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Results of a quality control on non-interventional studies.

Non-interventional studies (NIS) have for decades been an established part of post-authorisation medicinal research. As early as the mid-nineties, there were at least rudimentary demands for controllable data quality. Beginning with the recommendations of the Federal Institute for Drugs and Medical Devices (BfArM) on the execution of non interventional (observational) studies of 1998 and finally with the guidelines and recommendations for ensuring Good Epidemiological Practice (GEP), with the VFA (Verband der forschenden Arzneimittelhersteller [German Association of Research-Based Pharmaceutic

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ROS 2020 Abstract

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… Abstract ID: 51 Clinical audit/service evaluation Subcategory: DXA Are DXA scans in the older adult clinically important? … Abstract ID: 76 Clinical audit/service evaluation Subcategory: Fracture risk UK FRAX Vs. …

агитационные рамки ИИ, связывающие языковые модели с электронными медицинскими записями, и график биомедицинских знаний для реальных доказательств.

Доступ к крупномасштабным клиническим и биомедицинским базам данных по-прежнему является серьезным препятствием для клинических и научных работников, требующим значительных вычислительных знаний. Агентские системы искусственного интеллекта, в которых крупные языковые модели (МПМ) организуют многоэтапное рассмотрение и выполнение запросов под интерактивным контролем человека, открывают возможности для демократизации доступа к данным и ускорения процесса получения доказательств. MethodsWe применяли Типовой контекстный протокол (МКП) для интеграции в рамках одного агентского рабочего процесса ста

Proceedings of the RAMI Intern Section Meeting.

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… Audit of the quality of consent form completion in the Temple Street Children’s University Hospital Poppleton D 1 , Somanadhan S 2 , O’Connor C 3 , Day P 4 1 Medical Intern (SVUH); 2 Clinical Audit Facilitator; 3 Nurse Practice Development Unit; 4 Risk & Legal Services Aim: To audit quality of consent … Constantinou,S. & Dimitriadis, A.P.( 2012) Audit of the quality of consent form completion and improvement of practice, Clinical Audit, September 2012. …

Assessment of errors in death certification and mortality patterns and trends among medical patients at Korle Bu Teaching Hospital, 2019-2023.

ObjectivesThis study audited the Medical Certification of Cause of Death (MCCD) forms issued at Korle-Bu Teaching Hospital, assessing their accuracy, completeness, and consistency while analysing trends in mortality causes.DesignRetrospective review of completed MCCD forms.SettingKorle-Bu Teaching Hospital, Department of Medicine.ParticipantsAll duplicate MCCD forms issued between January 1st, 2019, and December 31st, 2023, were included.InterventionsNo intervention.Main outcome measuresFrequency of major and minor errors in completing the MCCD forms and leading causes of death in the departme

Рамки качества " Эхокардиографии " : всеобъемлющий подход к обеспечению качества и непрерывному совершенствованию услуг с учетом интересов пациентов.

Система качества " Echocardicography Framework " (EQF) представляет собой уникальный, всеобъемлющий, целостный подход к совершенствованию всех аспектов службы эхокардиографии. EQF представляет собой ориентированную на пациентов программу, объединяющую обеспечение качества и непрерывное совершенствование обслуживания. Эта рамочная основа охватывает следующие показатели: i) качество эхокардографии, ii) воспроизводимость и последовательность, iii) образование и профессиональная подготовка и iv) обратная связь с клиентами. EQF масштабируется и адаптируется для использования любой эхокард

Drotrecogin alfa (activated): real-life use and outcomes for the UK.

IntroductionIn March 2001, the results of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study were published, which indicated a 6.1% absolute reduction in 28-day mortality. Drotrecogin alfa (activated; DrotAA) was subsequently approved for use in patients with severe sepsis.MethodsIn December 2002, critical care units in England, Wales and Northern Ireland were invited to participate in an audit of DrotAA. Data for each infusion of DrotAA were linked to case mix and outcome data from a national audit. Use of DrotAA was described and a nonrandomized c

Alcohol use, intentions to reduce consumption, and perceived motivations and barriers among cancer survivors.

PurposeTo characterize alcohol use patterns, awareness of alcohol's oncologic risks, and efforts and intentions to reduce consumption among cancer survivors in New Hampshire and Vermont.MethodsCross-sectional survey of 471 cancer survivors aged ≥21 years enrolled in two state-wide, online panels. Participants reported their current or former alcohol use, completed the Alcohol Use Disorders Identification (AUDIT), and replied to a series of items regarding any efforts to reduce consumption and related motivations and barriers.ResultsAmong 471 survivors, 34.2% of which had an alcohol-related can

Measuring quality of life in people living with and beyond cancer in the UK.

PurposeThe aim of this study was to identify the most appropriate measure of quality of life (QoL) for patients living with and beyond cancer.MethodsOne hundred eighty-two people attending cancer clinics in Central London at various stages post-treatment, completed a series of QoL measures: FACT-G, EORTC QLQ-C30 , IOCv2 (positive and negative subscales) and WEMWBS, a wellbeing measure. These measures were chosen as the commonest measures used in previous research. Correlation tests were used to assess the association between scales. Participants were also asked about pertinence and ease of com

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… Therefore, research projects and clinical audit projects serve different purposes with the latter forming part of the continuous quality improvement process [ 22 ]. … Walshe K Principles for best practice in clinical audit Qual Saf Health Care 2002 11 4 392 392 10.1136/qhc.11.4.392 23. …

[Psychiatric manifestations of lupus erythematosus systemic and Sjogren's syndrome].

UNLABELLED: We present one case of Sjögren's syndrome (SS) secondary to systemic lupus erythematosus (SLE) with predominant psychiatric manifestations, treated with success by cyclophosphamide. From this case, we review the psychiatric aspects of these two autoimmune diseases as described in the literature and we present the etiopathogenic hypothesis and treatment of the psychiatric disorders. Case report--In August 1996, a 38 year old man was admitted in our psychiatric department for agitation. Primary SS had been diagnosed in July 1996. He had previously attempted to suicide but was never h

Профессиональная реабилитация лиц с множественным склерозом в национальной системе здравоохранения Соединенного Королевства: оценка реального положения.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Имеются ограниченные данные о том, каким образом профессиональная реабилитация лиц с множественным склерозом (МС) может осуществляться через Национальную службу здравоохранения (НСЗ) Соединенного Королевства (Соединенное Королевство) и как она работает. AIM: Уяснить механизмы и контекст осуществления VR-терапии для лиц, имеющих MS в ГСЗ, и разработать теорию пояснительных программ. МЕТОДЫ: Реалистичная оценка, включая обзор доказательств, а затем полуструктурированные собеседования. Был проведен реалистический обзор VR для лиц, имеющих MS в НСЗ six Электронные базы данны

Abstracts from the 13th International Conference for Healthcare and Medical Students (ICHAMS).

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… Methods: Clinical audit of 327 adult patients who received a CI between January 1, 2009, and November 31, 2019, at National Hearing Implant and Research Centre in Ireland. Prospectively collected data was extracted from patient records. …

Continuous non-invasive monitoring of the skin temperature of HSCT recipients.

Goals of workEmpirical antibiotic therapy usually started in patients who are neutropenic following treatment with cytostatic chemotherapy for a haematological malignancy as soon as fever develops to forestall fulminant sepsis. Hence, accurate and timely detection of fever is crucial to the successful management of infectious complications in these patients. We report an investigation of the feasibility and validity of continuous non-invasive body temperature measurement.Patients and methodsThe feasibility of non-invasive continuous measurement of the skin temperature was investigated using th

CARBOMETASPINE: protocol for a multicenter, prospective, randomized controlled trial of carbonfiber spinal fixation in metastatic disease.

BACKGROUND: Spinal metastases frequently cause neurological compromise and mechanical instability. Titanium fixation limits postoperative imaging and hinders stereotactic body radiotherapy (SBRT) planning because of artefacts. METHODS: CARBOMETASPINE is a multicentre, prospective, randomised controlled trial. A total of 226 adults with unstable or epidurally infiltrating spinal metastases will be randomised 1 : 1 : 1 to: (I) carbonfibre/PEEK fixation + postoperative SBRT (5 × 5 Gy); (II) titanium fixation + postoperative SBRT; (III) preoperative SBRT + titanium fixation. The primary endpoint i

Pharmaceutical expenditure on drugs for rare diseases in Canada: a historical (2007-13) and prospective (2014-18) MIDAS sales data analysis.

BackgroundHealth Canada has defined rare diseases as life-threatening, seriously debilitating, or serious chronic conditions affecting a very small number of patients (~1 in 2,000 persons). An estimated 9 % of Canadians suffer from a rare disease. Drugs treating rare diseases (DRDs) are also known as orphan drugs. While Canada is currently developing an orphan drug framework, in the United States (US), the Orphan Drug Act (ODA) of 1983 established incentives for the development of orphan drugs. This study measured total annual expenditure of orphan drugs in Canada (2007-13) and estimated futur

Bone metastases: Are we failing our patients?

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Symptom Management Guideline Implementation Among Nurses in Cancer-Specific Outpatient Settings: A Scoping Review of Barriers, Facilitators, and Implementation Strategies.

BackgroundOncology outpatients experience high levels of distressing cancer-related symptoms. Nurses can provide high-quality outpatient cancer symptom management following clinical practice guideline recommendations; however, these guidelines are inconsistently used in practice. Understanding contextual factors influencing implementation is necessary to develop tailored implementation strategies.ObjectivesTo identify and describe (1) barriers and facilitators influencing symptom management guideline adoption, implementation, and/or sustainability among nurses in cancer-specific outpatient set

Multisite Quality Improvement Initiative to Identify and Address Racial Disparities and Deficiencies in Delivering Equitable, Patient-Centered Care for Multiple Myeloma-Exploring the Differences between Academic and Community Oncology Centers.

Treatment of multiple myeloma (MM) is complex; however, with equal access to care, clinical outcomes for Black patients match those in other patient groups. To reveal and begin to address clinical practice barriers to equitable, patient-centered MM care, this quality improvement (QI) initiative assessed patient electronic medical records (EMRs) and surveyed patients and providers at two large hospital systems and four community-based practices. For the educational intervention, providers participated in feedback-focused grand rounds sessions to reflect on system barriers and develop action pla

Quality indicators and development targets in the national clinical quality registries in cancer care and screening.

BackgroundThe Danish clinical quality registries monitor and improve the quality of care, using quality indicators and defined development targets referred to as 'standards'. This study aims to investigate the fulfilment of standards in the Danish clinical quality registries in cancer care and screening.MethodsData was included from annual reports in the 27 Danish clinical quality registries in cancer care and screening. The most recent report from each registry was downloaded the 13 December 2023. Indicators were included if: evaluating care or screening over 12 months, presenting a well-defi