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Воздействие акватической терапии на усталость, мобильность, физическую функцию и качество жизни людей с множественным склерозом: систематический обзор и мета-анализ.

Справочная информация: Водная терапия стала перспективной стратегией реабилитации людей с множественным склерозом (МС), потенциально повышающей физические и психологические результаты благодаря уникальным свойствам воды. Цель этого исследования заключалась в систематической оценке воздействия водной терапии на усталость, мобильность, физическую функцию и качество жизни людей, имеющих MS. Методы: В соответствии с руководящими принципами ПРИСМА был проведен систематический обзор и метаанализ. Электронные базы данных (PubMed, Scopus, Web of Science, PEDro, CINAHL и Cochrane) подвергались обыску с

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… Arroyo-Morales M. Moreno-Lorenzo C. Hydrotherapy for the Treatment of Pain in People with Multiple Sclerosis: A Randomized Controlled Trial Evid. Based. Complement. Altern. Med. 2012 2012 473963 10.1155/2012/473963 21785645 PMC3138085 19. Latimer-Cheung A.E. Martin Ginis K.A. Hicks A.L. Motl R.W. …

Cardiac amyloidosis detection from a single echocardiographic video clip: a novel artificial intelligence-based screening tool.

Background and aimsAccurate differentiation of cardiac amyloidosis (CA) from phenotypic mimics remains challenging using current clinical and echocardiographic techniques. The accuracy of a novel artificial intelligence (AI) screening algorithm for echocardiography-based CA detection was assessed.MethodsUtilizing a multisite, multiethnic dataset (n = 2612, 52% CA), a convolutional neural network was trained to differentiate CA from phenotypic controls using transthoracic apical four-chamber video clips. External validation was conducted globally across 18 sites including 597 CA cases and 2122

The experience of patients with hematological malignancy in their terminal stage: a phenomenological study from Jordan's perspective.

BackgroundPatients diagnosed with hematological malignancies residing in low-middle-income countries undergo significant physical and psychological stressors. Despite this, only 16% of them receive proper care during the terminal stages. It is therefore crucial to gain insight into the unique experiences of this population.AimTo have a better understanding of the needs and experiences of adult patients with advanced hematological malignancy by exploring their perspectives.MethodsA qualitative interpretive design was employed to collect and analyze data using a phenomenological approach. The st

Differential risk of 23 site-specific incident cancers and cancer-related mortality among patients with metabolic dysfunction-associated fatty liver disease: a population-based cohort study with 9.7 million Korean subjects.

IntroductionAlthough an association between metabolic dysfunction-associated fatty liver disease (MAFLD) and cardiovascular disease or overall mortality has been reported, it is unclear whether there is an association between MAFLD and cancer incidence or mortality. We aimed to investigate the differential risk of all- and site-specific cancer incidence and mortality according to MAFLD subgroups categorized by additional etiologies of liver disease.MethodsUsing the Korean National Health Insurance Service database, we stratified the participants into three groups: (1) single-etiology MAFLD (S-

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… Sat‐Muñoz D, Martínez‐Herrera BE, Quiroga‐Morales LA, Trujillo‐Hernández B, González‐Rodríguez JA, Gutiérrez‐Rodríguez LX, et al. …

Management of Multiple Myeloma: A Review for General Practitioners in Oncology.

Multiple myeloma (MM) is a malignant clonal plasma cell disorder in the bone marrow and is the second-most common hematologic malignancy in adults. Although patients with MM have a moderate life expectancy, it remains a heterogeneous disease that often requires multiple lines of chemotherapy for durable control and long-term survival. This review outlines current management strategies for both transplant-eligible and transplant-ineligible patients as well as for relapsed and refractory disease. Advances in drug therapies have widened management options and improved survival. In this paper, we

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… Morales Rodríguez E., Lorenzo Calvo J., Granado-Peinado M., Pérez-Bilbao T., San Juan A.F. Effects of Exercise Programs on Psychoemotional and Quality-of-Life Factors in Adult Patients with Cancer and Hematopoietic Stem Cell Transplantation or Bone Marrow Transplantation: A Systematic Review. Int. …

The Disruptive Impact of COVID-19 on the Utilization of Cancer Chemotherapy-Related Healthcare Assistance at the Principal Nationwide Referral Hospital in Kenya.

Background Lockdown measures to reduce the outbreak of COVID-19 negatively impacted the administration of cancer chemotherapy globally; however, data from Kenya are limited. Researchers strove to address this information gap and assess chemotherapy trends before and during the pandemic at Kenyatta National Hospital (KNH), the most wide-ranging referral infirmary in Kenya, along with associated factors to provide future guidance. Methods Time series analyses and patient interviews were undertaken at the KNH Cancer Treatment Centre. Patient data were analyzed descriptively and inferentially. The

Severe autoimmune hemolytic anemia; epidemiology, clinical management, outcomes and knowledge gaps.

Autoimmune hemolytic anemia (AIHA) is an acquired hemolytic disorder, mediated by auto-antibodies, and has a variable clinical course ranging from fully compensated low grade hemolysis to severe life-threatening cases. The rarity, heterogeneity and incomplete understanding of severe AIHA complicate the recognition and management of severe cases. In this review, we describe how severe AIHA can be defined and what is currently known of the severity and outcome of AIHA. There are no validated predictors for severe clinical course, but certain risk factors for poor outcomes (hospitalisation, trans

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… Blood ( 2020 ) 136 : 480–8 . doi: 10.1182/BLOOD.2020005674 32374875 20 Su J Bylsma LC Jiang X Morales Arias J Jain N Nordyke RJ . Healthcare resource utilization among commercially insured patients with cold agglutinin disease in the United States . …

Cardiac transplantation in adult congenital heart disease: a narrative review.

BACKGROUND AND OBJECTIVE: As more children with congenital heart disease survive to adulthood, adult congenital heart disease (ACHD) prevalence will increase (currently ~1 million US patients). Heart failure (HF) accounts for 26-42% of ACHD deaths. The rate of ACHD heart transplantations (ACHD HTx) is also increasing. We describe the ACHD HTx recipient/candidate cohort, analyze ACHD HTx outcomes, identify ACHD HTx specific challenges, and discuss opportunities to better serve more patients with ACHD HF. METHODS: PubMed literature search including articles published from 2010-2023. Reviewed 89

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… J Heart Lung Transplant 2019 ; 38 : 107 - 9 . 10.1016/j.healun.2018.09.010 30391196 57 Bryant R 3rd Morales D. Overview of adult congenital heart transplants. Ann Cardiothorac Surg 2018 ; 7 : 143 - 51 . 10.21037/acs.2018.01.01 29492392 PMC5827121 58 Yuki K. …

Do Cancer and Cancer Treatments Accelerate Aging?

Purpose of reviewThis review focuses on describing the mechanisms and clinical manifestations that underlie accelerated aging associated with cancer and its treatment.Recent findingsThe direct and indirect effects of cancer and its treatment are associated with late occurrence of comorbidities that happen earlier or more frequently in cancer survivors compared to cancer-free individuals, otherwise known as accelerated aging. Use of senolytics and dietary and exercise interventions including prehabilitation, caloric restriction, and rehabilitation are currently under investigation to reverse or

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… Sanchez-Lara K Ugalde-Morales E Motola-Kuba D Green D Gastrointestinal symptoms and weight loss in cancer patients receiving chemotherapy Br J Nutr 2013 109 5 894 897 22691288 10.1017/S0007114512002073 31. …

Hydralazine and Panobinostat Attenuate Malignant Properties of Prostate Cancer Cell Lines.

Among the well-established alterations contributing to prostate cancer (PCa) pathogenesis, epigenetics is an important player in its development and aggressive disease state. Moreover, since no curative therapies are available for advanced stage disease, there is an urgent need for novel therapeutic strategies targeting this subset of patients. Thus, we aimed to evaluate the combined antineoplastic effects of DNA methylation inhibitor hydralazine and histone deacetylase inhibitors panobinostat and valproic acid in several prostate cell lines. The effect of these drugs was assessed in four PCa

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… Morales J.C. Saldivia M.A. Schulze-osthoff K. Rodrı J.M. Ruiz-ruiz C. The DNA Methyltransferase Inhibitors Zebularine and Decitabine Induce Mitochondria-Mediated Apoptosis and DNA Damage in P53 Mutant Leukemic T Cells Int. J. Cancer 2012 130 1195 1207 10.1002/ijc.26107 21455989 69. Kim H.J. …

Research prioritization of men's health and urologic diseases.

OBJECTIVES: We sought to determine whether disease representation in the Cochrane Database of Systematic Reviews (CDSR) reflects disease burden, measured by the Global Burden of Disease (GBD) Study as disability-adjusted life-years (DALYs). MATERIALS AND METHODS: Two investigators performed independent assessment of ten men's health and urologic diseases (MHUDs) in CDSR for systematic review and protocol representation, which were compared with percentage of total 2010 DALYs for the ten conditions. Data were analyzed for correlation using Spearman rank analysis. RESULTS: Nine of ten MHUDs we

FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy.

BackgroundFifty percent of patients with muscle-invasive bladder cancer (MI-BC) die from their disease and current chemotherapy treatment only marginally increases survival. Novel therapies targeting receptor tyrosine kinases or activated oncogenes may improve outcome. Hence, it is necessary to stratify patients based on mutations in relevant oncogenes. Patients with non-muscle-invasive bladder cancer (NMI-BC) have excellent survival, however two-thirds develop recurrences. Tumor specific mutations can be used to detect recurrences in urine assays, presenting a more patient-friendly diagnostic

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… Eur Urol 55 650 657 18584939 10.1016/j.eururo.2008.06.013 66 Grossman HB Gomella L Fradet Y Morales A Presti J 2007 A phase III, multicenter comparison of hexaminolevulinate fluorescence cystoscopy and white light cystoscopy for the detection of superficial papillary lesions in patients with bladder …

Research Advances on Targets and Mechanisms in Cancers Complicated by Cardiovascular Diseases.

PurposeCancers complicated by cardiovascular diseases (CVDs) are increasingly becoming major limiting factors affecting patients' long-term quality of life and clinical outcomes. Systematic identification of therapeutic targets and their clinical development status is crucial for optimizing treatment strategies. Therefore, this study aimed to establish a target-based analytical framework to systematically map the distribution, developmental stage, maturity, and mechanistic characteristics of clinical trials investigating tumors co-occurring with CVD, thereby identifying potential therapeutic t

Нацеливание на Икароса и Айолоса: следующие циклоны Цереблона Е3 Ligase Modulars в MM.

Множественная миелома (ММ) остается неизлечимой нечистотой плазменных клеток, характеризующейся повторяющимися рецидивами и, в конечном итоге, рефракторностью стандартных агентов, включая протеазонные ингибиторы (ИП), иммунодуляторные препараты (ИМИД), и anti-CD38 Моноклональные антитела. В связи с тем, что прифронтовые терапевтические стратегии все чаще предусматривают использование четырехструнных индукционных режимов и продолжительное техническое обслуживание линалидоидной системы, все более широко распространено сопротивление традиционным IMID, что создает срочную потребность в модуляторах

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… Chrisochoidou Y., Scarpino A., Morales S., et al., “Evaluating the Impact of CRBN Mutations on Response to Immunomodulatory Drugs and Novel Cereblon E3 Ligase Modulators in Myeloma,” Blood 145, no. 22 (2025): 2630–2644. 28. Bjorklund C. …

Association between advanced lung cancer inflammation index levels and ischemic stroke in patients with atrial fibrillation: a propensity score-matching analysis.

IntroductionInflammation is closely associated with atrial fibrillation (AF) complicated by stroke. The Advanced Lung Cancer Index (ALI) is a comprehensive indicator of inflammation; however, its relationship with AF-related stroke is unclear. Therefore, this retrospective study was conducted to explore the correlation between ALI and ischemic stroke in patients with AF.MethodsPatients were divided into two groups according to the optimal cutoff value of ALI: low ALI and high ALI groups. The primary outcome was ischemic stroke in patients with AF. To ensure robustness of the findings, propensi

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… Escudero-Martinez I, Morales-Caba L, Segura T. Atrial fibrillation and stroke: A review and new insights. Trends Cardiovasc Med. (2023) 33:23–9. doi: 10.1016/j.tcm.2021.12.001, 33. Seiffge DJ, Cancelloni V, Räber L, Paciaroni M, Metzner A, Kirchhof P, et al. …

Acute and Chronic Cardiovascular Adverse Events in Patients with Acute Myeloid Leukemia: A Systematic Review.

Background/Objectives: Patients with acute myeloid leukemia (AML) have a higher propensity for adverse cardiovascular outcomes, primarily due to the toxic effects of chemotherapeutic agents. The purpose of this systematic review is to explore the association of acute myeloid leukemia treatment with adverse cardiovascular events. Methods: We systematically screened the literature for studies providing comparative data on cardiovascular toxicities in patients treated for acute myeloid leukemia. After the initial search, 3649 papers were screened and a final total number of 46 were included for t

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… Bosch X., Rovira M., Sitges M., Domenech A., Ortiz-Perez J.T., de Caralt T.M., Morales-Ruiz M., Perea R.J., Monzó M., Esteve J. …

Prognostic value of CA15-3, CA125, CEA in breast cancer patients undergoing chemotherapy.

BackgroundTo explore the prognostic value of cancer antigen 15-3 (CA15-3), Carbohydrate antigen 125 (CA125), and carcino-embryonic antigen (CEA) in breast cancer patients undergoing chemotherapy.MethodsThe data of 100 patients with breast cancer who received chemotherapy in a hospital from May 2022 to May 2024 were selected. Patients were divided into control and test groups based on different intervention methods and hospital stays. The control group receives routine nursing interventions. The test group implements exercise intervention under planned behaviour planning, with 50 cases in each

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… Conflict of Interest: The authors stated that they have no conflicts of interest regarding the publication of this article. 1 790 11 797 41 2020 Pagola I Morales J S Alejo L B Barcelo O Montil M Oliván J et al International Journal of Sports Medicine Concurrent exercise interventions in breast cancer …

Move more, age well: prescribing physical activity for older adults.

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… Fernández-Rodríguez R, Álvarez-Bueno C, Ferri-Morales A, et al. Pilates improves physical performance and decreases risk of falls in older adults: a systematic review and meta-analysis. Physiotherapy 2021;112:163–77. 36. Sherrington C, Tiedemann A, Fairhall N, et al. …

A Dyadic Approach to Cancer Care: Examining the Feasibility and Preliminary Effectiveness of a Partner-Based Exercise Intervention for Caregivers and Their Care Recipients.

Despite being key partners in the supportive care of the cancer patient, family caregivers are often inadequately prepared for or supported to take on this critical role, subsequently putting their own wellbeing at risk and, by extension, that of the patient. Exercise interventions show promise in mitigating caregiver burden and improving health outcomes for both caregivers and patients; however, the interrelationship between family caregiver and care recipient has gone largely unexplored. Thus, we conducted a single-group pilot study to examine the feasibility and preliminary effectiveness of

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… Morales L.S. The RAND-36 Measure of Health-Related Quality of Life Ann. Med. 2001 33 350 357 10.3109/07853890109002089 11491194 37. Hays R.D. Sherbourne C.D. Mazel R.M. The RAND 36-Item Health Survey 1.0 Health Econ. 1993 2 217 227 10.1002/hec.4730020305 8275167 38. Herdman M. Gudex C. Lloyd A. …

Implementation of Virtual Integrative Oncology Shared Medical Appointment Series (VIOSMAS) Within Mixed Diagnosis Population.

BackgroundIntegrative oncology [IO] is sought-after by patients, endorsed by clinical guidelines, and valued within National Cancer Institute Centers. Shared Medical Appointments [SMA] leverage health education and social connection to deliver enhanced patient experience, population health, cost-reduction, and clinician well-being. Integrative Oncology Shared Medical Appointments increase access to integrative medicine but delivering these services via telehealth have not been evaluated.ObjectiveWe created, and pilot tested a Virtual Integrative Oncology Shared Medical Appointment Series (VIOS

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… The fourth aspect of the quadruple aim in health cancer systems was achieved with our clinicians experiencing higher clinician morale, sense of purpose, productivity, and rapport. …