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Cancer treatment-related financial toxicity in Japan: a scoping review.

Financial toxicity during cancer survival has been studied mainly in the United States; 47-49% of cancer survivors reported financial hardships and 12-63% reported debt owing to treatment costs. Financial toxicity is influenced by each country's economic status and healthcare system. We aimed to review the evidence on financial toxicity in Japan. A systematic search was performed using PubMed and Ichushi databases. We included English or Japanese peer-reviewed articles that (1) explored the experiences of cancer patients facing financial toxicity due to cancer diagnosis and treatment, (2) were

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… In addition to direct financial problems such as high medical, treatment, and hospitalization costs for cancer treatment, they struggled to cope with reduced income, loss of income due to spousal leave, or retirement due to changes in lifestyle patterns ( Okubo, 2013 ). … Employment status among non-retired cancer survivors in Japan. Eur. J. Cancer Care 24, 718–723. doi: 10.1111/ecc.12304, PMID: Kaneko S., Noguchi H., Fu R., Kang C., Kawamura A., Amano S., et al. (2020). …

Анализ затрат и затрат на ранний и поздний период использования натененизумаба в высокоактивных релапсирующих множественных склерозах: имитационное исследование.

Натальизумаб (NAT) представляет собой установившуюся терапию для изменения заболеваний (DMT) для высокоактивного множественного склероза (MS). Однако его использование сопряжено со сложным процессом принятия решений, что зачастую приводит к первоначальному использованию методов лечения с низкой эффективностью. Недавно был утвержден первый биоаналогичный НАТ, что позволило обеспечить конкурентное ценообразование. В рамках этого исследования была проведена оценка социальных последствий инициирования НАТ в различных сценариях на основе анализа затрат и затрат. МЕТОДЫ: А 10-year Была использована

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… consultation costs, examination costs, costs for DMTs, and other medications), direct non-medical costs (services and informal care costs: community and social services, investments and purchases, and informal care), and indirect costs (short-term absence and long-term absence from work, invalidity, and early retirement … indirect costs g Direct medical costs = inpatient care costs + outpatient costs + consultation costs + examination costs + medication costs h Direct non-medical costs = community services + investments + informal care costs i Indirect costs = short-term absence + long-term absence, invalidity and early retirement …

The Impact of a Health Coaching App on the Subjective Well-Being of Individuals With Multimorbidity: Mixed Methods Study.

BackgroundMultimorbidity, the coexistence of 2 or more chronic conditions, is associated with poor well-being. Health coaching apps offer cost-effective and accessible support. However, there is a lack of evidence of the impact of health coaching apps on individuals with multimorbidity.ObjectiveThis study aimed to assess the impact and acceptability of a health coaching app (the Holly Health [HH] app) on the subjective well-being (SWB) of adults with multimorbidity.MethodsThis study used an explanatory-sequential mixed methods design, with quantitative secondary data analysis in the first phas

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… In fact, our qualitative findings identified that retirement appeared to facilitate greater app engagement, providing individuals with more time to achieve daily goals. … This observation aligns with previous research that associates retirement with increased leisure activities, including personal growth and physical exercise [ 69 ]. …

Trichloroethylene: An Invisible Cause of Parkinson's Disease?

The etiologies of Parkinson's disease (PD) remain unclear. Some, such as certain genetic mutations and head trauma, are widely known or easily identified. However, these causes or risk factors do not account for the majority of cases. Other, less visible factors must be at play. Among these is a widely used industrial solvent and common environmental contaminant little recognized for its likely role in PD: trichloroethylene (TCE). TCE is a simple, six-atom molecule that can decaffeinate coffee, degrease metal parts, and dry clean clothes. The colorless chemical was first linked to parkinsonism

Частота воздействия факторов риска на презенциальные катаракты среди пациентов в возрасте 30-50 лет: перекрестное исследование в больнице Шафа, Керман (2024-2025 годы).

ЦЕЛЬ: Это исследование было направлено на определение частотности и характеристик ключевых факторов риска для катаракты передозировки у пациентов в возрасте от 30 до 50 лет в Кермане, Иран, регионе, характеризующемся высоким воздействием солнечной энергии и конкретными социально-поведенческими тенденциями. МЕТОДЫ: В 2024 году в отделении офтальмологии больницы Шафа было проведено аналитическое перекрестное исследование. Согласно методу переписи 245 пациентов (468 глаз) нуждались в катаракте. Данные о демографических, профессиональных, системных и поведенческих факторах собирались с использован

The role of social networks in prognostic understanding of older adults with advanced cancer.

ObjectivesExplore how older patients utilize their social networks to inform prognostic understanding.MethodsIn a pilot study of adults (≥65 years old) with advanced cancer, 16 patients completed surveys, social network maps, and semi-structured interviews exploring with whom they preferred to communicate about their illness. Interviews were analyzed using open-coding, and codes were categorized into emergent themes. Social network maps and themes were analyzed via mixed-methods social network analysis (MMSNA). Three case examples with diverse network characteristics and communication patterns

Fear of cancer recurrence in patients with multiple myeloma: Prevalence and predictors based on a family model analysis.

ObjectiveFear of cancer recurrence (FCR) is a common psychosocial sequela among cancer survivors, but data on patients with multiple myeloma are scarce. This study calculated the prevalence of FCR and identified family and social factors that predict FCR in the study population.MethodsWe recruited 127 myeloma patients and their partners to participate in a cross-sectional survey from a regional tertiary cancer centre in China. The questionnaires included items on demographic characteristics and from the fear of disease progression simplified scale, family hardiness index and Social Support Sca

Множественный опыт и предпочтения в области миеломы: исследование смешанных методов лечения пациентов и партнеров по уходу в Соединенных Штатах.

ЦЕЛЬ: Множественная миелома (ММ) характеризуется рецидивом лечения и сопротивлением, что требует принятия последовательных решений о лечении на протяжении всего курса лечения. Для того чтобы понять, каким образом состояние заболеваний и изменение условий лечения влияют на решения, принимаемые пациентами и партнерами по уходу, было проведено исследование по изучению неинтервенционных смешанных методов. ПАТИЕНТЫ И МЕТОДЫ: Пациенты, самоотчитывающиеся MM и партнеры по уходу, были набраны через Гритское сообщество по борьбе с раком, социальные сети и снежные шары для участия в этом исследовании, п

Symptom burden and health-related quality of life six months after hyperbaric oxygen therapy in cancer survivors with pelvic radiation injuries

Abstract Purpose Late radiation tissue injuries (LRTIs) after treatment for pelvic cancer may impair health related quality of life (HRQoL). Hyperbaric oxygen therapy is an adjuvant therapy for LRTIs, but limited studied. The aim of this study was to explore the development and association between symptoms of LRTI and HRQoL following hyperbaric oxygen treatment. Methods A pretest–posttest design was used to evaluate the changes in pelvic LRTIs and HRQoL from baseline (T1), immediately after treatment (T2) and at six-month follow-up (T3). EPIC and EORTC-QLQ-C30 were used to assess LRTIs and HRQ

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… Table 1 Sample characteristics ( N = 95) n (%) Gender Male 50 (52.6) Female 45 (47.4) Age, years (mean (SD, range)) 65 (11.6, 32–84) Work status Sick leave/disability pension/retired 78 (82.1) Full time/part time employment 17 (17.9) Civil status Married/cohabiting 67 (70.5) Single 28 (29.5) Children … This can partly be explained by the participants’ age and retirement. However, most participants in working age were on sick leave or disability pension. …

Quality-of-life issues and symptoms reported by patients living with haematological malignancy: a qualitative study.

BackgroundOur aim was to identify health-related quality-of-life (HRQoL) issues and symptoms in patients with haematological malignancies (HMs) and develop a conceptual framework to reflect the inter-relation between them.MethodsA total of 129 patients with HMs were interviewed in a UK multicentre qualitative study. All interviews were audio recorded, transcribed and analysed using NVivo-11.ResultsOverall, 34 issues were reported by patients and were grouped into two parts: quality of life (QoL) and symptoms. The most prevalent HRQoL issues were: eating and drinking habits; social life; physic

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… This was experienced in the early course of the disease and was raised by 38 (54.3%) patients who were retired, with the highest being among the 65–75 years’ age group. Tiredness, lack of energy and low muscular strength were the main reasons for limited physical activities [ Table 4 : 3(a)]. … A total of 55 patients (42%) reported a negative impact on their work life, of whom 10 had to take early retirement. In addition, three patients had given up their jobs, two were dismissed and three made redundant. …

Health-related quality of life and function in middle-aged individuals with thalidomide embryopathy.

ObjectivesThe aim of this study was to evaluate the effect of limb malformations on health-related quality of life (HRQL) and function of the extremities in middle-aged individuals with thalidomide embryopathy (TE). Between 1959 and 1962, approximately 150 children with multiple malformations were born in Sweden following the maternal intake of thalidomide during pregnancy, of whom 100 survived.MethodsThirty-one individuals with TE underwent evaluations of musculoskeletal manifestations by clinical examination. Validated questionnaires were used for the assessment of general HRQL [the 36-Item

Sociodemographic, Clinical, and Therapeutic Characterization of Multiple Myeloma Patients (CharisMMa Study) with Symptomatic Relapse and/or Refractory Disease: An Observational, Multicenter Study in Portugal.

OBJECTIVES: Real-world information on relapsed and/or refractory multiple myeloma (rrMM) clinical management in Portugal is scarce. The CharisMMa Portugal study aimed to characterize rrMM patients through socio-demographic and clinical parameters and describe treatment patterns. METHODS: This was an observational, cross-sectional, multicenter study with 62 rrMM patients routinely treated at seven hospitals in Portugal. Data were collected from medical records during clinical appointments (2020-2022) after written informed consent was obtained (ClincialTrials.gov ID-NCT04135963). Patients who

Classification of symptom subtypes in patients with multiple myeloma during treatment: a cross-sectional survey study in China.

OBJECTIVES: To classify subgroups of cancer-related symptoms in patients with multiple myeloma (MM) during treatment and examine between-group differences in demographic and clinical characteristics in addition to functional status. DESIGN: Cross-sectional survey study. SETTING: Haematology department of two tertiary hospitals affiliated with Guilin Medical University in China. PARTICIPANTS: Using a convenience sampling method, questionnaires were distributed to patients with MM visiting two hospitals in Guilin, China. INTERVENTIONS: The patients were categorised into subgroups based on ca

Dependence and clinical fragility in hematopoietic stem cell transplant and CAR-T therapy: a retrospective study.

PurposeAutologous and allogeneic hematopoietic stem cell transplantation and CAR-T cell therapy are standard treatments for patients affected by hematologic malignancies at different stages of their clinical pathway. Several adverse events accompany these therapies during patients' hospital stay, including psycho-emotional distress and various functional and social impairments.MethodsIn this monocentric study on 498 patients, various clinical and social fragility indices, registered within clinical documentation during the hospital stay, specifically at admission (within 24 h of entry) and dis

Comparison of the long-term prognostic value of different frailty instruments in older inpatients: a 5-year prospective cohort study.

BackgroundFrailty is associated with increased mortality in older adults, but limited studies compare frailty instruments among inpatients with long-term follow-up.AimsTo evaluate five frailty scales for predicting 5-year all-cause mortality in older inpatients.MethodsThis prospective cohort study enrolled 917 inpatients aged ≥ 65 years. We used five commonly used scales [Clinical Frailty Scale (CFS), FRAIL, Fried, Edmonton, and the comprehensive geriatric assessment-frailty index (CGA-FI)] to screen or assess frailty and then conducted a 5-year telephone follow-up. The primary endpoint was 5-

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… Model 2 was further adjusted for age, gender, years of education, retirement income, BMI, atrial fibrillation, heart failure, cancer, lg (NT-proBNP), hsCRP, hemoglobin, prealbumin, and creatinine. … Prevalence of frailty status among the European elderly population: findings from the Survey of Health, Aging and Retirement in Europe. Geriatr Gerontol Int. 2019;19(8):723–9. 10.1111/ggi.13689. 5. Hoogendijk EO, Afilalo J, Ensrud KE, Kowal P, Onder G, Fried LP. …

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OBJECTIF: La présente directive clinique examine les avantages potentiels de la salpingectomie opportuniste pour prévenir le développement du cancer séreux de grade élevé de l'ovaire, de la trompe de Fallope et du péritoine à la lumière de données probantes actuelles selon lesquelles ce type de cancer prendrait naissance dans la trompe de Fallope. UTILISATEURS CIBLES: Gynécologues, obstétriciens, médecins de famille, infirmières autorisées, infirmières praticiennes, résidents et fournisseurs de soins de santé. POPULATION CIBLE: Femmes adultes (18 ans et plus) : OPTIONS: Les femmes envisagean

Продольные траектории цифровых когнитивных биомаркеров для множественных склерозов.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Когнитивное повреждение - это one - наиболее распространенные и изнурительные симптомы повторного излучаемого множественным склерозом (RRMS). Цифровые когнитивные биомаркеры требуют меньше времени и ресурсов и быстро набирают популярность в клинических условиях. Мы изучили продольную траекторию испытания на скорость обработки на основе iPad (PST) и прогнозы значений PST. Мы, вероятно, зачислили пациентов из RRMS между 2017 и 2021 по всему району six Австралийские центры НР. Продольные данные анализировались с помощью моделей смешанного воздействия и скрытых моделей смеша

Навязчивое сексуальное поведение и изменения в одиночных сексуальных поступках во время пандемии COVID-19

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Financial Toxicity of Hematologic Malignancy Therapies, Including Cellular Therapy and Its Impact on Access to Care: Prospective Pilot Study.

BackgroundPatients with cancer often face significant financial challenges, known as financial toxicity (FT), which is associated with reduced quality of life. Patients with hematologic malignancies (HMs) are especially vulnerable due to intensive and prolonged treatments, frequent hospital visits, and a high risk of complications. While FT affects many in the general population, it is particularly severe among racial and ethnic minorities, especially those below the poverty line. To our knowledge, no studies have specifically examined FT in this vulnerable group in the United States.Objective

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… Over a third (n=32, 37%) of our patients were employed, while more than 60% were retired, disabled, or unemployed ( Table 1 ). Table 6 and Figure 2 show the results of our investigator-based questionnaire. … As their cancer treatment progresses, which is often prolonged in HM, they may face increasing financial burdens, leading them to adopt coping strategies such as relying on retirement savings, selling valuables, or borrowing from friends, family, or financial institutions [ 32 ]. …

Patient-Caregiver Portal System in Palliative Oncology: Assessment of Usability and Perceived Benefit.

BackgroundThe engagement of family caregivers in oncology is not universal or systematic.ObjectiveWe implemented a process intervention (ie, patient-caregiver portal system) with an existing patient portal system to (1) allow a patient to specify their caregiver and communication preferences with that caregiver, (2) connect the caregiver to a unique caregiver-specific portal page to indicate their needs, and (3) provide an electronic notification of the dyad's responses to the care team to inform clinicians and connect the caregiver to resources as needed.MethodsWe assessed usability and satis