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A population-based analysis of hematological malignancies from a French-West-Indies cancer registry's data (2009-2018).

BackgroundA worldwide increased incidence of HM has been marked in recent decades. Therefore, to update epidemiological characteristics of HM in a French West Indies territory, we have performed analysis through Martinique's population-based cancer registry database.MethodsWe included cancer case data, from 2009-2018, coded in strict compliance with international standards set by International Agency for Research on Cancer. We calculated standardized incidence rates, cumulative rate (ages 0-74), and temporal trends for cases and deaths using the global population standard, by sex and five age

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… More recently, a significant and original study used 2012–2017 vital statistics data and cancer mortality data from four states: California, Florida, Minnesota, and New York. … These states provided a balance of West Africans, more common in New York, with East Africans, more common in Minnesota, and African-Caribbean, found mainly in Florida and New York. African-Americans born in the United States showed highest burden of cancer mortality for MM and LAM [ 17 ]. …

Глобальная перспектива развития связанных с медсестрой исследований в области первичных злокачественных опухолей костей 2004 в адрес 2025:: Библиометрическое картирование и визуальное исследование.

КОЛИЧЕСТВО: Первичные злокачественные опухоли костей, поскольку болезни, которые в основном происходят в подростковом возрасте, оказывают серьезное воздействие на все аспекты жизни пациентов и их семей. Эффективное лечение опухоли кости имеет важное значение для поддержания или улучшения качества жизни пациентов. Следовательно, исследование опухоли кости имеет огромное значение. Цель этого исследования состояла в том, чтобы обеспечить всеобъемлющее и обновленное обобщение всех опубликованных исследовательских статей по проблеме опухоли костей и прогнозировать будущие области исследований и нов

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… . * University of Florida, University of Pennsylvania, and Duke University ranked 10th. … Jude Children’s Research Hospital | 18 7 | Netherlands | 41 | University of Toronto | 17 8 | France | 39 | National Cancer Institute | 15 9 | Japan | 34 | University of Minnesota System | 13 10 | India | 29 | University of Florida * | 12 Figure 3. …

Abstracts From JADPRO Live at APSHO 2017.

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… , Nicole Kahle, MS, RN, OCN®, BMTCN, Moffitt Cancer Center, Tampa, Florida, and Carol Sheridan, RN, MSN, OCN®, BMTCN, Montefiore Medical Center, Bronx, New York Background: Chimeric antigen receptor (CAR) T-cell therapy is a promising treatment option for patients with refractory aggressive non-Hodgkin … Rituximab and Melanoma: A Case Report Shimika Rasha, MD, MPH, Abhishek Nair, MD, and Zdenka Segota, MD; University of Miami, Miller School of Medicine, Holy Cross Hospital, Fort Lauderdale, Florida Background: Rituximab is a monoclonal antibody directed against CD20 used in hematology for the treatment …

Best of JACC: Case Reports From ACC.23.

This dedicated issue of JACC: Case Reports highlights the top ranked Complex Clinical Cases from the ACC 2023 Scientific Sessions. These cases were reviewed and selected by a committee of peers in the months leading up to the annual meeting. These reviewers were ACC members with no affiliation to the JACC: Case Reports Editorial Board. While the cases were presented at the meeting and included in the formal Abstract Book from ACC, they have not been published elsewhere. These cases illustrate how the ACC can be a place for cardiovascular professionals to come together to learn, grow, and share

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… Baran, Mauricio Velez, David Snipelisky, Cleveland Clinic Florida, Weston, FL, USA Background Cardiorenal syndrome (CRS) increases morbidity in Heart Failure (HF) Case 56 yr old male with history of radiation-induced restrictive cardiomyopathy presented in decompensated HF. … Mester, Doniya Milani, HCA Florida Brandon Hospital, Tampa, FL, USA Background Human Monkeypox is a zoonotic orthopoxvirus previously endemic to Western and Central Africa. An increased incidence of the virus worldwide has led to identification of novel clinical manifestations. …

Оптимизация результатов цилтакабтагенской автолейкеля: реальный опыт и передовая практика одного учебного центра.

Ciltacabtagen autoleucel (cilta-cel), антигенная зрелость B-клеток (BCMA), направленная на химерик антиген-рецептор Т-клектор (CAR-T), изменила методы лечения повторной или рефрактной множественной миеломы и продемонстрировала долговременную, бестерапную ремиссию у пациентов (CAR-T).CARTITUDE-1:: медианный показатель общего выживания, 60.7 месяцев и 33% Число пациентов, выживавших без прогрессирования ≥5 США). Хотя ключевые клинические испытания продемонстрировали беспрецедентную глубину и долговечность реакции, население реального мира иногда может отличаться от когорт, пригодных для проведен

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… Xie Z, Blue B, et al. (2025). “ Bridging therapy response and low pre-lymphodepletion plasma cell burden are associated with improved safety and efficacy outcomes of ciltacabtagene autoleucel in multiple myeloma”, in: 67th American Society of Hematology (ASH) Annual Meeting and Exposition (Orlando, Florida … 2025). “ Enhancing the safety of ciltacabtagene autoleucel in relapsed multiple myeloma (MM): identification of potentially modifiable risk-factors associated with delayed neurotoxicity and non-relapse mortality”, in: 67th American Society of Hematology (ASH) Annual Meeting and Exposition (Orlando, Florida …

Клиническое и экономическое воздействие работников, обеспечивающих уход за пациентами, страдающими множественным склерозом, в зависимости от состояния болезни.

Справочная информация: Исследования по вопросу о партнерах по уходу за пациентами с множественным склерозом (МС) являются ограниченными. Цели: Клиническое и экономическое воздействие на партнеров по уходу за работниками оценивалось с точки зрения степени заболеваемости MS. Методы: работники с супругами/домашними партнерами с НР из базы данных о партнерах по работе (Jan. 1, 2010- Декабрь. 31, 2019) имеют право на получение пособия, если: супруг/партнер имел по крайней мере 3 Связанная с НРICD-9-CM/ICD-10-CM::340xx/G35) заявления пациентов/акушеров/болезней в рамках 1 год (последняя претензия =

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… representing certain US states: 0 = Connecticut, Massachusetts, Maine, New Hampshire, New Jersey, Puerto Rico, Rhode Island, Vermont, and Virgin Islands; 1 =Delaware, New York, and Pennsylvania; 2 = District of Columbia, Maryland, North Carolina, South Carolina, Virginia, and West Virginia; 3 = Alabama, Florida … Meeting Presentation This study was presented as a poster at the Consortium of Multiple Sclerosis Centers (CMSC) Annual Meeting; October 25-28, 2021; Orlando, Florida. Data Availability The data were obtained through a license agreement with Workpartners. …

Unc-51 like kinase 3 (ULK3) contributes to autophagy and cell survival in multiple myeloma.

Despite effective therapies such as proteasome inhibitors, multiple myeloma (MM) patients relapse with refractory disease. Analysis of RNA sequencing data from CD138 + MM patient cells (n = 813) across disease stages identifies an autophagy gene signature. Particularly elevated ULK3 expression is strongly associated with disease progression. Functional studies reveal that ULK3 supports MM cell survival via the ULK-ATG13-FIP200 complex. We generate small-molecule kinase inhibitors (SG3-014/MA9-060) exhibiting nanomolar potency against ULK3, with binding confirmed by co-crystallization. While ex

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… Animal experimentation All animal experiments were performed with approval from the Moffitt/University of South Florida Institutional Animal Care and Use Committee (Protocol #10955R, Title: Role of ULK3 in Sensitive and Refractory Multiple Myeloma). … Microsome stability assay The assay was conducted by the Exploratory Pharmacology Core at the Sanford Burnham Prebys Medical Discovery Institute in Orlando, Florida, following established procedures as previously reported 37 . …

2022 International Cancer Education Conference Late-Breaking Abstracts

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… P49-A: Increasing Awareness of Colorectal Cancer Screening Among Patients of a Federally Qualified Health Center: A Dialogue of Screening Motivators and Barr Sabrina Dickey Florida State University, Tallahassee, FL, USA Abstract: Background/Purpose. … The study was qualitative and utilized phone interviews of individuals who were verified patients at a federally qualified health center in the panhandle of Florida. Eligibility criteria was 45 to 75 years, able to read and understand English, and have access to a phone. …

Hormone therapy use and cancer survivorship.

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… Coming next in the Step-by-Step series: Ashley Wentworth, MD, senior associate consultant, Department of Dermatology, Mayo Clinic, Jacksonville, Florida, reviews the menopause-related skin changes linked to the abrupt decline in estrogen levels, such as increased dryness (xerosis), pruritus, thinning …

Delayed Presentation of Thymoma-Related Aplastic Anemia: An Unusual Presentation of a Rare Complication.

A 68-year-old Caucasian man presented with gross hematuria and oral mucosal bleeding. The patient was known to have an anterior mediastinal mass, highly suspicious for thymoma, which was incidentally identified on imaging, 8 years prior. The patient then declined treatment and was lost to follow-up. On presentation, imaging re-demonstrated the anterior mediastinal mass and the patient was found to have profound pancytopenia. Bone marrow biopsy confirmed the diagnosis of aplastic anemia (AA). Despite optimal treatment, the patient expired on day 9 of admission. In this case we report an unusual

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… Acknowledgments We would to acknowledge the multidisciplinary team at Mount Sinai Medical Center of Florida who were involved in the care of the patient described in this manuscript. Financial Disclosure None to declare. Conflict of Interest None to declare. Informed Consent Not applicable. …

Management of an oral ingestion of transdermal fentanyl patches: a case report and literature review.

Purpose. Fentanyl is available as a transdermal system for the treatment of chronic pain in opioid-tolerant patients; however, it carries a black box warning due to both the potency of the product and the potential for abuse. In this report, we describe a case of transbuccal and gastrointestinal ingestion of fentanyl patches and the management of such ingestion. Summary. A 32-year-old man was brought to the emergency department (ED) via emergency medical services for toxic ingestion and suicide attempt. The patient chewed and ingested two illegally purchased transdermal fentanyl patches. In th

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… In 2005, Goldberger and colleagues presented data from the state of Florida which found fentanyl as the cause of 115 deaths [ 4 ]. Although anecdotal reports exist, there is little published in medical literature regarding oral intoxication of fentanyl patches [ 5 – 8 ]. …

Emerging markers of cachexia predict survival in cancer patients.

BACKGROUND: Cachexia may occur in 40% of cancer patients, representing the major cause of death in more than 20% of them. The aim of this study was to investigate the role of leptin, ghrelin and obestatin as diagnostic and predictive markers of cachexia in oncologic patients. Their impact on patient survival was also evaluated. METHODS: 140 adults with different cancer diagnoses were recruited. Thirty healthy volunteers served as control. Serum ghrelin, obestatin and leptin were tested at baseline and after a follow-up period of 18 months. RESULTS: Ghrelin levels were significantly higher in

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… After this she obtained her Master’s in Public Health at the University of Florida and then continued studies with a Ph.D. degree focusing on assessments of the clinical utility of brain damage biomarkers to assist in the management of severe traumatic brain injury patients. … For the past 5 years she has been attending the Division of Critical Care Medicine at the University of Florida. Her clinical and PhD training led her to also assume the responsibility of Director of Clinical Research at the biotech company, Banyan Biomarkers, Inc. …

Surveillance for Violent Deaths - National Violent Death Reporting System, 48 States, the District of Columbia, and Puerto Rico, 2020.

PROBLEM/CONDITION: In 2020, approximately 71,000 persons died of violence-related injuries in the United States. This report summarizes data … lent deaths that occurred in 2020. Data were collected from 48 states (all states with exception of Florida and Hawaii), the District of Columbia, and Puerto Rico. Forty-six states had statewide data, two additional states had data from counties representing a subset of their population (35 California counties, representing 71% of its population, and four …

Accuracy and Reliability of Internet Resources for Information on Monoclonal Gammopathy of Undetermined Significance-What Information Is out There for Our Patients?

BACKGROUND: Online information gathering can increase patients' engagement in decision-making. The quality of online resources available for monoclonal gammopathy of undetermined significance (MGUS) was evaluated. METHODS: 900 websites from Google, Bing, Yahoo, and 150 YouTube videos were assessed. RESULTS: The websites did not differ regarding their search rank or between the search engines. The median time since last update was 24 months. The 86 unique websites showed a medium to poor general quality (JAMA score 3/4, only 8.1% websites with a valid HON certificate). The patient- (user-) fo

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… Naval Technical Training Command Millington TN Research Branch, Florida, USA, University of Central Florida; Orlando, FL, USA: 1975. pp. 8–75. Research Branch Report. 22. Scheid C., Driessen C., Knop S., Krauth M.T., Naumann R., Schieferdecker A., Weisel K. …

ASENT 2022 Annual Meeting.

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… , John de Groot 8 , Andreas F Hottinger 9 , L Burt Nabors 10 , Ruiyang Shi 1 , Kai Li 1 , Patrice Melikian 1 , Shijie Tang 1 , Sharon Tamir 1 , Eran Shacham 1 , Jatin Shah 1 , Sharon Shacham 1 , Patrick Wen 11 1 Karyopharm Therapeutics Inc, Newton MA; 2 Miami Cancer Institute, Baptist Health South Florida … GM6 Attenuates Activated Cofilin and Beta-arrestin2 Impact On Pathological Tau and Decreasing Tau Aggregates in Alzheimer’s Disease (AD) and Frontotemporal Lobar Degeneration (FTLD) Mark Kindy, PhD, University of South Florida; Dorothy Ko, Genervon Biopharmaceuticals Abstract Alzheimer's disease (AD …

SUBJECT INDEX Volume 125 (JANUARY–JUNE, 2004)

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… oxygenation during exercise in cardiac patients, 182 natriuretic peptide; a 44-year-old man with suspected exacerbation of COPD and atrial fibrillation, 2340 natriuretic peptide in the management of heart failure: the versatile neurohormone, 652 survival after prolonged submersion in freshwater in Florida … 815 use of, during resection of locally advanced thoracic malignancies: a 10-year, two-center experience, 1581 Cardiopulmonary exercise testing: See Exercise Cardiopulmonary resuscitation, survival after prolonged submersion in freshwater in Florida, 1948 Cardiopulmonary stress testing: See Exercise …

Meperidine compared to morphine for rigors associated with monoclonal antibody-related infusion reactions.

IntroductionInfusion reactions, characterized by symptoms such as rigors, fever, and hypotension, are common adverse events that occur during monoclonal antibody (MAB) therapy. The treatment of rigors often involves opioids, most commonly meperidine, despite limited evidence supporting use in the setting of MAB infusions. This study aims to compare the efficacy and safety of intravenous (IV) meperidine and morphine is treatment of MAB-related rigors, filling a significant gap in the literature.MethodsThis was a single-center, retrospective cohort study which reviewed patients either inpatient

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… In: Presented at: Annual meeting of the hematology/oncology pharmacy association , Tampa, Florida , 2020 March . 6 Dawson K . Managing infusion-related reactions for patients with chronic lymphocytic leukemia receiving obinutuzumab . …

Geographic and Racial Disparities in Access to Chimeric Antigen Receptor-T Cells and Bispecific Antibodies Trials for Multiple Myeloma.

ImportanceThe use of chimeric antigen receptor-T cell (CAR-T) therapy and bispecific antibodies in multiple myeloma is expanding, with encouraging early results. It is unknown if the current geographic distribution of CAR-T therapy and bispecific antibodies in multiple myeloma allows access for patients in need, especially for Black populations, which have a higher incidence of multiple myeloma.ObjectiveTo investigate if the current geographic distribution of CAR-T cell therapy and bispecific antibodies for multiple myeloma allows equitable access for Black patients with multiple myeloma.Desig

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… The highest numbers of study locations were in New York (12 locations), Florida (11), and Texas (10) while the highest numbers of open studies were in New York (37 locations), California (34), and Texas (30). Figure. …

Histone deacetylase upregulation of neuropilin-1 in osteosarcoma is essential for pulmonary metastasis.

The lungs represent the most common site of metastasis for osteosarcoma (OS). Despite our advances in developing targeted therapies for treating solid malignancies, broad acting chemotherapies remain the first line treatment for OS. In assaying the efficacy of approved therapeutics for non-OS malignancies, we previously identified the histone deacetylase 1 and 2 (HDAC1 and 2) inhibitor, romidepsin, as effective for the treatment of established lung metastatic OS. Yet, romidepsin has noted toxicities in humans and so here we aimed to define the primary mechanisms through which HDAC1/2 mediate O

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… All animal experiments were conducted in compliance with relevant ethical regulations and protocols and approved by the Institutional Animal Care and Use Committee (IACUC) at the University of South Florida under protocols IS00007896R (approved on 5/4/20) and IS00011705R (approved on 2/24/23). … This work has been financially supported in part by the Live Like Bella Pediatric Cancer Research Initiative, Florida Department of Health (23L09 CCL), Chotiner foundation (CCL), the H. …

Mayo Clinic Hematology Fellowship for Advanced Practice Providers.

Advanced practice providers (APPs), including nurse practitioners (NPs) and physician assistants (PAs), are part of a growing cancer care workforce. Current hematology-specific education provided by most graduate NP and PA school educations is limited. Mayo Clinic School of Health Sciences launched a hematology-specific fellowship in 2018 to provide APPs with the skills and knowledge required to deliver high-quality specialty care in hematology and blood and marrow transplant (BMT). The fellowship curriculum was developed based on a needs-based assessment study as well as the qualitative repor

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… The project included a retrospective review of the 5-year APP workforce data and a prospective web-based survey of current APP employees in hematology and BMT at three Mayo Clinic sites (Rochester, Minnesota; Scottsdale, Arizona; and Jacksonville, Florida). …