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Последние достижения в лечении и профилактике периферической нейропатии после многократного лечения миеломы.

Заболеваемость множественной миеломой (ММ) из года в год увеличивается, и для контроля за состоянием требуется химиотерапия. С появлением новых протеиновых ингибиторов, иммуномодуляторов и моноклональных антител, прогнозы пациентов значительно улучшились. Однако периферическая нейропатия, вызванная лекарственными препаратами, ограничивает дозу и продолжительность лечения, что серьезно сказывается на качестве жизни пациентов и результатах лечения. Несмотря на то, что нейропатии, вызванные химиотерапией, привлекли к себе большое внимание, их механизм и эффективные профилактические и лечебные мер

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… So cannabinoids are likely to be effective drugs for the effective treatment of BIPN. 43 Paeoniflorin Paeoniflorin is a bioactive compound isolated from the Chinese herbal medicine plant Paeonia lactiflora , which has a wide range of anti‐inflammatory, analgesic and immunomodulatory effects. 50 In …

Apoptotic Pathway as the Therapeutic Target for Anticancer Traditional Chinese Medicines.

Cancer is a leading cause of morbidity and mortality worldwide. Apoptosis is a process of programmed cell death and it plays a vital role in human development and tissue homeostasis. Mounting evidence indicates that apoptosis is closely related to the survival of cancer and it has emerged as a key target for the discovery and development of novel anticancer drugs. Various studies indicate that targeting the apoptotic signaling pathway by anticancer drugs is an important mechanism in cancer therapy. Therefore, numerous novel anticancer agents have been discovered and developed from traditional

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… Paeonia lactiflora Pall (Ranunculaceae) is a flowering plant and well-known TCM used for the treatment of rheumatoid arthritis in China for over a thousand years ( He and Dai, 2011 ). … (Triptolide, Minnelide), Rubia yunnanensis (RA-XII, rubiarbonol G), Scutellaria baicalensis Georgi (wogonin, baicalein, baicalin), Lycium chinense Miller (Cortex lycii radices), Paeonia lactiflora Pall (paeoniflorin), Nigella sativa | NF-κB Curcuma longa Linn (Curcumin, B63, B19, EF24, WZ26, WZ35, L48H37 …

Efficacy and safety of modified Bushen Yiqi formulas (MBYF) as an add-on to formoterol and budesonide in the management of COPD: study protocol for a multicentre, double-blind, placebo-controlled, parallel-group, randomized clinical trial: FB-MBYF Trial.

BackgroundInhaled glucocorticoid corticosteroid (ICS), long-acting β2-adrenoceptor agonist (LABA), and other drugs have limited therapeutic effects on COPD with significant individual differences. Traditional Chinese medicine (TCM)-modified Bushen Yiqi formula (MBYF) demonstrates advantages in COPD management in China. This study aims to evaluate the efficacy and safety of MBYF as an add-on to budesonide/formoterol in COPD patients and confirm the related genes affecting the therapeutic effect in the treatment of COPD.MethodsIn this multicentre, randomised, double-blind, placebo-controlled, pa

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… folium | The dried leaf of Epimedium brevicomu Maxim | 0.5 | 4.87 Dihuang | Rehmanniae Radix | The dried root of Rehmannia glutinosa Libosch | 3 | 29.30 | Huangqin | Scutelllariae radix | The dried root of Scutellaria baicalensis Georgi | 2.24 | 21.87 Chishao | Peaoniae radix rubra | The dried root of paeonia …

Mechanism and therapeutic potential of traditional Chinese medicine extracts in sepsis.

Sepsis is a complex syndrome characterized by multi-organ dysfunction, due to the presence of harmful microorganisms in blood which could cause mortality. Complications associated with sepsis involve multiple organ dysfunction. The pathogenesis of sepsis remains intricate, with limited treatment options and high mortality rates. Traditional Chinese medicine (TCM) has consistently demonstrated to have a potential on various disease management. Its complements include reduction of oxidative stress, inhibiting inflammatory pathways, regulating immune responses, and improving microcirculation. Tra

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… Maesen & S.M.Almeida ex Sanjappa & Predeep | D-galactose model ICR mice | 60, 120 mg/kg | Neuroendocrine immune network | ↑: ChAT, ACh | Brain | NA | Pan et al. (2008) Paeoniflorin | Paeonia lactiflora Pall. | MCAO model SD rats | 2.5, 5, 10 mg/kg | Neuroendocrine immune network | ↓: M2 receptor ↑: M1 … group receptor, ACh, Kir6.2/Kir6.1 | Brain | NA | Wang et al. (2012) Paeoniflorin | Paeonia lactiflora Pall. | Human umbilical vein endothelial cells after ischemia reperfusion | 0.078, 0.156, 0.312 mg/mL | Neuroendocrine immune network | ↓: ICAM-1, VCAM-1, p-p38 MAPK | NA | NA | Wang et al. (2016) …

Network pharmacology- and molecular docking-based investigation of the therapeutic potential and mechanism of daucosterol against multiple myeloma.

BackgroundSome studies have shown that daucosterol has potential anti-tumor activity, but its therapeutic effect on multiple myeloma (MM) has not been reported. This study aimed to evaluate the therapeutic effect daucosterol against MM and explore its possible mechanism through network pharmacology.MethodsWe collected daucosterol and approved drugs for MM, and their potential target profiles were obtained. We used 2 major methods to collect the gene sets related to the physiological process of MM. Based on the protein-protein interaction (PPI) network in the STRING database, the correlation be

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… Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells. …

Managing fatigue in patients with primary Sjögren's syndrome: challenges and solutions.

Primary Sjögren's syndrome (pSS) patients identify fatigue as their most important symptom and the one most difficult to cope with, but there are still many challenges and few solutions to manage this debilitating symptom. Promising pharmacological treatments, such as rituximab, have failed in more stringent tests including randomized controlled trials (RCTs) and meta-analysis. While non-pharmacological interventions may be safer, less costly, and address other common comorbidities, to date only aerobic exercise seems to be effective at reducing fatigue in pSS. All interventions, pharmacologic

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… TGP are extracted from the root of the Paeonia lactiflora pall and have been demonstrated to have immunomodulatory effects, such as inhibition of dendritic cell maturation and function. …

Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer.

The complex pathology of cancer development requires correspondingly complex treatments. The traditional application of individual single-target drugs fails to sufficiently treat cancer with durable therapeutic effects and tolerable adverse events. Therefore, synergistic combinations of drugs represent a promising way to enhance efficacy, overcome toxicity and optimize safety. Chinese Herbal Medicines (CHMs) have long been used as such synergistic combinations. Therefore, we summarized the synergistic combinations of CHMs used in the treatment of cancer and their roles in chemotherapy in terms

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… PHY906 consists of Gancao (Glycyrrhiza uralensis Fisch), Shaoyao (Paeonia lactiflora Pall), Huangqin (Scutellaria baicalensis Georgi) and Dazao (Ziziphus jujuba Mill) and has long been used for a variety of maladies. …

Properties of Approved Antitumour Chinese Herbal Medicines: Integrating Evidence and Tradition.

The properties and meridian affinities of Chinese herbal medicine are closely associated with their therapeutic efficacy. This review focuses on approved antitumour Chinese medicines listed in the Pharmacopoeia of the People's Republic of China (2020 Edition, Volume I), highlighting their key components. Statistical methods were used to analyse the properties, flavours and channel tropisms of antitumour traditional Chinese medicine (TCM), including both proprietary formulations and commercially available individual herbs. Distinctive patterns were identified by comparing herb profiles with con

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… These bioactive compounds regulate critical oncogenic processes, including cell-cycle progression, telomerase activity and signal transduction cascades, culminating in broad anticancer efficacy. 2–6 For instance, paeoniflorin, a major component of Paeoniae Radix Rubra , induces tumour cell apoptosis …

Wnt/β-catenin signaling pathway: proteins' roles in osteoporosis and cancer diseases and the regulatory effects of natural compounds on osteoporosis.

Osteoblasts are mainly derived from mesenchymal stem cells in the bone marrow. These stem cells can differentiate into osteoblasts, which have the functions of secreting bone matrix, promoting bone formation, and participating in bone remodeling. The abnormality of osteoblasts can cause a variety of bone-related diseases, including osteoporosis, delayed fracture healing, and skeletal deformities. In recent years, with the side effects caused by the application of PTH drugs, biphosphonate drugs, and calmodulin drugs, people have carried out more in-depth research on the mechanism of osteoblast

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… Paeonia lactiflora (PL) is often used to treat a variety of conditions such as irregular menstruation and dysmenorrhea, and has a variety of biological activities such as anti-inflammatory, anti-cancer, and anti-pigmentation. … Bone marrow mesenchymal stem cells Osteogenesis imperfecta Neural progenitor cells Lysophosphatidic acid Extracellular vesicles Bone mineral density N-Methyl-N'-nitro-N-nitrosoguanidine Retinitis pigmentosa Multiple myeloma CXXC finger protein 5 Ubiquitin-specific enzyme 4 Ginkgolide B Paeonia …

Anticancer potential of decursin, decursinol angelate, and decursinol from Angelica gigas Nakai: A comprehensive review and future therapeutic prospects.

Many naturally derived compounds are currently used in oncotherapy. Besides official medicine, complementary and alternative medicine practices, including old herbal remedies, are widely used and accepted as additional tools in cancer treatment. Angelica gigas Nakai (AGN), a medicinal herb in Asia, has roots historically used in medicine. This review focuses on key bioactive compounds from AGN roots - decursin, decursinol angelate (DA), and decursinol (DOH). Exploring their source, biosynthesis, and therapeutic mechanisms, the review highlights their role in cancer treatment. Biotechnological

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… Standardized extract (HemoHIM) from Angelica gigas Nakai, Cnidium officinale , Makino and Paeonia lactiflora Pallas extract attenuates acetaminophen‐induced liver injury in human hepatocellular carcinoma cells and mice model. Indian Journal of Pharmaceutical Sciences, 83, 195–203. …

Quantification of promoting efficiency and reducing toxicity of Traditional Chinese Medicine: A case study of the combination of Tripterygium wilfordii hook. f. and Lysimachia christinae hance in the treatment of lung cancer.

Traditional Chinese medicine (TCM) usually acts in the form of compound prescriptions in the treatment of complex diseases. The herbs contained in each prescription have the dual nature of efficiency and toxicity due to their complex chemical component, and the principle of prescription is usually to increase efficiency and reduce toxicity. At present, the studies on prescriptions have mainly focused on the consideration of the material basis and possible mechanism of the action mode, but the quantitative research on the compatibility rule of increasing efficiency and reducing toxicity is stil

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… Among these anti-tumor drug pairs, there are also some frequently used herb pairs such as Tripterygium wilfordii Hook. f. with Glycyrrhiza uralensis Fisch., Pteris multifida Poir., and Lysimachia christinae Hance; Paeonia lactiflora Pall. …

Muscle and Bone Defects in Metastatic Disease.

PURPOSE OF REVIEW: The present review addresses most recently identified mechanisms implicated in metastasis-induced bone resorption and muscle-wasting syndrome, known as cachexia. RECENT FINDINGS: Metastatic disease in bone and soft tissues is often associated with skeletal muscle defects. Recent studies have identified a number of secreted molecules and extracellular vesicles that contribute to cancer cell growth and metastasis leading to bone destruction and muscle atrophy. In addition, alterations in muscle microenvironment including dysfunctions in hepatic and mitochondrial metabolism ha

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… Paeonia lactiflora root extract suppresses cancer cachexia by down-regulating muscular NF-κB signalling and muscle-specific E3 ubiquitin ligases in cancer-bearing mice. J Ethnopharmacol [Internet]. 2020;246:112222. …

Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science.

Traditional Chinese medicine (TCM) has been practiced for thousands of years and at the present time is widely accepted as an alternative treatment for cancer. In this review, we sought to summarize the molecular and cellular mechanisms underlying the chemopreventive and therapeutic activity of TCM, especially that of the Chinese herbal medicine-derived phytochemicals curcumin, resveratrol, and berberine. Numerous genes have been reported to be involved when using TCM treatments and so we have selectively highlighted the role of a number of oncogene and tumor suppressor genes in TCM therapy. I

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… PHY906, formulated using the herbs Scutellaria baicalensis , Ziziphus jujuba , Paeonia lactiflora, and Glycyrrhiza glabra, has been reported to reduce the adverse effects of capecitabine in advanced hepatocellular carcinoma patients in a phase I/II clinical study. 22 , 155 It was shown that oral CHM …

A Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases.

The drugs used for treating bone diseases (BDs), at present, elicit hazardous side effects that include certain types of cancers and strokes, hence the ongoing quest for the discovery of alternatives with little or no side effects. Natural products (NPs), mainly of plant origin, have shown compelling promise in the treatments of BDs, with little or no side effects. However, the paucity in knowledge of the mechanisms behind their activities on bone remodeling has remained a hindrance to NPs' adoption. This review discusses the pathological development of some BDs, the NP-targeted components, an

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… Notably, albiflorin ( 34 ) and paeoniflorin ( 35 ) isolated from Paeonia lactiflora enhanced OBG in MC3T3-E1 cells by upregulating the mRNA expression of Wnt (Wnt10b), β-catenin (ctnnb1), LRP5, LRP6, Dvl2, and cyclin D1 (Ccnd1) [ 144 ], suggesting the involvement of BMP2-Wnt/β-catenin signaling pathway …

Combinational Antitumor Strategies Based on the Active Ingredients of Toad Skin and Toad Venom.

A multidrug combination strategy is an important mean to improve the treatment of cancer and is the mainstream scheme of clinical cancer treatment. The active ingredients of traditional Chinese medicine, represented by toad skin and toad venom, have the advantages of high efficiency, low toxicity, wide action and multiple targets and have become ideal targets in combined treatment strategies for tumors in recent years. Toad skin and toad venom are traditional Chinese animal medicines derived from Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider that have shown excellent therapeutic

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… National Drug Standards of the National State Food and Drug Administration, WS 3 -B-3345-98-2013 Tianchan capsule (天蟾胶囊) Corydalis Decumbentis Rhizoma, Aconiti Radix Cocta, Bufonis Venenum, Cirald Daphne Bark, Chelidonii Herba, Gentianae Macrophyllae Radix, Angelicae Dahuricae Radix, Chuanxiong Rhizoma, Paeoniae … National Drug Standards of the National State Food and Drug Administration, WS 3 -B-3345-98-2013 Tianchan capsule (天蟾胶囊) | Corydalis Decumbentis Rhizoma, Aconiti Radix Cocta, Bufonis Venenum, Cirald Daphne Bark, Chelidonii Herba, Gentianae Macrophyllae Radix, Angelicae Dahuricae Radix, Chuanxiong Rhizoma, Paeoniae …

A review of chemotherapeutic drugs-induced arrhythmia and potential intervention with traditional Chinese medicines.

Significant advances in chemotherapy drugs have reduced mortality in patients with malignant tumors. However, chemotherapy-related cardiotoxicity increases the morbidity and mortality of patients, and has become the second leading cause of death after tumor recurrence, which has received more and more attention in recent years. Arrhythmia is one of the common types of chemotherapy-induced cardiotoxicity, and has become a new risk related to chemotherapy treatment, which seriously affects the therapeutic outcome in patients. Traditional Chinese medicine has experienced thousands of years of cli

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… et al., 2015 ). 4.2 Chinese medicine Combination Formula 4.2.1 Qishen Huanwu Capsule Qishen Huanwu Capsule (QSHWC) is a compound preparation mainly composed of Huangqi (Astragalus), Taizishen (Pseudostellaria heterophylla), Chuanxiong (Ligusticum chuanxiong), Danggui (Angelica sinensis), Chishao (Paeonia …

Interplay of non-coding RNAs and approved antimetabolites such as gemcitabine and pemetrexed in mesothelioma.

Gemcitabine and pemetrexed are clinically approved antimetabolites for the therapy of mesothelioma diseases. These drugs are often applied in combination with platinum complexes and other drugs. The activity of antimetabolites depended on the expression levels of certain non-coding RNAs, in particular, of small microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). The development of tumor resistance towards antimetabolites was regulated by non-coding RNAs. An overview of the interplay between gemcitabine/pemetrexed antimetabolites and non-coding RNAs in mesothelioma is provided. Further to th

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… Paeoniflorin, a glucosylated monoterpene from Paeonia lactiflora , led to miR-16 upregulation in cancer cells [ 149 ]. …

Эпигенетика и метаболическая метаболическая дисфункция при многоразовом склерозе: обзор подходов к травяным лекарствам и текущих клинических испытаний.

Множественный склероз (MS) — сложная аутоиммунная болезнь, характеризующаяся воспалением, обезвоживанием и нейродегенерацией в центральной нервной системе (КНС). Хотя точные причины остаются неясными, недавние исследования подчеркивают важную роль эпигенетических изменений и митохондриальной дисфункции в начале и развитии болезни. Эпигенетические изменения, такие, как метилация ДНК, модификация гистона и регулирование микроРНК, влияют на генное выражение, не изменяя последовательности ДНК, что приводит к иммунной дисрегуляции и воспалению. Аналогичным образом, митохондриальная дисфункция, отме

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