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Epidemiology of Bacteremia in Patients with Hematological Malignancies and Hematopoietic Stem Cell Transplantation and the Impact of Antibiotic Resistance on Mortality: Data from a Multicenter Study in Argentina.

The epidemiology of bacteremia and the antibiotic resistance profile (ARP) of Gram-negative bacilli (GNB) in hematological malignancies (HM) and hematopoietic stem cell transplant (HSCT) patients may differ according to geographic region. In addition, multidrug-resistant organisms (MDROs) may impact mortality. This is a prospective, observational, and multicenter study. The first episodes of bacteremia in adult patients with HM or HSCT were included. The risk factors for 30-day mortality were identified. One thousand two hundred and seventy-seven episodes were included (HM: 920; HSCT: 357). GN

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… Español-Morales I. Fernandez-Abellán P. Gudiol C. González-Sierra P. Rojas R. High Rate of Inappropriate Antibiotics in Patients with Hematologic Malignancies and Pseudomonas aeruginosa Bacteremia following International Guideline Recommendations Microbiol. …

Generic Health Utility Measures in Exercise Oncology: A Scoping Review and Future Directions.

Despite the evidence that exercise is effective at mitigating common side effects in adults with cancer, it is rarely part of usual cancer care. One reason for this is the lack of economic evidence supporting the benefit of exercise. Economic evaluations often rely on the use of generic utility measures to assess cost effectiveness. This review identifies and synthesizes the literature on the use of generic utility measures used to evaluate exercise interventions for adults with cancer. A systematic search of the literature from January 2000 to February 2023 was conducted using four databases

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… Arroyo-Morales M. A multimodal physiotherapy programme plus deep water running for improving cancer-related fatigue and quality of life in breast cancer survivors Eur. J. Cancer Care 2014 23 15 21 10.1111/ecc.12114 23947581 34. Rosero I.D. Ramirez-Velez R. Martinez-Velilla N. Cedeno-Veloz B.A. …

Cardiotoxicity of Non-Anthracycline Cancer Chemotherapy Agents.

Throughout the last decades, newly developed chemotherapeutic agents and immunotherapies that target signaling pathways have provided patients with better prognoses, improved their quality of life and increased survival rates, thus converting cancer to a stable chronic disease. However, non-anthracycline cancer chemotherapy agents and immunotherapies including human epidermal growth factor receptor 2 (HER2) inhibitors, vascular endothelial growth factor (VEGF) inhibitors, Bcr-Abl tyrosine-kinase inhibitors (TKI), proteasome inhibitors, immune checkpoint inhibitors and chimeric antigen receptor

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… Bosch X., Rovira M., Sitges M., Domènech A., Ortiz-Pérez J.T., de Caralt T.M., Morales-Ruiz M., Perea R.J., Monzó M., Esteve J. …

Гейт-образец у людей с множественным склерозом: систематический обзор

Цель настоящего систематического обзора состояла в том, чтобы описать походку у людей с множественным склерозом (МС) путем обобщения основных выводов, полученных в ходе исследований с использованием three- размерные системы захвата человеческого движения. Поиск проводился в базах данных PubMed, Web of Science, Physiophicy Database (PEDro) и Cumulative Index to Medersing and Allid Health (CINAHL). Использовавшиеся исследования three- были включены системы анализа размеров походов, в которых анализировались спектральные, кинетические, кинетические или электромиографические параметры. Качество ис

Efficiency and Tolerability of Induction and Consolidation Therapy with Arsenic Trioxide/Bortezomib/Ascorbic Acid/Dexamethasone (ABCD) Regimen Compared to Bortezomib/Dexamethasone (BD) Regimen in Newly Diagnosed Myeloma Patients.

PurposeThis study was aimed at comparing the efficacy and tolerability of an arsenic trioxide/bortezomib/ascorbic acid/dexamethasone (ABCD) regimen with efficacy and tolerability of a bortezomib/dexamethasone (BD) regimen in patients with newly diagnosed myeloma.Patients and methodsFifty-seven and sixty-four patients were treated with the ABCD and BD regimens, respectively. Eligible and agreeable patients received autologous hematopoietic stem cell transplantation followed by consolidation.ResultsThe response rates (above VGPR) were 74.1% and 32.8% in the ABCD- and BD-treated groups, respectiv

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… Matulis SM, Morales AA, Yehiayan L, Lee KP, Cai Y, Boise LH. Alterations in glutathione levels and apoptotic regulators are associated with acquisition of arsenic trioxide resistance in multiple myeloma. PLoS One . 2012;7:e52662. doi: 10.1371/journal.pone.0052662 22. …

Improving Patient Access to New Drugs in South Korea: Evaluation of the National Drug Formulary System.

This study reviews and evaluates the national drug formulary system used to improve patient access to new drugs by making reimbursement decisions for new drugs as part of the South Korean national health insurance system. The national health insurance utilizes three methods for improving patient access to costly drugs: risk-sharing agreements, designation of essential drugs, and a waiver of cost-effectiveness analysis. Patients want reimbursement for new drugs to be processed quickly to improve their access to these drugs, whereas payers are careful about listing them given the associated fina

Cardiac Amyloidosis and its New Clinical Phenotype: Heart Failure with Preserved Ejection Fraction.

Heart failure with preserved ejection fraction (HFpEF) is now an emerging cardiovascular epidemic, being identified as the main phenotype observed in clinical practice. It is more associated with female gender, advanced age and comorbidities such as hypertension, diabetes, obesity and chronic kidney disease. Amyloidosis is a clinical disorder characterized by the deposition of aggregates of insoluble fibrils originating from proteins that exhibit anomalous folding. Recently, pictures of senile amyloidosis have been described in patients with HFpEF, demonstrating the need for clinical cardiolog

Integrating Emerging Data Into Clinical Practice: A Case-Based Approach for Multiple Myeloma.

Selected Patient Cases From the APSHO Regional Lecture SeriesINTRODUCTION As the official publication of the Advanced Practitioner Society for Hematology and Oncology (APSHO), JADPRO is pleased to offer Part 2 of an accredited educational activity based on the recently concluded APSHO Regional Lecture Series. Hosted in collaboration with major cancer centers around the country, the APSHO Regional Lecture Series brought case-based didactic presentations and skills workshops to advanced practitioners. In the spirit of JADPRO, three accredited Grand Rounds articles by Beth Eaby-Sandy, MSN, CRNP,

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… Ludwig H, Miguel J S, Dimopoulos M A, Palumbo A, Garcia Sanz R, Powles R, Lentzsch S, Ming Chen W, Hou J, Jurczyszyn A, Romeril K, Hajek R, Terpos E, Shimizu K, Joshua D, Hungria V, Rodriguez Morales A, Ben-Yehuda D, Sondergeld P, Zamagni E, Durie B. …

Assessing Heterogeneity of Osteolytic Lesions in Multiple Myeloma by ¹H HR-MAS NMR Metabolomics.

Multiple myeloma (MM) is a malignancy of plasma cells characterized by multifocal osteolytic bone lesions. Macroscopic and genetic heterogeneity has been documented within MM lesions. Understanding the bases of such heterogeneity may unveil relevant features of MM pathobiology. To this aim, we deployed unbiased ¹H high-resolution magic-angle spinning (HR-MAS) nuclear magnetic resonance (NMR) metabolomics to analyze multiple biopsy specimens of osteolytic lesions from one case of pathological fracture caused by MM. Multivariate analyses on normalized metabolite peak integrals allowed clusteriza

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… Morales J.M. Gonzalez-Darder J. Talamantes F. Cortés O. Gil-Benso R. López-Ginés C. Cerdá-Nicolás M. Celda B. Benign and atypical meningioma metabolic signatures by high-resolution magic-angle spinning molecular profiling J. Proteome Res. 2008 7 2882 2888 10.1021/pr800110a 18507434 34. Chae E.Y. …

Bortezomib treatment causes long-term testicular dysfunction in young male mice.

BackgroundWith increased long-term survivors of childhood cancer patients, therapy-associated infertility has become one of the most common late side-effects and significantly affects their life-quality. Therefore, evaluation of anti-cancer agents on male reproduction and infertility prevention are urgently demanding. The proteasome inhibitor bortezomib has been launched in clinical trials for childhood cancers, however, its potential side effects on reproduction have so far been neither investigated experimentally nor reported in treated children. Thus the present study is designed to explore

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… 10.1002/jcp.21789 PMC2732714 Wang YL Liu W Sun YJ Kwon J Setsuie R Osaka H Noda M Aoki S Yoshikawa Y Wada K Overexpression of ubiquitin carboxyl-terminal hydrolase L1 arrests spermatogenesis in transgenic mice Mol Reprod Dev 2006 73 40 49 16177983 10.1002/mrd.20364 Bedard N Hingamp P Pang Z Karaplis A Morales …

Cyclic nucleotide phosphodiesterases as drug targets.

Cyclic nucleotides are synthesized by adenylyl and/or guanylyl cyclase, and downstream of this synthesis, the cyclic nucleotide phosphodiesterase families (PDEs) specifically hydrolyze cyclic nucleotides. PDEs control cyclic adenosine-3',5'monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) intracellular levels by mediating their quick return to the basal steady state levels. This often takes place in subcellular nanodomains. Thus, PDEs govern short-term protein phosphorylation, long-term protein expression, and even epigenetic mechanisms by modulating cyclic nucleotide levels

Antitumor Activity of Cannabinoids and Their Interaction with Chemotherapy: A Systematic Review and Meta-Analysis of Preclinical Evidence.

Background: Cannabinoids are studied as anticancer agents, but their effects vary across tumors, compounds, and experimental settings, underscoring the need to define consistent patterns. Our objective was to map cannabinoid efficacy across cancer preclinical models and identify tumor settings with the greatest translational promise. Methods: The protocol was registered on PROSPERO (CRD42025543744); PubMed, Embase, and CENTRAL were searched on 4 April 2024 for in vitro and in vivo studies assessing cannabinoid antitumor effects alone or with chemotherapy versus vehicle or chemotherapy only. Ra

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… 19 ], Shrivastava et al., 2011 [ 88 ], Mohammadpour et al., 2017 [ 91 ] Pro-tumor | McKallip et al., 2005 [ 24 ] Unclear | Caffarel et al., 2006 [ 84 ], Hanlon et al., 2016 [ 92 ], Ward et al., 2014 [ 17 ], Almeida et al., 2023 [ 14 ], Amaral et al., 2021 [ 93 ], Caffarel et al., 2010 [ 94 ], García-Morales … García-Morales L., Mendoza-Rodríguez M.G., Tapia Ramírez J., Meza I. CBD Inhibits In Vivo Development of Human Breast Cancer Tumors. Int. J. Mol. Sci. 2023;24:13235. doi: 10.3390/ijms241713235. 22. …

Decoding Waldenström Macroglobulinemia Through Genomics, Epigenomics and Cellular Interactions

Waldenström macroglobulinemia is a rare lymphoplasmacytic malignancy characterized by bone marrow infiltration and monoclonal immunoglobulin M production. Despite its indolent clinical course, the disease exhibits considerable biological complexity driven by recurrent genetic alterations, dysregulated signaling pathways, and a supportive bone marrow microenvironment. The identification of MYD88 and CXCR4 mutations has significantly advanced understanding of disease pathogenesis, clonal evolution, and treatment response. Additional insights from cytogenetic, epigenetic, and microRNA studies hav

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… Morales J. Pujar S. Loveland J.E. Astashyn A. Bennett R. Berry A. Cox E. Davidson C. Ermolaeva O. Farrell C.M. A Joint NCBI and EMBL-EBI Transcript Set for Clinical Genomics and Research Nature 2022 604 310 315 10.1038/s41586-022-04558-8 35388217 PMC9007741 83. Treon S.P. Xu L. Hunter Z. … Morales T.H. Hanson L.M. Brown N.E. Gong X. Stephens J. Preclinical Characterization of Pirtobrutinib, a Highly Selective, Noncovalent (Reversible) BTK Inhibitor Blood 2023 142 62 72 10.1182/blood.2022018674 36796019 PMC10651869 199. Palomba M.L. Patel M.R. Eyre T.A. Jurczak W. Lewis D.J. …

Advances and Hurdles in CAR T Cell Immune Therapy for Solid Tumors.

Chimeric antigen receptor (CAR) T cells in solid tumors have so far yielded limited results, in terms of therapeutic effects, as compared to the dramatic results observed for hematological malignancies. Many factors involve both the tumor cells and the microenvironment. The lack of specific target antigens and severe, potentially fatal, toxicities caused by on-target off-tumor toxicities constitute major hurdles. Furthermore, the tumor microenvironment is usually characterized by chronic inflammation, the presence of immunosuppressive molecules, and immune cells that can reduce CAR T cell effi

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… Morales R.T. Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy eLife 2020 9 e52253 10.7554/eLife.52253 32909947 PMC7556869 137. Grabowski M.M. Sankey E.W. Ryan K.J. Chongsathidkiet P. Lorrey S.J. Wilkinson D.S. Fecci P.E. … Morales R.T. Qian W. Wang H. Gagner J.P. Dolgalev I. Placantonakis D. Zagzag D. Cimmino L. Snuderl M. Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis Biomaterials 2018 161 164 178 10.1016/j.biomaterials.2018.01.053 29421553 PMC8059366 147. Close H.J. …

KSHV and cancer: understanding the oncogenic machinery for next-generation diagnostic tools and therapies.

Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV-8), is an oncogenic virus responsible for Kaposi's sarcoma (KS) and lymphoproliferative disorders like primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD). This review explores KSHV's oncogenic mechanisms, focusing on its ability to manipulate host cell signaling, evade immune detection, and promote tumorigenesis through latent and lytic viral proteins. Key oncoproteins, such as LANA, vCyc, vFLIP, and vGPCR, activate cancer hallmarks, as sustained proliferation, immune evasion, angiogenesis, and re

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… The NF-κB complex activates the transcription of inflammatory cytokine genes, in addition to mobilizing the Wilms tumor protein - WT1 (already reported to be overexpressed in KS lesions and other tumors), which creates a favorable microenvironment for tumor development (Morales 2021 ). …

Immunotherapy and CRISPR Cas Systems: Potential Cure of COVID-19?

The COVID-19 has plunged the world into a pandemic that affected millions. The continually emerging new variants of concern raise the question as to whether the existing vaccines will continue to provide sufficient protection for individuals from SARS-CoV-2 during natural infection. This narrative review aims to briefly outline various immunotherapeutic options and discuss the potential of clustered regularly interspaced short palindromic repeat (CRISPR Cas system technology against COVID-19 treatment as specific cure. As the development of vaccine, convalescent plasma, neutralizing antibodies

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… in vivo with high efficacy, however challenges needs to be overcome in order to discover suitable delivery system for the CRISPR Cas tools, and it is necessary to eliminate any potential off-target effects to ensure precision and safety for it’s utilization against SARS-CoV-2 in vivo, and there are moral … Rodríguez-Morales AJ , MacGregor K , Kanagarajah S , Patel D , Schlagenhauf P . Going global – travel and the 2019 novel coronavirus . Travel Med Infect Dis . 2020 ; 33 : 101578 . PMID: 32044389; PMCID: PMC7128681 . doi: 10.1016/j.tmaid.2020.101578 32044389 PMC7128681 2. …

Image-Guided Percutaneous Ablation for Primary and Metastatic Tumors.

Image-guided percutaneous ablation methods have been further developed during the recent two decades and have transformed the minimally invasive and precision features of treatment options targeting primary and metastatic tumors. They work by percutaneously introducing applicators to precisely destroy a tumor and offer much lower risks than conventional methods. There are usually shorter recovery periods, less bleeding, and more preservation of organ parenchyma, expanding the treatment options of patients with cancer who may not be eligible for resection. Image-guided ablation techniques are c

Application of the CRISPR/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer.

The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and Jennifer Doudna for the development of the Clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease9 (CRISPR/Cas9) gene editing technology that provided new tools for precise gene editing. It is possible to target any genomic locus virtually using only a complex nuclease protein with short RNA as a site-specific endonuclease. Since cancer is caused by genomic changes in tumor cells, CRISPR/Cas9 can be used in the field of cancer research to edit genomes for exploration of the mechanisms of t

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… Tang KJ Constanzo JD Venkateswaran N Melegari M Ilcheva M Morales JC Focal adhesion kinase regulates the DNA damage response and its inhibition Radiosensitizes mutant KRAS lung Cancer Clin Cancer Res 2016 22 5851 5863 10.1158/1078-0432.CCR-15-2603 27220963 PMC5122471 69. …

Influence of the Mediterranean Diet on Healthy Aging.

The life expectancy of the global population has increased. Aging is a natural physiological process that poses major challenges in an increasingly long-lived and frail population. Several molecular mechanisms are involved in aging. Likewise, the gut microbiota, which is influenced by environmental factors such as diet, plays a crucial role in the modulation of these mechanisms. The Mediterranean diet, as well as the components present in it, offer some proof of this. Achieving healthy aging should be focused on the promotion of healthy lifestyle habits that reduce the development of pathologi

Building Trust in a Newly Established Physician-Patient Relationship: A Scoping Review.

BackgroundTrust is a fundamental component of the physician-patient relationship, influencing cooperation, adherence, and patient outcomes. While much research has focused on long-term relationships, little is known about the factors that shape trust during the very first physician-patient encounter.ObjectiveThe aim of this study was to assess the factors contributing to the development of patients' trust in a newly established physician-patient relationship.Search strategyWe conducted a scoping review and applied thematic analysis to synthesise findings from identified studies. PubMed databas