Результаты поиска

Discriminant analysis of various concentric needle EMG and macro-EMG parameters in detecting myopathic abnormality.

OBJECTIVES: The aim of the study was to evaluate the effectiveness of various concentric needle electromyography (EMG) motor unit action potentials (cnMUPs) and macro-EMG motor unit potentials (mMUPs) parameters for differentiation between myopathic motor unit action potentials (MUPs) and normal MUPs. METHODS: We have analyzed 112 cnMUPs and 84 mMUPs recorded from 7 patients with myopathy and 256 cnMUPs, 256 mMUPs from 14 healthy subjects. Biceps brachii muscle was investigated. Evaluated variables were duration, amplitude, area, number of phases, area/amplitude ratio, size index and area/num

Electrodiagnostic methods for neurogenic dysphagia.

OBJECTIVE: Swallowing mechanisms and neurogenic dysphagia have not been systematically studied by the EMG technique. It is desirable to evaluate neurogenic dysphagia for diagnostic and possibly for therapeutic purposes using electrophysiological methods. METHODS: The following methods were described: mechanical upward/downward movements of the larynx were detected using a piezoelectric sensor, while submental integrated EMG activity was recorded during dry and wet swallowing. The EMG activity of cricopharyngeal muscle of the upper oesophageal sphincter was also recorded in some normal subject

Cytokine production in muscle tissue of patients with idiopathic inflammatory myopathies.

OBJECTIVE: To study cytokine expression in muscle tissues of patients with inflammatory myopathies and to compare the profiles of patients with polymyositis (PM), inclusion body myositis (IBM), and dermatomyositis (DM). METHODS: We performed indirect immunohistochemistry studies of muscle tissue sections with a panel of 16 different cytokine-specific monoclonal antibodies, directed against interleukin-1alpha, (IL-1alpha), IL-1beta, IL-1 receptor antagonist (IL-1Ra), IL-2, IL-3, IL-4, IL-6, IL-8, IL-10, IL-13, interferon-gamma (IFN gamma), tumor necrosis factor alpha (TNF alpha), granulocyte-m…

Real-World Distributions and Concordance of C-Reactive Protein and Erythrocyte Sedimentation Rate Across Rheumatic Diseases.

Objective: The objective of this study was to characterize real-world distributions of C-reactive protein (CRP) and erythrocyte sedimentatio … erythematosus, mixed connective tissue disease, Sjogren's disease, systemic sclerosis, and dermato/polymyositis) and osteoarthritis; CRP distributions were more strongly right-tailed than ESR. Merging yielded 44,427 same-day CRP-ESR pairs from 16,824 patients (99.1% match). CRP and ESR were moderately correlated at measurement and patient levels, yet discorda …

Риск системных ревматических заболеваний у людей с раздражающим синдромом кишечника: когортный анализ с глобальной федерацией.

Синдром кишечника (IBS) — широко распространенное расстройство взаимодействия кишечника и мозга, все больше связанное с иммунным и подстрекательским регулированием. Остается неясным, предрасположена ли IBS к системным ревматическим болезням. Methods Мы провели ретроспективное когортное исследование с использованием Глобальной сети сотрудничества TriNetX, которая объединяет анонимные электронные медицинские записи, полученные от более, чем 150 Организации здравоохранения и 150 million Пациенты по всему миру. Взрослые≥18 год) с диагнозом IBS≥2 посещения) между 2015 и 2023 были сопоставлены с соо

Совпадение в аннотации оригинала
BackgroundIrritable bowel syndrome (IBS) is a prevalent disorder of gut-brain interaction increasingly linked to immune and inflammatory dys … ssue disorders (systemic lupus erythematosus, systemic sclerosis, Sjögren syndrome, dermatomyositis/polymyositis). Risk estimates were generated using the TriNetX analytic function, reporting hazard ratios with 95% confidence intervals. Sensitivity analyses included alternative definitions, extended washout periods (24 and 36 months), varying follow-up duratio …

Chimeric antigen receptor T-cell (CAR-T) therapy and other cellular immunotherapy treatments for idiopathic inflammatory myopathies.

Idiopathic inflammatory myopathies (IIM), including immune-mediated necrotizing myopathy (IMNM), dermatomyositis (DM), anti-synthetase syndrome (ASyS), overlap myositis and polymyositis, are heterogeneous autoimmune diseases characterized by immune-mediated skeletal muscle injury and frequent extra-muscular organ involvement. Despite recent therapeutic advances, many IIM patients have persistent disease activity, medication toxicity, or steroid dependence with current treatments. Increasing evidence implicates autoreactive B cells and autoantibody-producing plasma cells as central drivers of d…

Spectrum of clinical phenotypes associated with myositis-specific and myositis-associated antibodies in juvenile idiopathic inflammatory myositis: Our experience from North India.

BACKGROUND: Myositis-specific autoantibodies (MSAs) and myositis-associated autoantibodies (MAAs) are increasingly being identified in juven … myositis (n=89), clinically amyopathic dermatomyositis (n=8), overlap myositis (n=13), and juvenile polymyositis (n=3). Autoantibody positivity was seen in 72.5% (82/113; MSA =70, MAA=12) of the children, with anti-NXP2 (n=24) being the most common followed by anti-MDA5 (n=14), anti-TIF-1γ (n=12), anti-Mi 2 (n=9) in that order. Patients with NXP2 positivity we …

Объединение терапевтического плазменного обмена с функциональными результатами в отдельных неврологических расстройствах: ретроспективное когортное исследование из одного третичного центра в Саудовской Аравии.

КОЛИЧЕСТВО: Неврологические расстройства связаны со значительной заболеваемостью и воздействием на здоровье. Терапевтический плазменный обмен (TPE) представляет собой вмешательство, которое удаляет патогенные антитела, иммунные комплексы и другие плазменные компоненты из циркуляции. Предыдущие исследования свидетельствуют о том, что ППО может быть увязано с улучшением результатов в отдельных неврологических расстройствах. ЦЕЛИ: Оценка функциональных результатов после терапевтического обмена плазмой у пациентов с отдельными неврологическими расстройствами в Национальной гвардии по вопросам здра

Совпадение в аннотации оригинала
BACKGROUND: Neurological disorders are associated with considerable morbidity and healthcare impact. Therapeutic plasma exchange (TPE) is an … ateral sclerosis (ALS), transverse myelitis, cerebellar ataxia, paraneoplastic neurologic syndrome, polymyositis, and central nervous system (CNS) infections. The effectiveness of TPE was assessed using the Modified Rankin Scale (mRS) before and 90 days following the final TPE session. Statistical analysis included Wilcoxon signed-rank tests and Mann-Whitney U …

Persistent B Cell Depletion After Rituximab for Autoimmune and Glomerular Diseases: A Case Series.

INTRODUCTION: Persistent B cell depletion is a rare complication of rituximab treatment, and its clinical implications are unknown. METHODS … asculitis (n = 2), anti-glomerular basement membrane disease (n = 1), Behcet's disease (n = 1), and polymyositis (n = 1). The median age was 64.5 (interquartile range [IQR]: 44-77) years. Before the last dose of rituximab, all patients except 2 used cytotoxic agents, often prolonged (> 1 year) or recycling courses, and 60% (18 of 30) received a period of long- …

Dysphagia During Pharyngeal and Esophageal Phase of Seronegative Immune-Mediated Necrotizing Myopathy: A Case Report.

Immune-mediated necrotizing myopathy (IMNM) is a category of inflammatory muscle diseases that was identified as distinct from polymyositis. The majority of IMNM cases involve the presence of myositis-specific autoantibodies, specifically anti-signal recognition particle (anti-SRP) or anti-3-hydroxy-3-methylglutaryl-coA reductase (anti-HMGCR). However, some IMNM patients do not exhibit these antibodies, which is referred to as seronegative status. Swallowing difficulties are a common symptom in muscle diseases, including IMNM. However, there is a lack of research specifically investigating the…

Rituximab Treatment in Adult Patients With Idiopathic Inflammatory Myositis: A Systematic Review and Meta-analysis.

OBJECTIVE: This systematic review and meta-analysis assess the efficacy and safety of rituximab (RTX) in treating idiopathic inflammatory my … ignificant heterogeneity. Subgroup analysis revealed high response rates across all myositis types: polymyositis 69%, dermatomyositis 67%, antisynthetase syndrome 70%, juvenile dermatomyositis 60%, and immune-mediated necrotizing myopathy 86%. Response rates were similar between RTX induction doses of 1 g IV on days 0 and 14 (68%) and 375 mg/m 2 weekly for 4 w …

Tofacitinib for new-onset adult patients with anti-melanoma differentiation-associated 5 gene antibody positive dermatomyositis.

OBJECTIVE: We aimed to investigate the efficacy and safety of tofacitinib in adult anti-melanoma differentiation-associated 5 gene (Anti-MDA … of Rheumatology/ European League Against Rheumatism (ACR/EULAR) response criteria for adult DM and polymyositis. Secondary outcomes after 6 months treatment comprised the change in predicted forced vital capacity, the percentage of predicted carbon monoxide diffusion capacity, ferritin level and peripheral blood lymphocyte subsets measured by flow cytometry. …

Myositis-related autoantibody profile and clinical characteristics stratified by anti-cytosolic 5'-nucleotidase 1A status in connective tissue diseases.

INTRODUCTION/AIMS: Cytosolic 5'-nucleotidase 1A (cN-1A) autoantibodies have been recognized as myositis-related autoantibodies. However, the … 04). In the non-IBM IIM group, being anti-cN-1A antibody positive was associated with the diagnosis polymyositis (p = .04) and overlap-myositis (p = .04) and less disease damage evaluated by physician global damage score (p < .001). DISCUSSION: cN-1A autoantibodies were predominantly found in IIM patients and was associated with dysphagia in sIBM patients. No …

Role of mitochondria in the myopathy of juvenile dermatomyositis and implications for skeletal muscle calcinosis.

OBJECTIVES: To elucidate mechanisms contributing to skeletal muscle calcinosis in patients with juvenile dermatomyositis. METHODS: A well-characterized cohorts of JDM (n = 68), disease controls (polymyositis, n = 7; juvenile SLE, n = 10, and RNP + overlap syndrome, n = 12), and age-matched health controls (n = 17) were analyzed for circulating levels of mitochondrial (mt) markers including mtDNA, mt-nd6, and anti-mitochondrial antibodies (AMAs) using standard qPCR, ELISA, and novel-in-house assays, respectively. Mitochondrial calcification of affected tissue biopsies was confirmed using elect…

Interstitial Lung Disease Is a Major Characteristic of Patients Who Test Positive for Anti-PM/Scl Antibody.

OBJECTIVE: This study aimed to analyze the clinical features of anti-PM/Scl antibodies in Chinese patients. METHOD: We reviewed the clinical data of anti-PM/Scl antibody-positive patients, including their long-term follow-up. RESULTS: A total of 30 patients carried anti-PM/Scl antibodies, 21 (70%) were females, and the mean age was 55.4 years, 15 (50%) and 10 (33.3%) patients were positive for anti-PM/Scl-75 and anti-PM/Scl-100, respectively. Fifteen cases (50%) were diagnosed as inflammatory myopathy, namely, 11 dermatomyositis (DM) and 4 polymyositis (PM). Five (16.7%) patients were diagno…

Clinical and histopathological features of myositis in systemic lupus erythematosus.

OBJECTIVE: The objectives of this study were to compare the clinical features of patients with SLE with and without myopathy and to describe … ween patients with SLE with and without myopathy. Muscle biopsies were histologically classified as polymyositis, dermatomyositis, necrotising myopathy or non-specific myositis. RESULTS: From among 2437 patients with SLE, 179 (7.3%) had myopathy. African American patients were more likely to develop myositis than Caucasian patients (p<0.0001). Compared with t …

Serum MUC5AC protein levels are correlated with the development and severity of connective tissue disease-associated pulmonary interstitial lesions.

BACKGROUND: Mucin 5AC (MUC5AC) and mucin 5B (MUC5B) are the major components of airway mucins. The expression levels of MUC5AC and MUC5B are … uals with CTD, 70 had primary Sjögren's syndrome (pSS), 64 had systemic sclerosis (SSc), and 34 had polymyositis/dermatomyositis (PM/DM). There were 116 cases with concurrent ILD; ILD scores were 1 (n=23), 2 (n=41), and 3 (n=52). Serum MUC5AC and MUC5B protein levels were considerably higher in CTD-ILD than CTD-only individuals or healthy controls (both p<0.00 …

Phenotyping of myocardial involvement by cardiac magnetic resonance in idiopathic inflammatory myopathies.

OBJECTIVES: Cardiac dysfunction is commonly noted in patients with idiopathic inflammatory myopathies (IIMs). This study aimed to investigate the characteristics of cardiac dysfunction using cardiac magnetic resonance (CMR) in polymyositis (PM), dermatomyositis (DM) and necrotising myositis (NM). METHODS: Fifty-one patients with IIMs and 20 matched healthy controls (HCs) were assessed using CMR examination. The clinical data, cardiac serum markers and autoimmune antibodies were determined for all patients. Cardiac involvement was identified by myocardial native T1, extracellular volume (ECV),…

Anti-mitochondrial autoantibodies are associated with cardiomyopathy, dysphagia, and features of more severe disease in adult-onset myositis.

We analyzed the prevalence of anti-mitochondrial autoantibodies (AMA) in adult- and juvenile-onset myositis longitudinal cohorts and investigated phenotypic differences in myositis patients with AMA. We screened sera from myositis patients including 619 adult- and 371 juvenile-onset dermatomyositis (DM, JDM), polymyositis (PM, JPM), inclusion body myositis (IBM), or amyopathic DM patients and from healthy controls, including 164 adults and 92 children, for AMA by ELISA. Clinical characteristics were compared between myositis patients with and without AMA. AMA were present in 5% of adult myosit…

Management of Myositis-Associated Interstitial Lung Disease.

Idiopathic inflammatory myopathies, including polymyositis (PM), dermatomyositis (DM), and clinically amyopathic DM (CADM), are a diverse group of autoimmune diseases characterized by muscular involvement and extramuscular manifestations. Interstitial lung disease (ILD) has major pulmonary involvement and is associated with increased mortality in PM/DM/CADM. The management of PM-/DM-/CADM-associated ILD (PM/DM/CADM-ILD) requires careful evaluation of the disease severity and clinical subtype, including the ILD forms (acute/subacute or chronic), because of the substantial heterogeneity of their…