Результаты поиска

Influence and Role of Regulatory B Cells in Organ Transplantation: The State of the Art, Prospects, and Emerging Insights.

B cells have attracted increasing interest in the field of organ transplantation due to their newly discovered immunoregulatory properties in alloimmune responses. Traditionally, B cells have been primarily associated with adaptive immunity to foreign substances and alloreactive immune response to allografts, differentiating into antibody-producing plasma cells or memory cells upon antigen recognition and T cell collaboration. However, the existence of B cells with regulatory functions (Bregs) in humans has been widely confirmed, highlighting the presence of this subset, which has immunosuppre

A Look to the Future: Potential Theranostic Applications in Head and Neck Tumors.

Theranostics, the practice of using a diagnostic radiopharmaceutical to guide radiotherapy with a chemically identical (or nearly identical) therapeutic radiopharmaceutical, is an exciting new field under development within the auspices of nuclear medicine. We aim to provide a narrative review of the areas of theranostics use and development which are occurring specifically in the head and neck, with attention to the therapeutic use of existing diagnostically used radiotracers such as agents that target prostate-specific membrane antigen (PSMA) and somatostatin receptors (e.g., DOTATATE deriva

Совпадение в полном тексте источника
… Quintos-Meneses H.A., Aranda-Lara L., Morales-Avila E., Torres-Garcia E., Camacho-Lopez M.A., Sanchez-Holguin M., Luna-Gutierrez M.A., Ramirez-Duran N., Isaac-Olive K. In vitro irradiation of doxorubicin with (18)F-FDG Cerenkov radiation and its potential application as a theragnostic system. J. …

Barriers to Recruitment and Retention Among Underrepresented Populations in Cancer Clinical Trials: A Qualitative Study of the Perspectives of Clinical Trial Research Coordinating Staff at a Cancer Center.

BackgroundAlthough US research agencies have instituted peer review processes to require participant diversity in clinical trials before funding decisions are made, the underrepresentation of certain populations (eg, racial and ethnic minorities) in clinical trials remains a persistent challenge in biomedical research. This issue has the potential to affect the generalizability of findings and impede efforts to ensure the provision of high-quality healthcare across all populations. In this study, we examined barriers to the recruitment and retention of underrepresented populations in cancer cl

Совпадение в полном тексте источника
… They also shared that the absence of a consistent structure to address these challenges could eventually lead to low staff morale, ultimately impacting patient care and organizational effectiveness. …

Diabetes and obesity: the role of stress in the development of cancer.

Diabesity is a condition where an individual has both diabetes and obesity, which can lead to severe complications including cardiovascular disease, a leading cause of mortality. Recently, cancer has become a leading cause of excess hospitalizations, and both diabetes and obesity are associated with a higher risk of developing several types of cancer. In this review, we propose that chronic stress significantly increases this association. Managing diabetes and obesity is challenging as they both cause significant distress. The relationship between stress and cancer is interconnected, with anxi

Совпадение в полном тексте источника
… Morales, Association between diabetes and cancer. Current mechanistic insights into the association and future challenges. Mol. Cell Biochem. 478 (8), 1743–1758 (2023) 79. M.J. Iqbal, A. Kabeer, Z. Abbas, H.A. Siddiqui, D. Calina, J. Sharifi-Rad, W.C. …

Multiple myeloma in Latin America: A systematic review.

The incidence of multiple myeloma (MM) has surged globally, particularly in Latin American countries, and is attributable to an aging population and increased life expectancy. This systematic review analyzes the epidemiology, patient characteristics, and treatment outcomes for MM in selected Latin American countries: Brazil, Mexico, Colombia, Argentina, Chile, Peru, and Uruguay. PubMed and the Latin American and Caribbean Health Sciences Literature (LILACS), conference abstracts (between June 2019 and June 2022), and GLOBOCAN registry (January 2010 to June 2022) were electronically searched. Q

Совпадение в полном тексте источника
… Legües ME, Morales P, Valenzuela M, Encina A, Martí MJ, Bascuñán C, et al. Características citogenéticas y detección de anormalidades de alto riesgo en mieloma múltiple [High risk cytogenetic abnormalities in patients with multiple myeloma]. Rev Med Chile. 2019;147(1):61–64. 34. …

Exploring the association and causal effect between white blood cells and psoriasis using large-scale population data.

IntroductionPsoriasis is a chronic inflammatory disease of the skin. A few studies have shown that psoriasis is an immune-mediated disease in which multiple immune cells play crucial roles. However, the association between circulating immune cells and psoriasis remains elusive.MethodsTo explore the role of circulating immune cells in psoriasis, 361,322 individuals from the UK Biobank (UKB) and 3,971 patients with psoriasis from China were included to investigate the association between white blood cells and psoriasis via an observational study. Genome-wide association studies (GWAS) and Mendel

Совпадение в полном тексте источника
… Budu-Aggrey A, Brumpton B, Tyrrell J, Watkins S, Modalsli EH, Celis-Morales C, et al. Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study. PloS Med (2019) 16:e1002739. doi: 10.1371/journal.pmed.1002739 29. …

The link between bone-derived factors osteocalcin, fibroblast growth factor 23, sclerostin, lipocalin 2 and tumor bone metastasis.

The skeleton is the third most common site of metastatic disease, which causes serious bone complications and short-term prognosis in cancer patients. Prostate and breast cancers are responsible for the majority of bone metastasis, resulting in osteolytic or osteoblastic lesions. The crosstalk between bone cells and their interactions with tumor cells are important in the development of lesions. Recently, both preclinical and clinical studies documented the clinical relevance of bone-derived factors, including osteocalcin (OC) and its undercarboxylated form (ucOC), fibroblast growth factor 23

Совпадение в полном тексте источника
… García-Fontana B, Morales-Santana S, Varsavsky M, García-Martín A, García-Salcedo JA, Reyes-García R, et al. Sclerostin serum levels in prostate cancer patients and their relationship with sex steroids. Osteoporos Int (2014) 25:645–51. doi: 10.1007/s00198-013-2462-y 62. …

Targeting pancreatic cancer immune evasion by inhibiting histone deacetylases.

The immune system plays a vital role in maintaining the delicate balance between immune recognition and tumor development. Regardless, it is not uncommon that cancerous cells can intelligently acquire abilities to bypass the antitumor immune responses, thus allowing continuous tumor growth and development. Immune evasion has emerged as a significant factor contributing to the progression and immune resistance of pancreatic cancer. Compared with other cancers, pancreatic cancer has a tumor microenvironment that can resist most treatment modalities, including emerging immunotherapy. Sadly, the u

Burden of hospitalizations and outpatient visits associated with moderate and severe acute graft-versus-host disease in Finland and Sweden: a real-world data study.

PurposeThe aim of this study was to describe patient characteristics and quantify hospital stays and outpatient visits (H&OV) following diagnosis with moderate-to-severe acute graft-versus-host disease (aGVHD) in Finland and Sweden.MethodsA retrospective chart audit collected data from patient medical records of 3 specialized centers performing allogeneic hematopoietic stem cell transplantation (HSCT; Finland, n = 2; Sweden, n = 1). Eligible patients received allogeneic HSCT (January 1, 2016-June 30, 2017) from any donor source, were diagnosed with grade II-IV aGVHD (MAGIC or modified Glucksbe

Совпадение в полном тексте источника
… Major-Monfried H Renteria AS Pawarode A Reddy P Ayuk F Holler E Efebera YA Hogan WJ Wolfl M Qayed M Hexner EO Wudhikarn K Ordemann R Young R Shah J Hartwell MJ Chaudhry MS Aziz M Etra A Yanik GA Kroger N Weber D Chen YB Nakamura R Rosler W Kitko CL Harris AC Pulsipher M Reshef R Kowalyk S Morales G Torres …

Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma.

Despite several new developments in the treatment of multiple myeloma, all available therapies are only palliative without curative potential and all patients ultimately relapse. Thus, novel therapeutic options are urgently required to prolong survival of or to even cure myeloma. Here, we show that multiple myeloma cells express the potassium channel Kv1.3 in their mitochondria. The mitochondrial Kv1.3 inhibitors PAPTP and PCARBTP are efficient against two tested human multiple myeloma cell lines (L-363 and RPMI-8226) and against ex vivo cultured, patient-derived myeloma cells, while healthy b

Совпадение в полном тексте источника
… Morales A.A. Boise L.H. Acquisition of a Multidrug-Resistant Phenotype with a Proteasome Inhibitor in Multiple Myeloma Leukemia 2009 23 2181 2183 10.1038/leu.2009.123 19516276 PMC2783738 34. Hawley T.S. Riz I. Yang W. Wakabayashi Y. Depalma L. Chang Y.T. Peng W. Zhu J. Hawley R.G. …

Living and dying with incurable cancer: a qualitative study on older patients' life values and healthcare professionals' responsivity.

BackgroundIn ageing Western societies, many older persons live with and die from cancer. Despite that present-day healthcare aims to be patient-centered, scientific literature has little knowledge to offer about how cancer and its treatment impact older persons' various outlooks on life and underlying life values. Therefore, the aims of this paper are to: 1) describe outlooks on life and life values of older people (≥ 70) living with incurable cancer; 2) elicit how healthcare professionals react and respond to these.MethodsSemi-structured qualitative interviews with 12 older persons with advan

Cardio-oncology: conflicting priorities of anticancer treatment and cardiovascular outcome.

BackgroundThis article about the emerging field of cardio-oncology highlights typical side effects of oncological therapies in the cardiovascular system, cardiovascular complications of malignancies itself, and potential preventive or therapeutic modalities.MethodsWe performed a selective literature search in PubMed until September 2016.ResultsCardiovascular events in cancer patients can be frequently attributed to oncological therapies or to the underlying malignancy itself. Furthermore, many patients with cancer have pre-existing cardiovascular diseases that can be aggravated by the malignan

Совпадение в полном тексте источника
… Bosch X Rovira M Sitges M Domenech A Ortiz-Perez JT de Caralt TM Morales-Ruiz M Perea RJ Monzo M Esteve J Enalapril and carvedilol for preventing chemotherapy-induced left ventricular systolic dysfunction in patients with malignant hemopathies: the OVERCOME trial (preventiOn of left Ventricular dysfunction …

Amelioration of the cyclophosphamide induced genotoxic damage in mice by the ethanolic extract of Equisetum arvense.

In the present study, we evaluated the potential of the plant E. arvense against the cytotoxic and mutagenic effects induced by cyclophosphamide (chemotherapeutic agent) in the bone marrow cells of mice using the Chromosome assay (CA) and Mitotic index (MI) in vivo as the biomarkers. The study was performed following 3 protocols: pre-treatment, simultaneous treatment and post-treatment with the ethanolic extract of the plant. The results demonstrated that the plant extract was not cytotoxic and mutagenic and has a protective effect against the mutagenicity induced by cyclophosphamide in pre, s

Совпадение в полном тексте источника
… Morales P. Martínez A. Marín M.L. Haza A.I. Cambero M.I. Antimutagenic effect of fruit and vegetable ethanolic extracts against N-nitrosamines evaluated by the Ames test J. Agric. Food Chem. 47 1999 3257 3264 10552641 10.1021/jf990166n 56 Heo M.Y. Sohn S.J. Au W.W. …

Correlation of long non-coding RNA expression with metastasis, drug resistance and clinical outcome in cancer.

The therapeutic response and clinical outcome of patients diagnosed with the same cancer type and that receive identical treatment is highly variable to reflect the genetic heterogeneity within tumor cells. Non-coding RNAs (ncRNAs) are recently discovered molecules that regulate eukaryotic gene expression and represent a significant advance towards a better understanding of the mechanisms that govern cellular growth. NcRNAs are essential for the proper regulation of cell proliferation and survival under physiologic conditions and are deregulated in many pathologies, e.g., human cancers. NcRNAs

Совпадение в полном тексте источника
… nucleases Genome Research 2011 21 11 1944 1954 21844124 10.1101/gr.122358.111 PMC3205578 75 Tsai M.C Long noncoding RNA as modular scaffold of histone modification complexes Science 2010 329 5992 689 693 20616235 10.1126/science.1192002 PMC2967777 76 Khalil AM Guttman M Huarte M Garber M Raj A Rivea Morales …

Drug-induced oxidative stress in cancer treatments: Angel or devil?

Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the most significant biological events in cancer progression. Cancer cells generally represent a higher oxidant level, which suggests a dual therapeutic strategy by regulating redox status (i.e., pro-oxidant therapy and/or antioxidant therapy). Indeed, pro-oxidant therapy exhibits a great anti-cancer capability, attributing to a higher oxidant accumulation within cancer cells, whereas antioxidant therapy to restore redox homeostasis has been claimed to fail in several clinical practices. Targeting the redox

Совпадение в полном тексте источника
… Carrasco R., Ramirez M.C., Nes K., Schuster A., Aguayo R., Morales M., Ramos C., Hasson D., Sotomayor C.G., Henriquez P., Cortés I., Erazo M., Salas C., Gormaz J.G. …

Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications.

Curcumin, a yellow polyphenolic pigment from the Curcuma longa L. (turmeric) rhizome, has been used for centuries for culinary and food coloring purposes, and as an ingredient for various medicinal preparations, widely used in Ayurveda and Chinese medicine. In recent decades, their biological activities have been extensively studied. Thus, this review aims to offer an in-depth discussion of curcumin applications for food and biotechnological industries, and on health promotion and disease prevention, with particular emphasis on its antioxidant, anti-inflammatory, neuroprotective, anticancer, h

Совпадение в полном тексте источника
… Morales P. Ferreira I. C. ( 2014 ). Adding molecules to food, pros and cons: A review on synthetic and natural food additives . Compr. Rev. Food Sci. Food Saf. 13 , 377 – 399 . 10.1111/1541-4337.12065 33412697 Chainani-Wu N. ( 2003 ). …

Повышение эффективности лечения нескольких миелом: интеграция четырехкратной и двойной антигенной терапии CAR-T.

Множественная миелома (ММ), своего рода гематологическая порча, характеризуется бесконтрольным распространением плазменных клеток в костном мозге. При лечении MM возникли серьезные проблемы, связанные с такими факторами, как рецидив, сопротивление и побег антигенов. За последнее десятилетие алгоритм лечения сместился с традиционной химиотерапии на иммунную терапию и четырехкратные индукционные режимы. Насколько нам известно, ни один опубликованный обзор пока не содержит комплексного анализа применяемых в настоящее время УЛХ методов лечения CAR-T и четырёхкратного лечения для MM. В настоящем об

Совпадение в полном тексте источника
… Gómez-Melero S., Hassouneh F., Vallejo-Bermúdez I.M., Agüera-Morales E., Solana R., Caballero-Villarraso J. Tandem CAR-T cell therapy: recent advances and current challenges. Front. Immunol. 2025;16 doi: 10.3389/fimmu.2025.1546172. 18. Awasthi R., Maier H.J., Zhang J., Lim S. …

The Relationship Between Obesity and Cancer: Epidemiology, Pathophysiology, and the Effect of Obesity Treatment on Cancer.

There is growing evidence relating to the risk of cancer in people with obesity. Obesity is already established as one of the strongest predisposing factors to cancer, and 'obesity-related' cancers have been defined in previous studies. In this review article, we examine the epidemiological relationship and describe the potential pathophysiological mechanisms that underpin the association between obesity and cancer. These include hormonal and growth factors that are in abundance in persons living with obesity and thereby increase cancer risk. Additionally, the increased disposition towards chr

Совпадение в полном тексте источника
… Parra-Soto S., Boonpor J., Lynskey N., Araya C., Ho F., Pell J.P., Celis-Morales C. Association between visceral adiposity index and cancer risk in the UK Biobank cohort. Cancer. 2025;131:e35576. doi: 10.1002/cncr.35576. 18. Hunter G.R., Gower B.A., Kane B.L. Age Related Shift in Visceral Fat. …

Mezigdomide-A Novel Cereblon E3 Ligase Moduler под следствием в Replapsed/ Refractory Multieloma.

Mezigomide — пероральный модулятор лигаса Е3 (CELMOD), который находится под клиническим исследованием у пациентов с множественным миэломой (MM) responsed/refractory (RR). Как и другие соединения CELMOD, мезигдомид действует, изменяя конформацию церебрально-церебрального узла Cullin 4A кольца Ligase-Cereblon (CRL4CRBN) E3 Ubisquitin Ligase, тем самым привлекая новые белковые субстраты для селективной протеасомальной деградации. К ним относятся: two Критические лимфоидные коэффициенты транскрипции, протеины цинкового пальца семейства Икарос 1 и 3 (IKZF1 и IKZF3), также известные как Ikaros и Ai

Совпадение в полном тексте источника
… Morales S. Martin S. Walker B.A. Li Y. Bird S. Pawlyn C. Investigating the Functional Impact of Crbn Mutations on Response to Imid/Celmod Agents in Myeloma Blood 2023 142 (Suppl. S1) 753 10.1182/blood-2023-179986 77. Gooding S. Ansari-Pour N. Towfic F. Ortiz Estevez M. Chamberlain P.P. Tsai K.T. …

Delving into Molecular Pathways: Analyzing the Mechanisms of Action of Monoclonal Antibodies Integrated in IMGT/mAb-DB for Myasthenia Gravis.

BackgroundMyasthenia Gravis (MG) is a rare autoimmune disease presenting with auto-antibodies that affect the neuromuscular junction. In addition to symptomatic treatment options, novel therapeutics include monoclonal antibodies (mAbs). IMGT®, the international ImMunoGeneTics information system®, extends the characterization of therapeutic antibodies with a systematic description of their mechanisms of action (MOA) and makes them available through its database for mAbs and fusion proteins, IMGT/mAb-DB.MethodsUsing available literature data combined with amino acid sequence analyses from mAbs m

Совпадение в полном тексте источника
… Sánchez-Tejerina D., Sotoca J., Llaurado A., López-Diego V., Juntas-Morales R., Salvado M. New Targeted Agents in Myasthenia Gravis and Future Therapeutic Strategies. J. Clin. Med. 2022;11:6394. doi: 10.3390/jcm11216394. 61. Menon D., Bril V. …