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Antibiotic use for common illnesses in children living with disability: a multi-country study across 42 low- and middle-income countries.

BACKGROUND: Approximately 240 million children worldwide are living with disabilities. Understanding the association between disability stat … = 0.85, 95% CI: 0.74-0.97, aOR = 0.78, 95% CI: 0.64-0.95, respectively). Lesotho, Iraq, Comoros and Honduras had higher odds of reported antibiotic use for children with disabilities, and in Pakistan where children with disabilities had lower odds of reported antibiotic use. Subgroup analyses showed that girls with disabilities were less likely to use anti …

HLA DOA1 and DOB1 loci in Honduran women with cervical dysplasia and invasive cervical carcinoma and their relationship to human papillomavirus infection.

Molecular and epidemiological studies have demonstrated that certain types of human papillomavirus (HPV), mainly HPV-16 and HPV-18, are the primary causes of cervical cancer and its precursor lesions; there is now evidence for a clear association with specific HLA class I and class II loci contributing independently to the expression of cervical cancer. Among Honduran women carcinoma of the cervix is the most common type of cancer, and infections with high-risk HPV types are highly prevalent. To study the interactive role of viral-host genetics, we performed PCR amplification of DNA and sequen

Association of candidate genes with nonsyndromic clefts in Honduran and Colombian populations.

OBJECTIVES/HYPOTHESIS: Orofacial clefts are the most common craniofacial birth defects in humans, with the majority of orofacial clefts occurring as nonsyndromic cleft lip with or without cleft palate (NSCLP). We previously demonstrated associations between single-nucleotide polymorphisms (SNPs) in the IRF6 gene and NSCLP in the Honduran population. Here we investigated other candidate genes and chromosomal regions associated with NSCLP identified from genome-wide association studies (GWAS), including MAFB, ABCA4, 8q24, 9q22, 10q25, and 17q22 in two independent Hispanic populations. STUDY DES

Performance of standardised colposcopy to detect cervical precancer and cancer for triage of women testing positive for human papillomavirus: results from the ESTAMPA multicentric screening study.

BACKGROUND: Colposcopy, currently included in WHO recommendations as an option to triage human papillomavirus (HPV)-positive women, remains … pitals, laboratories, and universities) in Latin America (Argentina, Bolivia, Colombia, Costa Rica, Honduras, Mexico, Paraguay, Peru, and Uruguay). Eligible women were aged 30-64 years, sexually active, did not have a history of cervical cancer or treatment for cervical precancer or a hysterectomy, and were not planning to move outside of the study area. W …

Head injury and neuropsychiatric sequelae in asylum seekers.

OBJECTIVE: Asylum seekers experience a high burden of physical and psychological trauma, yet there is a scarcity of literature regarding the epidemiology and sequelae of head injury (HI) in asylum seekers. We examined HI prevalence and association with neuropsychiatric comorbidities in asylum seekers. METHODS: A retrospective cross-sectional study was performed through review of 139 medical affidavits from an affidavit database. Affidavits written from 2010 to 2018 were included. Demographic and case-related data were collected and classified based on the presence of HI. For neuropsychiatric

Proteomic analysis of venom variability and ontogeny across the arboreal palm-pitvipers (genus Bothriechis).

UNLABELLED: Bothriechis is a genus of eleven currently recognized slender and arboreal venomous snakes, commonly called palm-pitvipers that … highland palm-pitvipers, B. thalassinus, B. aurifer, and B. bicolor from Guatemala, B. marchi from Honduras, and neonate Costa Rican B. lateralis and B. schlegelii, were investigated. B. thalassinus and B. aurifer venoms are comprised by similar toxin arsenals dominated by SVMPs (33-39% of the venom proteome), CTLs (11-16%), BPP-like molecules (10-13%), a …

Отчет о случае: несекретирующий множественный миелома с эозинофильной реакцией: диагностические вызовы и фокусированный обзор литературы.

Мы сообщаем редкий случай непродуктивного множественного миеломы (НММ) с выраженной эозинофильной апоптозом и значительными трудностями в диагностике. 56-летний мужчина был госпитализирован с повторяющейся болью в поясничной области более чем 10 лет, которая в последние 10 дней быстро усугубилась, сопровождаясь общей болью и потерей веса. Лабораторная оценка показала постоянную эозинофилию, тромбоцитопению, повышение лактата деhidрогеназы и увеличение воспалительных маркеров. Медицинские исследования выявили мультифокальные остеолитические поражения, затрагивающие череп, позвонки, ребра и таз.

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… Footnotes Edited by: Anna Maria Testi , Sapienza University of Rome, Italy Reviewed by: Nina Nurarifah , Saiful Anwar Region Hospital, Indonesia Carlos Solórzano Flores , National Autonomous University of Honduras, Honduras Data availability statement The original contributions presented in the …

Efficacy of a monovalent (D614) SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant in adults: a phase 3, multi-country study.

BACKGROUND: The literature on first generation COVID-19 vaccines show they were less effective against new SARS-CoV-2 variants of concern in … 9) among adults (≥18 years) was conducted in 53 research centres in eight countries (United States, Honduras, Japan, Colombia, Kenya, India, Ghana, Nepal). Participants were randomized 1:1 to receive two intramuscular injections of a monovalent SARS-CoV-2 recombinant protein vaccine with AS03-adjuvant (10 μg of the spike (S) protein from the ancestral D614 …

Solitary Plasmacytoma of the Breast: A Case of an Uncommon Breast Neoplasm.

Plasmacytoma is a rare cancer that originates from a single plasma cell and is characterized by the abnormal proliferation of monoclonal plasma cells. It is typically localized in a single area of the body, most commonly in the bone or soft tissue. Solitary plasmacytoma can be further classified as either solitary plasmacytoma of bone (SPB) or solitary extramedullary plasmacytoma (SEP or EMP). Diagnosis may be delayed in symptomatically silent plasmacytomas, but early diagnosis and prompt treatment are crucial for the management of this disease. The mean age for patients with plasmacytoma vari

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… Case Presentation The patient was a 79-year-old female originally from Honduras. She was referred to our clinic from dermatology due to a complaint of a 0.5 centimeter erythematous, flat, painless lesion on her right breast for 3 years. …

Interventions for improving coverage of childhood immunisation in low- and middle-income countries.

BACKGROUND: Immunisation plays a major role in reducing childhood morbidity and mortality. Getting children immunised against potentially fa … ntries (China, Georgia, Mexico, Guatemala), 11 lower-middle-income countries (Côte d'Ivoire, Ghana, Honduras, India, Indonesia, Kenya, Nigeria, Nepal, Nicaragua, Pakistan, Zimbabwe), and three lower-income countries (Afghanistan, Mali, Rwanda). The interventions evaluated in the studies were health education (seven studies), patient reminders (13 studies), …

Donor Evaluation for Hematopoietic Stem and Progenitor Cell Collection

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… and Prevention 2017 ) Americas Anguilla Antigua Argentina Aruba Barbados Belize Bolivia Bonaire Brazil Colombia Commonwealth of Puerto Rico, US territory Costa Rica Cuba Curacao Dominica Dominican Republic Ecuador El Salvador Florida, state of∗ French Guiana Grenada Guadeloupe Guatemala Guyana Haiti Honduras … Prevention 2017 ) Americas | | Anguilla Antigua Argentina Aruba Barbados Belize Bolivia Bonaire Brazil Colombia Commonwealth of Puerto Rico, US territory Costa Rica Cuba Curacao Dominica | Dominican Republic Ecuador El Salvador Florida, state of∗ French Guiana Grenada Guadeloupe Guatemala Guyana Haiti Honduras …

Safety and immunogenicity of an AS03-adjuvanted SARS-CoV-2 recombinant protein vaccine (CoV2 preS dTM) in healthy adults: interim findings from a phase 2, randomised, dose-finding, multicentre study.

BACKGROUND: We evaluated our SARS-CoV-2 prefusion spike recombinant protein vaccine (CoV2 preS dTM) with different adjuvants, unadjuvanted, … th a potentially increased risk for severe COVID-19, at 20 clinical research centres in the USA and Honduras. Women who were pregnant or lactating or, for those of childbearing potential, not using an effective method of contraception or abstinence, and those who had received a COVID-19 vaccine, were excluded. Participants were randomly assigned (1:1:1) us …

The 2023 Latin America report of the Lancet Countdown on health and climate change: the imperative for health-centred climate-resilient development.

In 2023, a series of climatological and political events unfolded, partly driving forward the global climate and health agenda while simulta … phical scope adding Mexico and five Central American countries: Costa Rica, El Salvador, Guatemala, Honduras, and Panama, as a response to the need for stronger collaboration in a region with significant social disparities, including research capacities and funding. The centre is an independent and multidisciplinary collaboration that tracks the links betw …

Immunogenicity and shedding of live-attenuated intranasal respiratory syncytial virus vaccine in children aged 6-18 months by baseline serostatus: a multicentre, randomised, placebo-controlled, phase 1/2 trial.

BACKGROUND: Respiratory syncytial virus (RSV) causes acute respiratory illness in young children. The live-attenuated RSV vaccine candidate … ised, placebo-controlled, phase 1/2 trial, children in the USA (N=22 sites), Chile (N=2 sites), and Honduras (N=2 sites) were recruited as participants. Healthy children aged 6-18 months at enrolment who were born at or after 34 weeks of gestation (if age 1 year or older) or children younger than 1 year at enrolment who were born at or after 37 weeks of ge …

A multicountry ecological study of cancer incidence rates in 2008 with respect to various risk-modifying factors.

Observational and ecological studies are generally used to determine the presence of effect of cancer risk-modifying factors. Researchers generally agree that environmental factors such as smoking, alcohol consumption, poor diet, lack of physical activity, and low serum 25-hdyroxyvitamin D levels are important cancer risk factors. This ecological study used age-adjusted incidence rates for 21 cancers for 157 countries (87 with high-quality data) in 2008 with respect to dietary supply and other factors, including per capita gross domestic product, life expectancy, lung cancer incidence rate (an

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… The other 70 countries: Algeria, Angola, Bangladesh, Benin, Bolivia, Botswana, Burkina Faso, Burundi, Cambodia, Cameroon, Cape Verde, Central African Republic, Chad, Chile, China, Comoros, Djibouti, Ethiopia, French Polynesia, Gabon, Gambia, Ghana, Guadeloupe, Guinea, Guinea-Bissau, Honduras, India, …

New butterfly taxa and findings from genomic analyses.

Continuing our genomics-driven exploration of butterfly taxonomy, we integrate phylogenetic trees from all protein-coding genes with existin … 5 as a species-level taxon confirmed by sequencing of additional specimens extending its range from Honduras to include El Salvador, Nicaragua, and Costa Rica; a second specimen of Gorgythion cerrada Grishin, 2025; a possible paralectotype of Antigonus ruptifasciata Plötz, 1884, also from Jamaica as deduced by genomic comparison; the holotype of Pamphila p …

Wearables research for continuous monitoring of patient outcomes: A scoping review.

BackgroundThe use of wearable devices for remote health monitoring is a rapidly expanding field. These devices might benefit patients and providers; however, they are not yet widely used in healthcare. This scoping review assesses the current state of the literature on wearable devices for remote health monitoring in non-hospital settings.MethodsCINAHL, Scopus, Embase and MEDLINE were searched until August 5, 2024. We performed citation searching and searched Google Scholar. Studies on wearable devices in an outpatient setting with a clinically relevant, measurable outcome were included and we

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… ., 2020 | USA | Prospective | Yes | 5262 (32) | 44 | COVID-19/ heart rate, number of daily steps, time asleep | N/R | Smartwatches (Fitbits, Apple watches, Garmin, other) | Device detected COVID-19 before or at symptom onset. [ 93 ] | Smarr et al., 2020 | USA, UK, Finland, Austria, Canada, Germany, Honduras …