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Anti-resorptive therapy in the osteometabolic patient affected by periodontitis. A joint position paper of the Italian Society of Orthopaedics and Traumatology (SIOT) and the Italian Society of Periodontology and Implantology (SIdP).

This joint report from the Italian Society of Orthopaedics and Traumatology (SIOT) and the Italian Society of Periodontology and Implantology (SIdP) aims for a consensus around the scientific rationale and clinical strategy for the management of osteoporotic patients affected by periodontitis who are undergoing anti-resorptive (AR) therapy to manage the risk of the occurrence of a medication-related osteonecrosis of the jaws (MRONJ). Osteoporosis and periodontitis are chronic diseases with a high prevalence in aging patients, and they share some of the same pathogenetic mechanisms based upon i

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… Morales A, Strauss FJ, Hämmerle CHF, Romandini M, Cavalla F, Baeza M, Gamonal J (2022) Performance of the 2017 AAP/EFP case definition compared with the CDC/AAP definition in population-based studies. J Periodontol. 93(7):1003–13. 10.1002/JPER.21-0276 52. …

Bruton's tyrosine kinase inhibition-An emerging therapeutic strategy in immune-mediated dermatological conditions.

Bruton's tyrosine kinase (BTK), a member of the Tec kinase family, is critically involved in a range of immunological pathways. The clinical application of BTK inhibitors for B-cell malignancies has proven successful, and there is strong rationale for the potential benefits of BTK inhibitors in some autoimmune and allergic conditions, including immune-mediated dermatological diseases. However, the established risk-to-benefit profile of "first-generation" BTK inhibitors cannot be extrapolated to these emerging, non-oncological, indications. "Next-generation" BTK inhibitors such as remibrutinib

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… J Allergy Clin Immunol . 2020 ; 145 ( 6 ): 1510 ‐ 1516 . 32224275 10.1016/j.jaci.2020.03.005 121 Iyer AS , Morales JL , Huang W , et al. …

Magnetic Resonance Imaging in 50 Captive Non-domestic Felids - Technique and Imaging Diagnoses.

Magnetic resonance imaging (MRI) is the recognized gold standard for diagnostic imaging of the central nervous system in human and veterinary patients. Information on the use of this modality and possible imaging abnormalities in captive non-domestic felids is currently limited to individual case reports or small case series. This retrospective study provides information on technique and imaging findings in a cohort of cases undergoing MRI at an academic Veterinary Medical Center. The University of Tennessee College of Veterinary Medicine MRI database was searched for non-domestic felids under

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… Weston P, Morales C, Dunning M, Parry A. Carrera I. Susceptibility weighted imaging at 15 Tesla magnetic resonance imaging in dogs: Comparison with T2 * -weighted gradient echo sequence and its clinical indications. Vet Radiol Ultrasound. (2020) 61:566–76. 10.1111/vru.12894 40. …

Anaesthesia as an influence in tumour progression.

PURPOSE: Tumour growth and the formation of metastases are essential elements in the progression of cancer. The centre of treatment is the surgical resection of primary solid tumours. But even if the tumour can be removed without microscopic residual cells, local recurrences and distant metastases occur and determine the patient's fate. During the operation, tumour cells are shed from the primary tumour and released into the circulation. These circulating tumour cells might play an important role in the formation of new tumour sites. Therefore, a functional innate and adaptive immune system is

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… Muñoz M Laso-Morales MJ Gómez-Ramírez S Cadellas M Núñez-Matas MJ García-Erce JA Pre-operative haemoglobin levels and iron status in a large multicentre cohort of patients undergoing major elective surgery Anaesthesia 2017 72 7 826 834 10.1111/anae.13840 28382661 76. …

Multidrug-Resistant Gram-Negative Bacteria Decolonization in Immunocompromised Patients: A Focus on Fecal Microbiota Transplantation.

Antimicrobial resistance is an important issue for global health; in immunocompromised patients, such as solid organ and hematological transplant recipients, it poses an even bigger threat. Colonization by multidrug-resistant (MDR) bacteria was acknowledged as a strong risk factor to subsequent infections, especially in individuals with a compromised immune system. A growing pile of studies has linked the imbalance caused by the dominance of certain taxa populating the gut, also known as intestinal microbiota dysbiosis, to an increased risk of MDR bacteria colonization. Several attempts were p

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… Villarreal-Morales S. Flores-Gallegos A. Aguirre-Joya J. Morlett-Chavez J.A. Aguilar C. Rodríguez-Herrera R. Bacteriocins and its use for multidrug-resistant bacteria control Antibiotic Resistance Elsevier BV Cambridge, UK 2016 329 349 14. Rea M.C. Dobson A. O’Sullivan O. Crispie F. Fouhy F. …

New strategies and perspectives on managing IgA nephropathy.

IgA nephropathy is an inflammatory renal disease characterised by the deposition of IgA in the glomerular mesangium and is the most commonly reported primary glomerulonephritis worldwide. Thirty to forty percent of patients with the disease develop progressive renal function decline, requiring renal replacement therapy within two decades of diagnosis. Despite this, accurate individual risk stratification at diagnosis and predicting treatment response remains a challenge. Furthermore, there are currently no disease specific treatments currently licensed to treat the condition due to long standi

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… Praga M Gutiérrez E González E Morales E Hernández E Treatment of IgA nephropathy with ACE inhibitors: a randomized and controlled trial J Am Soc Nephrol 2003 14 6 1578 1583 12761258 10.1097/01.asn.0000068460.37369.dc 43. …

Ремонт тканей в центральной нервной системе: эпигенетическое программирование регуляторных Т клеток.

Регулирующие Т клетки хорошо известны своей иммуномодуляционной ролью, но также их регенеративная функция все чаще признается в различных типах тканей, включая скелетные мышцы, легкие и центральную нервную систему (ЦНС). В CNS Tregs, как было показано, поощряют дифференциацию олигодендроцитов в прекурсорных клетках, и их взаимодействие с микроглией поддерживает стимулирующую регенеративную микроокружную среду в мозгу. Подавляющая функция Tregs в значительной степени зависит от эпигенетической сигнатуры, в частности метилации ДНК, определенной сети связанных с Treg генов, включая FOXP3, CTLA4,

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… Tapia-Maltos MA, Treviño-Frenk I, García-González HB, Rosetti M, Barriga-Maldonado V, Morales-Ramírez F, et al. Identification of regulatory T cell molecules associated with severity of multiple sclerosis. Mult Scler J. (2021) 27:1695–705. doi: 10.1177/1352458520977045 14. …

Lymphangioleiomyomatosis and Pregnancy-Do We Have All the Answers for a Woman Who Desires to Conceive?-Literature Review.

Lymphangioleiomyomatosis (LAM) is a rare, progressive, and poor-prognosis systemic disorder that primarily affects women of reproductive age, with a higher prevalence among individuals of Caucasian origin. However, there are limited reliable data on the prevalence of LAM during pregnancy. The fulminant respiratory clinical presentation that often includes progressive dyspnea on exertion, cough, or hemoptysis, frequently complicated by pneumothorax, and the increased risk of spontaneous abortion due to increased estrogen and progesterone production during gestation, are arguments that most ofte

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… Lara B., Fornet I., Goya M., López F., De Miguel J.R., Molina M., Morales P., Quintana E., Salicrú S., Suárez E., et al. Contraception, Pregnancy and Rare Respiratory Diseases. Arch. Bronc. 2012;48:372–378. doi: 10.1016/j.arbres.2012.04.012. 37. …

Public Omics Explorer (POE): Создание возможностей для комплексного семантического поиска по наборам данных GEO omics на основе публикаций PubMed.

Экспоненциальный рост общедоступных массивов данных об омиках и биомедицинской литературы создает как возможности, так и проблемы для открытия данных в области биологических наук. В то время как " Gene Express Omnibus " (GEO) содержит миллионы высокопроизводительных экспериментальных наборов данных, Европейский архив нуклеотидов (ENA) хранит соответствующие исходные данные о последовательности, а " PubMed " содержит большой объем соответствующих научных публикаций, комплексное исследование этих ресурсов по-прежнему носит ограниченный характер. Мы представляем "Public Omics

Антимикробный спектр деятельности и механизм действий линейных альфа-гелипических Пептидов, вдохновляемых креветочными антилиполисахаридами.

Креветочные антилипополизакхаридные факторы (АФО) образуют многофункциональное и разнообразное семейство противомикробных защитных пептидов (АМП), состоящих из seven Члены (группы А-G), которые различаются по своей первичной структуре и биохимическим свойствам. Это амфипатические пептиды с two Сохраненные остатки цистейна стабилизируют центральный β-волокн, который, как считается, является основным районом их биологической деятельности. В этом исследовании мы синтезировали three Линейные (без цистейна) пептиды, основанные на аминокислотной последовательности центральных β-волокн недавно иденти

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… Morales-Covarrubias M.S., Cuéllar-Anjel J., Varela-Mejías A., Elizondo-Ovares C. Shrimp Bacterial Infections in Latin America: A Review. Asian Fish. Sci. 2018;31S:76–87. doi: 10.33997/j.afs.2018.31.S1.005. 36. Pan C.-Y., Chen J.-Y., Cheng Y.-S.E., Chen C.-Y., Ni I.-H., Sheen J.-F., Pan Y. …

Translational Bioinformatics Applied to the Study of Complex Diseases.

Translational Bioinformatics (TBI) is defined as the union of translational medicine and bioinformatics. It emerges as a major advance in science and technology by covering everything, from the most basic database discoveries, to the development of algorithms for molecular and cellular analysis, as well as their clinical applications. This technology makes it possible to access the knowledge of scientific evidence and apply it to clinical practice. This manuscript aims to highlight the role of TBI in the study of complex diseases, as well as its application to the understanding and treatment o

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… Klee E.W., Cousin M.A., Pinto e Vairo F., Morales-Rosado J.A., Macke E.L., Jenkinson W.G., Ferrer A., Schultz-Rogers L.E., Olson R.J., Oliver G.R., et al. Impact of integrated translational research on clinical exome sequencing. Genet. Med. 2021;23:498–507. doi: 10.1038/s41436-020-01005-9. 75. …

How I treat cytopenias after CAR T-cell therapy.

Increasing use of chimeric antigen receptor T-cell therapy (CAR-T) has unveiled diverse toxicities warranting specific recognition and management. Cytopenias occurring after CAR-T infusion invariably manifest early (90 days). Variable etiologies of these cytopenias, some of which remain incompletely understood, create clinical conundrums and uncertainties about optimal management strategies. These cytopenias may cause additional sequelae, decreased quality of life, and increased resource use. Early cytopenias are typically attributed to lymphodepletion chemotherapy, however, infections and hyp

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… aplastic anemia that can be sustained on discontinuation of drug Blood 123 12 2014 1818 1825 24345753 10.1182/blood-2013-10-534743 PMC3962161 73 Barrett AJ Battiwalla M Relapse after allogeneic stem cell transplantation Expert Rev Hematol 3 4 2010 429 441 21083034 10.1586/ehm.10.32 PMC3426446 74 Morales-Mantilla …

Towards an adiposity-related disease framework for the diagnosis and management of obesities.

Obesity is a complex disease that relapses frequently and associates with multiple complications that comprise a worldwide health priority because of its rising prevalence and association with numerous complications, including metabolic disorders, mechanic pathologies, and cancer, among others. Noteworthy, excess adiposity is accompanied by chronic inflammation, oxidative stress, insulin resistance, and subsequent organ dysfunction. This dysfunctional adipose tissue is initially stored in the visceral depot, overflowing subsequently to produce lipotoxicity in ectopic depots like liver, heart,

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… Zhou Z, Macpherson J, Gray SR, Gill JMR, Welsh P, Celis-Morales C, et al. Are people with metabolically healthy obesity really healthy? A prospective cohort study of 381,363 UK Biobank participants. Diabetologia. 2021;64:1963–1972. doi: 10.1007/s00125-021-05484-6. 122. …

Epidemiology and Factors Associated with Treatment Success of Invasive Fungal Infections Among Newly Hematologic Malignancy Patients Receiving Chemotherapy or Hematopoietic Stem Cell Transplant in Thailand.

PurposeInvasive fungal infection (IFI) causes disability/death in patients with hematologic malignancy (HM) receiving chemotherapy or hematopoietic stem cell transplant (HSCT). There is limited epidemiological data, treatment outcomes, and factors associated with IFI treatment success in Thailand. This study aimed to identify factors associated with IFI treatment success among new HM patients receiving chemotherapy or HSCT, determine IFI incidence among HM patients receiving chemotherapy or HSCT, and the IFI incidence of a breakthrough in patients receiving primary antifungal prophylaxis, and

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… Souza L , Nouer SA , Morales H , et al. Epidemiology of invasive fungal disease in haematologic patients . Mycoses . 2021 ; 64 ( 3 ): 252 – 256 . 33141969 10.1111/myc.13205 32. Perea S , Patterson TF . Invasive Aspergillus infections in hematologic malignancy patients . …

Quality of Online Information on Multiple Myeloma Available for Laypersons.

Online information can increase patients' competence and engagement. However, there are concerns regarding invalid information. Overall, 300 websites and 50 YouTube videos on multiple myeloma (MM) were evaluated. The websites did not differ between the search engines or search ranks. The median time since the last update was 9 months. The 63 unique websites showed a poor general quality (median JAMA score 2 of 4, only 18% with a valid HON certificate). The patient- (user-) focused quality was medium to poor (median sum DISCERN score 41 out of 80 points). The overall reading level was difficult

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… Berland G.K., Elliott M.N., Morales L.S., Algazy J.I., Kravitz R.L., Broder M.S., Kanouse D.E., Munoz J.A., Puyol J.A., Lara M., et al. Health information on the Internet: Accessibility, quality, and readability in English and Spanish. JAMA. 2001;285:2612–2621. doi: 10.1001/jama.285.20.2612. 10. …

Effectiveness, immunogenicity, and safety of COVID-19 vaccines for individuals with hematological malignancies: a systematic review.

The efficacy of SARS-CoV-2 vaccination in patients with hematological malignancies (HM) appears limited due to disease and treatment-associated immune impairment. We conducted a systematic review of prospective studies published from 10/12/2021 onwards in medical databases to assess clinical efficacy parameters, humoral and cellular immunogenicity and adverse events (AE) following two doses of COVID-19 approved vaccines. In 57 eligible studies reporting 7393 patients, clinical outcomes were rarely reported and rates of SARS-CoV-2 infection (range 0-11.9%), symptomatic disease (0-2.7%), hospita

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… Piñana JL, Martino R, García-García I, Parody R, Morales MD, Benzo G, et al. Risk factors and outcome of COVID-19 in patients with hematological malignancies. Exp Hematol Oncol. 2020;9:21. doi: 10.1186/s40164-020-00177-z. 5. …

Insights into platinum-induced peripheral neuropathy-current perspective.

Cancer is a global health problem that is often successfully addressed by therapy, with cancer survivors increasing in numbers and living longer world around. Although new cancer treatment options are continuously explored, platinum based chemotherapy agents remain in use due to their efficiency and availability. Unfortunately, all cancer therapies affect normal tissues as well as cancer, and more than 40 specific side effects of platinum based drugs documented so far decrease the quality of life of cancer survivors. Chemotherapy-induced peripheral neuropathy is a frequent side effects of plat

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… Chan A, Hertz DL, Morales M, Adams EJ, Gordon S, Tan CJ, Staff NP, Kamath J, Oh J, Shinde S, Pon D, Dixit N, D’Olimpio J, Dumitrescu C, Gobbo M, Kober K, Mayo S, Pang L, Subbiah I, Beutler AS, et al. …

Systematic Review of Intravenous Ascorbate in Cancer Clinical Trials.

BackgroundAscorbate (vitamin C) has been evaluated as a potential treatment for cancer as an independent agent and in combination with standard chemotherapies. This review assesses the evidence for safety and clinical effectiveness of intravenous (IV) ascorbate in treating various types of cancer.MethodsSingle arm and randomized Phase I/II trials were included in this review. The PubMed, MEDLINE, and Cochrane databases were searched. Results were screened by three of the authors (GN, RP, and CJP) to determine if they met inclusion criteria, and then summarized using a narrative approach.Result

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… Cramer-Morales K.L. Furqan M. Sandhu S. Carlisle T.L. Smith M.C. Abu Hejleh T. …

Double jeopardy: how BRCA2, TP53, and DNMT3A redefine the link between infertility and cancer risk.

BackgroundGermline mutations in genes governing DNA repair, cell cycle regulation, and epigenetic modification are now recognized as common etiological factors for both cancer predisposition and reproductive dysfunction. This reveals a profound intersection between reproductive biology and oncogenesis.MethodA systematic narrative review was conducted. The literature search spanned PubMed/MEDLINE, Scopus, and Web of Science using keywords and MeSH terms related to infertility phenotypes, cancer predisposition syndromes, and shared molecular mechanisms (e.g., DNA repair, epigenetics).OutcomesThe

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… Additional evidence demonstrates that combining PGT-M with mitochondrial DNA analysis can enhance assisted reproduction success rates, particularly for individuals carrying TP53mutations ( Morales, 2024 ). FIGURE 5 Key steps in IVF with genetic screening (PGT-M). …

Cancer-Therapy-Related Cardiac Dysfunction: Latest Advances in Prevention and Treatment.

The increasing efficacy of cancer therapies has significantly improved survival rates, but it has also highlighted the prevalence of cancer-therapy-related cardiac dysfunction (CTRCD). This review provides a comprehensive overview of the identification, monitoring, and management of CTRCD, a condition resulting from several treatments, such as anthracyclines, HER2-targeted therapies, target therapies, and radiotherapy. The paper includes a discussion of the mechanisms of CTRCD associated with various cancer treatments. Early detection through serum biomarkers and advanced imaging techniques is