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Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research.

Lower urinary tract dysfunction (LUTD) is nearly ubiquitous in men of advancing age and exerts substantial physical, mental, social, and financial costs to society. While a large body of research is focused on the molecular, genetic, and epigenetic underpinnings of the disease, little research has been dedicated to the influence of environmental chemicals on disease initiation, progression, or severity. Despite a few recent studies indicating a potential developmental origin of male LUTD linked to chemical exposures in the womb, it remains a grossly understudied endpoint in toxicology research

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… Morales O., Romanus R. Urethrography in the male: The boundaries of the different urethral parts and detail studies of the urethral mucous membrane and its motility. J. Urol. 1955;73:162–171. doi: 10.1016/S0022-5347(17)67380-4. 86. … Dillner K., Kindblom J., Flores-Morales A., Pang S.T., Tornell J., Wennbo H., Norstedt G. Molecular characterization of prostate hyperplasia in prolactin-transgenic mice by using cDNA representational difference analysis. Prostate. 2002;52:139–149. doi: 10.1002/pros.10102. 194. …

Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease.

Patients with multiple myeloma, an incurable malignancy of plasma cells, frequently develop osteolytic bone lesions that severely impact quality of life and clinical outcomes. Eliglustat, a U.S. Food and Drug Administration-approved glucosylceramide synthase inhibitor, reduced osteoclast-driven bone loss in preclinical in vivo models of myeloma. In combination with zoledronic acid, a bisphosphonate that treats myeloma bone disease, eliglustat provided further protection from bone loss. Autophagic degradation of TRAF3, a key step for osteoclast differentiation, was inhibited by eliglustat as ev

Inherited Platelet Disorders: An Updated Overview.

Platelets play a major role in hemostasis as ppwell as in many other physiological and pathological processes. Accordingly, production of about 1011 platelet per day as well as appropriate survival and functions are life essential events. Inherited platelet disorders (IPDs), affecting either platelet count or platelet functions, comprise a heterogenous group of about sixty rare diseases caused by molecular anomalies in many culprit genes. Their clinical relevance is highly variable according to the specific disease and even within the same type, ranging from almost negligible to life-threateni

PROCEEDINGS 32nd Symposium ESVN-ECVN WROCLAW, POLAND 12th-14th September 2019. Selected research communications of the 32nd Symposium of the ESVN-ECVN Wroclaw, Poland 12th to 14th September 2019.

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… Morales 4 , M. Lowrie 5 , I. … Morales 2 , A. Parry 1 , I. …

Social support and care burden in family caregivers of patients with hematologic malignancies: a parallel mediation model of coping strategies.

ObjectiveWith the rising incidence of hematologic malignancies (HMs) in recent years, caregivers of HMs patients have increasingly emerged as a significant factor affecting the treatment of these conditions. This study aimed to explore the association of coping strategies on the relationship between care burden and social support among family caregivers of HMs patients.MethodologyA questionnaire survey was conducted involving 207 family caregivers of hospitalized HMs patients in a tertiary hospital in Dalian from October 2023 to May 2024 and 200 valid responses were collected. We used hierarch

Метод пилатеса как биопсихосоциальное вмешательство на современном рабочем месте: систематический обзор физических, психических и профессиональных пособий.

Справочная информация/задачи: На здоровье и производительности рабочей силы существенно сказываются связанные с работой расстройства мускулоскелета (ВМСД) и профессиональный стресс. Цель этого систематического обзора заключалась в обобщении данных об эффективности метода пилатеса как биопсихосоциального вмешательства для работников, а также в изучении его воздействия на физические, психологические и профессиональные результаты. Методы: Был проведен систематический поиск по основным электронным базам данных и поисковым системам (PubMed, Scopus, Web of Science, PEDro и Google Scientific) после P

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… Ferri-Morales A. Torres-Costoso A.I. Cavero-Redondo I. Martínez-Vizcaíno V. Pilates Method Improves Cardiorespiratory Fitness: A Systematic Review and Meta-Analysis J. Clin. Med. 2019 8 1761 10.3390/jcm8111761 31652806 PMC6912807 41. Maslach C. Leiter M.P. …

Voices of Survivorship: The Unmet Needs of Italian Cancer Survivors. A Qualitative Study.

BackgroundThe increasing number of cancer survivors (CSs) globally highlights the critical need for healthcare systems to address their unmet needs. These needs span physical, psychosocial, spiritual, informational, and practical dimensions and, if unaddressed, can impact quality of life and healthcare satisfaction.AimsThis study aimed to identify and understand the unmet needs of CSs in Italy to guide the development of patient-centered survivorship care services.MethodsA cross-sectional qualitative study was conducted between April 2023 and January 2024 at the Comprehensive Cancer Centre of

Simple, Effective and Validated. VTE CASE Risk Assessment Score for Venous Thromboembolism in Metastatic Germ Cell Tumour Patients Before First-Line Chemotherapy.

BackgroundVenous thromboembolism (VTE) may jeopardise excellent treatment results of germ cell tumours (GCT). We previously constructed a VTE risk score for GCT patients qualified for first-line chemotherapy (CTH), including vein compression, clinical stage (CS) and haemoglobin concentration.AimValidating our score in a separate cohort and establishing the cut-off point for the score. Re-assessing the numerical score in the training cohort.Materials and methodsWe retrospectively analysed a new cohort of GCT patients staged IS-IIIC. Area under the curve of receiver-operating characteristic (AUC

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… Tran B., Ruiz‐Morales J. …

High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial.

UNLABELLED: High-dose intravenous vitamin C (HDIVC) administered to produce pharmacologic concentrations shows promise in preclinical models and small clinical trials, but larger prospective randomized trials are lacking. We evaluated the clinical benefit of combining HDIVC with docetaxel in patients with progressive metastatic castration-resistant prostate cancer (mCRPC). In this double-blind, placebo-controlled phase II trial, 47 patients were randomized 2:1 to receive docetaxel (75 mg/m2 i.v.) with either HDIVC (1 g/kg) or placebo. Coprimary endpoints were PSA50 response and adverse event r

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… Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, Furqan M, et al. O 2 − and H 2 O 2 − mediated disruption of Fe metabolism causes the differential susceptibility of NSCLC and GBM cancer cells to pharmacological ascorbate. Cancer Cell 2017;31:487–500.e8. 26. …

Церковная боль и воздействие на качество жизни пациентов с множественным склерозом.

Основная цель этого исследования заключалась в оценке воздействия шейной боли на качество жизни пациентов с множественным склерозом по сравнению с группой здоровых людей (без болезней центральной нервной системы). Материалы и методы: В период с ноября 2023 года по август 2024 года данные были собраны в специализированном госпитале Сент-Лукаша в Коньском (Польша). Критерием включения в это исследование были следующие: возраст (20-50 лет), женщины и мужчины, здоровые люди (без болезней центральной нервной системы) и люди, страдающие множественным склерозом. Лицам из исследовательской группы был

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… Martinez-Calderon J., Flores-Cortes M., Morales-Asencio J.M., Luque-Suarez A. Which psychological factors are involved in the onset and/or persistence of musculoskeletal pain? An umbrella review of systematic reviews and Meta-analyses of prospective cohort studies. Clin. J. …

Ebastine exerts antitumor activity and induces autophagy by activating AMPK/ULK1 signaling in an IPMK-dependent manner in osteosarcoma.

Numerous studies have confirmed that in addition to interfering with the tumor inflammatory environment, anti-inflammatory agents can directly increase apoptosis and sensitivity to conventional therapies and decrease invasion and metastasis, making them useful candidates for cancer therapy. Here, we first used high-throughput screening and had screened one compound candidate, ebastine (a H1-histamine receptor antagonist), for osteosarcoma therapy. Cell viability assays, colony formation assays, wound healing assays, and Transwell assays demonstrated that ebastine elicited antitumor effects in

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… Phytother Res 2019 33 1794 804 30993793 10.1002/ptr.6367 42 Jia J Abudu YP Claude-Taupin A Gu Y Kumar S Choi SW Galectins control MTOR and AMPK in response to lysosomal damage to induce autophagy Autophagy 2019 15 169 71 30081722 10.1080/15548627.2018.1505155 PMC6287685 43 Kim M Jung J-Y Choi S Lee H Morales …

Development, acceptability and uptake of an on-line communication skills education program targeting challenging conversations for oncology health professionals related to identifying and responding to anxiety and depression.

BackgroundAnxiety and depression screening and management in cancer settings occurs inconsistently in Australia. We developed a clinical pathway (ADAPT CP) to promote standardized assessment and response to affected patients and enhance uptake of psychosocial interventions. Health professional education is a common strategy utilised to support implementation of practice change interventions. We developed an interactive on-line education program to support staff communication and confidence with anxiety/depression screening and referral prior to the ADAPT CP being implemented in 12 oncology ser

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… The lack of organisational support for training impacts not only on staff morale and levels of burnout [ 37 ] but negatively impacts clinical efficiency and patient outcomes [ 37 ]. Organisational commitment to improving communication is a key driver of communication skills training [ 38 ]. …

Integrating Quality of Life in the Care Pathway of Cancer Patients Undergoing Immunotherapy Treatment: Descriptive, Cross-sectional Survey of an Online Patient Community's Experiences and Expectations.

BackgroundNew cancer treatments, such as immune checkpoint inhibitors (ICIs), can improve survival and health-related quality of life (HRQoL) in patients with cancer. Although long-term monitoring of HRQoL has been shown to improve survival, integration of HRQoL into everyday practice remains poorly documented.ObjectiveThis study describes experiences and expectations of patients treated with ICIs regarding a discussion of HRQoL with health care professionals (HCPs) in cancer management.MethodsThis cross-sectional study was conducted in an online patient community (Carenity) in France. Patient

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… Total | 36 | 25 (30%, 21%-41%) | Shopping | 10 | — | Washing/dressing | 6 | — | Gardening/jobs in the house | 5 | — | Cleaning | 4 | — | Driving | 4 | — | Cooking | 3 | — | Daily activities | 3 | — | Keeping appointments | 1 | — Emotional well-being | Total | 33 | 25 (30%, 21%-41%) | Daily morale …

Effect of Workplace Violence on Turnover Intention: The Mediating Roles of Job Control, Psychological Demands, and Social Support.

Exposing nursing staff to workplace violence workplace violence (WV) affects their psychological, emotional, and physical health; engenders increased workload; affects the medical reciprocity between nurses and patients; and ultimately leads to staff turnover intention. To preventing WV, development of intervention strategies and WV prevention measures are crucial. This study discusses the mediating effect of job control, psychological needs, and social support on WV and turnover intention. Through this discussion, this study aims to aid medical institutions in reducing their nursing staff tur

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… This study determined that social support enhanced employee morale and ability to cope with WV. Effective social support intervention can prevent employees subjected to WV from further depleting their resources, reducing their turnover intention. …

Matrix stimulation in cancer pain: Methodology, safety and effectiveness.

BackgroundThis feasibility study addresses the applicability of matrix electrodes for the reduction of ongoing pain in cancer patients via low-frequency electrical stimulation (LFS).MethodsLow-frequency matrix stimulation (4 Hz) was applied to the skin within the 'Head's zones' referring to the tumour localization of cancer pain patients. Pain at baseline was compared to a 3-day treatment interval consisting of 5 min of matrix stimulation in the morning and evening followed by a 3-day follow-up period without therapy. Main outcome parameters included numeric rating scale values (rating scale 0

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… Veiga, V.F. , Nimrichter, L. , Teixeira, C.A. , Morales, M.M. , Alviano, C.S. , Rodrigues, M.L. , Holandino, C. (2005). Exposure of human leukemic cells to direct electric current: Generation of toxic compounds inducing cell death by different mechanisms. Cell Biochem Biophys 42, 61–74. …

Role of bone-anabolic agents in the treatment of breast cancer bone metastases.

Skeletal metastases are an incurable complication afflicting the majority of patients who die from advanced breast cancer. They are most often osteolytic, characterized by net bone destruction and suppressed new bone formation. Life expectancy from first diagnosis of breast cancer bone metastases is several years, during which time skeletal-related events - including pain, fracture, hypercalcemia, and spinal cord compression - significantly degrade quality of life. The bone marrow niche can also confer hormonal and chemo-resistance. Most treatments for skeletal metastases target bone-destroyin

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… Tarragona M, Pavlovic M, Arnal-Estape A, Urosevic J, Morales M, Guiu M, Planet E, Gonzalez-Suarez E, Gomis RR. Identification of NOG as a specific breast cancer bone metastasis-supporting gene. J Biol Chem. 2012;287:21346–21355. doi: 10.1074/jbc.M112.355834. 57. Matsuo K, Otaki N. …

A qualitative study on blood and marrow transplant recipients' perceptions of health professional roles following BMT and preferences for ongoing care.

PurposeSurvivors of blood and marrow transplantation (BMT) require life-long follow-up involving both tertiary transplant and primary care services. This paper explores the attitudes and preferences of BMT survivors and their carers regarding the transition from BMT centre care to primary care.MethodsThis qualitative study involved semi-structured interviews with BMT survivors and carers from New South Wales, Australia. Interviews were audio-recorded, transcribed verbatim and thematically analysed.ResultsTwenty-two BMT survivors and six carers were interviewed. Two themes emerged: (1) 'Relatio

Toxic Epidermal Necrolysis Mimicking Severe Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation: A Diagnostic Challenge.

Background: Toxic epidermal necrolysis (TEN) is a rare but life-threatening complication that may occur in patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT), particularly in the context of extensive drug exposure. In this population, TEN can closely resemble severe acute graft-versus-host disease (GVHD), making diagnosis and management challenging. Case presentation: We report the clinical course of an allo-HSCT recipient who developed a rapidly progressive skin rash early after transplantation, and we analyzed the clinical features, histopathology, treatment and ou

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… Gaytán-Morales J.F. Mendoza-Camargo F.O. Gómez-Domínguez Y.A. Graft-versus-host disease variety toxic epidermal necrolysis: Case report Bol. Med. Hosp. Infant. Mex. 2024 81 368 371 10.24875/bmhim.24000048 39576704 24. Abtahi-Naeini B. Pourmahdi-Boroujeni M. Rastegarnasab F. Emamjomeh A. …

'Nelfinavir sensitizes a clinically relevant chemo-radioresistant cervical cancer in-vitro model by targeting the AKT-USP15/USP11-HPV16 E6/E7 axis.

Resistance to standard therapies is a major challenge in managing cervical cancer, often leading to systemic relapse. This study aimed to develop an in-vitro model of chemo-radioresistant cervical cancer that mimics clinical conditions and also explore the therapeutic potential of the repurposed drug nelfinavir, an HIV protease inhibitor. HPV16-positive SiHa cervical cancer cells were subjected to concurrent cisplatin and ionizing radiation, to simulate the clinical treatment regimen for locally advanced cervical cancer. The resulting chemo-radioresistant subline exhibited increased IC50-value

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… Valdovinos-Torres H., Orozco-Morales M., Pedroza-Saavedra A., Padilla-Noriega L., Esquivel-Guadarrama F., Gutierrez-Xicotencatl L. Different isoforms of HPV-16 E7 protein are present in cytoplasm and nucleus. Open Virol. J. 2008;2:15. doi: 10.2174/1874357900802010015. 35. …

Оценка Саркопсии у пациентов с моноклональной гаммопатией неизвестного значения.

Предыстория: Мы стремились определить распространенность саркопии у пациентов с моноклонной гаммопатией неопределенного значения (MGUS) и оценить связи между MGS и саркопией. Методы: Eighty-two В исследование были зачислены пациенты с диагнозом MGUS. Прочность мышечника измерялась с помощью динамометра для рукоятки. Физическая эффективность оценивалась на основе оценки скорости похода по сравнению с 6-minute Прохождение теста. Масса мышц определяется с помощью анализатора биоэлектрического импульса. Результаты: Саркопания была подтверждена в 34.15% пациентов. Мужское превосходство было продемо

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… Petermann-Rocha F., Balntzi V., Gray S.R., Lara J., Ho F.K., Pell J.P., Celis-Morales C. Global prevalence of sarcopenia and severe sarcopenia: A systematic review and meta-analysis. J. Cachexia Sarcopenia Muscle. 2022;13:86–99. doi: 10.1002/jcsm.12783. 8. …