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Predictors of periapical bone healing associated with teeth having large periapical lesions following nonsurgical root canal treatment or retreatment: A cone beam computed tomography-based retrospective study.

AIM: Several factors influence the condition of the periapical tissues associated with root filled teeth. The primary objective of this study was to retrospectively evaluate the extent and speed of bone healing of large periapical lesions associated with nonsurgical root canal treatment or retreatment. The secondary objective was to analyse the relationship between the time to complete healing when analysed using cone beam computed tomography (CBCT) and other possible predictors that affect healing. METHODOLOGY: Seventy-nine patients were treated during the years 2013-2020 with large periapic…

Removal of overextended root canal filling beyond the apex in lower premolar teeth using two different retreatment rotary files versus manual files: a comparative in vitro study.

BACKGROUND: The aim of the study was to compare the time required for complete removal of overextended root canal filling in lower premolar teeth using two different rotary file systems; ProTaper Universal Retreatment (PTUR) system, XP-endo Retreatment (XPER) system versus manual Hedstrom (H-Files). METHODS: Thirty-six extracted permanent mandibular premolars with single canal were set to a standard length of 19 mm and prepared beyond the apical foramen by 3 mm up to F2 file of the ProTaper Gold system. Overextended obturation was performed by a size (25/08) gutta-percha and AH-Plus sealer us…

Tremelimumab plus durvalumab retreatment and 4-year outcomes in patients with mesothelioma: a follow-up of the open label, non-randomised, phase 2 NIBIT-MESO-1 study.

BACKGROUND: The NIBIT-MESO-1 study demonstrated the efficacy and safety of tremelimumab combined with durvalumab in patient with unresectable mesothelioma followed up for a median of 52 months [IQR 49-53]. Here, we report 4-year survival and outcomes after retreatment, and the role of tumour mutational burden (TMB) in identifying patients who might have a better outcome in response to combined therapy. METHODS: NIBIT-MESO-1 was an open-label, non-randomised, phase 2 trial of patients with unresectable pleural or peritoneal mesothelioma who received intravenous tremelimumab (1 mg/kg bodyweight…

Global evolutionary analysis of chronic hepatitis C patients revealed significant effect of baseline viral resistance, including novel non-target sites, for DAA-based treatment and retreatment outcome.

Direct-acting antivirals (DAAs) have proven highly effective against chronic hepatitis C virus (HCV) infection. However, some patients exper … . Mutations outside of the DAA targets can be associated with DAA treatment failure. Successful DAA retreatment in patients with treatment failure was hampered by previously selected RASs.

Clinical outcomes of retreatment or discontinuation after interruption of nivolumab plus ipilimumab due to immune-related adverse events in metastatic renal cell carcinoma patients: A retrospective multicenter study.

INTRODUCTION: We aimed to investigate clinical outcomes in patients with metastatic renal cell carcinoma (mRCC) treated with nivolumab plus … those without treatment interruption ("no interruption"), those who resumed treatment after irAEs ("retreatment"), and those who permanently discontinued treatment after irAEs ("discontinuation"). RESULTS: The no interruption, retreatment, and discontinuation group included 58, 35, and 36 patients, respectively. Median time to initial irAE requiring treatmen …

Abrocitinib induction, randomized withdrawal, and retreatment in patients with moderate-to-severe atopic dermatitis: Results from the JAK1 Atopic Dermatitis Efficacy and Safety (JADE) REGIMEN phase 3 trial.

BACKGROUND: The heterogeneous course of moderate-to-severe atopic dermatitis necessitates treatment flexibility. OBJECTIVE: We evaluated the maintenance of abrocitinib-induced response with continuous abrocitinib treatment, dose reduction or withdrawal, and response to treatment reintroduction following flare (JAK1 Atopic Dermatitis Efficacy and Safety [JADE] REGIMEN: National Clinical Trial 03627767). METHODS: Patients with moderate-to-severe atopic dermatitis responding to open-label abrocitinib 200 mg monotherapy for 12 weeks were randomly assigned in a 1:1:1 ratio to blinded abrocitinib

Haemolytic uremic syndrome as a cause of chronic kidney disease stage 5 in children is in retreat: results from the Polish Registry of Kidney Replacement Therapy in children (2000-2023).

BACKGROUND: Haemolytic uremic syndrome (HUS) is a life-threatening disease with a historically poor prognosis in children receiving maintenance kidney replacement therapy (KRT). This study aimed to analyse the incidence and outcome of chronic kidney disease stage 5 (CKD5) due to Escherichia coli-HUS (STEC-HUS) and complement-mediated HUS (CM-HUS) in children, compared with controls with non-HUS CKD5 over the last 24 years. METHODS: The study included 1488 children undergoing KRT in Poland between 2000 and 2023. Thirty-nine patients with CM-HUS and 18 with STEC-HUS were identified and analysed

Presence of small and large branch vessels from intracranial aneurysms increases the risk of post-treatment recurrence and retreatment following endovascular coiling: insights from a propensity score-matched cohort.

OBJECTIVE: Aneurysms with involvement of a branch vessel within the sac represent a particularly challenging morphological feature in the context of coil embolization. The aim of this propensity score-matched cohort study was to determine the impact of branch vessel involvement on angiographic occlusion, clinical outcomes, recurrence, and retreatment after endovascular coiling. METHODS: We conducted a single-center retrospective cohort study of intracranial aneurysms treated with conventional, balloon-assisted, or stent-assisted coiling. Propensity score matching was performed to reduce confo…

Evaluation of nucleic acid-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for rapid identification of Mycobacterium tuberculosis and drug resistance in patients with retreatment tuberculosis.

OBJECTIVE: This study aimed to evaluate the value of nucleic acid-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in identifying mycobacterial species and detecting drug resistance in patients with retreatment pulmonary tuberculosis (TB). METHODS: The clinical data of 100 patients with retreatment pulmonary TB treated at Wenzhou Central Hospital between 1 June 2022 and 31 December 2023 were retrospectively collected and analyzed. Respiratory secretions were examined using BACTEC MGIT 960 Rapid Liquid Culture (MGIT 960 culture), drug-sensitive …

Nonsurgical Endodontic Retreatment of a Large Cyst-Like Periapical Lesion With Buccal and Palatal Cortical Plate Perforations and Maxillary Sinus Involvement: A 2-Year CBCT Follow-Up Case Report.

Large cyst-like periapical radiolucencies with cortical perforations are traditionally managed surgically. However, nonsurgical retreatment may be effective when adequate disinfection and seal are achieved. This case report describes the management of a large maxillary periapical lesion involving five endodontically treated teeth (from 21 to 25), associated with buccal and palatal cortical perforations and maxillary sinus involvement. Nonsurgical retreatment using enhanced disinfection and obturation with a hydraulic calcium-silicate sealer was performed. Successfully establishing patency was …

Therapeutic Response to Anti-Vascular Endothelial Growth Factor Retreatment Among Eyes With Stabilized Vision After Being Lost to Follow-Up in Diabetic Macular Edema: A Nationwide, Registry-Based Cohort Study.

PURPOSE: To describe the visual and anatomical changes after restarting anti-vascular endothelial growth factor (VEGF) therapy in patients with diabetic macular edema who returned with stabilized vision after being lost to follow-up (LTFU), and to explore the distinct predictors of clinical benefits upon retreatment. DESIGN: Retrospective clinical cohort study. METHODS: In this study, 976 patients who returned after being LTFU for ≥6 months were included. All participants had center-involved diabetic macular edema and presented with visual acuity (VA) <20/25 and central foveal thickness (CFT…

Direct-Acting Antivirals Remain Cost-Effective Treatments for Chronic Hepatitis C in Australia Despite Changes to the Treated Population and the Availability of Retreatment: The Glecaprevir/Pibrentasvir (Maviret®) Example.

INTRODUCTION: The first direct-acting antiviral (DAA) therapies for chronic hepatitis C virus (HCV) infection were reimbursed via Australia' … vir, accounting for the changes to the HCV population currently seeking treatment and incorporating retreatment in first-line failures and the treatment of new infections in previously treated individuals. METHODS: To assess the cost-effectiveness 7 years after initial listing of DAAs, an update was made to the Markov model used to achieve PBS reimbursement …

A Prospective Study on the Effect of Coronal Tooth Structure Loss on the Survival of Root Canal-Retreated Posterior Teeth Restored With Metal Ceramic Crowns With up to 10-Year Follow-Up.

AIM: The primary aim of this study was to evaluate whether the volume of residual coronal tooth structure influences the survival of root canal-retreated posterior teeth with up to 10-year follow-up. Secondary aims were to assess whether 12-month radiographic findings and the Dental Practicality Index (DPI) could predict long-term survival. METHODOLOGY: A total of 156 posterior teeth in 140 patients underwent clinical examination, baseline CBCT and PA prior to retreatment in a postgraduate endodontic unit under specialist supervision. Residual coronal tooth volume was quantified using intraor…

Long-Term Follow-up and Outcomes of Retreatment in an Expanded 50-Patient Single-Center Phase II Prospective Trial of 177Lu-PSMA-617 Theranostics in Metastatic Castration-Resistant Prostate Cancer.

177Lu-PSMA-617 is a radioligand with high affinity for prostate-specific membrane antigen (PSMA), enabling targeted β-irradiation of prostat … experienced a PSA decline of at least 50%. There were no unexpected adverse events with 177Lu-PSMA retreatment. Conclusion: This expanded 50-patient cohort of men with extensive prior therapy confirms our earlier report of high response rates, low toxicity, and improved quality of life with 177Lu-PSMA radioligand therapy. On progression, rechallenge 177Lu-PS …

A controlled study of rifabutin and an uncontrolled study of ofloxacin in the retreatment of patients with pulmonary tuberculosis resistant to isoniazid, streptomycin and rifampicin. Hong Kong Chest Service/British Medical Research Council.

A study of rifabutin in the retreatment of patients with chronic pulmonary tuberculosis whose strains of tubercle bacilli were resistant to all three of the drugs isoniazid, streptomycin, and rifampicin, and usually to others as well, was undertaken in 22 Chinese patients in Hong Kong. They were arranged in 11 pairs such that the resistance pattern of the strains for both patients was the same or closely similar. One of each pair was allocated at random to receive rifabutin (B) daily and the other rifampicin (R) daily. The two members of each pair were also prescribed the same or similar compa…

Распространенность симптомов посттравматического стресса и связанных факторов у пациентов с туберкулезом (ТБ), рецидивом ТБ и/или ТБ-ВИЧ-инфекцией в трех районах ЮАР.

Высокие уровни туберкулеза (ТБ) и коинфекции ТБ/ВИЧ часто связаны с проблемами психического здоровья, такими как симптомы посттравматического стрессового расстройства (ПТСР), что дополнительно связано с плохими результатами в области здоровья. В стране вроде ЮАР, где уровни этих инфекционных заболеваний высоки, обеспечение ограниченными или отсутствующими данными о распространенности психических расстройств, таких как ПТСР и его связанных факторах, является обеспокоительным. Поэтому целью этого исследования было определить распространенность симптомов ПТСР и связанных с ним факторов у пациенто

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High rates of tuberculosis (TB) and TB/HIV co-infection is often linked with mental health issues such as post-traumatic stress disorder (PT … aim of this study was to establish the prevalence of PTSD symptoms and associated factors in TB, TB retreatment and/or TB-HIV co-infected primary public health-care patients in three districts in South Africa. Brief screening self-report tools were used to measure: PTSD symptoms, psychological distress (anxiety and depression) and alcohol misuse. Other releva …

Orthodontic retreatment of a patient with a severe deep bite and low-level horizontal impaction of the right mandibular second molars by using a custom-cast anchorage appliance and clear aligners: a case report.

BACKGROUND: A severe deep bite, when combined with an impacted mandibular second molar, presents a complex clinical challenge. Managing this condition requires not only precise control over tooth movements but also careful consideration of the relationship between the impacted tooth and its adjacent teeth. Orthodontists must conduct a thorough assessment of the patient's condition to develop a rational and feasible treatment plan. CASE PRESENTATION: This report discusses a case involving a 24-year-old female patient who requested an orthodontic consultation of "anterior deep overbite", with a

Adult nonsurgical retreatment of a skeletal Class I hypodivergent, Class II subdivision malocclusion with an iatrogenic postextraction bowing pattern using buccal fixed appliances and miniscrew-supported maxillary distalization: A case report.

Orthodontic retreatment after extraction-based therapy can be complicated by iatrogenic bowing ("roller-coaster") patterns with residual spaces, posterior segment tipping, and loss of incisor torque, often accompanied by bite deepening. This case report describes nonsurgical retreatment of a 29-year-old woman with a skeletal Class I, hypodivergent pattern and a Class II left subdivision who presented with severe deep overbite, increased overjet, marked bimaxillary incisor retroclination with clinical labial root prominence of the maxillary and mandibular incisors, residual maxillary extraction…

Evaluation of the effects of calcium hydroxide-based, calcium silicate-based, and epoxy resin-based sealers on postoperative pain after a single session non-surgical endodontic retreatment: a randomized clinical trial.

OBJECTIVES: This randomized clinical trial aimed to evaluate the effect of calcium hydroxide-based, calcium silicate-based and epoxy resin-based root canal sealers on postoperative pain (PP) after a single session of non-surgical endodontic retreatment of the teeth with chronic apical periodontitis. MATERIALS AND METHODS: Ninety-six participants who had teeth with previously root canal treatment, asymptomatic, a single root and single canal, chronic apical periodontitis, were included in the study and then were randomly allocated to one of three experimental groups. (n = 32 per group).An endo…