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Primary Repair of Complete Quadriceps Tendon Rupture with Extensor Mechanism Deficit.

BACKGROUND: Whereas partial quadriceps tendon ruptures may be treated nonoperatively if the extensor mechanism remains functional, complete … g the longitudinal axis of the patella. The knee is placed in full extension, with a bump under the heel in order to provide slight recurvatum at the knee and to allow for a properly tensioned repair. In pairs, the free ends of the sutures are passed through the tunnels. The sutures are tensioned and tied together in pairs at the distal aspect of the p …

mHealth-Supported Exercise Rehabilitation to Reverse Frailty After Autologous Transplantation in Multiple Myeloma: Randomized Controlled Trial.

BACKGROUND: Frailty is highly prevalent in survivors of multiple myeloma (MM) after autologous hematopoietic cell transplantation and is associated with poor functional recovery and adverse clinical outcomes. Although exercise is known to improve physical function, traditional center-based rehabilitation models are often inaccessible to this population during early posttransplant recovery. Mobile health (mHealth)-supported exercise may offer a scalable alternative; however, evidence in hematologic malignancies remains limited. OBJECTIVE: This study aimed to evaluate the effects of a 16-week m

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… We evaluated timed balance under three conditions: (1) side-by-side stand with both feet placed on the ground for 10 seconds or when the participant steps out of position, (2) semitandem stand with the side of the heel of one foot touching the big toe of the other foot for 10 seconds or when the participant … steps out of position, and (3) tandem stand with the heel of one foot touching the big toe of the other foot for 10 seconds or when the participant steps out of position. …

Effects of Physical Exercise Intervention on Psychological and Physical Fitness in Lymphoma Patients.

Background and objectives: Lymphoma patients experience a psychological and physiological decline that could be reversed by exercise. However, little is known about the effects of the exercise on psychological and physical fitness variables. Therefore, the purpose of this longitudinal study was to assess self-efficacy, fatigue and physical fitness before and after an eight-week exercise intervention. Materials and Methods: Thirty-six participants (54.4 ± 19.1 years) performed a supervised exercise program (~60 min, 2d·wk-1). Each session included a combined progressive training of cardiorespir

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… Participants stood on the floor with arms in the neutral position, heels together, knees and back straight. Then they bent toward the right/left with elbow and fingers straight and attached hand on their lateral side of leg. … The trial ended when the heel of the involved leg touched the floor, the hands came off the hips, or the opposite foot was removed from the stance leg. This test was conducted with eyes opened only. The participants performed three attempts and the best time (section.) was recorded for analysis. …

Italian Real-Life Experience of Patients with Hereditary Transthyretin Amyloidosis Treated with Patisiran.

Hereditary transthyretin amyloidosis (ATTRv) is a multisystemic, rare, inherited, progressive and adult-onset disease, affecting the sensorimotor nerves, heart, autonomic function and other organs. The actual scenario of pharmaceutical approaches for ATTRv amyloidosis includes five main groups: TTR stabilizers, TTR mRNA silencers, TTR fibril disruptors, inhibitor of TTR fibril seeding and gene therapy. Patisiran is a small, double-stranded interfering RNA encapsulated in a lipid nanoparticle, able to penetrate into hepatocytes, where it selectively targets TTR mRNA, reducing TTR production. We

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… He was unable to walk on his heels or toes. … The neurological examination showed a mild broad-based gait, with inability to tandem walk or walk on his toes, and difficulties in walking on his heels. Romberg sign was negative; the left thenar muscle was hypotrophic. …

'Unpacking' pathways to lymphoma and myeloma diagnosis: Do experiences align with the Model of Pathways to Treatment? Findings from a UK qualitative study with patients and relatives.

ObjectivesTo explore alignment of experiences before lymphoma and myeloma diagnosis with the appraisal, help seeking and diagnostic intervals in the Model of Pathways to Treatment (MPT).DesignA qualitative study using in-depth semistructured interviews with patients and relatives. Interviews were transcribed verbatim, anonymised and analysed using qualitative description.SettingA UK population-based haematological malignancy patient cohort.ParticipantsFifty-five patients (35 lymphoma, 20 myeloma: diagnosed 2014-2016) and 28 relatives participated, within around a year of the patient's diagnosi

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… Some relatives said they adapted their own behaviour to accord with the patient, often over long time periods: ‘patient’s) height loss, was gradual, at first, so, I noticed…I stopped buying shoes with heels, because I was getting to be, you know, too tall (for him) when I was wearing shoes with heels …

Induction of Pro-Apoptotic Endoplasmic Reticulum Stress in Multiple Myeloma Cells by NEO214, Perillyl Alcohol Conjugated to Rolipram.

Despite the introduction of new therapies for multiple myeloma (MM), many patients are still dying from this disease and novel treatments are urgently needed. We have designed a novel hybrid molecule, called NEO214, that was generated by covalent conjugation of the natural monoterpene perillyl alcohol (POH), an inducer of endoplasmic reticulum (ER) stress, to rolipram (Rp), an inhibitor of phosphodiesterase-4 (PDE4). Its potential anticancer effects were investigated in a panel of MM cell lines. We found that NEO214 effectively killed MM cells in vitro with a potency that was over an order of

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… In this context, ER stress has been considered the Achilles’ heel of MM [ 12 ]. We have been studying approaches to further aggravate chronic ER stress in cancer cells in order to achieve optimized tumor cell killing. … Endoplasmic reticulum stress and the unfolded protein response: Targeting the Achilles heel of multiple myeloma Mol. Cancer Ther. 2013 12 831 843 10.1158/1535-7163.MCT-12-0782 23729400 13. Schönthal A.H. Chen T.C. Hofman F.M. Louie S.G. Petasis N.A. …

Apoprotein E epsilon4 allele ассоциируется с лучшим языком выступления и визуальной памятью в спинномозговой атаксии типа 3.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Регулирующая роль аполипопротеина E (APOE) 4 аллеля в клинических проявлениях спинномозговой атаксии типа 3 (SCA3) остается неясной. Цель этого исследования заключалась в оценке воздействия аллея APOE 4 на когнитивные и моторные функции пациентов SCA3. В этом исследовании приняли участие 281 пациент, не связанный с системой SCA3, и 182 пациента. Генотипы APOE были проанализированы с использованием PCR амплификации в сочетании с последовательностью Sanger. Кроме того, 96 пациентов SCA3 были набраны для оценки нейропсихологических и моторных функций. Нейропсихологические ф

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… SARA evaluates eight primary symptoms: gait, stance, sitting, speech disturbance, finger chase, nose‐finger test, fast alternating hand movements, and heel‐shin slide [ 28 ]. … | 1.77 (1.15) | 0.806 Finger chase | 1.04 (0.62) | 0.68 (0.52) | 0.053 | 0.67 (0.61) | 1.00 (0.31) | 0.259 Nose‐finger tese | 1.08 (1.00) | 0.84 (0.70) | 0.513 | 1.00 (1.10) | 0.91 (0.80) | 1.000 Fast alternating hand movements | 0.92 (0.64) | 0.93 (0.75) | 0.979 | 1.42 (0.80) | 1.21 (0.70) | 0.336 Heel‐shin …

Multi-focal Lytic Lesions in a Patient with Myelofibrosis: A Case Report.

Myelofibrosis is a rare disorder that is classified as one of the myeloproliferative disorders. This particular disorder results in the abnormal proliferation of hematopoietic stem cells in the bone marrow. In some cases, such as ours, pathologic fractures can occur due to skeletal manifestations. We report on a rare finding of rapidly progressive lytic lesions in multiple regions throughout the body. This presentation of myelofibrosis behaving in a metastatic-like fashion has not been previously described.

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… During radiation treatment for his right proximal femur, he developed progressively worsening right heel pain. Over several months, it became swollen and allodynic. Radiographs demonstrated a subtle, postero-superior calcaneal lucency (Figure 3A ). …

European guidance for the diagnosis and management of osteoporosis in postmenopausal women.

UnlabelledGuidance is provided in a European setting on the assessment and treatment of postmenopausal women at risk of fractures due to osteoporosis.IntroductionThe International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis published guidance for the diagnosis and management of osteoporosis in 2008. This manuscript updates these in a European setting.MethodsSystematic literature reviews.ResultsThe following areas are reviewed: the role of bone mineral density measurement for the diagnosis of osteoporosis and assessment of fr

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… | QCT | −2.5 | Osteoporosis | 50 Spine | Lateral DXA | −2.2 | Low bone mass | 38 Spine | DXA | −1.3 | Low bone mass | 14 Forearm | DXA | −1. 4 | Low bone mass | 12 Heel | Achilles | −1.5 | Low bone mass | 11 Total hip | DXA | −0.9 | Normal | 6 Heel | Sahara | −0.7 | Normal | 3 These considerations … Most studies suggest that measurements of broadband ultrasound attenuation or speed of sound at the heel are associated with a 1.5- to 2-fold increase in risk for each standard deviation decrease in the measured variable [ 32 , 54 ]. …

Neuromuscular electrical stimulation for physical function maintenance during hematopoietic stem cell transplantation: Study protocol.

Hematopoietic stem cell transplantation is a common life-saving treatment for hematologic malignancies, though can lead to long-term functional impairment, fatigue, muscle atrophy, with decreased quality of life. Although traditional exercise has helped reduce these effects, it is inconsistently recommended and infrequently maintained, and most patients remain sedentary during and after treatment. There is need for alternative rehabilitation strategies, like neuromuscular electrical stimulation, that may be more amenable to the capabilities of hematopoietic stem cell transplant recipients. Pat

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… Each participant begins with the semi-tandem stand, in which the heel of one foot is placed to the side of the first toe of the other foot, with the participant choosing which foot to place forward. … Those able to maintain the semi-tandem position for 10 seconds are further evaluated with the feet in full tandem position, with the heel of one foot directly in front of the toes of the other foot. …

Multidimensional analysis of screening results of deafness susceptibility genes in 3066 newborns of different altitudes and nationalities in Xining, Qinghai(ISRCTN89197487).

OBJECTIVE: In Xining City, Qinghai Province, which is located in a high-altitude hypoxic environment, this study employs high-throughput seq … h the full informed consent of the participants, the team systematically and continuously collected heel blood samples from multi-ethnic newborns living in areas at different altitudes, and successfully obtained 3,615 complete blood samples required for the study. Subsequently, high-throughput sequencing technology was applied to detect these samples, …

Surgical versus non-surgical interventions for displaced intra-articular calcaneal fractures.

BACKGROUND: Fractures of the calcaneus (heel bone) comprise up to 2% of all fractures. These fractures are mostly caused by a fall from a height, and are common in younger adults. Treatment can be surgical or non-surgical; however, there is clinical uncertainty over optimal management. This is an update of a Cochrane Review first published in 2013. OBJECTIVES: To assess the effects (benefits and harms) of surgical versus conservative treatment of displaced intra-articular calcaneal fractures. SEARCH METHODS: We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register, C…

Patient and lay carer education for preventing pressure ulceration in at-risk populations.

BACKGROUND: Pressure ulcers (PUs) are injuries to the skin and underlying tissues that occur most commonly over bony prominences, such as the hips and heels as a result of pressure and shear forces. PUs cause pain, discomfort, longer hospital stays, and decreased quality of life. They are also very costly to treat and consume substantial parts of healthcare budgets. PUs are largely preventable, and education targeted at patients and their carers is considered important. OBJECTIVES: To assess the effects of patient and/or lay carer education on preventing pressure ulceration in at-risk people,…

Tatami Mats: A Source of Pitted Keratolysis in a Martial Arts Athlete?

Dear Editor, Pitted keratolysis (PK), also known as keratosis plantaris sulcatum, is a non-inflammatory, bacterial, superficial cutaneous in … d with asymptomatic, malodorous punched-out pits and erosions along with hyperkeratotic skin on the heel and metatarsal region of the plantar aspect of both feet. The arches, toes, and sides of the feet were spared (Figure 1). Except for these skin changes, the patient was healthy and denied any other medical issues. He was an athlete active in martial …

Development of a Mindfulness-Based Stress Reduction Program for Hematologic Malignancy Patients: A Delphi Study.

PurposeHematologic malignancies (HM) are a group of malignant clonal diseases that pose significant treatment challenges and adversely impact patient survival and quality of life. This study aimed to develop a Mindfulness-Based Stress Reduction (MBSR) program specifically for HM patients and to refine it for application in China.Patients and methodsA research team comprised of nursing directors, psychology experts, and other professionals was established, and then a literature review was conducted to assemble information needed to develop the MBSR intervention protocol. Following this, a Delph

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… With each inhalation, lift one foot, and with each exhalation, take a half step forward, starting with the right foot so that the heel of your right foot is parallel to the toes of your left foot. Ensure that the heel and sole of your foot touch the ground before your toes. … Become increasingly aware of the contact of your heel, sole, and toes with the floor/ground. All your attention and awareness are focused on your breath synchronized with the movement of your legs. Inhale through the nose. Lift one foot on the inhale and let it touch the ground on the exhale. …

Extracorporeal Shock Wave Therapy for the Treatment of Musculoskeletal Pain: A Narrative Review.

UNLABELLED: Extracorporeal shock waves are high-intensity mechanical waves (500-1000 bar) of a microsecond duration with a morphology characterized by a rapid positive phase followed by a negative phase. BACKGROUND: Extracorporeal shock waves have been used for pain treatment for various sub-acute and chronic musculoskeletal (MSK) problems since 2000. The aim of this article is to update information on the role of extracorporeal shock wave therapy (ESWT) in the treatment of various pathologies that cause MSK pain. METHODS: Given that in the last two years, articles of interest (including sys

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… Role of ESWT in Plantar Fasciitis Plantar fasciitis is a clinical diagnosis that involves pain in the heel, which may affect the inner or outer area of the heel and increases with standing and walking [ 63 ]. …

Feasibility of whole body vibration during intensive chemotherapy in patients with hematological malignancies - a randomized controlled pilot study.

BackgroundHospitalized cancer patients undergoing intensive or high-dose chemotherapy often experience a considerable decline in functional performance associated with the increased risk of adverse health events. Exercises, particularly resistance-based exercises that may counteract this decline are restricted by therapy-related side effects. Since whole body vibration (WBV) is known to efficiently stimulate the neuromuscular system without significantly raising blood pressure, we hypothesize that especially WBV is particularly feasible even during intensive or high-dose chemotherapy (primary

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… The IG’s exercise protocol included three sets of two to four different exercises (static and dynamic squats, heel raise and combination of both) on the Galileo® Sport vibration platform (Novotec Medical GmbH, Pforzheim, Germany) which is adjustable in steps of 0.5 Hz within a range of 5–30 Hz. … If patients couldn’t maintain the forefoot position throughout the exercise period, we supported their stance position via a heel foam wedge. The CG performed aerobic exercises on a bicycle ergometer. Exercise sessions also lasted up to 20 min with the same intensity prescription as the IG. …

Integrating imaging and biomarker assessment to better define psoriatic arthritis and predict response to biologic therapy.

The treatment options for PsA have substantially expanded over the last decade. Approximately 40% of patients will not respond to first-line anti-TNF-α therapies. There is limited data to help clinicians select the most appropriate biologic therapy for PsA patients, including guidance for decisions on biologic therapy switching. In this review we will examine the current understanding of predictors of response to treatment. Imaging technology has evolved to allow us to better study psoriatic disease and define disease activity, including synovitis and enthesitis. Enthesitis is implicated in th

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… The OMERACT MRI in enthesitis initiative: definitions of key pathologies, suggested MRI sequences, and a novel heel enthesitis scoring system. J Rheumatol 2019;46:1232–8. 61. Terslev L, Naredo E, Iagnocco A. et al. ; Outcome Measures in Rheumatology Ultrasound Task Force. … Atlas of the OMERACT Heel Enthesitis MRI Scoring System (HEMRIS). RMD Open 1975;24:1639–41. 63. De Miguel E, Cobo T, Muñoz-Femández S. et al. Validity of enthesis ultrasound assessment in spondyloarthropathy. Ann Rheum Dis 2009;68:169–74. 64. Balint PV, Kane D, Wilson H, McInnes IB, Sturrock RD.. …

Wnt inhibitors reduce the unfolded protein response and enhance bortezomib-induced cell death in multiple myeloma.

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… Endoplasmic reticulum stress and the unfolded protein response: targeting the Achilles heel of multiple myeloma. Mol Cancer Ther. 2013;12(6):831–843. doi: 10.1158/1535-7163.MCT-12-0782. 19. …

Extra-Axial Skeletal Metastasis of Malignant Melanoma: Case Report and Literature Review.

The incidence of malignant melanoma is increasing worldwide and is one of the major causes of skin cancer deaths in the United States. Although melanoma has the potential to metastasize to any organ, the incidence of bone metastasis is low (~25%) compared to liver or lung metastasis. However, when a bone is involved, metastasis occurs to the axial skeleton in most cases (80%-90%), and involvement of the appendicular skeleton is relatively rare. We here describe the case of a patient who presented with a pathological fracture due to extra-axial skeletal metastasis of a widespread malignant mela

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… 37 3 | Gómez-León N et al. [ 8 ] | 38 | F | Mild local pain | NA/Malignant melanoma | Knee | BRAF inhibitors | 24 4 | Herrera-Perez M et al. [ 11 ] | 39 | M | Pain | Abdominal flank/ Malignant melanoma | Distal tibia | Chemotherapy + local radiotherapy | NA 5 | Huang KY et al. [ 12 ] | 67 | F | NA | Heel …