Результаты поиска

Воспаление у людей с множественным склерозом, обработанных ингибиторами иммунных контрольно-пропускных пунктов.

В ходе этого исследования была проведена оценка заболеваемости у людей с множественным склерозом (PwMS), которые получили ингибиторы на иммунных контрольно-пропускных пунктах (ИКИ), по сравнению с PwMS, которые не лечились с ICI. Существует 108 PwMS, в том числе (27 PwMS+ICIS и 81 PwMS-контроль), совместимые с возрастом, полом, продолжительностью болезни, DMT и курсами по заболеваниям MS. Из 27 PwMS+ICIs один (4%) имел рецидив, а четыре (15%) - новые МРТ-вреды без клинических симптомов. Время рецидива и активность МРТ сравнивались с использованием кривых Каплан-Мейер и моделей регрессии Кокса.

Совпадение в полном тексте источника
… Methods In this retrospective multicenter cohort study, we identified adult PwMS from the Cleveland Clinic Mellen Center registry ( n = 9158) and cases exposed to ICIs (CTLA4, PD1 or PDL1 inhibitors) at Cleveland Clinic (Ohio, Florida, Nevada) between 2017 and 2023. …

A Perplexing Case of Bladder Mass Biopsy-Proven Neurosarcoidosis.

Sarcoidosis is a multi-organ systemic disease that presents with several clinical manifestations, and patients can develop neurologic complications. Neurosarcoidosis may be life-threatening; therefore, early recognition and treatment are key. Here, we present a case of a 55-year-old African American male who presented with a complaint of dizziness and left-sided weakness; he ultimately received a diagnosis of neurosarcoidosis after elaborate radiographic investigations and bladder mass biopsy. Neurosarcoidosis remains a diagnostic dilemma as it can clinically and radiographically mimic multipl

Совпадение в полном тексте источника
… This case was previously presented as a poster at the Florida Society of Rheumatology Annual Fellow Poster Presentation on July 09, 2022. …

Опыт и экспертный консенсус в отношении промежуточной терапии до клеточной терапии против BCMA CAR-T в множестве миеломы.

Расширяется применение антиклеточной терапии против созревания (BCMA) химерика антигенного рецептора Т-клетки (CAR-T) для лечения повторной/охлажденной множественной миеломы. Исследования показывают, что эффективная переходная терапия (БТ) до антиБМА CAR-T терапия может повысить эффективность и безопасность. На основе качественных опросов и проведения рабочего совещания на основе консенсуса, 10 Европейские эксперты поделились своим клиническим опытом в отношении оптимального выбора, эффективности, безопасности и результатов после CAR-T, сосредотачивая внимание на пациентах, прошедших интенсивн

Совпадение в полном тексте источника
… Orlando, Florida; 2025. 27. Bridging therapy response and low pre-lymphodepletion plasma cell burden are associated with improved safety and efficacy outcomes of ciltacabtagene autoleucel in multiple myeloma. In: 67th ASH Annual Meeting and Exposition. Orlando, Florida; 2025. 28. …

Surveillance for Violent Deaths - National Violent Death Reporting System, 50 States, the District of Columbia, and Puerto Rico, 2023.

PROBLEM/CONDITION: In 2023, approximately 23,000 persons died of homicide and 49,000 persons died of suicide in the United States, according … ting a subset of their population (31 California counties, representing 74.1% of its population; 38 Florida counties, representing 59.3% of its population; and 13 Texas counties, representing 62.9% of its population), and the District of Columbia and Puerto Rico had jurisdiction-wide data. NVDRS collates information for each death and links deaths that ar …

Тенденции в области смертности, связанной с множественной миеломой в Соединенных Штатах, 1999-2023.

Несмотря на значительные терапевтические достижения, большое число миелом (ММ) по-прежнему является важным фактором смертности от рака в Соединенных Штатах. Понимание долгосрочных моделей смертности имеет важное значение для разработки справедливых стратегий в области клинического и общественного здравоохранения. 1999-2023 для оценки связанных с MM смертей среди взрослых ≥25 Годы. Коэффициенты смертности, скорректированные с учетом возраста, рассчитывались на основе прямой стандартизации 2000 Население США. Временные тенденции были изучены с использованием регрессии " Compoint " для

Совпадение в полном тексте источника
… Connecticut | 137 | 112 | 3311 | -18.25 | 5.72 (4.76 to 6.67) | 3.35 (2.72 to 3.98) | -1.63 (-2.12 to -1.13)* Delaware | 22 | 43 | 985 | 95.45 | 4.24 (2.66 to 6.42) | 4.40 (3.15 to 5.96) | -0.23 (-1.02 to 0.56) District of Columbia | 35 | 20 | 735 | -42.86 | 9.76 (6.80 to 13.57) | 4.43 (2.70 to 6.84) | NA Florida … As shown in Figure 1A , in terms of absolute death counts, MM-related deaths were primarily concentrated in highly populated states such as California, Texas, Florida, New York, and Pennsylvania, whereas states with smaller populations—such as Alaska, Wyoming, and Vermont—reported the fewest deaths. …

Targeting the Endocannabinoidome in Pancreatic Cancer.

Pancreatic Ductal adenocarcinoma (PDAC), the most common malignancy of the pancreas, is an aggressive and lethal form of cancer with a very high mortality rate. High heterogeneity, asymptomatic initial stages and a lack of specific diagnostic markers result in an end-stage diagnosis when the tumour has locally advanced or metastasised. PDAC is resistant to most of the available chemotherapy and radiation therapy treatments, making surgery the most potent curative treatment. The desmoplastic tumour microenvironment contributes to determining PDAC pathophysiology, immune response and therapeutic

Совпадение в полном тексте источника
… Chemotherapy in Patients with Advanced Tumours | NCT02423239 | Germany, Poland, Spain, United Kingdom | Unknown Cancer of Pancreas, Liver, Rectum, Colon, Gall Bladder | A Study of the Efficacy of Cannabidiol Patients with Multiple Myeloma, Glioblastoma Multiforme, and GI Malignancies | NCT03607643 | Florida … , United States | Unknown Hepatocellular Carcinoma, Cholangiocarcinoma, GastroEsophageal, Colorectal and Pancreatic cancer | TPST-1120 as Monotherapy and in Combination with Nivolumab in Subjects with Advanced Cancers | NCT03829436 | California, Florida, Maryland, Michigan, New York, North Carolina, …

Минимальная информация для исследований внеклеточной везиклетки (MISEV2023): от базовых до передовых подходов.

Внеклеточные везиклолы (ЭМ) с помощью своего сложного груза могут отражать состояние клетки их происхождения и изменять функции и фенотипы других ячеек. Эти особенности свидетельствуют о значительном биомаркировании и терапевтическом потенциале и вызывают широкий интерес, о чем свидетельствует постоянное увеличение числа научных публикаций об ЭМ за год. Значительные успехи были достигнуты в области ЭВМ, а также в понимании и применении биологии ЭМ. Вместе с тем сохраняются препятствия на пути реализации потенциала ЭМ в различных областях - от базовой биологии до клинического применения - в свя

Increased Indoleamine 2, 3-Dioxygenase expression modulates Th1/Th17/Th22 and Treg pathway in humans with Helicobacter Pylori-Infected gastric mucosa.

Introduction and purposeIndoleamine 2, 3- dioxygenase (IDO) plays an importantrole in immunosuppressive pathway, as inhibits responsesof T cells and promotes immune tolerance. Host responsetoHelicobacter pylori (H. pylori) is involved in the infection persistenceand it is also associatedwith different clinical outcomes. The aim of this study was to investigate the role of IDO in H. pylori-infected patients with gastritis diseases and peptic ulcer diseases (PUD) through the assessment of the relationship among IDO protein expression and the numbers of T helper (Th)-1, Th17, Th22, and T regulato

R WE ready for reimbursement? A round-up of developments in real-world evidence relating to health technology assessment: part 25.

In this update, we discuss the use of real-world data in the Haute Autorité de Santé assessment of economic evaluations, review how real-world evidence is supporting regulatory approvals in multiple myeloma, and consider lessons from the failed EVOKE trials of semaglutide in Alzheimer's disease for the broader application of target trial emulation.

Совпадение в полном тексте источника
… Tang and colleagues conducted a target trial emulation using the OneFlorida+ Clinical Research Consortium, which integrates electronic health records from approximately 17 million patients across Florida, Georgia and Alabama [ 16 ]. …

Humoral Responses After SARS-CoV-2 mRNA Vaccination and Breakthrough Infection in Cancer Patients.

ObjectiveTo evaluate the magnitude of humoral response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccines in patients with cancer receiving active therapies.Patients and methodsPatients 18 years or older in whom SARS-CoV-2 spike antibody (anti-S Ab) levels were measured after 2 doses of SARS-CoV-2 mRNA vaccines were included. Patients with prior coronavirus disease 2019 (COVID-19) infection or receiving other immunosuppressive therapy were excluded.ResultsAmong 201 patients who met the criteria, 61 were immunocompetent, 91 had a hematologic malignancy

Совпадение в полном тексте источника
… Patients and Methods Patient Selection We conducted a retrospective cross-sectional study of patients 18 years or older who had SARS-CoV-2 spike antibody (anti-S Ab) tests performed after 2 doses of SARS-CoV-2 mRNA vaccines between 12 and 90 days at the 3 Mayo Clinic sites in Minnesota, Florida, and …

Neutropenic Enterocolitis as a Complication of Autologous Stem Cell Transplant in Patients With Multiple Myeloma: A Case Series.

Neutropenic enterocolitis (NE) is a rare but severe complication occurring in neutropenic patients undergoing intensive chemotherapy. Mortality is high, so early diagnosis is required to start urgent medical or surgical treatment. Data analysis of the development of NE after hematopoietic stem cell transplantation remains scarce. The aim of this case series is to discuss five out of 100 patients receiving autologous stem cell transplants (ASCTs) for multiple myeloma complicated with NE between 2016 and 2020 in the hematology department of the Cheikh Khalifa International University Hospital, C

Совпадение в полном тексте источника
… StatPearls [Internet] Treasure Island, Florida: StatPearls Publishing LLC; 2021. Neutropenic Enterocolitis (Typhlitis) 16. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america. …

2020 ACVIM Forum On Demand Research Abstract Program.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Atkins 1 ; Darcy Adin 2 ; Catherine Glahn 3 ; Oliver Domenig 4 ; Teresa DeFrancesco 1 ; Kate Meurs 1 1 North Carolina State University; 2 University of Florida; 3 Coastal Cat Clinic; 4 Attoquant Diagnostics Chronic Renin‐Angiotensin‐Aldosterone‐System (RAAS) activation is harmful. … Adin 1 ; Clarke Atkins 2 ; Steven Friedenberg 3 ; Joshua Stern 4 ; Kathryn Meurs 2 1 University of Florida; 2 North Carolina State University; 3 University of Minnesota; 4 University of California, Davis The angiotensin‐converting enzyme (ACE) gene intronic polymorphism at canine chromosome 9:11507816 …

Tumoral parkinsonism-Parkinsonism secondary to brain tumors, paraneoplastic syndromes, intracranial malformations, or oncological intervention, and the effect of dopaminergic treatment.

INTRODUCTION: Secondary tumoral parkinsonism is a rare phenomenon that develops as a direct or indirect result of brain neoplasms or related conditions. OBJECTIVES: The first objective was to explore to what extent brain neoplasms, cavernomas, cysts, paraneoplastic syndromes (PNSs), and oncological treatment methods cause parkinsonism. The second objective was to investigate the effect of dopaminergic therapy on the symptomatology in patients with tumoral parkinsonism. METHODS: A systematic literature review was conducted in the databases PubMed and Embase. Search terms like "secondary parki

Совпадение в полном тексте источника
… The use of basal ganglia drugs as palliative therapy for secondary parkinsonism in malignant CNS tumor patients: A University of Florida experience. | Partial | Methylphenidate, modafinil, levodopa, amantadine | 21 | Malignant glioma Pranzatelli et al. … The use of basal ganglia drugs as palliative therapy for secondary parkinsonism in malignant CNS tumor patients: A University of Florida experience . Movement Disorders , 27 , S388 – S3S9 . Ertan , S. , Benbir , G. , Tanriverdi , T. , Alver , I. , & Uzan , M. ( 2005 ). …

2023 Scientific Session of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Montréal, Canada, 19 March–April 1 2023: Posters

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

LncRNA Gas5, a Target of the Nonsense-Mediated Decay Pathway in the Brain, Regulates Neuroinflammation and Neurodegenerative Disease Pathways in a Tauopathy Mouse Model.

Dysregulation of target genes of nonsense-mediated decay (NMD) in the brain remains sparsely known in tauopathies. PS19 transgenic mice expressing human mutant P301S tau were evaluated for levels of lncRNA Gas5, a target of NMD. The results show Gas5 decreased in the brains of PS19 mice as they aged. We evaluated the consequences of blocking the NMD-mediated turnover of Gas5 using a small molecule administered intranasally to PS19 mice. The results show NPC86 disassociated Upf1 and Gas5, thereby hindering NMD. NPC86 treatment increased Gas5 levels in the cortex of male PS19 mice concurrent wit

Совпадение в полном тексте источника
… Haley Veteran’s Hospital and University of South Florida Institutional Animal Care and Use Committee (IACUC) approved all experimental procedures with animals consistent with the governing guidelines and recommendations of AWA and HREA. All experiments complied with the ARRIVE guidelines. … Haley Veteran’s Hospital and the University of South Florida IACUC Protocol # IS00009728 (approved 8 September 2021) and renewed with approval # IS000013147 (approved 11 July 2024). Informed Consent Statement Not applicable. …

Study protocol: Close Assessment and Testing for Chronic Graft-vs.-Host disease (CATCH).

Chronic graft-versus-host disease (GVHD) is an immune-mediated disorder that causes significant late morbidity and mortality following allogeneic hematopoietic cell transplantation. The "Close Assessment and Testing for Chronic GVHD (CATCH)" study is a multi-center Chronic GVHD Consortium prospective, longitudinal cohort study designed to enroll patients before hematopoietic cell transplantation and follow them closely to capture the development of chronic GVHD and to identify clinical and biologic biomarkers of chronic GVHD onset. Data are collected pre-transplant and every two months through

Совпадение в полном тексте источника
… Lee Moffitt Cancer Center and Research Institute | | 39 (21.0%) | Cleveland Clinic | | 22 (11.8%) | Roswell Park Cancer Institute | | 16 (8.6%) | University of Florida | | 4 (2.2%) | National Cancer Institute | | 3 (1.6%) | Vanderbilt | | 1 (0.6%) Recipient age at HCT in years | Median: IQR …

Treatment-Associated Acute Lymphoblastic Leukemia Following Autologous Hematopoietic Stem Cell Transplant and Lenalidomide Maintenance in Patients With Multiple Myeloma.

Secondary malignancies including leukemia are an increasing concern in patients with prior primary malignancies treated with alkylating agents or topoisomerase II inhibitors. These can also be referred to as therapy-related leukemia. Therapy-related leukemia most commonly results in myelodysplastic syndrome or acute myeloid leukemia. The alkylating agent can cause chromosomal aberrations typically manifest as deletions in chromosome 11 or loss of part of complete loss of chromosomes 5 and 7. Conversely, acute lymphoblastic leukemia (ALL) has been described following maintenance therapy with im

Совпадение в полном тексте источника
… Footnotes Authors’ Note: This case was submitted as a poster to Florida ACP. The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. …

Applications of bio-enhanced cementitious composites for sustainable building materials: emission-reduction and carbon-sequestration pathways.

Ampligen [polyI:polyC12U] is a mismatched double-stranded RNA that acts by inducing interferon production (immunomodulator) and by activatin … troviral therapy and at risk of viral relapse will be enrolled at centres in Connecticut, New York, Florida and California. A second phase IIb study evaluating the effect of Ampligen on structured treatment interruptions (STI) is also underway. Final results from this study were reported in December 2002. NIH sponsored studies of potential therapies for S …

Эпидемиология множественного склероза: глобальные, региональные, национальные и субнациональные оценки и будущие прогнозы.

ИСТОРИЯ ВОПРОСА: Эпидемиология множественных склерозов (МС) является сложной в силу взаимодействия различных факторов риска. В настоящем исследовании дается оценка глобального, регионального, национального и субнационального бремени НР и прогнозируются будущие тенденции. МЕТОДЫ: Данные, полученные в ходе глобального исследования бремени болезней 2021 был проанализирован с целью оценки эпидемиологии MS 1990 в адрес 2021. Данные Всемирного банка использовались для определения социально-демографических прогнозов распространенности НР с использованием многовариантного анализа. РЕЗУЛЬТАТЫ: НА глоба

Совпадение в полном тексте источника
… Michigan 4.26 4.55 6.8 New Hampshire 4.34 4.48 3.3 South Dakota 4.05 4.45 10.0 Washington 4.45 4.45 0.1 Wisconsin 4.44 4.44 0.1 Vermont 4.15 4.40 6.0 States with the lowest rates Tennessee 3.03 3.22 6.6 South Carolina 2.79 3.08 10.2 Georgia 2.63 2.90 10.0 Oklahoma 2.81 2.87 2.2 Alabama 2.68 2.85 6.5 Florida …

Liver failure due to relapsed myeloma and hepatic iron overload.

Multiple myeloma is a hematologic malignancy that classically manifests with hypercalcaemia, renal insufficiency, anaemia and lytic bone lesions. Liver dysfunction in multiple myeloma is a lesser known complication that occurs through biliary obstruction, liver infiltration by plasma cells, amyloid/light chain deposition or due to liver injury from medications. Although transfusion-related hepatic iron overload-leading to significant liver disease-is a recognised complication in certain hematologic malignancies, little is known about transfusional iron overload in patients with multiple myelom

Совпадение в полном тексте источника
… Acknowledgments The authors acknowledge the contributions of their patient and thank the Hematology malignancy research fund at Maroone Cancer Center of Cleveland Clinic Florida, Weston FL, USA. References 1. Koreth J, Antin JH. …