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Docosahexaenoic Acid Modulates a HER2-Associated Lipogenic Phenotype, Induces Apoptosis, and Increases Trastuzumab Action in HER2-Overexpressing Breast Carcinoma Cells.

In breast cancer, lipid metabolic alterations have been recognized as potential oncogenic stimuli that may promote malignancy. To investigate whether the oncogenic nature of lipogenesis closely depends on the overexpression of HER2 protooncogene, the normal breast cell line, HB4a, was transfected with HER2 cDNA to obtain HER2-overexpressing HB4aC5.2 cells. Both cell lines were treated with trastuzumab and docosahexaenoic acid. HER2 overexpression was accompanied by an increase in the expression of lipogenic genes involved in uptake (CD36), transport (FABP4), and storage (DGAT) of exogenous fat

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… From a clinical perspective, the dependence of cancer cells on lipogenesis for survival and proliferation may represent the “Achilles' heel” of HER2-driven oncogenesis. …

Bilateral Pathological Femoral Fractures Secondary to Long-Term Tenofovir Disoproxil Fumarate-Induced Osteomalacia in a Woman Living with HIV: A Case Report.

BACKGROUND: People living with HIV on long-term antiretroviral therapy (ART) face increased risks of bone loss and fragility fractures, partly due to tenofovir disoproxil fumarate (TDF), a commonly used nucleoside reverse transcriptase inhibitor. TDF is associated with proximal tubular dysfunction, renal phosphate wasting, osteomalacia, and pathological fractures. This case highlights severe, bilateral femoral fractures as a rare but debilitating manifestation of chronic TDF-induced osteomalacia in a postmenopausal woman. CASE PRESENTATION: A 43-year-old African woman with HIV (diagnosed >15

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… This involved twice-daily cleansing initially followed by once daily cleansing, surgical debridement of necrotic tissue and slough as required, application of hydrocolloid foam, matched to exudate levels and infection risk, two-hourly turning schedules, and protective devices for heels and elbows. …

Adjuvant A-PRF Application in Patients with Various Stages of Medication-Related Osteonecrosis of the Jaw (MRONJ): Case Series.

Background and Clinical Significance: Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication of antiresorptive therapies such as Zolendronic acid, used for bone metastases. Its management remains challenging, with outcomes often unpredictable. Platelet-rich fibrin (PRF), rich in growth factors, has been proposed as a potential adjunct to surgical treatment, aiming to promote tissue regeneration and improve patient outcomes. Case Presentation: We reported three clinical cases of MRONJ in patients previously treated with Zolendronic acid. All patients underwent surgical seq

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… Complete heeling is noted. 2.2. The Second Case (See Table 1 ) The second patient was an 82-year-old female with osteonecrosis of the mandible in the fourth quadrant, which developed after the removal of tooth 46 on November 2023 (see Figure 4 ). …

Comparative effects of dual-task training versus combined exercise training in water and on land on patients with multiple sclerosis: a study protocol of a randomised factorial trial.

INTRODUCTION: People with multiple sclerosis (PwMS) experience cognitive and motor impairments, including cognitive training and exercise training. This study compares dual task and combined exercise training in water and on land. Water-based training may enhance cognitive and motor function more effectively than land-based training, presenting a promising intervention for PwMS. We explore dual-task training (DTT), including cognitive and motor exercise, with combined exercise in water and on land on the cognition, balance and gait PwMS. METHODS AND ANALYSIS: This is a double-blind 3*2*2 fact

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… lateral 1/3 surface of the right thigh; knee: on the lateral epicondyle of the knee; left tibia: over the lower 1/3 surface of the shank; right tibia: over the upper 1/3 surface of the right shank; ankle: on the lateral malleolus along an imaginary line that passes through the transmalleolar axis; heel …

Прогнозирование реальной в мире физической активности при множественном склерозе: комплексный подход с использованием клинических, сенсорных и самоотчетных мер.

Множественный склероз (MS) — хроническое нейродегенеративное заболевание, характеризующееся нарушениями подвижности, ограничивающими физическую активность и снижающими качество жизни. Хотя традиционные клинические меры и результаты, о которых сообщают участники, позволяют получить ценную информацию, они зачастую не позволяют в полной мере осознать сложности реальной мобильности. В этом исследовании оценивается прогнозируемая ценность сочетания сенсорных клинических мер и результатов, сообщаемых участниками, для более точного прогнозирования возможных уровней физической активности у отдельных л

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… Participants stood with feet shoulder-width apart as research staff placed hands on their scapulae and instructed them to lean backward until their body’s midline slightly exceeded their heels in the sagittal plane. …

Quality of life and its selected determinants in the group of patients with surgically treated spinal tumors.

INTRODUCTION: Spinal metastases are a common manifestation of advanced neoplastic disease. Destructive neoplastic lesions within the axial skeleton cause unrelieved pain and nervous system disorders involving spinal stenosis and other neural structures. The development of new systemic therapies, radiotherapy and minimally invasive spinal surgeries has increased patients' quality of life by minimising pain and neurological disorders due to vertebral neoplastic infiltration. The aim of the study was to assess the patients' quality of life before and after spine stabilisation surgery with spinal

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… Management of a heel wound as part of the holistic care of patients at the end of their lives – a literature review and own professional experience. Medycyna Paliatywna/Palliative Med (2021) 13(3):112–23. doi: 10.5114/mp.2021.108688 4. Langemo DK, Black J, National Pressure Ulcer Advisory Panel . …

Electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy in multiple myeloma: a feasibility study.

BackgroundThis single-arm study evaluated feasibility, safety, and initial efficacy of electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy (PN) in cancer patients with multiple myeloma.MethodsPatients with neuropathy ≥ grade 2 received 20 acupuncture treatments over 9 weeks.ResultsFor the 19 evaluable patients, Functional Assessment of Cancer Therapy/Gynecological Oncology Group-Neurotoxicity (FACT/GOG/NTX) mean (SD) scores improved significantly between baseline and week 13 (20.8 [9.6] vs 13.2 [8.5], p = 0.0002). Moderate effect size differences began on week 4, with t

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… . | Oblique (towards the heel) | 36 Assessments To determine feasibility and safety, we tracked subject recruitment, attrition, compliance with treatment and follow-up regimens, and adverse events. …

A comprehensive review on pain: Model, target, therapy, and prospect (Review).

Pain serves as both a protective physiological response essential for species survival and a global health issue affecting human well‑being and societal development. The present review systematically summarized and analyzed the research progresses on pain through a multidimensional analytical framework encompassing animal models, molecular targets, therapeutic approaches and future prospects. In animal modeling, neuropathic pain paradigms have evolved from traditional mechanical compression to composite models that combine dynamic displacement and chemical stimulation. Cancer‑induced pain mode

Унификация одиссеи: искусственный интеллект для диагностирования и лечения редких заболеваний.

Подытожить текущие проблемы в диагностике и лечении редких заболеваний (РД), осветить последние достижения в области искусственного интеллекта (АИ) для РД и предложить модель будущего состояния лечения пациентов РД. Многодисциплинарный экспертный обзор с кратким изложением современных практических задач и мер по ограничению ставок в области РД-клиентов с учетом ключевых клинических и исследовательских соображений в отношении нормативных и экономических ограничений. 10,000 известные РД оказывают коллективное воздействие 1 В 10 Американцы, в целом 30 million Люди. Ежегодно на РД приходится свыше

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… NBS is technically limited, relying on biochemical screening of blood spots from newborn heel pricks. Furthermore, no state covers all 38 core and 26 secondary conditions listed in the Recommended Uniform Screening Panel (RUSP) from the U.S. Department of Health and Human Services (HHS) [ 7 ]. …

Micro- and Macrovascular Complications in Early-Onset Type 2 Diabetes in Indians: Prevalence and Predictors in a Prospective Cross-Sectional Study.

Introductionand Aims: The prevalence of T2DM is rising among young people, placing them at greater risk for complications. We studied the prevalence and predictors of micro- and macrovascular complications in early-onset diabetes subjects (EOD, MethodsA total of 800 subjects (400 EOD, 400 LOD), matched for gender and diabetes duration, were prospectively recruited and assessed for the prevalence of peripheral neuropathy, retinopathy, nephropathy, and ASCVD. Multivariate logistic regression analyzed predictors of diabetes complications.ResultsThe median age at diagnosis of diabetes was 35 years

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… Monofilament testing The test was conducted using Semmes-Weinstein monofilaments (5.07/10 g) and performed at ten sites: the dorsal surface (between the base of digits 1 and 2), ventral surface (digits 1, 3, and 5), metatarsal heads (1, 3, and 5), medial and lateral midfoot, and the heel. …

Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress.

The proteasome inhibitor bortezomib has proven to be invaluable in the treatment of myeloma. By exploiting the inherent high immunoglobulin protein production of malignant plasma cells, bortezomib induces endoplasmic reticulum (ER) stress and the unfolded protein response (UPR), resulting in myeloma cell death. In most cases, however, the disease remains incurable highlighting the need for new therapeutic targets. Sphingosine kinase 2 (SK2) has been proposed as one such therapeutic target for myeloma. Our observations that bortezomib and SK2 inhibitors independently elicited induction of ER st

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… 24433105 10.1586/17474086.2014.870030 3 Lu S Wang J The resistance mechanisms of proteasome inhibitor bortezomib Biomark Res 2013 1 13 24252210 10.1186/2050-7771-1-13 PMC4177604 4 Vincenz L Jager R O’Dwyer M Samali A Endoplasmic reticulum stress and the unfolded protein response: targeting the Achilles heel …

Нацеливание экспорта эндоплазмического ретикулума нарушает метаболическую устойчивость в множестве миэломы.

Множественная миелома (ММ) характеризуется производством и секрецией большого количества иммуноглобулинов, в результате чего эта злонамеренность в значительной степени зависит от механизмов, которые поддерживают клеточный протеостаз. Несмотря на значительный клинический прогресс, достигнутый в области деградативной ветки протеостаза, гораздо меньше внимания уделяется биосинтетической ветке. В этом исследовании мы продемонстрировали, что сдерживание экспорта эндоплазмического ретикулума (ER), зависящего от COPII, приводит к смерти клеток в нескольких линиях ММ и основных клеток, созданных пацие

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… Discussion A hallmark of MM cells is the production and secretion of vast amounts of immunoglobulins, thus making proteostasis a potential Achilles heel in secretory MM. …

Цена дисбаланса: как балансирование проблем влияет на стоимость энергии при ходьбе у людей с множественным склерозом.

ВВЕДЕНИЕ: Люди с множественным склерозом испытывают трудности в ходьбе и демонстрируют высокую энергетическую стоимость ходьбы. Это может способствовать возникновению проблем с балансом. AIM: Изучение взаимосвязи между динамическим балансом и энергозатратами на ходьбу людей с множественным склерозом, а также вопроса о том, влияет ли скорость ходьбы на эту связь. В когорте с поперечным сечением 20 человек с множественным склерозом шли по беговой дорожке с помощью приборов на удобной и быстрой ходьбе. Энергозатраты на ходьбу были обусловлены потреблением кислорода. Динамический баланс был прибли

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… ML MoS was calculated at the instant of ipsilateral heel contact for each stride, defined as the first sample of each kinematic gait cycle. The mean ML MoS across all strides was used for statistical analysis, consistent with the approach described by Peebles et al. ( 16 ). …

Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis.

Periodontitis is a polymicrobial infectious disease characterized by alveolar bone loss. Systemic diseases or local infections, such as diabetes, postmenopausal osteoporosis, obesity, and inflammatory bowel disease, promote the development and progression of periodontitis. Accumulating evidences have revealed the pivotal effects of gut microbiota on bone health via gut-alveolar-bone axis. Gut pathogens or metabolites may translocate to distant alveolar bone via circulation and regulate bone homeostasis. In addition, gut pathogens can induce aberrant gut immune responses and subsequent homing o

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… The analyses via Mendelian randomization approach or polygenetic risk scoring suggest significant association between gut microbiota and human bone mineral density (BMD) in different sites, such as heel or pelvis, by utilizing gut microbiota statistic from genome-wide association study (GWAS) and BMD … Assessing Causal Relationship From Gut Microbiota to Heel Bone Mineral Density. Bone 143, 115652. doi: 10.1016/j.bone.2020.115652 Novince C. M., Whittow C. R., Aartun J. D., Hathaway J. D., Poulides N., Chavez M. B., et al. (2017). …

Homocysteine and Multiple Health Outcomes: An Outcome-Wide Umbrella Review of Meta-analyses and Mendelian Randomization Studies.

Elevated levels of homocysteine (Hcy) are associated with various health outcomes. We aimed to systematically assess the credibility and certainty of evidence of associations of Hcy and Hcy-lowering therapies with various health outcomes. We retrieved observational meta-analyses examining the associations between Hcy and health outcomes, interventional meta-analyses investigating health outcomes related to Hcy-lowering treatments, and Mendelian randomization (MR) studies exploring the causal associations of Hcy with health outcomes to perform an umbrella review. A total of 135 observational me

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… mineral density | Mixed | 49,988/NR | 5 | 1.78 | beta | –0.02 (0.058) | 0.731 | NA | per 1-unit inc | Y/Y/Y Wang et al., 2021 [ 150 ] | Lumbar spine bone mineral density | Mixed | 44,731/NR | 5 | 1.78 | beta | –0.001 (0.068) | 0.989 | NA | per 1-unit inc | Y/Y/Y Wang et al., 2021 [ 150 ] | Estimated heel … 2023 [ 153 ] | Forearm bone mineral density | Euro | 8143/NR | 8 | NR | OR | 0.96 (0.77, 1.19) | 0.69 | NA | per 1 SD inc | Y/Y/Y Wang et al., 2023 [ 153 ] | Lumbar bone mineral density | Euro | 28,498/NR | 7 | NR | OR | 0.86 (0.72, 1.02) | 0.077 | NA | per 1 SD inc | Y/Y/Y Wang et al., 2023 [ 153 ] | Heel …

Case Report with Literature Review: Tumor-induced osteomalacia from a soft-tissue phosphaturic mesenchymal tumor of the trunk.

BACKGROUND: Tumor-induced osteomalacia (TIO), a type of acquired hypophosphatemic osteomalacia, is brought on by tumors producing excessive levels of fibroblast growth factor 23, which raises renal phosphorus excretion. METHODS: Through a review of the literature, we have outlined the clinical characteristics of 33 patients with soft-tissue TIO of the trunk and described a case of TIO brought on by a soft-tissue tumor on the back. RESULTS: A 63-year-old woman who had been experiencing generalized bone pain for approximately three years visited the hospital. Physical examination revealed a ro

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… fatigue and, muscle weakness | 3 | 1.6 mg/dL (2.3–4.7 mg/mL) | Physical examination, ultrasound | Subcutaneous mass in right scapula area | 2.7 × 2.1 × 0.6 cm | Surgical resection | Complete resolution | 45 | PMT | NA Zura et al. ( 14 ) | 1999 | 46 M | Right groin and leg pain accompanied by bilateral heel …

Cardiac transplantation in adult congenital heart disease: a narrative review.

BACKGROUND AND OBJECTIVE: As more children with congenital heart disease survive to adulthood, adult congenital heart disease (ACHD) prevalence will increase (currently ~1 million US patients). Heart failure (HF) accounts for 26-42% of ACHD deaths. The rate of ACHD heart transplantations (ACHD HTx) is also increasing. We describe the ACHD HTx recipient/candidate cohort, analyze ACHD HTx outcomes, identify ACHD HTx specific challenges, and discuss opportunities to better serve more patients with ACHD HF. METHODS: PubMed literature search including articles published from 2010-2023. Reviewed 89

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… Heart 2010 ; 96 : 1217 - 22 . 10.1136/hrt.2009.184713 20639237 52 Shah DK Deo SV Althouse AD Perioperative mortality is the Achilles heel for cardiac transplantation in adults with congenital heart disease: Evidence from analysis of the UNOS registry. …

Оценка в реальном мире физиотерапевтических упражнений в процессе предварительной абилитации и реабилитации во время аутологической трансплантации стволовых клеток в миэломе: опыт работы в одном центре.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Имеются новые данные, свидетельствующие о роли упражнений в оптимизации функций, качестве жизни (QoL) и сокращении продолжительности пребывания в больнице, если они начались до пересадки аутологических стволовых клеток (ASCT). Проведенное на местном уровне экспериментальное исследование в области предабилитации и реабилитации пациентов миломы в ходе АОПП показало обнадеживающие результаты и было адаптировано к местным медицинским услугам. Цель настоящего доклада состоит в том, чтобы дать общее представление о недавно внедренной физиотерапевтической службе предварительной

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… 6-minute walk test distance of adults with pathology: a systematic review J Eval Clin Pract 2017 23 377 81 10.1111/jep.12629 27592691 32 Segura-Ortí E Martínez-Olmos FJ Test-retest reliability and minimal detectable change scores for sit-to-stand-to-sit tests, the six-minute walk test, the one-leg heel-rise …

Bibliometric analysis of research trends in the relationship between frailty and neoplasms over the past decade.

BackgroundThe relationship between frailty and neoplasms has attracted increasing attention from researchers in recent years. This study aims to identify current research hotspots and status in this field through bibliometric and visualization analysis.MethodsLiterature on the relationship between frailty and neoplasms, meeting the inclusion criteria, was collected from the Core Collection. Bibliometric analysis and visualization were performed using WoS, VOSviewer, and CiteSpace.ResultsOur study included 7410 documents on frailty and neoplasms, authored by 43,605 researchers from 9478 institu

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… Table 6 The top 10 studies with the most citations on the relationship between frailty and neoplasms Document | Citations | Links Oxidative stress, aging, and diseases | 1732 | 0 Inflammageing: chronic inflammation in aging, cardiovascular disease, and frailty | 1422 | 1 The Achilles’ heel of senescent …

Peripheral Nervous, Hepatic, and Gastrointestinal Endpoints for AL Amyloidosis Clinical Trials: Report from the Amyloidosis Forum Multi-organ System Working Group.

Systemic immunoglobulin light chain (AL) amyloidosis is a heterogeneous rare disease driven by a destructive monoclonal gammopathy and typified by misfolded immunoglobulin light and/or heavy chains which aggregate and deposit in organs as insoluble amyloid fibrils. Disease heterogeneity is driven by the degree of multi-systemic involvement; cardiac, renal, neurological, and gastrointestinal (GI) systems are affected to varying degrees in different patients. While prognosis is primarily driven by hematologic response to treatment and outcomes associated with cardiac events and overall survival,

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… The utility of the lower limb function test was an exploratory endpoint in Neuro-TTR and assessed the patient’s ability to walk on their toes, walk on their heels, and rise from a kneeling position and shown to be able to detect change in neuropathy impairments in those with early disease over 15 months …