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Extra-Axial Skeletal Metastasis of Malignant Melanoma: Case Report and Literature Review.

The incidence of malignant melanoma is increasing worldwide and is one of the major causes of skin cancer deaths in the United States. Although melanoma has the potential to metastasize to any organ, the incidence of bone metastasis is low (~25%) compared to liver or lung metastasis. However, when a bone is involved, metastasis occurs to the axial skeleton in most cases (80%-90%), and involvement of the appendicular skeleton is relatively rare. We here describe the case of a patient who presented with a pathological fracture due to extra-axial skeletal metastasis of a widespread malignant mela

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… 37 3 | Gómez-León N et al. [ 8 ] | 38 | F | Mild local pain | NA/Malignant melanoma | Knee | BRAF inhibitors | 24 4 | Herrera-Perez M et al. [ 11 ] | 39 | M | Pain | Abdominal flank/ Malignant melanoma | Distal tibia | Chemotherapy + local radiotherapy | NA 5 | Huang KY et al. [ 12 ] | 67 | F | NA | Heel …

Telehealth exercise to Improve Physical function and frailty in patients with multiple myeloma treated with autologous hematopoietic Stem cell transplantation (TIPS): protocol of a randomized controlled trial.

BACKGROUND: Advances in autologous hematopoietic stem cell transplantation (HSCT) and supportive care have led to marked improvements in survival for patients with multiple myeloma. Despite these improvements, patients with multiple myeloma remain at high risk of physical dysfunction and frailty due to HSCT and its associated exposures. Although traditional supervised exercise programs can improve frailty in cancer patients and survivors, rehabilitation facilities are typically far from a patient's residence, are offered on fixed days/hours, contain uniform activities for everyone, and carry a

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… We will assess timed balance under three conditions: (a) side-by-side stand with both feet placed on the ground for 10 s or when the subject steps out of position; (b) semi-tandem stand with the side of the heel of one foot touching the big toe of the other foot for 10 s or when the subject steps out … of position; and (c) tandem stand with the heel of one foot touching the big toe of the other foot for 10 s or when the subject steps out of position. …

Non-pharmacological management of infant and young child procedural pain.

BACKGROUND: Despite evidence of the long-term implications of unrelieved pain during infancy, it is evident that infant pain is still under- … to 90%); considerable heterogeneity (75% to 100%). The most commonly studied acute procedures were heel sticks (63 studies) and needlestick procedures for the purposes of vaccines/vitamins (35 studies). We judged most studies to have high risk of bias (103 out of 138), with the most common methodological concerns relating to blinding of personnel and …

Diffuse and Prolonged Bone Pain Revealing Tumor-Induced Osteomalacia: A Case Report.

Tumor-induced osteomalacia should be considered in patients with unexplained bone pain and fractures. Advanced imaging, such as Ga68-DOTATATE PET/CT, enables precise tumor localization, and surgical excision can rapidly normalize phosphate metabolism and resolve symptoms, underscoring the importance of early diagnosis and intervention.

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… He also complained of chronic bilateral pain in the back, knees, ankles, and heels, persisting for several years. He denied experiencing constitutional symptoms such as fever, significant weight loss, or night sweats (B symptoms). …

Защитное воздействие кварчена на экспериментальный склероз, вызванный купризоном, у самца C57BL/6 Мыши.

Цель этого исследования состояла в том, чтобы определить защитное воздействие Quercetiна на экспериментальный склероз (MS) в C57BL (Male)/6 Мыши. Forty мужского пола C57BL/6 Мыши были разделены на 4 Экспериментальные группы. Контрольная группа получила стандартную диету. Группа 2, мыши получили питание, содержащее 0.2 % (w/w) CPZ смешивается с наземным чау в течение всего периода 4 недель (Чху и др., 2021). Группа 3, мыши получили Quercetin150 мг/кг) в устной форме каждый день 4 недель. Группа 4, мыши получили диету 0.2 % CPZ и Quercetin150 мг/кг) перорально для 4 недель. После обнаружения при

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… A line was drawn from the heel to the tip of the toe, and the angle between them was measured ( Feather-Schussler and Ferguson, 2016 ). Hind limb suspension Mice's hind legs were hung over a wire tied between two ends, and their posture was observed. …

Targeting the FGFR signaling pathway in cholangiocarcinoma: promise or delusion?

Cholangiocarcinoma (CCA) is a refractory cancer with limited treatment options and poorly understood molecular mechanisms underlying tumor development. The most effective treatment is surgical resection; however, patients are highly prone to recurrence. Moreover, considering that most patients are diagnosed in advanced stages, treatment options are restricted to palliative care, which results in poor prognosis. Due to the limited effect of chemotherapy and radiotherapy, targeted therapy is becoming a hot topic in the field of biliary cancer treatment. The fibroblast growth factor/fibroblast gr

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… cardiomyocyte and vascular damage, and cardiovascular abnormalities such as impaired contractility, reduced cardiac output (CO), and arrhythmia. 62 , 63 Bétrian et al. have reported two cases where patients developed severe straightening of scalp hair, eyelash trichomegaly, acral desquamation, xerostomia, and heel … Cancer Res 2010 ; 70 : 7630 – 7639 . 20709759 10.1158/0008-5472.CAN-10-1489 55 Mahipal A Tella SH Kommalapati A , et al FGFR2 genomic aberrations: Achilles heel in the management of advanced cholangiocarcinoma . …

The impact of incident vertebral and non-vertebral fractures on health related quality of life in postmenopausal women.

BACKGROUND: Little empirical research has examined the multiple consequences of osteoporosis on quality of life. METHODS: Health related quality of life (HRQL) was examined in relationship to incident fractures in 2009 postmenopausal women 50 years and older who were seen in consultation at our tertiary care, university teaching hospital-affiliated office and who were registered in the Canadian Database of Osteoporosis and Osteopenia (CANDOO) patients. Patients were divided into three study groups according to incident fracture status: vertebral fractures, non-vertebral fractures and no fract

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… Incident non-vertebral fractures included the ankle, arm, clavicle, elbow, heel, hip, knee, leg, nose, pelvis, rib, shoulder, sacrum, and wrist. Group III: patients who did not report an incident fracture. …

Характеристики контроля за Pelvic во время статического равновесия у пациентов с множественным склерозом: исследование на основе новинок-сенсоров.

Фон/цели: Множественный склероз (MS) является воспалительным и нейродегенеративным заболеванием центральной нервной системы. Повреждения MS могут влиять на мотор, сенсорные и зрительные нервы, что приводит к нарушению равновесия, мышечному натяжению и боли. Вышеупомянутое может существенно повлиять на качество жизни. В этой связи необходимо использовать объективные методы функциональной оценки для установления баланса и выявления расстройств, связанных с походкой, у пациентов, имеющих MS. Цель исследования заключалась в оценке функционального состояния и качества жизни людей с множественным ск

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… During this test, the patient must assume a tandem position, which means that the feet should be positioned one behind the other, with the toes of the forward foot touching the heel of the forward foot. The patient then rotates 180°. … This suggests shifting the center of gravity further forward, which increases the surface area of the forefoot and, consequently, reduces the load on the heels and the overall load on the lower limbs. …

Idiopathic osteoporosis, Ehlers-Danlos syndrome, postural orthostatic tachycardia syndrome, and mast cell activation disorder in a 27-year-old male patient: A unique case presentation.

A young male patient presents with widespread pain and varying chronic inflammatory symptoms for three years and idiopathic low bone density for more than ten years. Based on the patient's clinical history, the patient has been diagnosed with an hypermobile Ehlers-Danlos syndrome, postural orthostatic tachycardia syndrome, and mast cell activation disorder trifecta with affiliated inflammation-induced osteoporosis.

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… Bilateral piezogenic papules of the heel 5. Recurrent or multiple abdominal hernia(s) (e.g., umbilical, inguinal, and crural) 6. Atrophic scarring involving at least two sites and without the formation of truly papyraceous and/or hemosideric scars as seen in classical EDS 7. …

A Borate-Based Bioactive Glass Advances Wound Healing in Non-Healing Wagner Grade 1 Diabetic Foot Ulcers: A Randomised Controlled Clinical Trial.

A novel advanced synthetic bioactive glass matrix was studied in patients with non-healing diabetic foot ulcers (DFUs). Bioactive glasses can be constructed to be biocompatible, with water-soluble materials in multiple geometries including fibre scaffolds that mimic the 3D architecture of a fibrin clot. In this trial, chronic, Wagner Grade 1 DFUs were randomised to receive borate-based bioactive glass Fibre Matrix (BBGFM) plus standard of care (SOC) therapy for 12 weeks or SOC alone. The primary study endpoint was the proportion of subjects that obtained complete wound closure at 12 weeks. Sec

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… Vertical location | | | 0.67 Plantar | 52 (78) | 54 (82) Dorsal | 15 (22) | 12 (18) Position | | | 0.61 Medial | 35 (52) | 37 (57) Lateral | 32 (48) | 28 (43) Anatomical location | | | 0.85 Toe | 13 (19) | 10 (15) Forefoot | 29 (43) | 24 (36) Midfoot | 12 (18) | 17 (26) Hindfoot | 2 (4) | 2 (3) Heel … 17.8 Vertical location | | | 1.0 Plantar | 34 (77) | 29 (76) Dorsal | 10 (23) | 9 (24) Position | | | 0.66 Medial | 26 (59) | 20 (54) Lateral | 18 (41) | 17 (46) Anatomical location | | | 0.58 Toe | 13 (30) | 6 (16) Forefoot | 18 (41) | 15 (39) Midfoot | 5 (11) | 7 (18) Hindfoot | 1 (2) | 1 (3) Heel …

National guidelines for diagnosis and treatment of osteoporosis in Slovakia.

BACKGROUND: Osteoporosis is a chronic, systemic skeletal disease characterized by decreased bone mass and microarchitectural deterioration, leading to increased fracture risk. In Slovakia, its prevalence is estimated at 6%, with substantial health, social, and economic burdens. OBJECTIVE: The Slovak national guideline provides an overview for the diagnosis, prevention, and treatment of osteoporosis in Slovakia, reflecting recent scientific advances and recommendations from international bodies. METHODS: The guidelines were developed by a multidisciplinary expert panel and officially adopted

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… Ultrasound measurement of bone density in the heel region has only predictive value for fracture risk assessment. The measurement is not suitable for establishing a diagnosis of osteoporosis. … Central densitometry in the forearm area—or ultrasound densitometry in the heel area—is not suitable for monitoring changes in bone density. …

Effects of Closed Kinetic Chain Exercises in Chemotherapy-Induced Peripheral Neuropathy: A Case Report.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse reaction to many first- and second-line chemotherapy medications that can be debilitating, severe, and often dose-limiting. Treatment options for CIPN are limited. We report a case of a 52-year-old female patient with Stage II ovarian cancer who was hospitalised in the chemotherapy ward for a second round of chemotherapy. We describe the effectiveness of closed kinetic chain (CKC) exercises for the management of CIPN symptoms. The patient was advised to take neurophysiotherapy. The patient complained of pain, tingling in bot

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… . | 10 reps with 3 sets 4 | To improve the strength of lower limb muscles | CKC exercises: Terminal knee extension exercise, lateral step-ups, wall squats, side stepping, standing heel raise - single leg | Exercises using the CKC have demonstrated enhanced Ia muscle spindle afferent firing. …

A randomized trial of amifostine in patients with high-dose VIC chemotherapy plus autologous blood stem cell transplantation.

This pilot study evaluates the degree of side effects during high-dose chemotherapy (HD-VIC) plus autologous bone marrow transplant (HDCT) and its possible prevention by the cytoprotective thiol-derivate amifostine. Additionally, the in-patient medical costs of both treatment arms were compared. 40 patients with solid tumours were randomized to receive HD-VIC chemotherapy with or without amifostine (910 mg/m(2)at day 1-3) given as a short infusion prior to carboplatin and ifosfamide. Patients were stratified according to pretreatment. HDCT consisted of an 18 h infusion of carboplatin (500 mg/m

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… Heel R. C. Carboplatin. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the treatment of cancer. 37 2 2 1989 162 190 Drugs 2649354 10.2165/00003495-198937020-00005 Wilson W. H. Jain V. Bryant G. Cowan K. H. Carter C. Cottler-Fox M. …

Management of Foot Ulcers and Chronic Wounds with Amniotic Membrane in Comorbid Patients: A Successful Experience.

Chronic wounds are defined as those with disturbances in normal healing. They involve symptoms like exudate, odor, pain or impaired mobility, severely impacting life quality. In the case of patients with additional comorbidities, these are known to aggravate the healing impairment. Amniotic membrane (AM) is gaining attention for its regenerative potential, as it has shown promise in treating hard-to-heal wounds, such as diabetic foot ulcers. This work examines a series of five patients who, while suffering an array of other chronic conditions, were treated with AM for the management of non-hea

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… Pathologies | Type of Wound/Location | Time of Evolution | Number of AM Applications | Time of Treatment | % Epithelialization Heart disease, venous insufficiency, arterial hypertension, renal failure, peripheral arterial disease, diabetes mellitus type II (patient 1) | Right heel arterial ulcer | 6 …

Cancer Prevalence among Physicians in Korea: A Single Center Study.

BackgroundThere is little research regarding whether working as a physician affects cancer risk. Moreover, there is no research on cancer prevalence among physicians in Korea. This study utilized the Korea National Cancer Incidence Database to determine whether the prevalence of cancer among physicians differs from the prevalence of cancer within the general population.MethodsWe analyzed the medical records of a representative sample of 382 doctors who underwent a health examination between 2010 and 2013 at a health examination center in a Ewha Womans University Medical Center.Cancer incidence

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… Height was measured down to 0.1 cm while subjects wore a light gown, with their heels flat on the ground and their back straight. Weight was measured while subjects wore a light gown of less than 0.1 kg. Body mass index (BMI) was defined as weight (kg) divided by the square of their height (m). …

Доклад о деле: Редкие неблагоприятные явления после лечения CAR-T у пациентов с рецидивной/нереактивной диффузной большой лимфомой B-клеток.

Химерическая антигенная рецепторная терапия T-клетка (CAR-T) представляет собой значительное изменение в лечении раковых заболеваний, которое используется для лечения заболеваний B-клеток, включая B-клеточные лимфоболические лейкемии, рецидивные и рефрактные лимфомы и множественные миеломы. CAR-T требует сбора Т-клеток от пациента, который генетически разработан для выражения синтетического рецептора, связывающего его с антигеном конкретной опухоли. Клетки CAR-T затем вводятся обратно в пациента, который работает, чтобы атаковать стойкие раковые клетки. Побочные эффекты CAR-T включают синдром

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… Panel D highlights the sole of a foot with a large blister on the heel. Panel E shows a side view of a foot with several blisters along the arch and ankle. The patient was discharged on day +14 and steroids were tapered off at discharge. …

Исследование сбалансированности восприятия и сбалансированности в неврологических расстройствах для целевых стратегий реабилитации.

ВАЖНОСТЬ: У людей с неврологическими расстройствами (PwND) характерен дефицит баланса по конкретным задачам, что существенно влияет на их повседневную жизнь (ADLs). Однако связь между дефицитом баланса и АДЛ, измеряемая по результатам, о которых сообщают пациенты, плохо изучена, что ограничивает выбор конкретных статических и динамических задач, которые должны использоваться для подготовки к данной деятельности. ЦЕЛЬ: Цель исследования состояла в том, чтобы создать клиническую основу, увязывающую ADL, задачи и ресурсы для поддержки процесса принятия решений врачами при планировании ориентирова

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… The exercises included self-destabilization exercises where patients perform voluntary movements in static and dynamic conditions like shifting weight to toes and heels or bouncing a ball while walking (relying on APAs); exercises included tasks that externally induced destabilization of the center-of-body …

Evolving treatment strategies for myeloma.

In this article, we will discuss how treatment strategies for myeloma have evolved and outline the challenges now faced following the introduction of a number of novel active agents. In particular, we will focus on how achieving a maximum response and maintaining such responses is becoming a key therapeutic strategy and how novel agents can be used to achieve this in the context of current strategies such as autologous transplantation.

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… Indeed protein synthesis may be the Achilles heel of the myeloma cell as it clearly distinguishes plasma cells from many other cells within the body. …

Individualized Hospital to Home, Exercise-Nutrition Self-Managed Intervention for Pre-Frail and Frail Hospitalized Older Adults: The INDEPENDENCE Randomized Controlled Pilot Trial.

PurposePre-frailty and frailty in older adults are associated with poor health outcomes and increase health-care costs, and further worsening during hospitalization. This study aimed to examine the effect of an individualized hospital to home, exercise-nutrition self-managed intervention for pre-frail and frail hospitalized older adults.Patients and methodsOlder adults admitted to an acute medical unit of a tertiary hospital in South Australia who were pre-frail or frail were recruited from September 2020 to June 2021, randomized to either control or intervention group and followed up at 3 and

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… For the STAND-Cph component, following a range of motion “warm-up”, participants completed chair stand and heel raise exercises at their maximum tolerated intensity, with options for progression and regression as per the STAND-Cph program. … home-based exercise program, the focus was resistance training for completion 3 days a week along with muscle strengthening exercises which were derived from the Otago community exercise program. 24 The original Otago exercise program consist of 17 strength (eg, knee extensor, hip adductor) and balance (eg, heel …

Zoledronic acid infusion for prevention and treatment of osteoporosis.

Osteoporotic fractures are associated with significant morbidity, reduced quality of life, increased mortality, and high health care costs. Bisphosphonates are standard therapy for treatment of osteoporosis. However, patient compliance and persistence with oral weekly or monthly bisphosphonate therapy are suboptimal and may lead to reduced effectiveness. Zoledronic acid (ZOL) is an intravenous bisphosphonate that is given once yearly for the treatment of osteoporosis via a medically supervised 15-minute infusion. This ensures compliance for a full 12 months. In clinical trials, an annual infus

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… Non-compliance: the Achilles’ heel of anti-fracture efficacy. Osteoporos Int. 2007;18:711–719. doi: 10.1007/s00198-006-0294-8. 28. Earnshaw SR, Graham CN, Ettinger B, Amonkar MM, Lynch NO, Middelhoven H. …