Результаты поиска

Acute Respiratory Failure After Hematopoietic Stem Cell Transplantation

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… BO bronchiolitis obliterans, CHF congestive heart failure, CMV cytomegalovirus, COP cryptogenic-organizing pneumonia, DAH diffuse alveolar hemorrhage. Amy K. Chi, Ayman O. Soubani, Alexander C. White, Kenneth B. Miller. … Late Noninfectious Complications Noninfectious pulmonary complications in the late posttransplant phase include bronchiolitis obliterans (BO) and cryptogenic organizing pneumonia (COP) especially in those patients with chronic GVHD [ 4 ]. …

Noninfectious pulmonary complications of haematopoietic stem cell transplantation.

Haematopoietic stem cell transplantation (HSCT) is an established treatment for a variety of malignant and nonmalignant conditions. Pulmonary complications, both infectious and noninfectious, are a major cause of morbidity and mortality in patients who undergo HSCT. Recent advances in prophylaxis and treatment of infectious complications has increased the significance of noninfectious pulmonary conditions. Acute lung injury associated with idiopathic pneumonia syndrome remains a major acute complication with high morbidity and mortality. On the other hand, bronchiolitis obliterans syndrome is

Совпадение в полном тексте источника
… Cryptogenic organizing pneumonia. Semin Respir Crit Care Med 2001; 22: 449–460. doi: 10.1055/s-2001-17387 78. Nakasone H, Onizuka M, Suzuki N, et al. … Cryptogenic organizing pneumonia following allogeneic hematopoietic stem cell transplantation. Blood 2006; 108: 5330–5330. doi: 10.1182/blood.V108.11.5330.5330 85. Lazor R, Vandevenne A, Pelletier A, et al. Cryptogenic organizing pneumonia. characteristics of relapses in a series of 48 patients. …

Non-infectious pulmonary complications after haematopoietic progenitor transplantation: a diagnostic approach.

Haematopoietic stem cell transplantation (HCT) is an established treatment for a wide variety of haematological diseases, both malignant and non-malignant. Infectious and non-infectious post-HCT pulmonary complications are a major cause of morbidity and mortality, with non-infectious complications becoming more prominent in recent decades as prophylaxis has led to a decrease in infectious complications. Globally, these complications can be divided into three phases (neutropenic, early and late phase) depending on their time of onset in relation to the graft. There is a growing awareness that t

Совпадение в полном тексте источника
… A Case Report of Steroid-Resistant Cryptogenic Organizing Pneumonia Managed with Intravenous Immunoglobulins. Case Rep Pulmonol 2021;2021:9343491. 10.1155/2021/9343491 37. Shitenberg D, Fruchter O, Fridel L, et al. … Successful Rituximab Therapy in Steroid-Resistant, Cryptogenic Organizing Pneumonia: A Case Series. Respiration 2015;90:155-9. 10.1159/000430100 38. To Y, Sano Y, Sekiya T, et al. …

Coexistence of Autoantibodies against the Golgi Complex and Ro52 Antigen in a Patient with Nonspecific Interstitial Pneumonia.

Nonspecific interstitial pneumonia (NSIP) is often associated with connective tissue diseases (CTD). The diagnosis of NSIP was confirmed in a 63-year-old man by high-resolution computed tomography and an open lung biopsy. Anti-Golgi complex autoantibodies (AGA) and anti-Ro52 antibodies were simultaneously detected at high concentrations. Autoantibodies to aminoacyl-tRNA synthetases (ARS) were negative. The patient was treated with corticosteroids for six months. During the seven-year follow-up, NSIP had a slow progression and patient had not developed the clinical features of CTD. The present

Совпадение в полном тексте источника
… Fig. 7.6.49 An illustration demonstrates the different types of idiopathic interstitial pneumonias (IIPs) and their pathological distribution patterns: ( a ) idiopathic pulmonary fibrosis, ( b ) nonspecific interstitial pneumonia (NSIP), ( c ) cryptogenic organizing pneumonia (COP), ( d ) respiratory … Cryptogenic Organizing Pneumonia COP, formerly known as bronchiolitis obliterans with organizing pneumonia (BOOP), is a chronic pulmonary disease characterized by bronchiolar inflammation (bronchiolitis) and obstruction by a polypoid plug of granulation tissue formation (obliterans). …

Acute and Chronic Respiratory Failure in Cancer Patients

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… When no precipitating cause can be identified, it is referred to as cryptogenic organizing pneumonia [ 56 ]. Characteristic radiographic findings are included in Table 2 . … Alasaly K Muller N Ostrow DN Champion P FitzGerald JM Cryptogenic organizing pneumonia. A report of 25 cases and a review of the literature Medicine (Baltimore) 1995 74 201 211 10.1097/00005792-199507000-00004 7623655 5. …

Long-Term Health Effects of Curative Therapies on Heart, Lungs, and Kidneys for Individuals with Sickle Cell Disease Compared to Those with Hematologic Malignancies.

The goal of curing children and adults with sickle cell disease (SCD) is to maximize benefits and minimize intermediate and long-term adverse outcomes so that individuals can live an average life span with a high quality of life. While greater than 2000 individuals with SCD have been treated with curative therapy, systematic studies have not been performed to evaluate the long-term health effects of hematopoietic stem cell transplant (HSCT) in this population. Individuals with SCD suffer progressive heart, lung, and kidney disease prior to curative therapy. In adults, these sequalae are associ

Совпадение в полном тексте источника
… Cryptogenic organizing pneumonia post-allogeneic HSCT incidence ranges from 1.7% to 10.3% [ 94 , 95 , 96 , 97 ]. Patients with cryptogenic organizing pneumonia were more likely to have acute skin GVHD and chronic GVHD involving the oral cavity and gut [ 94 ]. … The mortality rate associated with cryptogenic organizing pneumonia is 21% [ 98 ]. …

Эффективность и безопасность иммуноадсорбции как спасательной терапии подстрекательских миопатий: доклад three - обзор дел и литературы.

Идиопатическая воспалительная миопатия (МИМ) резюмирует редкие, системные аутоиммунные условия, характеризующиеся главным образом провокационным повреждением скелетной мышцы. Несмотря на то, что мышечные мышцы повреждены в первую очередь, эти заболевания, связанные с IIM, связаны с другими органами, включая кожу, легкие, верхний желудочно-кишечный тракт, суставы и сердце. Несмотря на то, что многие пациенты адекватно реагируют на иммунодепрессивное лечение, некоторые пациенты развивают быстро прогрессивные и устойчивые к лечению жизнестойкие курсы. Для лечащего врача ИИМ является сложным делом

Совпадение в полном тексте источника
… In this patient, prior treatment with prednisolone, methotrexate, IVIG, rituximab, and MMF was either not tolerated or ineffective. 17 Further, another patient with refractory muscle weakness and dyspnea due to cryptogenic organizing pneumonia in the context of anti-signal recognition particle (SRP) … Signal recognition particle (SRP) positive myositis in a patient with cryptogenic organizing pneumonia (COP) . Rheumatol Int 2010 ; 30 : 1361 – 1365 . 19639324 10.1007/s00296-009-1059-4 19 Eller P Flick H Schilcher G , et al . …

Pulmonary and Hepatic Complications of Hematopoietic Cell Transplantation

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Cryptogenic organizing pneumonia. A report of 25 cases and a review of the literature. Medicine. 1995;74(4):201–211. doi: 10.1097/00005792-199507000-00004. Aronin PA, Mahaley MS, Jr, Rudnick SA, Dudka L, Donohue JF, Selker RG, Moore P. … Cryptogenic organizing pneumonia: CT findings in 43 patients. Am J Roentgenol. 1994;162(3):543–546. doi: 10.2214/ajr.162.3.8109493. Lewis ID, DeFor T, Weisdorf DJ. …

Cancer-associated stroke: Pathophysiology, detection and management (Review).

Numerous types of cancer have been shown to be associated with either ischemic or hemorrhagic stroke. In this review, the epidemiology and pathophysiology of stroke in cancer patients is discussed, while providing vital information on the diagnosis and management of patients with cancer and stroke. Cancer may mediate stroke pathophysiology either directly or via coagulation disorders that establish a state of hypercoagulation, as well as via infections. Cancer treatment options, such as chemotherapy, radiotherapy and surgery have all been shown to aggravate the risk of stroke as well. The clin

Chest and Mediastinum

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Positive Autoantibody Is Associated with Malignancies in Patients with Idiopathic Interstitial Pneumonias.

Various autoantibodies are associated with clinical outcomes in patients with idiopathic interstitial pneumonias (IIPs). We retrospectively analyzed the association between autoantibodies and malignancies in IIP patients. Comprehensive analyses of autoantibodies were performed using immunoprecipitation and enzyme-linked immunosorbent assays in 193 consecutive IIP patients. Cancer-related factors were analyzed using logistic regression analysis. In total, 22 of 193 patients (11.4%) with IIP had malignant disease. In univariate analysis, positivity for any autoantibody (odds ratio (OR), 3.1; 95%

Совпадение в полном тексте источника
… The study cohort consisted of 193 patients (141 males; median age, 68.0 years at the time of diagnosis with ILD), including 99 (51.3%) with IPF, 7 (3.6%) with non-specific interstitial pneumonia (NSIP), 1 (0.52%) with cryptogenic organizing pneumonia, and 86 (44.2%) with unclassifiable IIP. …

Pulmonary GvHD: is it time to change the NIH diagnostic criteria?

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… As mentioned above, the NIH criteria have certainly facilitated the diagnosis of BOS, but have overlooked several restrictive patterns of cGvHD, such as cryptogenic organizing pneumoniae (COP) and interstitial forms, which are often characterized by a reduction in the DLCO. …

What Has Been Learned from Postmortem Studies?

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Clinically, these cases can have subacute presentations similar to cryptogenic organizing pneumonia or have more rapid progression with clinical features similar to ARDS. …

Novel therapeutic approaches for pulmonary fibrosis.

Pulmonary fibrosis represents the end stage of a number of heterogeneous conditions and is, to a greater or lesser degree, the hallmark of the interstitial lung diseases. It is characterized by the excessive deposition of extracellular matrix proteins within the pulmonary interstitium leading to the obliteration of functional alveolar units and in many cases, respiratory failure. While a small number of interstitial lung diseases have known aetiologies, most are idiopathic in nature, and of these, idiopathic pulmonary fibrosis is the most common and carries with it an appalling prognosis - med

International Recommendations for Screening and Preventative Practices for Long-Term Survivors of Transplantation and Cellular Therapy: A 2023 Update.

As hematopoietic cell transplantation (HCT) and cellular therapy expand to new indications and international access improves, the number of HCTs performed annually continues to rise. Parallel improvements in HCT techniques and supportive care entails more patients surviving long term, creating further emphasis on survivorship needs. Survivors are at risk for developing late complications secondary to pretransplantation, peritransplantation, and post-transplantation exposures and other underlying risk factors. Guidelines for screening and preventive practices for HCT survivors were originally p

Совпадение в полном тексте источника
… RESPIRATORY COMPLICATIONS Late pulmonary complications include idiopathic pneumonia syndrome (IPS), pulmonary fibrosis, bronchiolitis obliterans syndrome (BOS), and cryptogenic organizing pneumonia (COP) ( Table 4 , Supplementary Table S5 ) [ 22 ]. … Nakasone H , Onizuka M , Suzuki N , Pre-transplant risk factors for cryptogenic organizing pneumonia/bronchiolitis obliterans organizing pneumonia after hematopoietic cell transplantation . Bone Marrow Transplant . 2013 ; 48 : 1317 – 1323 . 23933758 10.1038/bmt.2013.116 110. …

Role of Cardio-Oncology Rehabilitation in Hematopoietic Stem Cell Transplantation and Chimeric Antigen Receptor T-Cell (CAR-T) Therapy.

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) and chimeric antigen receptor T-cell (CAR-T) therapy often lead to severe sarcopenia and cachexia during treatment, making it difficult to maintain exercise tolerance. Consequently, "cancer rehabilitation" programs have been implemented to sustain and improve physical activity and motor function. Hematologic malignancies often involve the use of cardiotoxic drugs. Moreover, graft-vs.-host disease associated with allo-HSCT and the cytokine release syndrome in CAR-T therapy elevate the risk of cardiovascular complications. Thus, esta

Совпадение в полном тексте источника
… Neutropenia and immunosuppressive therapies can lead to bacterial, viral, or fungal pneumonia, posing a risk of severe complications. 46 Non-infectious lung injuries caused by GVHD, radiation therapy, or conditioning regimens have also been reported, including cryptogenic organizing pneumonia due to …

Frequent co-reactivation of Epstein-Barr virus in patients with cytomegalovirus viremia under immunosuppressive therapy and/or chemotherapy.

OBJECTIVE: Co-reactivation of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) occurs in iatrogenically immunosuppressed patients, but the clinical relevance of this is unknown. We aimed to determine the frequency of EBV reactivation in patients with CMV viremia and to explore its clinical significance. METHODS: Serum or plasma CMV and EBV DNA was detected by quantitative real-time PCR in 82 patients who received immunosuppressive therapy and/or chemotherapy and underwent CMV antigenemia tests. RESULTS: CMV DNA was positive in 55 patients, with EBV reactivation being found in 29 of these (

Nocardia Infection Presented as Intramuscular Abscess in a Kidney Transplant Recipient: Case Report and Literature Review.

BACKGROUND: Nocardia is a gram-positive bacterium capable of causing both local and systemic infections, typically in immunocompromised patients. The most common clinical presentation is pulmonary infection. Muscle abscess due to Nocardia infection without disseminated nocardiosis is rare. CASE REPORT: In this report, we describe the case of a 67-year-old male kidney transplant recipient who developed a swelling of the right biceps muscle. CT imaging showed an intramuscular abscess, which was subsequently surgically drained. The drained fluid grew Nocardia pseudobrasiliensis, which was resist

Rituximab-Induced Interstitial Lung Disease: A Possible Underestimated Complication-A Systematic Review.

Background: Rituximab, a monoclonal antibody targeting CD20, has revolutionized the management of B-cell lymphoproliferative disorders and some immune conditions, significantly improving disease control and patient survival. Beyond its indisputable therapeutic benefits, rituximab can cause serious pulmonary adverse events, particularly interstitial lung disease (R-ILD). Diagnosing R-ILD is challenging due to nonspecific clinical and imagistic features, and its true incidence is possibly underestimated. Methods: We conducted a systematic review to synthesize current evidence on R-ILD, focusing

Intrathoracic manifestations of hematologic malignancies: a narrative review.

BACKGROUND AND OBJECTIVE: Although the global incidence of hematologic malignancies is decreasing, the risk of developing these cancers is increasing due to increased lifespan and modern treatments including targeted therapy, chemotherapy, and radiation. Intrathoracic manifestations of hematologic malignancies may be the presenting sign leading to diagnosis or result from various treatment toxicity. The most common respiratory manifestation of hematologic malignancies is infectious, but up to half of pulmonary findings are from non-infectious etiologies. We aim to summarize the current literat

Совпадение в полном тексте источника
… Cryptogenic Organizing Pneumonia. N Engl J Med 2022;386:1058-69. 10.1056/NEJMra2116777 70. Hanania AN, Mainwaring W, Ghebre YT, et al. Radiation-Induced Lung Injury: Assessment and Management. Chest 2019;156:150-62. 10.1016/j.chest.2019.03.033 71. Haanen JBAG, Carbonnel F, Robert C, et al. …