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Цифровой дистанционный мониторинг людей с множественным склерозом.

ВВЕДЕНИЕ: Множественный склероз (MS) является хроническим нейродегенеративным заболеванием, которое затрагивает более 2,8 млн. человек во всем мире и приводит к значительным симптомам моторного и немоторного происхождения. Эффективный мониторинг заболеваний имеет решающее значение для улучшения результатов лечения пациентов, но часто затрудняется ограниченностью редких клинических оценок. Цифровые средства дистанционного мониторинга с использованием больших данных, и МА открывает новые возможности для отслеживания симптомов в режиме реального времени и выявления развития заболеваний. МЕТОДЫ: В

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… DL algorithms were also implemented retrospectively, to detect patients who had a positive recent history of falls (in the previous six months), by leveraging accelerometer data from sensors placed on the sternum, lower back, thigh, and shanks during a one-minute walking task in the clinic ( 19 ). … Chitnis et al. ( 27 ) collected data remotely from 23 pwMS wearing three sensors (placed on wrist, ankle, and sternum) for eight weeks during real-world daily activities. …

Effects of Radiotherapy in the treatment of multiple myeloma: a retrospective analysis of a Single Institution.

BACKGROUND: Palliative irradiation of osteolytic lesions is a considerable component in the treatment for patients with multiple myeloma. In this study, we analyzed the efficacy of irradiation in these patients. PATIENTS AND METHODS: We retrospectively analyzed 153 patients with multiple myeloma who were admitted to our department between 1989 and 2013. According to the staging system of Durie & Salmon 116 patients were classified as stage III. 107/153 patients were treated with radiotherapy of at least one and up to 6 bony lesions at different times. In order to evaluate the effect of local

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… Total Full Partial (Level I-II) Spine Thoracic Spine (TS) 32 84 38 47 20 Lumbar Spine (LS) 12 100 25 75 25 Cervical Spine (CS) 8 75 38 37 13 CS/TS 4 100 100 0 0 TS/LS 11 79 45 54 20 Extremities Superior 12 91 16 75 16 Inferior 15 80 0 80 8 Trunk Pelvis/Hip 24 87 41 45 19 Others Sternum 3 100 10 90 25 … 20 | Lumbar Spine (LS) | 12 | 100 | 25 | 75 | 25 | Cervical Spine (CS) | 8 | 75 | 38 | 37 | 13 | CS/TS | 4 | 100 | 100 | 0 | 0 | TS/LS | 11 | 79 | 45 | 54 | 20 Extremities | Superior | 12 | 91 | 16 | 75 | 16 | Inferior | 15 | 80 | 0 | 80 | 8 Trunk | Pelvis/Hip | 24 | 87 | 41 | 45 | 19 Others | Sternum …

Metastatic breast cancer or multiple myeloma? Camouflage by lytic lesions.

We report a case of a female with stage I infiltrating ductal carcinoma who received adjuvant therapy including trastuzumab. One year later she developed lytic lesions and was retreated with trastuzumab that was held after she developed symptomatic heart failure. Lytic lesions were attributed to relapse of breast cancer, and cardiac failure attributed to prior trastuzumab therapy. After complications necessitated multiple hospitalizations, a further workup revealed that the lytic lesions were not metastatic breast cancer but multiple myeloma. Her advanced multiple myeloma was associated with s

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… In January 2007, she developed pain in her sternum and back, and X-rays revealed multiple small lytic lesions. The diagnosis of metastatic breast cancer was made and she underwent radiation therapy to the symptomatic lesions as well as further trastuzumab treatment for metastatic disease. …

Limited versus full sternotomy for aortic valve replacement.

BACKGROUND: Aortic valve disease is a common condition that is easily treatable with cardiac surgery. This is conventionally performed by opening the sternum longitudinally down the centre ("median sternotomy") and replacing the valve under cardiopulmonary bypass. Median sternotomy is generally well tolerated, but as less invasive options have become available, the efficacy of limited incisions has been called into question. In particular, the effects of reducing the visibility and surgical access has raised safety concerns with regards to the placement of cannulae, venting of the heart, epica…

[Estimation of biocompatibility of fibers with large mechanical resistance].

Aramid fibers from aromatic polyamide group are plastic materials with high mechanical resistance to breaking, small elongation and low mass … mplantation on 60, 90, 180, 270 and 360 days of aramid and polyester fibers into xiphoid process of sternum. The quantitative microscopic estimation of the local reaction of tissue after implantation of fibers was performed using punctual estimation of tissue reaction. The research of proinflammatory cytokines IL-1beta and IL-6 induction after implantatio …

Morbidity and Mortality: A Case Report of Metastatic Bone Disease.

Metastatic prostate cancer and multiple myeloma (MM) usually present with bone lesions, posing a diagnostic challenge in males presenting in late stages. In this case report, an 86-year-old male who had not seen a physician in over 30 years presented with complaints of hip pain and progressive difficulty in walking for three weeks. Outpatient X-ray of the right hip showed multiple lytic bone lesions, raising suspicion of MM. Other laboratory tests revealed elevated serum calcium and elevated prostate-specific antigen (PSA), supporting a diagnosis of prostate cancer. The patient was admitted fo

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… Figure 5 Bone scan Showing metastatic disease in multiple areas including the shoulders, left wrist, left side of the pelvis, ribs, and sternum. Figure 2 X-ray of the femur Showing multiple lytic lesions; arrow points towards one big lytic lesion. …

Stereotactic radiotherapy for patients with bone metastases: a selected group with low rate of radiation treatment during the last month of life?

BackgroundComplex high-precision radiotherapy, such as stereotactic body radiotherapy (SBRT), should only be offered to patients with sufficiently long survival. In the context of bone metastases radiotherapy, low rates of treatment close to the end of life, e.g. last 30 days (RT30), may serve as a quality of care indicator. While traditional, pain-relieving short-course regimens have been studied comprehensively, real-world SBRT results are still limited.MethodsRetrospective analysis (2010-2023, n = 1117 episodes) of patients with bone metastases treated with traditional single-fraction (8 Gy

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… , 26–95 69, 34–92 73, 51–90 72, 24–86 < 0.001 Median Karnofsky performance status, range 70, 30–100 70, 30–100 70, 50–100 90, 60–100 < 0.001 Median LabBM score, range 2.0, 0–3.5 1.5, 0–3.5 1.5, 0–3.0 1.0, 0–3.0 < 0.001 SCLC: small cell lung cancer, NSCLC: non-small cell lung cancer 1 not displayed: sternum … patients were treated with traditional palliative radiotherapy (8 Gy single fraction or multiple fractions) or with stereotactic radiotherapy regimens (12-16 Gy single fraction or multiple fractions): baseline parameters SCLC: small cell lung cancer, NSCLC: non-small cell lung cancer 1 not displayed: sternum …

High serum IL-17A is associated with bone destruction in newly diagnosed multiple myeloma patients.

BACKGROUND: Multiple myeloma (MM) is a malignant proliferative disease of the blood system, characterized by the abnormal growth of clonal plasma cells in the bone marrow. The bone marrow microenvironment (BMM) is highly critical in the pathological process of MM. Many studies have shown that serum interleukin-17A (IL-17A) plays a key role in various infectious diseases, autoimmune diseases, and cancers. However, more clinical studies need to be performed to further prove the influence of serum IL-17A levels on multiple myeloma patients. METHODS: Among a total of 357 participants in our insti

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… Bone destruction in the skull, scapula, vertebrae, sternum/clavicle, ilium/pelvis/sacrum/pubis, and femur/humeral area detected by MR/CT/PET-CT was scored as 1 point. The total score of the bone-damage area was recorded as bone lesion level. Wherever detected, a fracture was recorded as 1. … Bone destruction in the skull, scapula, vertebrae, sternum/clavicle, ilium/pelvis/sacrum/pubis, and femur/humeral area detected by MR/CT/PET-CT scored 1 point, and the total score of the bone-damage area was recorded as bone lesion level. Wherever detected, a fracture was recorded as 1. …

Guillain-Barré syndrome in a patient with multiple myeloma after bortezomib therapy: A case report.

BackgroundBortezomib is a first-line drug approved for patients with multiple myeloma (MM) and has significantly increased their overall survival. However, bortezomib-induced peripheral neuropathy (PN) remains a significant side effect that has led to its discontinuation in some patients. Guillain-Barré syndrome (GBS) is recognized as an immune-mediated PN characterized by the involvement of multiple nerve roots and peripheral nerves and albuminocytologic dissociation in cerebrospinal fluid (CSF) tests. Intravenous immunoglobulin (IVIG) and plasmapheresis are effective.Case summaryA 45-year-ol

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… History of present illness A 45-year-old man was hospitalized at the First Affiliated Hospital of Guangxi Medical University for pain in the sternum and ribs. …

Hypercalcemia From Trenbolone Use: A Case Report.

In this case, a patient presented to the emergency department (ED) with fatigue after CareNow noted abnormal laboratory results. The patient reported using trenbolone, an anabolic-androgenic steroid (AAS) often used for athletic performance enhancement or cosmetic purposes. In the ED, the patient was noted to have significant hypercalcemia (15 mg/dL) and acute kidney injury (AKI) (creatinine 6.02 mg/dL). The workup ruled out malignancy, hyperparathyroidism, and vitamin D toxicity. The patient was admitted and received intravenous fluids and pamidronate, which improved the patient's hypercalcem

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… He described mid-epigastric pain radiating to the sternum associated with nausea without vomiting, as well as darker-than-normal urine. He reported working outdoors but noted difficulty maintaining adequate hydration. The patient denied any medication use at home, including no analgesics. …

Secondary fracture prevention in primary care: a narrative review.

The global burden of osteoporosis continues to rise with an ageing population. Untreated osteoporotic fractures not only heighten the risk of subsequent fractures but are associated with excess mortality. Although primary care guidelines consistently stress the importance of secondary fracture prevention, fewer than 20% of patients are appropriately treated for osteoporosis following an initial osteoporotic fracture. This worldwide phenomenon is known as the osteoporosis care gap. This literature review examines the barriers to secondary fracture prevention in primary care and evaluates the ef

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… Among those initially untreated at baseline: 40.4% in minimum group ( p < 0.0001 vs. control), 53.2% in intensive group ( p < 0.0001 vs. control), 18.8% in control group Confirmation with patient’s pharmacist Jaglal et al. 2012 (Canada) Patients ≥ 40 years with fracture of hip, forearm, wrist, rib, sternum … 28% in intervention group vs. 10% in control group ( p = 0.002) Rate of BMD test performed at 6 months: ▪ 53.5% in intervention group vs. 25.5% in control group ( p < 0.0001) Interview with patient Bessette et al. 2011 (Canada) Women ≥ 50 years with FF of wrist, forearm, humerus, scapula, clavicle, sternum …

A Rare Case of Oligosecretory Multiple Myeloma With Intracranial Plasmacytoma.

Multiple myeloma (MM) is a hematologic malignancy characterized by monoclonal plasma cell proliferation within the bone marrow. According to current International Myeloma Working Group (IMWG) criteria, true non-secretory multiple myeloma (NSMM) is defined by the absence of detectable monoclonal protein even on serum free light chain (FLC) assay, unlike oligosecretory multiple myeloma (OSMM), in which electrophoresis and immunofixation are negative but the FLC κ/λ ratio is pathological - making diagnosis particularly challenging by conventional techniques. The association of OSMM with an intrac

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… Whole-body MRI (coronal and sagittal acquisition of the spinal axis, pelvis, femurs, sternum, and shoulder girdles) Sequences weighted in T1, STIR, and DWI. Analysis according to MY-RADS criteria. …

Роль радиотерапии для пациентов с множественной миеломой в современную эпоху: реальный мировой опыт работы в одном центре.

Рентгенотерапия (RT) является хорошо зарекомендовавшей себя формой лечения в нескольких миеломах (ММ), особенно при событиях, связанных со скелетом. Однако его роль, по всей видимости, меняется с внедрением современных системных методов. MethodsWe провел ретроспективный анализ большой, одноцентровой группы MM, обработанной современными протоколами, для описания нынешних моделей использования RT.RecondsRT продолжает приносить клиническую пользу, при этом наблюдались изменения в моделях использования по сравнению с историческими группами. ConcernRT сохраняет свою актуальность в современном ландш

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… Type of tissue irradiated | Total = 331 RT sites Bony | 222 (67.1%) Bony/paramedullary | 73 (22.1%) Extramedullary | 36 (10.9%) Anatomical site | Spine | 131 (39.6%) Femur/tibia | 27 (8.2%) Humerus/radius | 25 (7.6%) Pelvis/sacrum | 48 (14.5%) Skull/facial bones | 27 (8.2%) Ribs/sternum | 22 (6.6%) …

Osteitis Fibrosa Cystica: The Hideous Face of Hyperparathyroidism.

Osteitis fibrosa cystica (OFC), the skeletal scourge of advanced hyperparathyroidism, unveils itself as a relentless destroyer of bone architecture, leaving behind a landscape of fragility and deformity. In the shadow of chronic kidney disease, where mineral imbalances reign, this rare but devastating entity emerges as a silent tormentor. We present the case of a hemodialysis patient who fell victim to this sinister complication, manifesting with excruciating bone pain, pathological fractures, and radiographic and histological evidence of cystic osteolytic lesions. Biological assessments revea

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… The predominant tumor locations include the ribs, sternum, clavicle, pelvis, and the diaphyseal regions of long bones. Spinal involvement is rarer and may occur with or without associated neurological symptoms [ 8 ]. …

Долговременная ремиссия CNS с эгранатамабом и внутритехологическая терапия в многократной миеломе.

Участие центральной нервной системы (ЦНС) в множестве миеломы (ММ) является редким, но разрушительным осложнением, связанным с плохим прогнозом и ограниченными терапевтическими возможностями. Мы сообщаем о 73-летней женщине с повышенным риском иг-каппой MM, которая прятала TP53 [del(17p)] и 13q, у которой появились внематочные и CNS болезни после шести предыдущих линий терапии, включая две аутологические трансплантации стволовых клеток, и которая была трехклассной рефракторной до протеозных ингибиторов, иммуномодуляторных агентов и антиCD38 моноклонных антител. При рецидиве CNS цитология цереб

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… Three months later, whole-body MRI revealed widespread disease involving the calvarium, sternum, vertebrae, and long bones. Therapy was changed to isatuximab, pomalidomide, and dexamethasone (Isa-Pd) in September 2023. …

Gangliocytic Paraganglioma with Carcinoma of the Ampulla of Vater.

The patient was a "73" -year-old woman who visited our hospital with the chief complaint of weight loss. Upper gastrointestinal endoscopy revealed an enlarged ampulla of Vater, and a biopsy led to a diagnosis of Group "4" gastric carcinoma; suspicious of adenocarcinoma. There were no findings suggesting invasion into the muscle layer of duodenum, despite tumor mass formation being observed in the sphincter of Oddi. We performed endoscopic papillectomy for both diagnostic and therapeutic purposes. Pathologically, a well-differentiated adenocarcinoma existed in the superficial layer of the mucou

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… However, more information on such cases should be accumulated in the future since there is also a report describing distant metastasis to the sternum “3” years after surgery and metastasis to mesenteric lymph nodes at “11” years ( 6 ). …

Where Is the 'Oma' in Multiple Myeloma? Origins and Limitations of some Myeloma-Related Terminology.

BackgroundMultiple myeloma, often simply called 'myeloma', is a clonal plasma cell malignancy that constitutes about one-tenth of all cancers managed by haematologists. Although the disease was first clearly described in the first half of the 19th century, it was only called multiple myeloma several decades later.AimsThis review summarizes myeloma-related terminology.ContentSeveral terms are commonly used in myeloma clinics, including paraprotein, immunoglobulins, kappa and lambda chains and plasma cells; other terms, such as dysproteinemia, are now less commonly used.SummaryIn this review, we

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… The first use of ‘multiple myeloma’ was by the obscure pathologist von Rusitzky in Kyiv in 1873 in a description of eight separate bone tumours thought to be arising from the marrow in a 47‐year‐old patient who presented with swelling of the temple, sternum and ribs [ 2 , 3 ]. …

Whole-body MRI for a patient with progressive multiple myeloma.

Multiple Myeloma represents a plasma cell disorder that can result in hallmark bony destructive change in addition to other signs of myelomatous disease. Imaging often helps in establishing the diagnosis and staging the patient. There are several different imaging modalities that can provide different levels of insight into the disease extent. We report a unique case of multiple myeloma where the progressive nature of the patient's disease highlights the strengths and limitations of the different imaging approaches. Whole-body MRI represents a noncontrast imaging technique that directly images

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… This included multiple hyper-metabolic findings within the liver in addition to extensive osseous involvement: (1) ribs with associated expansile and destructive soft tissue, (2) ilium, (3) sternum, (4) scapula, and (5) spine ( Figure 5B ). …

NTP Toxicology and Carcinogenesis Studies of Methyl Bromide (CAS: 74-83-9) in B6C3F1 Mice (Inhalation Studies).

Methyl bromide is widely used as a fumigant and pesticide. Toxicology and carcinogenesis studies were conducted by exposing groups of male a … there was an increase in the incidence of several nonneoplastic lesions in the brain, heart, bone (sternum), and nose. Degenerative changes in the cerebellum and cerebrum occurred in males and females exposed to 100 ppm. Myocardial degeneration and cardiomyopathy were observed in the hearts of mice exposed to 100 ppm. An increased incidence of sternal dy …

Successful sequential application of CAR T-cell-therapies in relapsed refractory multiple myeloma.

We here report on a patient with relapsed-refractory multiple myeloma (RRMM) who received chimeric antigen receptor (CAR) T-cells (Ciltacabtagene Autoleucel, cilta-cel, Carvykti®) after achieving a partial but not durable remission with Idecabtagene Vicleucel (ide-cel, Abecma®). Both CAR T-cells target the B-cell maturation antigen (BCMA) and their sequential use is as yet rare, thus data on safety and efficacy of their sequential employment are precious and relevant for the myeloma commmunity.

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… Our now 59-year-old patient was diagnosed with lambda light chain (LC) MM in 10/2015, suffering from hypercalcemia and diffuse osteolyses of the left acetabulum, ilium, sternum, thoracic spine, and scapulae (2/4 CRAB criteria). …