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Войти в исследования A Comprehensive Review of Modern Cancer Therapies Utilizing Oncolytic Viruses.
Oncolytic viruses (OVs) are gaining traction as advanced tools in cancer therapy. They are distinguished by their ability to destroy malignant cells while sparing normal tissue specifically. In addition to their direct tumor-lysing properties, an essential benefit of oncolytic virus therapy is its capacity to activate both the innate and adaptive immune systems. To enhance these therapeutic actions, many OVs have been genetically engineered to encode immune-modulating factors that reestablish or strengthen antitumor immune responses. Recent studies show that combining OVs with other forms of i
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… . | The first significant study documenting the oncolytic effect of viral infection.
1912 | De Pace, N. [ 9 ] | Attenuated Lyssavirus rabies ( Rhabdoviridae ) | Cervical cancer | Clinical study (8 patients) preceded by a case report demonstrating the oncolytic effect of an attenuated rabies vaccine. … Patients without hepatitis symptoms showed no remission. | The first major clinical study using a hepatitis virus and showing a clear and significant therapeutic effect.
1950 | Pack, G.T. [ 11 ] | Attenuated Lyssavirus rabies ( Rhabdoviridae ) | Melanoma | Clinical study of 12 private patients | Regressive …
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