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Оптимизированное назначение упражнений для уменьшения онкологической усталости у выживших после первичного лечения у женщин с раком молочной железы: систематический обзор и доза-ответный сетевой мета-анализ.

ОБЪЕКТ: Психофизиологический стресс у пациентов с онкологическими заболеваниями (CRF) значительно снижает качество жизни у выживших после рака молочной железы. Хотя физические упражнения рекомендуются в клинических руководствах для уменьшения CRF, эффективные и оптимальные дозы остаются неопределёнными. Настоящее исследование направлено на изучение зависимости дозы упражнений от CRF у выживших после рака молочной железы. МЕТОДЫ: Доза упражнений рассчитывалась как произведение продолжительности, частоты и интенсивности, выраженная в метаболических эквивалентах минут в неделю (METs-min/неделя),

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… Pagola I Morales JS Alejo LB Barcelo O Montil M Olivan J . Concurrent exercise interventions in breast cancer survivors with cancer-related fatigue . Int J Sports Med. ( 2020 ) 41 : 790 – 7 . doi: 10.1055/a-1147-1513 32599641 48. Paulsen Ø Laird B Aass N Lea T Fayers P Kaasa S . …

A machine-learning-derived online prediction model based on inflammatory and nutritional composite indicators for acute kidney injury in sepsis patients with multiple myeloma.

BACKGROUND: Acute kidney injury (AKI) frequently complicates sepsis in patients with multiple myeloma (MM), yet no validated predictive tool integrates the inflammatory and nutritional disturbances specific to this dual-disease population. We aimed to develop and externally validate an interpretable machine learning (ML) model-based on composite inflammatory-nutritional indices-to predict in-hospital AKI in septic patients with MM, and to deploy it as a web-based point-of-care tool. METHODS: In this retrospective cohort study, 362 septic MM patients (development cohort: 253 training, 109 inter

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… Rodriguez-Morales , Fundacion Universitaria Autónoma de las Américas, Colombia Reviewed by: Xudong Feng , Ningbo Medical Centre Lihuili Hospital, China Narjes Seddighi , Tabriz University of Medical Sciences, Iran https://gftcs94ast7omb44cg2izq.streamlit.app/ . …

Cardiotoxicity of Chemotherapy: A Multi-OMIC Perspective.

Chemotherapy-induced cardiotoxicity is a critical issue in cardio-oncology, as cancer treatments often lead to severe cardiovascular complications. Approximately 10% of cancer patients succumb to cardiovascular problems, with lung cancer patients frequently experiencing arrhythmias, cardiac failure, tamponade, and cardiac metastasis. The cardiotoxic effects of anti-cancer treatments manifest at both cellular and tissue levels, causing deformation of cardiomyocytes, leading to contractility issues and fibrosis. Repeated irradiation and chemotherapy increase the risk of valvular, pericardial, or

Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy.

The primary factors that can be modified in one's lifestyle are the most influential determinants and significant preventable causes of various types of cancer. Exercise has demonstrated numerous advantages in preventing cancer and aiding in its treatment. However, the precise mechanisms behind these effects are still not fully understood. To contribute to our comprehension of exercise's impact on cancer immunotherapy and provide recommendations for future research in exercise oncology, we will examine the roles and underlying mechanisms of exercise on immune cells. In addition to reducing the

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… Llavero F., Alejo L.B., Fiuza-Luces C., Lopez Soto A., Valenzuela P.L., Castillo-Garcia A., Morales J.S., Fernandez D., Aldazabal I.P., Ramirez M., et al. Exercise training effects on natural killer cells: A preliminary proteomics and systems biology approach. Exerc. Immunol. …

Cancer mortality by country of birth and cancer type in Sweden: A 25-year registry-based cohort study.

Numerous studies have reported lower overall cancer mortality rates among immigrants compared to native populations. However, limited information exists regarding cancer mortality among immigrants based on specific birth countries and cancer types. We used population-based registries and followed 10 million individuals aged 20 years or older in Sweden between 1992 and 2016. The Cox proportional hazard model was used to explore the disparities in cancer mortality by country of birth and cancer type, stratified by gender. Age-standardized mortality rates were also computed using the world standa

Polymorphic Variants of Genes Encoding Angiogenesis-Related Factors in Infertile Women with Recurrent Implantation Failure.

Recurrent implantation failure (RIF) is a global health issue affecting a significant number of infertile women who undergo in vitro fertilization (IVF) cycles. Extensive vasculogenesis and angiogenesis occur in both maternal and fetal placental tissues, and vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) family molecules and their receptors are potent angiogenic mediators in the placenta. Five single nucleotide polymorphisms (SNPs) in the genes encoding angiogenesis-related factors were selected and genotyped in 247 women who had undergone the ART procedure and 12

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… Morales R. Sanz J. Llácer J. Bernabeu R. Prevalence of candidate single nucleotide polymorphisms on p53 , IL-11 , IL-10 , VEGF and APOE in patients with repeated implantation failure (RIF) and pregnancy loss (RPL) Hum. Fertil. 2020 23 117 122 10.1080/14647273.2018.1524935 30332901 23. Vagnini L.D. …

Glucosylsphingosine (Lyso-Gb1) as a reliable biomarker in Gaucher disease: a narrative review.

BACKGROUND: Gaucher disease (GD) is a rare, inherited, autosomal recessive disorder caused by a deficiency of the lysosomal enzyme, acid β-glucosidase. Its diagnosis is achieved via measurements of acid β-glucosidase activity in either fresh peripheral blood leukocytes or dried blood spots, and confirmed by identifying characteristic mutations in the GBA1 gene. Currently, several biomarkers are available for disease monitoring. Chitotriosidase has been used over the last 20 years to assess the severity of GD, but lacks specificity in GD patients. Conversely, the deacylated form of glucosylcera

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… Morales LE. Gaucher's disease: a review. Ann Pharmacother. 1996;30(4):381–388. doi: 10.1177/106002809603000411. 2. Burlina AB, Polo G, Rubert L, Gueraldi D, Cazzorla C, Duro G, et al. Implementation of second-tier tests in newborn screening for lysosomal disorders in North Eastern Italy. …

Canine Gastric Cancer: Current Treatment Approaches.

Human gastric cancer (GC) ranks as the fifth most prevalent cancer worldwide, and is the third leading cause of cancer-related death. The incidence of GC is lower in dogs than in humans, accounting for less than 1% of all canine malignancies. In recent years, efforts have been made to understand the pathogenesis of GC and in find an appropriate therapy to maximize curative results, such as adjuvant chemotherapy treatments in addition to surgery. Although surgery is the first-line treatment, it is associated with several complications. In terms of chemotherapeutic intervention, canine gastric c

A machine learning framework supporting prospective clinical decisions applied to risk prediction in oncology.

We present a general framework for developing a machine learning (ML) tool that supports clinician assessment of patient risk using electronic health record-derived real-world data and apply the framework to a quality improvement use case in an oncology setting to identify patients at risk for a near-term (60 day) emergency department (ED) visit who could potentially be eligible for a home-based acute care program. Framework steps include defining clinical quality improvement goals, model development and validation, bias assessment, retrospective and prospective validation, and deployment in c

The Potential Role of Sildenafil in Cancer Management through EPR Augmentation.

Enhanced permeation retention (EPR) was a significant milestone discovery by Maeda et al. paving the path for the emerging field of nanomedicine to become a powerful tool in the fight against cancer. Sildenafil is a potent inhibitor of phosphodiesterase 5 (PDE-5) used for the treatment of erectile dysfunction (ED) through the relaxation of smooth muscles and the modulation of vascular endothelial permeability. Overexpression of PDE-5 has been reported in lung, colon, metastatic breast cancers, and bladder squamous carcinoma. Moreover, sildenafil has been reported to increase the sensitivity of

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… Morales J.C., Li L., Fattah F.J., Dong Y., Bey E.A., Patel M., Gao J., Boothman D.A. Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases. Crit. Rev. Eukaryot. …

End-stage kidney disease and rationing of kidney replacement therapy in the free state province, South Africa: a retrospective study.

BackgroundEnd-stage kidney disease (ESKD) and the required kidney replacement therapy (KRT) are significant public health challenges for low-and-middle-income countries. The South African government adopted a KRT rationing policy to balance the growing need for KRT and scarce resources. We aimed to describe the epidemiology and KRT access in patients with ESKD referred to the main public sector hospital in the Free State Province, South Africa.MethodsA retrospective study of adult patients with ESKD admitted to Universitas Academic Hospital for KRT, was conducted between 1 January 2016 and 31

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… Morales JM Marcén R del Castillo D Andres A Gonzalez-Molina M Oppenheimer F Risk factors for graft loss and mortality after renal transplantation according to recipient age: a prospective multicentre study Nephrol Dial Transplant 2012 Suppl 4 iv39-46 10.1093/ndt/gfs544 PMC3526982 23258810 48. …

The Role of Vitamin C in Cancer Prevention and Therapy: A Literature Review.

Vitamin C is a water-soluble antioxidant associated with the prevention of the common cold and is also a cofactor of hydrolases that participate in the synthesis of collagen and catecholamines, and in the regulation of gene expression. In cancer, vitamin C is associated with prevention, progression, and treatment, due to its general properties or its role as a pro-oxidant at high concentration. This review explores the role of vitamin C in cancer clinical trials and the aspects to consider in future studies, such as plasmatic vitamin C and metabolite excretion recording, and metabolism and tra

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… Villagran M., Muñoz M., Díaz F., Troncoso C., Celis-Morales C., Mardones L. Vitamin C in health and disease: A current perspective. Rev. Chil. Nutr. 2019;46:800–808. 10. Levine M., Padayatty S.J., Espey M.G. …

Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review.

Medicinal mushrooms are widely used in East Asia for the treatment of various diseases, especially in complementary cancer care. While there is a growing interest in medicinal mushrooms in Western countries and an increasing number of pre-clinical studies indicate distinct anti-cancer and regenerative properties, little is known about their potential relevance for clinical practice. This review aims to provide an overview of the clinical evidence, significance and potential role of medicinal mushrooms in complementary cancer care. Scientific databases for (randomized) controlled clinical trial

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… T., Morales P., Ferreira I. C. F. R., Vasconcelos M. H. (2015). Methanolic extract of Ganoderma lucidum induces autophagy of AGS human gastric tumor cells. Molecules 20, 17872–17882. 10.3390/molecules201017872 Rossi P., Difrancia R., Quagliariello V., Savino E., Tralongo P., Randazzo C. …

Immune System and DNA Repair Defects in Ovarian Cancer: Implications for Locoregional Approaches.

In the last few years, substantial progress has been made in the treatment of ovarian cancer, with increased knowledge about the biology of the disease. Ovarian cancer is a neoplasm strongly linked to defects in DNA repair mechanisms, where deficiency in the homologous recombination (HR) system results in a better response of ovarian cancers to therapy, whether platinum-based chemotherapy, anthracyclines, or poly (ADP-ribose) polymerase (PARP) inhibitors. More recently, it has been demonstrated that different ovarian cancer histotypes may have different immunogenicity. Interestingly, defects i

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… Morales-Oyarvide V. Campbell S. Longacre T.A. Oliva E. Mismatch Repair Protein Expression in Clear Cell Carcinoma of the Ovary: Incidence and Morphologic Associations in 109 Cases Am. J. Surg. Pathol. 2016 40 656 663 10.1097/PAS.0000000000000602 26813747 66. Llosa N.J. Cruise M. Tam A. Wicks E.C. …

A Role for Lipid Mediators in Acute Myeloid Leukemia.

In spite of therapeutic improvements in the treatment of different hematologic malignancies, the prognosis of acute myeloid leukemia (AML) treated solely with conventional induction and consolidation chemotherapy remains poor, especially in association with high risk chromosomal or molecular aberrations. Recent discoveries describe the complex interaction of immune effector cells, as well as the role of the bone marrow microenvironment in the development, maintenance and progression of AML. Lipids, and in particular omega-3 as well as omega-6 polyunsaturated fatty acids (PUFAs) have been shown

Respiratory Tract Infections: Sinusitis, Bronchitis, and Pneumonia

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… Santos M, Gil-Brusola A, Morales P. Infection by Nocardia in solid organ transplantation: thirty years of experience. Transplant Proc. 2011;43:2141–2144. doi: 10.1016/j.transproceed.2011.06.065. 87. Yu X, Han F, Wu J, He Q, Peng W, Wang Y, et al. …

Dissecting the role of bone marrow stromal cells on bone metastases.

Tumor-induced bone disease is a dynamic process that involves interactions with many cell types. Once metastatic cancer cells reach the bone, they are in contact with many different cell types that are present in the cell-rich bone marrow. These cells include the immune cells, myeloid cells, fibroblasts, osteoblasts, osteoclasts, and mesenchymal stem cells. Each of these cell populations can influence the behavior or gene expression of both the tumor cells and the bone microenvironment. Additionally, the tumor itself can alter the behavior of these bone marrow cells which further alters both t

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… Le HK, Graham L, Cha E, Morales JK, Manjili MH, Bear HD. Gemcitabine directly inhibits myeloid derived suppressor cells in BALB/c mice bearing 4T1 mammary carcinoma and augments expansion of T cells from tumor-bearing mice. …

Applied information retrieval and multidisciplinary research: new mechanistic hypotheses in complex regional pain syndrome.

BackgroundCollaborative efforts of physicians and basic scientists are often necessary in the investigation of complex disorders. Difficulties can arise, however, when large amounts of information need to reviewed. Advanced information retrieval can be beneficial in combining and reviewing data obtained from the various scientific fields. In this paper, a team of investigators with varying backgrounds has applied advanced information retrieval methods, in the form of text mining and entity relationship tools, to review the current literature, with the intention to generate new insights into th

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… endotoxin-induced nuclear factor-[kappa]B activation Am J Respir Cell Mol Biol 2003 29 124 132 12600832 10.1165/rcmb.2002-0126OC Xu L Fidler IJ Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells Cancer Res 2000 60 4610 4616 10969814 Chiechio S Copani A De Petris L Morales …

Role of mitochondria in physiological activities, diseases, and therapy.

Mitochondria are generally considered essential for life in eukaryotic organisms because they produce most of the energy or adenosine triphosphate (ATP) needed by the cell. Beyond energy production, it is now widely accepted that mitochondria also play a pivotal role in maintaining cellular homeostasis and signaling. The two core processes of mitochondrial dynamics, fission and fusion, serve as crucial foundations for maintaining mitochondrial morphology, distribution, and quantity, thereby ensuring cellular homeostasis. Mitochondrial autophagy (mitophagy) ensures the selective degradation of

Инструменты и наборы инструментальных средств по лечению рака и психическому здоровью: обзор с целью анализа в соответствии с Руководящими принципами ПОРСМА-СКР.

Справочная информация: Наборы инструментальных средств/наборы инструментальных средств представляют собой перспективный инструмент для лечения раковых заболеваний и охраны психического здоровья. Однако для определения их ключевых компонентов и эффективных стратегий осуществления необходимы исследования. Методы: В соответствии с PRISMA-ScR поиск проводился по пяти базам данных с использованием ключевых терминов. Включены исследования по вопросам психического здоровья или лечения раковых заболеваний с использованием комплектов инструментов или инструментов для взрослых, документируются стратегии

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… González-Morales M.G. Effectiveness of an Emotion Regulation Intervention versus an Active Control on Daily Well-Being and Cognitive Reappraisal: An Experience Sampling Randomized Controlled Trial Int. J. Stress Manag. 2022 29 400 412 10.1037/str0000259 48. Spoelstra S. Sikorskii A. Majumder A. …