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Effects of nurse-led symptom management in chronic myeloid malignancies: a randomized trial.

PurposeChronic hematological malignancies progress slowly, potentially manifesting symptoms spanning months to years. HM-PRO is developed as a comprehensive clinical tool for assessing symptoms in hematology. The aim was to investigate the effect of a nurse-led systematic approach to symptom identification and management using HM-PRO in outpatient care in patients with chronic hematological malignancies.MethodsThis is a randomized trial including 94 patients to investigate an intervention comprising (1) HM-PRO data collection, (2) HM-PRO assessment guided by an algorithm, and (3) nurse-led tai

Multimorbidity Patterns in US Adults with Subjective Cognitive Decline and Their Relationship with Functional Difficulties.

ObjectivesThis study identified different multimorbidity patterns among adults with subjective cognitive decline (SCD) and examined their association with SCD-related functional difficulties.MethodsData were obtained from the 2019 Behavioral Risk Factor Surveillance System. Latent class analysis was applied to identify different patterns of chronic conditions. Logistic regression was implemented to examine relationships between multimorbidity patterns and risk of SCD-related functional difficulties.ResultsFive multimorbidity patterns were identified: severely impaired (14.6%), respiratory/depr

Citizen participation in patient prioritization policy decisions: an empirical and experimental study on patients' characteristics.

Health systems worldwide are grappling with the need to control costs to maintain system viability. With the combination of worsening economic conditions, an aging population and reductions in tax revenues, the pressures to make structural changes are expected to continue growing. Common cost control mechanisms, e.g. curtailment of patient access and treatment prioritization, are likely to be adversely viewed by citizens. It seems therefore wise to include them in the decision making processes that lead up to policy changes. In the context of a multilevel iterative mixed-method design a quanti

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… For profiles with levels 68 or 87 years, the occupational status refers to the time before retirement. … The average de facto retirement age is 60 years in Germany. Socio-economic status According to the Winkler-index, 47% of the respondents belong to a lower social status, 39.8% to a middle social status, and 13% to a higher social status groups. …

A latent profile analysis of financial toxicity and its association with anxiety and depression in patients with hematologic malignancies.

OBJECTIVE: To identify latent subgroups of financial toxicity among patients with hematologic malignancies, examine associated sociodemographic and clinical predictors, and explore the relationship between financial toxicity and anxiety-depression symptoms. METHODS: A cross-sectional study was conducted among 486 patients with hematologic malignancies recruited through convenience sampling from provincial-level hospitals in Hunan Province, China. Participants completed the General Information Questionnaire, the Patient-Reported Outcome Financial Toxicity (PRO-FT) Scale, the Patient Health Que

Survival outcomes and healthcare utilization between immigrant patients and Danish-born patients with hematological cancers: a Danish population-based study.

Overall survival (OS) for patients with a hematological cancer may differ between immigrant and Danish-born patients due to disparities in socioeconomic status, health literacy, and language proficiency. This cohort study aimed to investigate survival and hospitalization according to immigrant status while controlling for confounders. Patients with newly diagnosed hematological cancer in 2000-2020 were identified in the Danish nationwide hematological registers and stratified into Danish-born, Western, and non-Western patients. Patients were followed from diagnosis until death, 31st December 2

Chemotherapy-based versus chemotherapy-free stem cell mobilization (± plerixafor) in multiple myeloma patients: an Italian cost-effectiveness analysis.

Given the availability and efficacy of the mobilizing agent plerixafor in augmenting hematopoietic progenitor cell mobilization with granulocyte colony-stimulating factor (G-CSF), there is a strong case for comparing the cost-effectiveness of mobilization with G-CSF + cyclophosphamide versus G-CSF alone. This study investigated the cost and effectiveness (i.e., successful 4 million-CD34+ collection) of G-CSF alone versus high-dose cyclophosphamide (4 g/m2) + G-CSF mobilization (± on-demand plerixafor) in patients with multiple myeloma (MM) eligible for autograft in Italy. A decision tree-suppo

The work of managing multiple myeloma and its implications for treatment-related decision making: a qualitative study of patient and caregiver experiences.

BackgroundThe evolving nature of multiple myeloma (MM) therapies, including the introduction of novel oral agents, has produced a shift in the delivery of care from hospital to home. Within this context, patients and their caregivers are becoming increasingly engaged in the work of illness management, however the exact nature of this work as well as the ways in which this work informs treatment preferences and decisions within this population has not been explored. This qualitative study sought to develop an in-depth understanding of patient and caregiver experiences with different MM treatmen

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… I mean I’ve got the time [retired] and my wife has a nursing background, so we could manage better than most people I think. So that is one potential gap, or crack maybe. Not everyone has those resources, I guess, to make informed decisions and advocate for what they want. … They expressed a sense of guilt for burdening their loved ones with worry, interrupting their social lives, and “derailing” plans they collectively made for the future (e.g. retirement plans, travel). …

Socioeconomic Burden of Cancer in Korea from 2011 to 2015.

PurposeThough the socioeconomic burden of cancer on patients is increasing in South Korea, there is little research regarding the type of cancer that incurs the highest costs. This study analyzed the socioeconomic burden on cancer patients from 2011 to 2015 according to sex and age.Materials and methodsA prevalence-based approach was applied utilizing claim data of the National Health Insurance Service in Korea to estimate the socioeconomic burden of cancer on patients. Patients who received treatment for cancer from 2011 to 2015 were the study subjects. The total socioeconomic burden of their

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… We used three groups for examining the productive population: those aged 60 years (the retirement age for civil servants) and younger, 64 years (the representative econom- ically active population) and younger, and 15 years and older. … The retirement age for public servants in Korea is 60 years [25], but not all individuals retire at that age. Therefore, in this study, three productive population groups were consid- ered: those 60 years old and younger, those 64 years old and younger, and those 15 years old and older. …

Treatment-related Decisional Conflict, Quality of Life, and Comorbidity in Older Adults with Cancer.

ObjectiveThe present study aims to examine the relationships between and among cancer treatment-related decisional conflict, quality of life, and comorbidity in older adults with cancer.MethodsA convenience sample of 200 older adults was recruited from outpatient medical oncology and radiation oncology practices in the northeastern United States. A cross-sectional, descriptive, correlational study design was used employing a survey method. Survey instruments included the Decisional Conflict scale (DCS) (with five subscales, including informed, values clarity, support, uncertainty, and effectiv

Финансовое бремя карманной нефармакологической терапии в австрийской многоклерозовой группе.

Учитывая финансовые трудности в области общественного здравоохранения, мы изучили ежемесячные фактические расходы на немедикаментозное лечение лиц с множественным склерозом (МС), хроническим неврологическим расстройством, которое в первую очередь затрагивает лиц трудоспособного возраста. В рамках этого межсекторального исследования использовался онлайновый вопросник для оценки расходов и использования нефармакологических методов лечения, а также еженедельной продолжительности рабочего дня 104 человек с повторными выбросами MS (RRMS, 79%), вторичным прогрессивным MS (SPMS, 12%) и первичным прог

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… Indeed, the employment rate drops soon after receiving a diagnosis of MS, and more than 30% of individuals with MS experienced early retirement, with an average retirement age of 43.6 years 20 . …

Association Between Gastrointestinal Symptoms and Disease Severity in Multiple Sclerosis Patients.

Introduction Multiple sclerosis (MS) is a chronic autoimmune neurodegenerative disease that typically leads to neurological signs along with physical and cognitive issues while affecting the gastrointestinal (GI) system. GI dysfunctions like constipation and indigestion frequently affect MS patients, although their relationship with MS disease progression is not well documented. Methods The research team conducted a cross-sectional quantitative study that enrolled 300 adult MS patients between 18 and 65 years of age through purposive sampling. Data collection occurred from January through Marc

Беспокойство, депрессия и расширение масштабов инвалидности независимо предсказывают восприятие инвалидности у лиц с множественным склерозом: перекрестное исследование.

Множественный склероз (MS) является наиболее распространенной причиной инвалидности среди молодых людей из-за нескольких моторных, сенсорных и когнитивных симптомов. Однако пока мало что известно о влиянии психологических, когнитивных и социальных факторов на субъективную инвалидность. Цель этого исследования заключается в изучении роли клинических, психологических, когнитивных и социальных переменных в прогнозировании уровней инвалидности, которые воспринимаются лицами с множественным склерозом (PwMS). График оценки инвалидности Всемирной организации здравоохранения (ВОЗДАС) 2.0В качестве суб

Latent profile analysis of fear of progression in Chinese hematologic malignancy survivors.

Fear of disease progression (FoP) is a multidimensional concept that refers to the fear or worry about disease progress. Little is known about the distinct FoP profiles and their determinants in culturally specific contexts, especially among hematologic malignancies (HM) patients in China. This study aimed to identify heterogeneous profiles of FoP and their associated predictors among Chinese patients with HM. A convenience sample of patients suffering from HM were enrolled from March 2023 to February 2024. To gather multidimensional data from the Fear of Progression Questionnaire-Short Form (

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… More than half of the participants were unemployed or retired ( n = 291; 63.96%). Table 1 Sociodemographic and clinical characteristics of participants ( n = 455). CNY is the standard currency symbol for China Yuan. … < 0.01 3000 ~ 5000 | 40(42.11) | 73(29.32) | 34(30.63) > 5000 | 29(30.53) | 54(21.69) | 18(16.22) Employment status | Full time job | 37(38.95) | 61(24.50) | 19(17.12) | 23.254 | < 0.01 Part-time job | 2(2.11) | 11(4.42) | 3(2.70) Retain the job but suspend the salary | 9(9.47) | 13(5.22) | 9(8.11) Retirement …

Societal Versus Healthcare Perspectives on the Cost Effectiveness of Ocrelizumab for Treatment of Primary Progressive Multiple Sclerosis in Aotearoa New Zealand.

OBJECTIVES: Multiple sclerosis (MS) is a progressive, degenerative, autoimmune neuronal disease. This study compares the impact of a societal versus a healthcare perspective on the cost effectiveness of treatment of primary progressive MS (PPMS) with ocrelizumab (OCR) versus best supportive care (BSC) in New Zealand. METHODS: The analysis utilises a lifetime cohort Markov model based on ten Expanded Disability Status Scale (EDSS) states, plus death. It has two structurally identical arms, with forward transition probabilities in the treatment arm obtained by multiplying forward transition pro

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… Societal costs in our model include direct non-medical costs and loss of income through lost productivity, early retirement, absenteeism and presenteeism. … This study, like ours, reported that income lost through early retirement was substantial throughout the range of EDSS [ 38 ]. Health State Utilities This study utilised European HSUs [ 37 ] because New Zealand HSUs are sparse. …

P1685: PATIENTS’ PREFERENCES FOR MULTIPLE MYELOMA (MM) TREATMENT INITIATION AND DISCONTINUATION IN THE US

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Physical function in patients newly diagnosed with multiple myeloma; a Danish cohort study.

BACKGROUND: Multiple myeloma is a cancer in the bone marrow causing bone destruction. Patients experience various symptoms related to the disease and/or treatment, such as pain and fatigue, leading to poorer quality of life. The symptom burden might affect physical function and physical activity levels, posing a risk of physical deterioration. The aim was to investigate whether physical function in newly diagnosed patients with multiple myeloma differs from the reference values of the normal population and other cancer patients. METHODS: The study is a cross sectional descriptive analysis of

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… | 56 (56) | 29 (50) | 27 (64) Early retirement | 3 (3) | 1 (2) | 2 (5) Off work sick, full time | 14 (14) | 8 (14) | 6 (14) Un-employed | 1 (1) | 0 (0) | 1 (2) On social security | 1 (1) | 0 (0) | 1 (2) Other reason | 2 (2) | 1 (2) | 1 (2) Missing | 3 (3) | 3 (5) | 0 (0) Mean age (SD) was 67.7 (10.3 … Over half were retired (56%), and 14% were on sick leave. Bone disease was present in 73% of the participants, and in three participants this caused restriction in testing (SST and unilateral knee extension strength) due to femoral bone involvement. Thirty-three per cent had fractures ( n = 33). …

The patient reported transformation of identity and voice in life-limiting illness.

BackgroundIndividuals facing life-limiting illnesses undergo a profound transformation that encompasses significant physiological changes, in the level of medical care received, and a shift in overall goals of care. This transformation is irreversible and involuntary. However, individuals living with mental health conditions and life-limiting illnesses are not able to go through transformation due to diagnostic overshadowing. Previous research has examined the transformations experienced by caregivers in the context of spinal cord injuries, as well as by professional caregivers in palliative c

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… Recruitment Participants were recruited from a retirement village in Perth, Australia, and Facebook. The recruitment was led by the CI, a PhD candidate and research assistant with experience in qualitative research. Seventeen participants joined, but three dropped out without providing reasons. … The following approach was used: Independent living organisation The study objectives and inclusion-exclusion criteria were shared with healthcare professionals, such as nurses, social workers, and medical doctors at the independent living retirement village. …

The impact of government reimbursement negotiation on targeted anticancer medicines use and cost in China: A cohort study based on national health insurance data.

BackgroundHigh prices of targeted anticancer medicines (TAMs) result in financial toxicity for patients and the health insurance system. How national price negotiation and reimbursement policy affect the accessibility of TAMs for cancer patients remains unknown.MethodsIn this population-based cohort study, we used national health insurance claims data in 2017 and identified adult patients with cancer diagnoses for which price-negotiated TAMs were indicated. We estimated the half-month prevalence of price-negotiated TAMs use before and after the policy implementation in September 2017. We calcu

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… Since 2015, the BMI consists of two health insurance schemes: the Urban Employee Basic Medical Insurance (UEBMI) for urban and retired employees and the Urban and Rural Resident Medical Insurance (URRMI) for other residents [ 13 ]. … Zhou Y, Wushouer H, Vuillermin D, Ni B, Guan X, Shi L.Medical insurance and healthcare utilization among the middle-aged and elderly in China: evidence from the China health and retirement longitudinal study 2011, 2013 and 2015. BMC Health Serv Res. 2020;20:654. 10.1186/s12913-020-05522-w 35. …

Disparities in Palliative and Hospice Care and Completion of Advance Care Planning and Directives Among Non-Hispanic Blacks: A Scoping Review of Recent Literature.

ObjectivesPublished research in disparities in advance care planning, palliative, and end-of-life care is limited. However, available data points to significant barriers to palliative and end-of-life care among minority adults. The main objective of this scoping review was to summarize the current published research and literature on disparities in palliative and hospice care and completion of advance care planning and directives among non-Hispanc Blacks.MethodsThe scoping review method was used because currently published research in disparities in palliative and hospice cares as well as adva

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… Baker (2018). 48 | 6,861 older adults | Cross sectional study of the Health and Retirement Study | White participants were twice as likely to engage in ACP. Including religiosity predictors did not close this gap. … Gender, age, retirement status, disabled employment status, educational attainment, religious affiliation, Internet access, preferences for physician-centered decision making, and desiring longevity regardless of functional status were independent predictors of advance directive possession. …

Знания, отношение и практика у пациентов с множественной миеломой: перекрестное исследование с использованием моделей структурного уравнения в одной третичной больнице в Вэньчжоу, Китай.

ВВЕДЕНИЕ: Это исследование было направлено на оценку знаний, отношения и практики пациентов с множественной миеломой (ММ) в отношении этого заболевания. МЕТОДЫ: Это перекрестное исследование проводилось среди пациентов с MM в Руанской народной больнице в провинции Чжэцзян, Китай, в период с августа по ноябрь. 2024. Данные собирались с использованием структурированного вопросника, предназначенного для сбора демографической информации и оценки КПД участников. РЕЗУЛЬТАТЫ: Всего 442 Были проанализированы действительные вопросники. Среди респондентов 226 (В тыс.51.1%) были мужчинами, и 298 (В тыс.6