественный анализ содержания.

ЦЕЛЬ: Большинство людей с множественным склерозом (МС) всегда стремятся получить многочисленные источники поддержки, чтобы приспособиться к этому состоянию здоровья; однако имеется ограниченная информация об их восприятии и опыте использования таких источников. Цель этого исследования заключалась в изучении представлений пациентов с НР об источниках поддержки, необходимой для их адаптации. МАТЕРИАЛЫ И МЕТОДЫ: Это качественное исследование было проведено в 2020-2022 годах на основе традиционного подхода к анализу содержания. Тринадцать пациентов с MS, одна пациентка, одна медсестра и один врач

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… “ I created a group on WhatsApp Messenger with two of my friends who were also suffering from MS, but had a very high morale. …

Characteristics of patients with newly diagnosed hematological malignancies referred for echocardiography.

ObjectiveThe importance of cardio-hemato-oncology programs is increasing. The main aim of the study was to identify all coexisting cardiovascular disorders in patients with new hematological malignancies referred for echocardiography during baseline evaluation before anticancer therapy.Material and methodsThe study was based on 900 echocardiographic examinations performed within 12 months at the Institute of Hematology and Transfusion Medicine in Poland: 669 tests (74.3%) were dedicated to hemato-oncology patients at the different stages of cancer therapy, however almost a third of the tests (

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… Serrano JM, González I, Del Castillo S, Muñiz J, Morales LJ, Moreno F, et al. Diastolic dysfunction following anthracycline-based chemotherapy in breast cancer patients: incidence and predictors. Oncologist (2015) 20:864–72. doi: 10.1634/theoncologist.2014-0500 41. …

Инновационные минимально инвазивные имплантаты для остеопороза позвоночных переломов.

С ростом старения населения все более распространенными становятся остеопорозные переломы позвоночных (ОВК), приводящие к сильной боли в спине и функциональным расстройствам. Перкутанная вертебропластика (ПВП) и перкутановая кипопластика (ПКП), поскольку минимально инвазивные процедуры привели к революции методов обработки ВОВК. Однако связанные с ПВП и ПКП осложнения, такие, как симптоматическая утечка цемента и прилегающие позвоночные переломы, по-прежнему страдают от врачей. В связи с этим в последнее время в целях устранения недостатков традиционных процедур было разработано все больше имп

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… Ortin-Barcelo A, Ortola Morales DJ, Rosa MA, Fenga D, Banuls-Pattarelli MA, Lopez-Prats FA. Adjacent single-level combined fixation using kyphoplasty and percutaneous pedicle screws in type A3 unstable vertebral fractures in elderly patients. …

Implementation of a hospital-at-home (HAH) unit for hematological patients during the COVID-19 pandemic: safety and feasibility.

Background"Hospital-at-home" (HAH) programs have been shown to optimize resource utilization, shorten hospitalization and prevent nosocomial infection.MethodsWe retrospectively analysed data regarding implementation of an HAH unit for caring patients with hematological malignancies in our center, during the COVID-19 pandemic.ResultsBetween January and November 2020, 105 patients were treated in the HAH unit for a total of 204 episodes. Nine patients with multiple myeloma (MM) received autologous HSCT (auto-HSCT). Three patients with acute myeloid leukemia (AML) received consolidation therapy,

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… Piñana JL, Martino R, García-García I, Parody R, Morales MD, Benzo G, et al. Risk factors and outcome of COVID-19 in patients with hematological malignancies. Exp Hematol Oncol. 2020;9:21. doi: 10.1186/s40164-020-00177-z. 17. …

Prevalence of transthyretin amyloidosis in patients with heart failure and no left ventricular hypertrophy.

AimsAs evidenced by scintigraphy imaging, the prevalence of transthyretin (TTR) cardiac amyloidosis in heart failure patients with preserved ejection fraction (HFpEF) and left ventricular hypertrophy (LVH) ranges between 13% and 19%. The natural evolution of cardiac amyloidosis begins with the deposition of amyloid material in the myocardium, with LVH ensuing at later stages. With current imaging modalities, it is possible to detect TTR cardiac amyloidosis before the hypertrophic stage. The aim of this study was to determine the prevalence of TTR cardiac amyloidosis in HFpEF patients without L

Multiple myeloma and physical activity: a scoping review.

ObjectivesMultiple myeloma is the second most common haematological cancer. A growing body of literature is emerging that investigates the role physical activity plays in all stages of multiple myeloma (prevention and survivorship) and to date no attempt has been made to collate and understand this literature. Therefore, this scoping review aims to (1) outline what is already known about physical activity in all stages of multiple myeloma (2) map the literature on physical activity and multiple myeloma and (3) identify future directions for research.DesignScoping Review.Data sourcesSearches we

Radiation induced oral mucositis.

PATIENTS RECEIVING RADIOTHERAPY OR CHEMOTHERAPY WILL RECEIVE SOME DEGREE OF ORAL MUCOSITIS THE INCIDENCE OF ORAL MUCOSITIS WAS ESPECIALLY HIGH IN PATIENTS: (i) With primary tumors in the oral cavity, oropharynx, or nasopharynx; (ii) who also received concomitant chemotherapy; (iii) who received a total dose over 5,000 cGy; and (iv) who were treated with altered fractionation radiation schedules. Radiation-induced oral mucositis affects the quality of life of the patients and the family concerned. The present day management of oral mucositis is mostly palliative and or supportive care. The newe

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… Gluckman E, Lotsberg J, Devergie A, Zhao XM, Melo R, Gomez-Morales M, et al. Oral acyclovir prophylactic treatment of herpes simplex infection after bone marrow transplantation. J Antimicrob Chemother. 1983;12:161–7. doi: 10.1093/jac/12.suppl_b.161. 43. …

Haemato-oncology and burnout: an Italian survey.

This cross-sectional survey aimed to evaluate the prevalence of burnout and estimated psychiatric disorders among haemato-oncology healthcare professionals in Italy. The aspects of work that respondents perceive as stressful and satisfying have also been examined. The assessments were made using the Maslach Burnout Inventory (MBI), General Health Questionnaire and a study-specific questionnaire. Logistic regression models were applied to show associations between different sources of work-related stress and burnout. Three hundred and eighty-seven out of 440 (87.95%) returned their questionnair

Текущая роль физиотерапии в системном свето-хайне (AL) амилоидозе и множественной миеломе.

Физиотерапия представляет собой научно обоснованную медицинскую работу, направленную на сотрудничество в диагностике, профилактике и лечении множества болезней и клинических сценариев на всех этапах жизни человека. Его развитие ускорилось за последние годы. two десятилетиями. Сфера физиотерапии постоянно эволютивна. Однако накопленных данных о редких заболеваниях мало. Следует отметить, что возможности для улучшения ситуации и получения потенциальных выгод от сложных заболеваний с низким уровнем заболеваемости также весьма высоки как в виде изолированного подхода, так и в рамках многодисциплин

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… Morales Palomares S. Lopane D. Sguanci M. Cosmai S. Nutritional Prehabilitation Intervention in Hematological Patients Undergoing Bone Marrow Transplant: A Systematic Review of the Literature Nutrients 2024 16 4387 10.3390/nu16244387 39771008 PMC11677489 84. Neupane K. Singstock M. Shah D. … Zegri-Reiriz I. de Haro-del Moral F.J. Dominguez F. Salas C. de la Cuadra P. Plaza A. Krsnik I. Gonzalez-Lopez E. Garcia-Pavia P. Prevalence of Cardiac Amyloidosis in Patients with Carpal Tunnel Syndrome J. Cardiovasc. Trans. Res. 2019 12 507 513 10.1007/s12265-019-09895-0 31214980 134. Muchtar E. …

Recent Advances in Therapeutics for the Treatment of Alzheimer's Disease.

The most prevalent chronic neurodegenerative illness in the world is Alzheimer's disease (AD). It results in mental symptoms including behavioral abnormalities and cognitive impairment, which have a substantial financial and psychological impact on the relatives of the patients. The review discusses various pathophysiological mechanisms contributing to AD, including amyloid beta, tau protein, inflammation, and other factors, while emphasizing the need for effective disease-modifying therapeutics that alter disease progression rather than merely alleviating symptoms. This review mainly covers m

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… García-Morales V. García-Cozar F.J. Ramos-Rodríguez J.J. Melguizo-Rodríguez L. Therapeutic Approach to Alzheimer’s Disease: Current Treatments and New Perspectives Pharmaceutics 2022 14 1117 10.3390/pharmaceutics14061117 35745693 PMC9228613 104. Selkoe D.J. … Morales J.F. Podichetty J. Challenges in Alzheimer’s Disease Drug Discovery and Development: The Role of Modeling, Simulation, and Open Data Clin. Pharmacol. Ther. 2020 107 796 805 31955409 10.1002/cpt.1782 194. Abduljawad A.A. Elawad M.A. Elkhalifa M.E.M. Ahmed A. Hamdoon A.A.E. Salim L.H.M. …

Towards Novel Gene and Cell Therapy Approaches for Cervical Cancer.

Cervical cancer is one of the most common malignancies in women, and the majority of cases are caused by infection with high-risk human papilloma virus (HPV) subtypes. Despite effective preventative measures, such as vaccinations against HPV, over 300,000 women die world-wide from cervical cancer each year. Once cervical cancer is diagnosed, treatment may consist of radial hysterectomy, or chemotherapy and radiotherapy, or a combination of therapies dependent upon the disease stage. Unfortunately, overall prognosis for patients with metastatic or recurrent disease remains poor. In these cases,

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… Morales A.J. Cargill M.J. Towlerton A.M.H. Coffey D.G. Warren E.H. Tykodi S.S. Preclinical development of T-cell receptor-engineered T-cell therapy targeting the 5T4 tumor antigen on renal cell carcinoma Cancer Immunol. … Morales J.F. Barrett D.M. A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release Cell Discov. 2018 4 62 10.1038/s41421-018-0066-6 30479831 PMC6242878 145. Harper J. Adams K.J. Bossi G. …

Routes of administration, reasons for use, and approved indications of medical cannabis in oncology: a scoping review.

INTRODUCTION: Some patients diagnosed with cancer use medical cannabis to self-manage undesirable symptoms, including nausea and pain. To improve patient safety and oncological care quality, the routes of administration for use of medical cannabis, patients' reasons, and prescribed indications must be better understood. METHODS: Based on the Joanna Briggs Institute guidelines, a scoping review was conducted to map the current evidence regarding the use of medical cannabis in oncological settings based on the experiences of patients diagnosed with cancer and their healthcare providers. A searc

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… X X Machado Rocha et al. (2008) X X X X Maida (2008) X Maida & Daeninck (2016) X X X X X X X X Maida et al. (2008) X Makary et al. (2019) X X X X X X Martell et al. (2018) X X X X May & Glode (2016) X X X X X X X Meiri et al. (2007) X X Meng et al. (2020) X X X X X X Mersiades et al. (2020) X X X X Morales … | X | Martell et al. (2018) | X | X | X | | | X | | | | | May & Glode (2016) | X | X | X | | | X | X | | X | X | Meiri et al. (2007) | X | | X | | | | | | | | Meng et al. (2020) | X | | X | X | X | | X | | X | | Mersiades et al. (2020) | X | | X | | X | X | | | | | Morales …

Treating Protein Misfolding Diseases: Therapeutic Successes Against Systemic Amyloidoses.

Misfolding and extracellular deposition of proteins is the hallmark of a heterogeneous group of conditions collectively termed protein misfolding and deposition diseases or amyloidoses. These include both localized (e.g. Alzheimer's disease, prion diseases, type 2 diabetes mellitus) and systemic amyloidoses. Historically regarded as a group of maladies with limited, even inexistent, therapeutic options, some forms of systemic amyloidoses have recently witnessed a series of unparalleled therapeutic successes, positively impacting on their natural history and sometimes even on their incidence. I

Окисляющие молекулярные сигнатуры в неизлечимых заболеваниях: систематический обзор комплексных подходов к машинному обучению и системной биологии.

Окисляющий стресс является одним из основных факторов патогенеза иммунных заболеваний в результате его воздействия на клеточный метаболизм, митохондриальную функцию, иммунную сигнализацию и воспалительную травму тканей. Разрушение гомеостазиса способствует метаболическому перепрограммированию и постоянной активации врожденной и адаптивной иммунной реакции, что способствует прогрессированию заболеваний через многочисленные подстрекательские и аутоиммунные расстройства. Последние достижения в области высокопроизводительных молекулярных технологий привели к созданию крупномасштабных многомерных н

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… Mendoza-Pinto C., Munguía-Realpozo P., Etchegaray-Morales I., Solis-Mendoza F., Gálvez-Romero J.L., Ramírez-Lara E., González M.A.T., Juárez B.M.S., Flores M.A.G., Méndez-Martínez S. …

Улучшить долгосрочные механические свойства термопластических короткокалорийных соединений с использованием альтернативных матриц.

Древесные пластиковые композитные материалы (ВКН) обеспечивают средства для уменьшения углеродного следа за счет использования натуральных волокон для повышения механических свойств. Однако имеется ограниченная информация о механических свойствах этих материалов во враждебных условиях. В этом исследовании была проведена оценка составов полипропилена (PP), полистирола (PS) и полилактической кислоты (PLA), обработанных путем экструдирования и инъекции. Были проведены испытания на прочность и модулю прочности на растяжение и флексур, температуру смещения тепла (HDT) и на анализ ползучести при раз

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… Agaliotis E.M., Ake-Concha B.D., May-Pat A., Morales-Arias J.P., Bernal C., Valadez-Gonzalez A., Herrera-Franco P.J., Proust G., Koh-Dzul J.F., Carrillo J.G., et al. Tensile Behavior of 3D Printed Polylactic Acid (PLA) Based Composites Reinforced with Natural Fiber. …

Clinical Posters From JADPRO Live 2022

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… Increasing workload and patient complexity in the setting of consistent staff turnover can lead to burnout, low morale, and thus poor quality of care provided. … The goal of this role was to support the overnight provider to dedicate increased attention toward higher acuity patients, provide adequate time for evaluation and management of new admissions, improve provider morale, decrease burnout, and remove tasks that may take concentration away from complex patients …