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Stakeholder Perceptions of Key Aspects of High-Quality Cancer Care to Assess with Patient Reported Outcome Measures: A Systematic Review.

Performance measurement is the process of collecting, analyzing, and reporting standardized measures of clinical performance that can be compared across practices to evaluate how well care was provided. We conducted a systematic review to identify stakeholder perceptions of key symptoms and health domains to test as patient-reported performance measures in oncology. Stakeholders included cancer patients, caregivers, clinicians, and healthcare administrators. Standard review methodology was used, consistent with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). MEDLIN

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… | Patients and clinicians | Patients: 24 Providers: 6 | Pain: abdominal, back, upper GI Bowel/digestive problems, nausea Reduced appetite, weight loss Cognitive difficulties Hair loss Neuropathy Emotional/psychological/social Physical function Islam, 2019 [ 21 ] | Cancer center | Midwestern States, Florida … A.M.S.: For unrelated projects, received small consulting fees or honoraria from Navigating Cancer, Association of Community Cancer Centers, Conquer Cancer Foundation, Genentech, Henry Ford Cancer Center, University of Florida, and a CDC award (CDFA 93.986). …

Наблюдение за финансовыми трудностями пациентов с множественной миеломой и хронической лимфоцитической лейкемией, проходящих лечение в онкологических клиниках США (Alliance A231602CD).

ЦЕЛИ: Оценка доли и корреляции финансовых трудностей, о которых сообщают сами пациенты с множественной миеломой (ММ) или хронической лимфоцитической лейкемией (КЛ). Вечеринка: Sixty-six Общинная практика США и практики меньшинств в области онкологии связана с Программой общинных онкологических исследований Национального института раковых заболеваний (НКОРП). Участники: в целом 521 (больные)≥18 С согласия MM или CLL и 416 :: ответы на опрос (процент завершения)79.8%). Респонденты имели диагноз MM (MM-диагностика)74.0%), степень бакалавра или выше (53.4%), белые (или белые).89.2%), застрахованны

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… , Connecticut, New York, New Jersey and Pennsylvania; Midwest : Ohio, Michigan, Indiana, Wisconsin, Illinois, Minnesota, Iowa, Missouri, North Dakota, South Dakota, Nebraska and Kansas; South: Delaware, Maryland, Virginia, West Virginia, Kentucky, North Carolina, South Carolina, Tennessee, Georgia, Florida … , Connecticut, New York, New Jersey and Pennsylvania; Midwest : Ohio, Michigan, Indiana, Wisconsin, Illinois, Minnesota, Iowa, Missouri, North Dakota, South Dakota, Nebraska and Kansas; South: Delaware, Maryland, Virginia, West Virginia, Kentucky, North Carolina, South Carolina, Tennessee, Georgia, Florida …

Использование биологов во время беременности среди пациентов с аутоиммунными условиями.

ВАЖНОСТЬ: Продолжение биологики у пациентов с аутоиммунным заболеванием, которые забеременеют, связано с взвешиванием последствий связанных с беременностью изменений степени серьезности заболеваний и потенциального тератогенного воздействия лекарств. Характеристика методов биологического лечения во время беременности может дать представление о рисках и выгодах, связанных с материнством и зародышом. ЦЕЛЬ: Описание схемы использования биологов у беременных с аутоиммунными заболеваниями. DESIGN, SETTING И УЧАСТНИКИ: В этом когортном исследовании использовались данные научно-исследовательских баз

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… The study was reviewed by the University of Florida Institutional Review Board, and the requirement for written informed consent was waived due to the deidentified nature of the data. …

Oral cancer therapy: policy implications for the uninsured and underinsured populations.

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… (2010), Kansas (2010), Colorado (2010), Minnesota (2010), Illinois (2011), New Mexico (2011), Texas (2011), New York (2011), Washington (2011), New Jersey (2012), Maryland (2012), Virginia (2012), Delaware (2012), Louisiana (2012), Massachusetts (2013), Utah (2013), Oklahoma (2013), Nevada (2013), Florida …

mRNA Vaccines: Current Applications and Future Directions.

Messenger RNA (mRNA) vaccines, as a novel class of biotherapeutics, leverage mRNA technology to instruct cells to produce specific antigens, thereby inducing an immune response. In recent years, significant progress has been made in applying these vaccines to infectious disease prevention and cancer treatment. Compared with traditional vaccines, mRNA vaccines offer high programmability, as well as greatly enhanced stability and immunogenicity, achieved through nucleotide modifications and advanced delivery systems such as lipid nanoparticles. However, many challenges remain in the design and d

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… . | Phase 1 | 2018/11/27 | 2024/05/17 NCT01066390 | Completed | Melanoma | Bart Neyns | Phase I | 2009/12/01 | 2014/05/06 NCT05264974 | Recruiting | Melanoma | University of Florida | Phase 1 | 2024/11/01 | 2024/10/29 NCT04932863 | Unknown | Neoplasms cancer, treatment‐related | Ente Ospedaliero Ospedali … amyloidosis chronic lymphocytic leukemia | Barbara Ann Karmanos Cancer Institute | Phase 2 | 2021/08/17 | 2023/12/20 NCT06156267 | Not yet recruiting | Pancreatic cancer | Fudan University | Early‐Phase 1 | 2024/01/01 | 2023/12/05 NCT01153113 | Withdrawn | Metastatic prostate cancer | University of Florida …

Oncolytic viruses on the cusp of success?: proceedings of the 9th International Conference on Oncolytic Virus Therapeutics

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… Grant McFadden (University of Florida, Gainesville) described studies in allogeneic grafts in which MYXV played two important roles: preventing graft-vs. …

Deciding to Enrol in a Cancer Trial: A Systematic Review of Qualitative Studies.

BackgroundClinical trials are essential for the advancement of cancer treatments; however, participation by patients is suboptimal. Currently, there is a lack of synthesized qualitative review evidence on the patient experience of trial entry from which to further develop decision support. The aim of this review is to synthesise literature reporting experiences of participants when deciding to enrol in a cancer clinical trial in order to inform practice.MethodsA systematic review and meta-synthesis of qualitative studies were conducted to describe the experiences of adult cancer patients who d

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… Multiple Case Study of Factors Associated with Enrollment of Women with Persistent or Recurrent Ovarian Cancer in Clinical Trials in Central Florida . Ann Arbor: University of South Florida; 2016:219. 48. Brown RF, Cadet DL, Houlihan RH, et al. …

Clinical challenges in the management of osteoporosis.

While knowledge regarding the diagnosis and treatment of osteoporosis has expanded dramatically over the last few years, gaps in knowledge still exist with guidance lacking on the appropriate management of several common clinical scenarios. This article uses fictional clinical scenarios to help answer three challenging questions commonly encountered in clinical practice. The first clinical challenge is when to initiate drug therapy in a patient with low bone density. It is estimated that 34 million America have low bone density and are at a higher risk for low trauma fractures. Limitations of

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… A study of older adults in south Florida revealed a 39% prevalence of vitamin D insufficiency (defined as a 25-OHD concentration <50 nmol/L or 20 ng/mL) and a 9% prevalence of severe deficiency (defined as a 25-OHD concentration <30 nmol/L or 12 ng/mL) ( Levis et al 2005 ). … M Underestimation of serum 25-hydroxyvitamin D by the Nichols Advantage Assay in patients receiving vitamin D replacement therapy Clin Chem 2005 51 1072 4 author reply 1074 15914797 10.1373/clinchem.2005.048355 Levis S Gomez A Jimenez C Vitamin d deficiency and seasonal variation in an adult South Florida …

Chemotherapy and Quality of Life: An Observational Study of Cancer Patients at the Oncology Unit of Tertiary Care Hospital in Islamabad.

BackgroundCancer is a global health challenge, with millions of new cases annually. While improving survival rates, the disease and its treatment, particularly chemotherapy, significantly impact patients' quality of life (QoL) and cause side effects that severely affect patients' physical, emotional, and social well-being. As the number of cancer patients is rising in Pakistan, the health care system still faces multiple issues that may have an impact on patient outcomes and QoL. So, this study aims to assess the QoL of cancer patients before and after chemotherapy at a tertiary care hospital

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… Florida, USA: CRC Press; 2021. Measuring the effect of cancer on quality of life; pp. 25–40. 18. Yeom E, Yu K. Understanding the molecular basis of anorexia and tissue wasting in cancer cachexia. Exp Mol Med. 2022;54(04):426–432. doi: 10.1038/s12276-022-00752-w. 19. …

:: Терапия антиB клеток антихимерной антигенной рецепции Т для лечения амилоидоза и конъюнктурного возврата/отвлечения нескольких миеломы: предварительная эффективность и безопасность.

В то время как иммунотерапии, такие, как терапия CAR T и би-специальные антитела, революционизировали лечение множественной миэломы (ММ), пациенты с амилоидозом были исключены из испытаний с этими агентами из-за проблем, связанных с основной автономией, сердечной травмой и почечной дисфункцией, что может привести к смертельной токсичности этих препаратов. В этом сообщении мы описали результаты two Пациенты с амилоидозом и одновременно с этим MM с основной сердечной и/или почечной дисфункцией, которые прошли антиBCMA CAR T клеточную терапию с синдромом id-cel или цилта-cel, получили профилактик

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… Institutional Review Board Statement The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Institutional Review Board of Mayo Clinic Florida (IRB# 23-001194). …

Surveillance for Violent Deaths - National Violent Death Reporting System, 48 States, the District of Columbia, and Puerto Rico, 2021.

PROBLEM/CONDITION: In 2021, approximately 75,000 persons died of violence-related injuries in the United States. This report summarizes data … lent deaths that occurred in 2021. Data were collected from 48 states (all states with exception of Florida and Hawaii), the District of Columbia, and Puerto Rico. Forty-six states had statewide data, two additional states had data from counties representing a subset of their population (31 California counties, representing 64% of its population, and 13 T …

План осуществления амбулаторного управления биконкретными антителами в множестве миеломы.

Удельные антитела (BsAbs) являются новыми иммунотерапевтическими агентами для лечения повторной/охлажденной множественной миеломы (RRMM). В настоящее время 3 БСАБ (теклистамб, талькетамаб и эль-Ранатамаб) утверждены для обработки РУМ. Для улучшения доступа к лечению и результатов лечения пациентов решающее значение имеет управление БСАБ в различных практических условиях. В настоящем докладе содержатся практические рекомендации по обеспечению безопасного и эффективного управления БСАБ для пациентов, имеющих ОРМ в амбулаторных и общинных условиях. В Соединенных Штатах, Европе и Латинской Америке

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… SR is employed by Florida Cancer Specialists and has an advisory role with Johnson & Johnson and Bristol Myers Squibb. CR has an advisory role with Bristol Myers Squibb, Johnson & Johnson, Takeda, Sanofi, and AbbVie. …

Emerging trends and disparities in mortality due to coexisting non-Hodgkin's lymphoma and respiratory infections: A U.S. nationwide retrospective analysis from 1999 to 2020.

Non-Hodgkin lymphoma (NHL) patients are highly susceptible to respiratory infections due to immunosuppression from both the disease and its treatments. Understanding mortality trends and disparities in this population is crucial for improving care and reducing the burden of coexisting conditions. This study analyzed death certificates from the Center of Disease Control Wide-Ranging Online Data for Epidemiologic Research database for individuals aged ≥ 25 years who died between 1999 and 2020 with both NHL and respiratory infections. Age-adjusted mortality rates (AAMRs) and annual percent change

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… States in the top 90th percentile (Oklahoma, West Virginia, Kentucky, South Dakota, Nebraska, Rhode Island, Vermont) had AAMRs nearly twice as high as those in the bottom 10th percentile (District of Columbia, Louisiana, Georgia, Arizona, Nevada, Virginia, Florida) (Fig. 4 , Table S7, Supplemental Digital …

Прогнозирующие показатели прогресса от одиночной плазмоцитомы до множественной миеломы: обзор нарации.

Одиночная плазменная цитома (СП), охватывающая как одиночную плазмоцитому (SBP), так и экстрамеуллярную плазмоцитому (EMP), представляет собой редкие плазменные опухоли клеток, которые сопряжены с риском продвижения к множественной миеломе (MM). В настоящем обзоре обобщается нынешняя литература по прогнозируемым показателям такого прогресса. Высокорисковые цитогенетические аномалии постоянно увязываются с более быстрым переходом на MM. Другие факторы, такие, как размер опухоли, возраст и устойчивые уровни M-протеина после лечения, также являются прогнозными факторами. Хотя радиотерапия остаетс

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… Similarly, a study conducted on patients from Florida reported that of the 32 patients in the study with plasmacytomas, there was a median time of 25.1 months for patients to progress to MM [ 22 ]. However, other studies demonstrate a slightly longer period of progression. …

Взаимосвязь между историей аутоиммунной болезни и развитием рака поджелудочной железы: тематическое исследование 32,640 Пациенты.

Рак поджелудочной железы - это очень смертельный рак с ростом заболеваемости и плохим прогнозом из-за позднего диагноза. Хотя известно несколько факторов риска, данные о потенциальной роли аутоиммунных заболеваний остаются ограниченными. С учетом растущей распространенности аутоиммунных заболеваний и их связи с различными вредителями цель этого исследования заключается в изучении их потенциальной связи с раком поджелудочной железы. МЕТОДЫ: 5,440 у пациентов с первым диагнозом рака поджелудочной железы и 27,200 В базе данных &quot; Analyzer &quot; (IQVIA) были выявлены лица, не страдающие раком

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… Permuth JB, Powers BD, Hodul PJ, Florida Pancreas C. A path forward for understanding and addressing multifaceted pancreatic cancer disparities. Gastroenterology. (2022) 163:51–3. doi: 10.1053/j.gastro.2022.04.047 2. Ilic I, Ilic M. …

Disease progression, hospital readmissions, and clinical outcomes for patients with steroid-refractory acute graft-versus-host disease: A multicenter, retrospective study.

Acute graft-versus-host disease (GVHD) is a significant cause of morbidity and mortality following allogeneic hematopoietic cell transplantation (HCT). This analysis of 168 patients (mean age, 54.8 years) from a multicenter, retrospective chart review describes the clinical course, treatment patterns, hospitalizations, and clinical outcomes of patients aged ≥12 years who developed grades II-IV acute GVHD after their first allogeneic HCT (January 1, 2014, to June 30, 2016) and were refractory to or dependent on corticosteroids. Between diagnosis and maximum grade (median, 6.0 days), 53.6% of pa

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… Acknowledgements The authors thank the 11 centers/institutions that provided data for the study: Atrium Health, Cleveland Medical Center, Duke University, Fred Hutchinson Cancer Research Center, Medical College of Wisconsin, Ohio State University, University of Florida, University of Illinois, University …

Antioxidant effects of Spirulina platensis (Arthrospira platensis) on cyclophosphamide-induced testicular injury in rats.

Cyclophosphamide (CP) is known to reduce fertility. The protective effects of Spirulina plantesis (SP) against CP-induced testicular toxicity were investigated. Male Wistar rats were categorized into eight groups (n = 7). Four groups of rats were administered CP at a dose of 5 mg in 5 mL distilled water kg-1 per day orally. Two of these groups were received SP (500 and 1000 mg kg-1 per day) orally after CP administration. One of these groups was also received vitamin E (100 mg kg-1 per day) intraperitoneally. A vehicle treated control group, two SP control groups (500 and 1000 mg kg-1 per day)

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… cyclophosphamide-induced toxicity in the male urinary system J Renal Inj Prev 2017 6 3 164 170 15 Vonshak A Spirulina platensis (Arthrospira): Physiology, cell biology and biotechnology 1997 1st ed London, UK Taylor & Francis 150 163 16 Gershwin ME Belay A Spirulina in human nutrition and health 2008 Florida …

The SMARTIE Program: A Novel Initiative to Evaluate the Impact of AP Continuing Education on Clinical Practice.

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… Viale, RN, MS, CNS, ANP Advanced Practitioner Society for Hematology and Oncology Constance Visovsky, PhD, RN, ACNP, FAAN University of South Florida Carolyn M. Grande, CRNP, AOCNP® University of Pennsylvania Erik D. Brady, PhD, CHCP EDBPhD Consulting, LLC Alana L. K. …

Can Melatonin Improve the Osteopenia of Perimenopausal and Postmenopausal Women? A Meta-Analysis.

ObjectiveTo assess the effectiveness and safety of melatonin for perimenopausal and postmenopausal women with osteopenia.MethodsIn this meta-analysis, data from randomized controlled trials were obtained to assess the effects of melatonin versus placebo or western medicine in perimenopausal and postmenopausal women with osteopenia. The study's registration number is CRD42018086238. The primary outcomes included bone mineral density (BMD) and T-score.ResultFrom 551 articles retrieved, three trials involving 121 patients were included. Due to the high-to-substantial heterogeneity (BMD: I2=96.9%,

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… Boca Raton, Florida, USA: CRC Press; 2011. 17. Sánchez-Barceló E. J., Mediavilla M. D., Tan D. X., Reiter R. J. Scientific basis for the potential use of melatonin in bone diseases: osteoporosis and adolescent idiopathic scoliosis. Journal of Osteoporosis. 2010 doi: 10.4061/2010/830231.830231 18. …

ESMO/ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2023.

The European Society for Medical Oncology (ESMO) and ASCO are publishing a new edition of the ESMO/ASCO Global Curriculum (GC) with contributions from more than 150 authors. The purpose of the GC is to provide recommendations for the training of physicians in medical oncology and to establish a set of educational standards for trainees to qualify as medical oncologists. This edition builds on prior ones in 2004, 2010, and 2016 and incorporates scientific advances and input from an ESMO ASCO survey on GC adoption conducted in 2019, which revealed that GC has been adopted or adapted in as many a