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[Psychiatric manifestations of lupus erythematosus systemic and Sjogren's syndrome].

UNLABELLED: We present one case of Sjögren's syndrome (SS) secondary to systemic lupus erythematosus (SLE) with predominant psychiatric mani … l distress. This slowly progressive fluctuating disease creates constant discomfort from dysphagia, dyspareunia and functional disability. Some of these manifestations can be treated by corticosteroids and psychotropic drugs. Drugs with anticholinergic side-effects, like phenothiazines, tricyclic antidepressants and hydroxyzine which can enhance the oral dryn …

Exosome-Enriched Hub Gene Networks Identify Diagnostic Biomarkers and Repurposable Therapeutic Targets in Endometriosis.

Endometriosis is a heterogeneous chronic inflammatory disorder associated with substantial diagnostic delay and limited therapeutic options, highlighting the need of robust non-invasive biomarkers and actionable molecular targets to complement existing low-sensitivity tests. To identify conserved pathogenic mechanisms with translational potential, here, we uniformly reprocessed three independent the Gene Expression Omnibus (GEO) microarray cohorts (GSE7305, GSE25628, and GSE11691) and applied a strict, directionally consistent intersection strategy to identify conserved transcriptional signals

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… Hallmark symptoms include chronic pelvic pain, dysmenorrhea, dyspareunia, bowel dysfunction, and infertility [ 5 , 7 , 11 ]. …

Мы игнорируем сексуальные различия в гематологии? Призыв к совершенствованию отчетности.

Существуют явные различия по признаку пола в частотности, факторах риска и смертности от большинства гематологов (ГМ). Несмотря на известные различия в физиологии, гематопоисеях, молекулярных профилях, фармакокинетике наркотиков, токсичности, связанной с лечением, и опыте лечения, мужчины и женщины получают стандартизованное и одинаковое лечение большинства ТМ. Предыдущая опубликованная работа продемонстрировала различия в представленности женщин в клинических испытаниях на рак и выявила недостаток информации о результатах дифференцированного лечения и токсичности в разбивке по полу. Мы проана

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… A recent scoping review uncovered gaps in gender‐specific research on sexual dysfunction after treatment for lymphoma. 56 Studies reported a high prevalence of erectile dysfunction among males, a lack of sexual interest or reduced libido, dyspareunia, vaginal dryness and pain among females but a paucity …

Familial aspects of fear of cancer recurrence: current insights and knowledge gaps.

Fear of cancer recurrence is fear or worry about cancer recurrence or progress. Fear of recurrence can impact patients' quality of life and wellbeing. Cancer survivors' families support them practically and emotionally, making them a vital supplement for official healthcare. Given the well-established important role of the family in dealing with cancer, we compiled the studies that examined the relationship between family-related factors and fear of cancer recurrence (FCR) among cancer survivors (CSs). One of the foremost studies in this field is the FCR model presented by Mellon and colleague

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… For example, women with breast cancer experience higher sexual dysfunction [including abnormalities in sexual desire, arousal, lubrication, satisfaction, orgasm, and dyspareunia ( Boquiren et al., 2016 )] in comparison with women with other cancer types ( Jing et al., 2019 ), which probably causes more …

Skin manifestations associated with systemic diseases - Part I.

The skin demonstrates what is happening in the body in many diseases, as it reflects some internal processes on the surface. In this sense, skin as an organ, goes beyond its protective and barrier functions, as it provides clues for the identification of some systemic diseases. The dermatologist then raises diagnostic hypotheses for conditions related to all systems and refers them to the appropriate specialty. With easy access to examination by trained eyes and biopsies, the skin can present specific or non specific alterations on histopathology. In the first case this combination establishes

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… Genital symptoms of Sicca syndrome include dyspareunia and vaginal pruritus. Ocular and oral dryness occurs in 85% of patients with pSS. 18 Xerostomia causes pain and a burning sensation in the oral mucosa, dysphagia, angular cheilitis, and a higher incidence of caries. …

Радиум - с момента открытия и до настоящего времени - обзор событий.

После его открытия радий первоначально пропагандировался в качестве терапевтического агента для широкого круга заболеваний, включая расстройства кожи, аллергию, проблемы зрения, боль в суставах и общее средство для укрепления здоровья. Однако последующие исследования продемонстрировали ее значительную радиологическую токсичность и вредное воздействие на здоровье человека. Несмотря на эти риски, более чем через сто лет после его открытия, некоторые радиевые изотопы по-прежнему имеют ограниченное применение в медицинских целях, особенно при лечении конкретных раковых заболеваний. После поглощени

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… It has also been shown that long-term radiation exposure can result in other types of reproductive system disorders, such as cystitis, sexual dysfunction, infertility, vaginal stenosis, nephropathy, dyspareunia, and early menopause [ 14 , 24 , 61 ]. …

Novel diagnostic options for endometriosis - Based on the glycome and microbiome.

BackgroundEndometriosis is a chronic gynaecological disease whose aetiology is still unknown. Despite its prevalence among women of reproductive age, the pathology of the disease has not yet been elucidated and only symptomatic treatment is available. Endometriosis has high latency and diagnostic methods are both limited and invasive.Aim of reviewThe aim of this review is to summarise minimally invasive or non-invasive diagnostic methods for endometriosis and their diagnostic efficiencies. Furthermore, we discuss the identification and diagnostic potential of novel disease biomarkers of microb

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… Background information on endometriosis Symptoms and presentation of disease There are many symptoms of EMS, but the most common are severe dysmenorrhea, deep dyspareunia, ovulation pain, irregular uterine bleeding, infertility, chronic fatigue, pelvic tenderness and chronic pelvic pain; although none …

Clinical Practice Guidelines for Menopause: An Executive Summary and Recommendations: Indian Menopause Society 2026.

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… Vaginal lubricants can be recommended for the subjective symptom improvement of dyspareunia (Grade B). [182,183] Vaginal moisturizers can be offered for vaginal dryness and dyspareunia (Grade B). [184] Use vaginal lubricants, moisturizers, and hygiene products with physiologic pH and low osmolality ( … Sexual dysfunction affects 40%–60% of midlife women globally and is even more prevalent in India (66%–80%) (Grade B), with common issues being low desire, dyspareunia, and arousal difficulties. [206] 124. …

No. 385-Indications for Pelvic Examination.

OBJECTIVE: The primary objective of this document is to clarify the indications for pelvic examination. INTENDED USERS: Physicians, includi … inal pain, increased abdominal size/bloating, and difficulty eating/early satiety), pelvic pain, or dyspareunia should undergo appropriate components of the pelvic examination to identify benign or malignant disease (strong, low). 2) Health care providers may consider discussing the risks and benefits of performing a baseline pelvic examination including visu …

Evaluation of the Enhanced Recovery After Surgery (ERAS) Guidance for Patients With Spinal Metastasis.

Surgery continues to remain the most effective treatment for spinal metastasis (SM). As the number of surgeries continues to grow, the need for consensus guidelines for optimal perioperative care is imperative. Enhanced recovery after surgery (ERAS) protocols were created for this purpose. The objective of this study is to review evidence-based ERAS guidelines for SM surgery. A group of multiple experienced spine surgeons was invited to participate in this study. This group identified 19 ERAS items for SM surgery. The principal literature search utilized MEDLINE, Embase, and Cochrane databases

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… The clinical presentation of patients with constipation is varied; even reports showed that constipation could lead to sexual dysfunction, urinary retention, and dyspareunia. Early treatment of constipation, including prevention and treatment, can reduce symptoms and improve quality of life. …

Existing and emerging strategies for fertility preservation in female patients with leukemia.

Leukemia, the most common malignancy in childhood, affects individuals from prepubertal girl to women of reproductive age. It originates from immature hematopoietic cells in the bone marrow and disseminates systemically via the blood and lymphatic circulations. Although survival rates have improved substantially, standard treatments, including intensive chemotherapy and hematopoietic stem cell transplantation, often combined with total body irradiation, are highly gonadotoxic. Consequently, a significant proportion of survivors experience long-term endocrine dysfunction and infertility, with f

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… Reduced vaginal elasticity, reduced lubrication, and deep and superficial dyspareunia in irradiated gynecological cancer survivors . Acta Oncol . ( 2015 ) 54 : 772–9 . doi: 10.3109/0284186x.2014.1001036 . PMID: 25761090 106 Yuan H-J Li Z-B Zhao X-Y Sun G-Y Wang G-L Zhao Y-Q . …

Linzagolix, with and without add-back therapy, in women with endometriosis-associated pain: results from EDELWEISS 6, a double-blind randomized extension and withdrawal study.

STUDY QUESTION: Was the efficacy of linzagolix, observed at 6 months in women with endometriosis-associated pain, maintained when administer … lix group and 67.6% in the 200 mg+ABT linzagolix group. A steady reduction in mean daily dyschezia, dyspareunia, and overall pelvic pain scores was observed in both linzagolix groups from baseline to Month 12, with a more marked reduction in the 200 mg+ABT linzagolix group. Quality of life was assessed using the EHP-30 questionnaire. At Month 12, clear improv …

The "Road" to Malignant Transformation from Endometriosis to Endometriosis-Associated Ovarian Cancers (EAOCs): An mTOR-Centred Review.

Ovarian cancer is an umbrella term covering a number of distinct subtypes. Endometrioid and clear-cell ovarian carcinoma are endometriosis-associated ovarian cancers (EAOCs) frequently arising from ectopic endometrium in the ovary. The mechanistic target of rapamycin (mTOR) is a crucial regulator of cellular homeostasis and is dysregulated in both endometriosis and endometriosis-associated ovarian cancer, potentially favouring carcinogenesis across a spectrum from benign disease with cancer-like characteristics, through an atypical phase, to frank malignancy. In this review, we focus on mTOR d

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… Symptoms may include dysmenorrhea, chronic pelvic pain, dyspareunia, dyschezia, and infertility [ 11 ]. Although less common, endometriosis has been reported in 2–4% of postmenopausal women [ 12 ]. …

Infectious Diseases

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… Complications include infertility, ectopic pregnancy, and chronic pelvic pain clinical features —lower abdominal pain, abnormal vaginal bleeding/discharge, and dyspareunia may be mild and non-specific. …

Clinical Manifestations of Human Exposure to Fungi.

Biological particles, along with inorganic gaseous and particulate pollutants, constitute an ever-present component of the atmosphere and surfaces. Among these particles are fungal species colonizing almost all ecosystems, including the human body. Although inoffensive to most people, fungi can be responsible for several health problems, such as allergic fungal diseases and fungal infections. Worldwide fungal disease incidence is increasing, with new emerging fungal diseases appearing yearly. Reasons for this increase are the expansion of life expectancy, the number of immunocompromised patien

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… The main signs and symptoms include edema, erythema, paresthesia, pruritus, odorless vaginal discharge with a cottage cheese appearance, vulvodynia, dyspareunia, and dysuria [ 170 ]. …

Infectious Diseases

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… Complications include infertility, ectopic pregnancy, and chronic pelvic pain clinical features —lower abdominal pain, abnormal vaginal bleeding/discharge, and dyspareunia may be mild and non-specific. …

Pharmacomicrobiomics in precision cancer therapy: bench to bedside.

The burgeoning field of pharmacomicrobiomics offers promising insights into the intricate interplay between the microbiome and cancer, shaping responses to diverse treatment modalities. This review aims to analyze the molecular mechanisms underlying interactions between distinct microbiota types and cancer, as well as their influence on treatment outcomes. We explore how the microbiome impacts antitumor immunity, and response to chemotherapy, immunotherapy, and radiation therapy, unveiling its multifaceted roles in cancer progression and therapy resistance. Moreover, we discuss the challenges

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… A study conducted on gynecologic cancer patients yielded similar findings, demonstrating that modifying the vaginal microbiota resulted in changes to radiation-induced vaginal toxicities, including pain, dyspareunia, and sexual dysfunction ( 103 ). …

The Italian Society of Andrology and Sexual Medicine (SIAMS), along with ten other Italian Scientific Societies, guidelines on the diagnosis and management of erectile dysfunction.

PURPOSE: Erectile dysfunction (ED) is one of the most prevalent male sexual dysfunctions. ED has been in the past mistakenly considered a purely psycho-sexological symptom by patients and doctors. However, an ever-growing body of evidence supporting the role of several organic factors in the pathophysiological mechanisms underlying ED has been recognized. METHODS: The Italian Society of Andrology and Sexual Medicine (SIAMS) commissioned an expert task force involving several other National Societies to provide an updated guideline on the diagnosis and management of ED. Derived recommendations

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… Another representation is anorgasmia [ 161 ], severe dyspareunia or vaginismus [ 162 ], where impossible penetration frequently reduces the patient’s self-esteem and self-confidence in his ability to obtain and maintain an erection. …

Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology.

Vulvar cancer (VC) is a specific form of malignancy accounting for 5-6% of all gynaecologic malignancies. Although VC occurs most commonly in women after 60 years of age, disease incidence has risen progressively in premenopausal women in recent decades. VC demonstrates particular features requiring well-adapted therapeutic approaches to avoid potential treatment-related complications. Significant improvements in disease-free survival and overall survival rates for patients diagnosed with post-stage I disease have been achieved by implementing a combination therapy consisting of radical surgic

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… Conversely, patients with vulva cancer precursors are often young, and the various repeated treatments throughout their lives, including skinning surgery or laser treatment, are associated with a risk of developing dyspareunia due to fibrosis, fissures, and loss of normal anatomy. …

Current State of Knowledge on Primary Sjögren's Syndrome, an Autoimmune Exocrinopathy.

Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune rheumatic disease characterized by lymphoplasmacytic infiltration of the salivary and lacrimal glands, whereby sicca syndrome and/or systemic manifestations are the clinical hallmarks, associated with a particular autoantibody profile. pSS is the most frequent connective tissue disease after rheumatoid arthritis, affecting 0.3-3% of the population. Women are more prone to develop pSS than men, with a sex ratio of 9:1. Considered in the past as innocent collateral passive victims of autoimmunity, the epithelial cells of the saliv

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… Gynaecological and Obstetrical Manifestations pSS does not have a negative impact on fertility, but chronic pain and vaginal dryness can be the cause of dyspareunia having a negative impact on the sexuality of female patients [ 244 ]. …