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Which cancer survivors are at risk for a physically inactive and sedentary lifestyle? Results from pooled accelerometer data of 1447 cancer survivors.

BackgroundPhysical activity has beneficial effects on the health of cancer survivors. We aimed to investigate accelerometer-assessed physical activity and sedentary time in cancer survivors, and describe activity profiles. Additionally, we identify demographic and clinical correlates of physical activity, sedentary time and activity profiles.MethodsAccelerometer, questionnaire and clinical data from eight studies conducted in four countries (n = 1447) were pooled. We calculated sedentary time and time spent in physical activity at various intensities using Freedson cut-points. We used latent p

Факторы, связанные с содержанием витамина D у монгольских пациентов с множественным склерозом.

ЦЕЛЬ: Множественный склероз (МС) вызывается генетическими и экологическими факторами. Витамин D был определен в качестве фактора экологического риска, причем в широтах, расположенных дальше от экватора, отмечается более высокий уровень его распространенности. В Монголии при температуре 45°N воздействие солнечного света ограничено, что повышает риск для населения в связи с дефицитом витамина D. ЦЕЛИ: Сопоставление уровней содержания витамина D среди лиц с НР (ПМК) и лиц, не имеющих НР, и выявление факторов, связанных с низким содержанием витамина D. Мы изучили связи с уровнями витамина D, испол

Agreement between the EQ-5D-5L anxiety/depression dimension and GAD-7/PHQ-9 for psychological distress assessment in patients with hematologic malignancies.

BACKGROUND: Patients with hematologic malignancies (HMs) often experience psychological distress, significantly impairing health-related quality of life (HRQoL) and deteriorating clinical prognosis. Although the widely used instrument EuroQol 5-Dimension 5-Level (EQ-5D-5L) has been validated in the general population for accurately identifying the psychological symptoms, its performance in HM patients remains unclear. We aimed to investigate whether the EQ-5D-5L questionnaire anxiety/depression (A/D) dimension, when already collected for HRQoL assessment, correlates with anxiety and depression

Mobility training for increasing mobility and functioning in older people with frailty.

BACKGROUND: Frailty is common in older people and is characterised by decline across multiple body systems, causing decreased physiological … places that do not provide rehabilitative services or residential health-related care, for example, retirement villages, sheltered housing, or hostels.  DATA COLLECTION AND ANALYSIS: We undertook an 'umbrella' comparison of all types of mobility training versus control. MAIN RESULTS: This review included 12 RCTs, with 1317 participants, carried out in 9 cou …

Voices of Survivorship: The Unmet Needs of Italian Cancer Survivors. A Qualitative Study.

BackgroundThe increasing number of cancer survivors (CSs) globally highlights the critical need for healthcare systems to address their unmet needs. These needs span physical, psychosocial, spiritual, informational, and practical dimensions and, if unaddressed, can impact quality of life and healthcare satisfaction.AimsThis study aimed to identify and understand the unmet needs of CSs in Italy to guide the development of patient-centered survivorship care services.MethodsA cross-sectional qualitative study was conducted between April 2023 and January 2024 at the Comprehensive Cancer Centre of

Качество жизни, связанное со здоровьем, и финансовая токсичность для китайских пациентов с множественной миеломой: a two- В реальном мире многоцентральное исследование.

Введение новых терапевтических агентов изменило условия лечения и значительно улучшило показатели выживания пациентов с множественной миеломой (ММ). Однако воздействие этих достижений на качество жизни, связанное со здоровьем (HRQOL), и финансовую токсичность в реальных условиях еще недостаточно изучено. Цель этого исследования заключалась в исследовании HRQoL и финансовой токсичности для китайских пациентов с MM в эпоху новых агентов. МЕТОДЫ: В ходе этого продольного, многоцентрального, реального исследования данные от китайских пациентов с MM были собраны в период с марта 2021 и июль 2023. H

Уровень рабочей способности определяет конкретный профиль обесценения комплексного основного набора МКФ для множественных склерозов.

Множественный склероз (МС) неблагоприятно влияет на трудоспособность. Комплекс комплексных международных классификаций функционирования, инвалидности и охраны здоровья для НР (КМГС-МС), опубликованный Всемирной организацией здравоохранения, еще не был расширен для оценки уровня работоспособности (ВКК). Оценить относительную значимость категорий CICF-MS в сравнении с WCL. Лица, имеющие MS (PwMS), N = 129, которые были направлены в Литовское управление по оценке инвалидности и рабочей способности для определения WCL, были разделены на три группы в зависимости от процентной доли оставшегося WCL (

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… The inclusion criteria were as follows: Aged older than 18 years but not older than retirement age, with an evaluated disability for MS at DWACO; MS diagnosis according to the McDonald criteria 2017 revisions 34 ; MS in remission and a stable neurological condition; Fluent in the Lithuanian language; … The WCL is established for people from 18 years of age to the age of retirement by assessing not only medical but also functional, professional, and other criteria that impact work capacity. The WCL is set at intervals of 5% by legal regulations regarding the process of setting the WCL. …

Impact of Social Needs and Identity Experiences on the Burden of Illness in Patients with Multiple Myeloma: A Mixed-Methods Study.

Multiple myeloma (MM) is a common hematologic malignancy, but due to its incurable nature, patients experience many relapses in their lifetime and hence face unique challenges. This mixed-methods study consisting of an online survey and subsequent focus groups aimed to understand how social and identity experiences affected the diagnostic, treatment, and care journey for patients with MM. Twenty-three adult patients with MM participated in this study. The survey participants identified common determinants negatively impacting their health, including mental health concerns (experienced by 90.5%

Impact of lanadelumab in hereditary angioedema: a case series of 12 patients in Canada.

BackgroundHereditary angioedema (HAE) is a rare autosomal dominant disease resulting in recurring episodes of swelling, leading to considerable patient morbidity and mortality. Lanadelumab is a plasma kallikrein inhibitor that is approved as 1st line therapy in Canada for long term prophylaxis of HAE attacks.ObjectiveTo describe our clinical findings from a case series of adult patients with HAE type 1/2 who have been initiated on lanadelumab.MethodsA chart review of HAE type 1/2 patients at three academic centers in Canada was undertaken with demographic and clinical data extracted. Patients

Patient and Physician Preferences for Acute Myeloid Leukemia Maintenance Treatments Following Hematopoietic Stem Cell Transplantation.

PurposeThis study assessed and compared preferences for treatment attributes of maintenance therapies post-hematopoietic stem cell transplantation (HSCT) in patients with acute myeloid leukemia (AML) and in physicians who treat these patients.Patients and methodsPatients with AML post HSCT and physicians from the United States, United Kingdom, Canada, and Australia (physicians only) completed a web-based discrete choice experiment (DCE). The DCE used inputs identified via a targeted literature review and qualitative interviews to ascertain relevant treatment attributes and associated levels. S

The Burden of a Multiple Myeloma Diagnosis on Patients and Caregivers in the First Year: Western European Findings.

BACKGROUND: This research aimed to quantify the burden of illness (BoI) in transplant eligible (TE) and transplant non-eligible (TNE) newly diagnosed multiple myeloma (NDMM) patients and their caregivers, in the first year after diagnosis: at months 0, 3, and 12. METHODS: Prospective, cross-sectional, observational NDMM study of TE and TNE patients and their caregivers from France, Germany, Italy, and Spain was conducted between May 2019 and January 2021. A structured, online questionnaire measuring disease burden, direct and costs, out-of-pocket expenses, and health-related quality of life (

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… 13 (8%) 7 (4%) 7 (12%) Other part time 0 (0%) 1 (1%) 21 (16%) Other not working, eg, homemaker, retired, unemployed 120 (73%) 127 (79%) 112 (84%) Support from an informal caregiver and living status (Patient reported) No informal caregiver support (family/friends/ acquaintances) 27 (16%) 22 (14%) 17 … According to these authors, more than half of patients changed from full-time employment to retirement after ASCT and during maintenance therapy. Amongst those keeping their jobs, worked hours dropped considerably due to reduced working hours and to absenteeism associated with disease impact. …

Predicting which patients with cancer will see a psychiatrist or counsellor from their initial oncology consultation document using natural language processing.

BackgroundPatients with cancer often have unmet psychosocial needs. Early detection of who requires referral to a counsellor or psychiatrist may improve their care. This work used natural language processing to predict which patients will see a counsellor or psychiatrist from a patient's initial oncology consultation document. We believe this is the first use of artificial intelligence to predict psychiatric outcomes from non-psychiatric medical documents.MethodsThis retrospective prognostic study used data from 47,625 patients at BC Cancer. We analyzed initial oncology consultation documents

Burden of Disease and Cost of Illness of Triple-Negative Breast Cancer in Portugal.

BackgroundTriple-negative breast cancer accounts for 15% of all breast cancer cases, and it has a lower survival rate and higher incidence of early recurrence, particularly during the first 10 years after diagnosis.ObjectiveThis study aimed to estimate the cost and burden of triple-negative breast cancer among the female population in 2019 in Portugal from a societal perspective.MethodsThe prevalence of triple-negative breast cancer was calculated using a cumulative incidence model on the basis of national epidemiological data. The burden of disease was expressed as disability-adjusted life ye

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… Expert estimates combined with the employer's wage payment per employed woman and estimates of the number of TNBC cases in employed women allowed estimating TNBC indirect costs related to absenteeism or early retirement from work. Table 4 Impact of TNBC on professional activity. … Regarding indirect costs, Miguel et al. (2022) estimated that approximately €3.6 million and €11.4 million are spent due to labour absenteeism and early retirement, respectively, due to multiple myeloma in Portugal. These results illustrate a slightly lower burden than that of TNBC [ 38 ]. …

Экономическое бремя множественного склероза в Словакии 2015 в адрес 2020.

Множественный склероз (MS) является хроническим, подстрекательским заболеванием центральной нервной системы, которое обычно диагностируется в молодом возрасте. Доля прямых и косвенных расходов на НР варьируется в зависимости от условий. Международное исследование по множественным склерозам, охватывающее 1152 пациенты, имеющие MS от 19 страны, сообщили, что среднегодовые расходы на одного пациента составляют евро41,212, с прямыми расходами на медицинское обслуживание в евро21,093, прямые немедицинские расходы в евро2110и евро16,318 , помеченные в качестве косвенных расходов. Однако точных данны

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… Similarly, the indirect costs also escalate caused by reduced work productivity due to short- or long-term sick leave, disability pension, early retirement, or premature death. The proportion of direct and indirect costs of MS vary across settings. … Indirect costs included in the analysis were: costs of short-term absence from work, long-term absence from work, and early retirement. …

National survey of patient perspectives on cost discussions among recipients of copay assistance.

BackgroundIndividuals with cancer and other medical conditions often experience financial concerns from high costs-of-care and may utilize copay assistance programs (CAP). We sought to describe CAP recipients' experiences/preferences for cost discussions with clinicians.MethodsWe conducted a national, cross-sectional electronic-survey from 10/2022 to 11/2022 of CAP recipients with cancer or autoimmune conditions to assess patient perspectives on cost discussions. We used multivariable logistic regression models to explore associations of patient perspectives on cost discussions with patient ch

Воздействие нефтеперерабатывающих и биотопливных заводов на здоровье человека: карта систематических доказательств и обзор скопирования.

ЦЕЛЬ ОБЗОРА: Нефтеперерабатывающие заводы являются важными источниками выбросов токсичных загрязнителей во всем мире, которые угрожают здоровью работников нефтеперерабатывающих предприятий и близлежащего населения. Мы провели обзор эпидемиологических данных об остром и хроническом воздействии нефтеперерабатывающих и биотопливных заводов на здоровье окружающих общин. Мы провели оценку доказательств с использованием оценок риска предубеждений и зафиксировали полученные результаты на карте доказательств для выявления пробелов в литературе. Мы систематически искали исследования, опубликованные к а

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015. METHODS: We estimated incid

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… Disability and retirement age As life expectancy has steadily increased in most countries, there have been calls in some high SDI countries to extend retirement ages to reflect these changes in survival. 28 , 29 , 30 A crucial factor in these debates is whether individuals are living for longer and … Ultimately, the debate on retirement age will hinge on the skill sets required for different types of work, whether work contributes to diminished or improved functional health status, and societal expectations for retirement. …

Cross-Cultural Validation of the COmprehensive Score for Financial Toxicity (COST) Measure in an Australian Sample.

IntroductionThe COmprehensive Score for Financial Toxicity (COST) measure developed in the United States measures the financial impact resulting from cancer and its treatment. This paper reports on an Australian cross-cultural validation of the COST measure.MethodsParticipant eligibility criteria included individuals aged ≥ 18, undergoing or completed primary treatment for cancer. Immediate family members of patients were also eligible for Phase 1. Face and content validity were assessed through concurrent interviews and a brief survey (Phase 1). The subsequent revised version of COST was fiel

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… | ≤ 1 year | 26 (21.3) > 1 year | 85 (69.7) Not specified | 11 (9.0) Marital status | Married/de facto | 81 (66.4) Divorced/separated/widowed | 20 (16.4) Never married | 16 (13.1) Not specified | 5 (4.1) Work status | Working full or part‐time, self‐employed | 43 (35.2) Not working c | 12 (9.8) Retired … Item | Questions | COST Cronbach's α = 0.901 | Australian‐COST Cronbach's α = 0.920 Corrected item‐total correlation | Cronbach's α if item deleted | Corrected item‐total correlation | Cronbach's α if item deleted 1 | I know that I have enough money in savings, retirement, or assets to cover the costs …

Treatment preferences of patients with relapsed and refractory multiple myeloma: a qualitative study.

BACKGROUND: Multiple myeloma is a haematological malignancy characterized by significant morbidity and mortality. This study sought to develop an in-depth understanding of patients' lived experiences of relapsed or refractory multiple myeloma (RRMM) and its treatment, and to identify which features of treatment were most important to them. METHODS: Qualitative interviews and focus groups (FGs) were conducted with 32 people living with RRMM across Canada. In Phase 1, interviews focused on participants' accounts of their experiences with the disease and its treatment and laid the groundwork for

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… The nature of RRMM is that it affects primarily older individuals, at a time when they may be retiring or contemplating retirement in many instances. … For many people in Canada, retirement is frequently viewed as a time when one has more time to enjoy family and friends and to fulfill long-deferred experiences, such as engaging in travel and leisure activities. …

Расследование COVID-19-Induced У иранских пациентов с множественным склерозом в пандемическое время.

СОСТОЯНИЕ: Болезнь коронавируса 2019 (В тыс.COVID-19) Вспышка вызвала много проблем, а также осложнения с физическим и психическим здоровьем, включая регуляционное расстройство (AD). Учитывая исключительную важность этого вопроса для уязвимых групп, настоящее исследование должно было быть посвящено изучению COVID-19-induced AD иранских пациентов, страдающих множественным склерозом (MS) 2020. МЕТОДЫ: Применяя проект межсекционных исследований, это исследование было проведено для статистической группы пациентов, страдающих НР. Кроме того, отбор проб осуществлялся в Иране через Porsline в качеств