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Fatigue, quality of life and physical fitness following an exercise intervention in multiple myeloma survivors (MASCOT): an exploratory randomised Phase 2 trial utilising a modified Zelen design.

BACKGROUND: Exercise may improve fatigue in multiple myeloma survivors, but trial evidence is limited, and exercise may be perceived as risky in this older patient group with osteolytic bone destruction. METHODS: In this Phase 2 Zelen trial, multiple myeloma survivors who had completed treatment at least 6 weeks ago, or were on maintenance only, were enrolled in a cohort study and randomly assigned to usual care or a 6-month exercise programme of tailored aerobic and resistance training. Outcome assessors and usual care participants were masked. The primary outcome was the FACIT-F fatigue sco

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… Participants wore a triaxial accelerometer (ActiGraph-wGT3X-BT, Florida, USA) for 7 consecutive days above the non-dominant hip, and physical activity data were integrated into 60-s epochs and converted into total daily activity adjusted for wear time as mean accelerometer counts per minute. …

A pilot study of improved psychological distress with art therapy in patients with cancer undergoing chemotherapy.

BACKGROUND: Art therapy may improve the physical, mental, and emotional wellbeing of individuals for a variety of purposes. It remains understudied and underutilized in cancer care. We sought to determine the ability of a pilot art therapy program to improve the physical, mental, and emotional well-being of cancer patients. METHODS: Chemotherapy-recipients, age 18 years and older, diagnosed with any type or stage of cancer, were considered eligible to participate in this single arm, pilot study, using four visual analog scales (VAS) with visually-similar, 0-10 scale (10 being worst) thermomet

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… thermometers testing (0–10 scale) emotional distress, pain, depression and anxiety experienced within the past week, with 0 being the least amount of upset/pain and 10 being the highest amount Art therapy sessions The art therapy sessions were led by the same art therapist, at the Cleveland Clinic Florida …

Воздействие фингозина-1-фосфатных модуляторов рецепторов на ремиелионацию при множественном склерозе: данные экспериментов in vitro, модели животных и исследования человека.

Сфингосин-1-фосфат (S1P) является классом терапевтических агентов, используемых для лечения множественного склероза (MS). В настоящее время Управление по контролю за продуктами питания и лекарствами/Европейское медицинское агентство (FDA/EMA) утвердило четыре модулятора S1P: финголимод, сипонимоз, понизимод и озанимод. Помимо их хорошо зарекомендовавших себя иммунодуляционных свойств, накапливаемые данные свидетельствуют о том, что эти молекулы оказывают прямое воздействие на клетки потомков олигодендроцитов (ОРК) и зрелые олигодендроциты, содействуя ремонту миелина с помощью различных механиз

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… Jank L, Singh SS, Lee J, Dhukhwa A, Siavoshi F, Joshi D, et al. “ Title: Restoring the multiple sclerosis associated imbalance of gut indole metabolites promotes remyelination and suppresses neuroinflammation”, in: Presented at ACTRIMS 2024, West Palm Beach, Florida, USA, February 29 - March 2, 2024 …

Areas of Uncertainty in SARS-CoV-2 Vaccination for Cancer Patients.

Early in the COVID-19 pandemic, it was recognized that infection with SARS-CoV-2 is associated with increased morbidity and mortality in patients with cancer; therefore, preventive vaccination in cancer survivors is expected to be particularly impactful. Heterogeneity in how a neoplastic disease diagnosis and treatment interferes with humoral and cellular immunity, however, poses a number of challenges in vaccination strategies. Herein, the available literature on the effectiveness of COVID-19 vaccines among patients with cancer is critically appraised under the lens of anti-neoplastic treatme

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… Evaluation of Antibody Response to SARS-CoV-2 mRNA-1273 Vaccination in Patients With Cancer in Florida JAMA Oncol. 2022 8 748 754 10.1001/jamaoncol.2022.0001 35266953 PMC8914884 30. Shree T. Shankar V. Lohmeyer J.J.K. Czerwinski D.K. Schroers-Martin J.G. Rodriguez G.M. Beygi S. Kanegai A.M. …

Disparities in the enrollment to systemic therapy and survival for patients with multiple myeloma.

BackgroundDisparities driven by socioeconomic factors have been shown to impact outcomes for cancer patients. We sought to explore this relationship among patients with multiple myeloma (MM) who were not considered for hematopoietic stem cell transplant in the first-line setting and how it varied over time.MethodsWe queried the National Cancer Database for patients diagnosed with MM between 2004 and 2016 and included only those who received systemic therapy as the first-line treatment. Enrollment rates for therapy were calculated as receipt of systemic therapy as the incident event of interest

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… Prior presentation: American Society of Hematology Annual Meeting, December 2019, Orlando Florida. …

Hematologic Malignancies: 2021 ASCO Annual Meeting Highlights for the Advanced Practitioner.

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… The trial suggests proof of concept in these preliminary data, with an objective response rate of 80% in relapsed or refractory CLL and activity in other hematologic malignancies,” said Sikander Ailawadhi, MD, of the Mayo Clinic, Jacksonville, Florida. …

Prospective and Multicenter Evaluation of Outcomes for Quality of Life and Activities of Daily Living for Balloon Kyphoplasty in the Treatment of Vertebral Compression Fractures: The EVOLVE Trial.

BACKGROUND: Osteoporotic and neoplastic vertebral compression fractures (VCF) are common and painful, threatening quality of life and increasing risk of morbidity and mortality. Balloon kyphoplasty is a percutaneous option for treating painful cancer- and osteoporosis-related VCFs, supported by 2 randomized trials demonstrating efficacy benefits of BKP over nonsurgical care. OBJECTIVE: To investigate 12-mo disability, quality of life, and safety outcomes specifically in a Medicare-eligible population, representing characteristic patients seen in routine clinical practice. METHODS: A total of

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… This work has been presented at the following meetings: American Society of Spine Radiology, San Diego, California, February 22-26, 2017; Society of Interventional Radiology, Washington, District of Columbia, March 6, 2017; The International Society for the Advancement of Spine Surgery, Boca Raton, Florida …

Randomized controlled trial on the effects of a supervised high intensity exercise program in patients with a hematologic malignancy treated with autologous stem cell transplantation: Results from the EXIST study.

BackgroundThis single blind, multicenter randomized controlled trial aimed to evaluate the effectiveness of a supervised high intensity exercise program on physical fitness and fatigue in patients with multiple myeloma or lymphoma recently treated with autologous stem cell transplantation.Methods109 patients were randomly assigned to the 18-week exercise intervention or the usual care control group. The primary outcomes included physical fitness (VO2peak and Wpeak determined using a cardiopulmonary exercise test; grip strength and the 30s chair stand test) and fatigue (Multidimensional Fatigue

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… Data were processed using ActiLife Software version 6.10.2 (ActiGraph, Pensacola, Florida, USA). Vertical accelerations were converted in counts per minute (cpm) and non-wear time was defined as >90 consecutive minutes of zero counts [ 31 ]. …

Towards the integration, annotation and association of historical microarray experiments with RNA-seq.

BackgroundTranscriptome analysis by microarrays has produced important advances in biomedicine. For instance in multiple myeloma (MM), microarray approaches led to the development of an effective disease subtyping via cluster assignment, and a 70 gene risk score. Both enabled an improved molecular understanding of MM, and have provided prognostic information for the purposes of clinical management. Many researchers are now transitioning to Next Generation Sequencing (NGS) approaches and RNA-seq in particular, due to its discovery-based nature, improved sensitivity, and dynamic range. Additiona

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… Orlando, Florida: ACM; 2012. An integer programming approach to novel transcript reconstruction from paired-end RNA-Seq reads; pp. 369–376. Nicolae M, Mangul S, Zelikovsky A. Estimation of alternative splicing isoform frequencies from RNA-Seq data. …

Exercise and cancer: a position statement from the Spanish Society of Medical Oncology.

Due to improvements in the number of cancer survivors and survival time, there is a growing interest in healthy behaviors, such as physical activity (PA), and their potential impact on cancer- and non-cancer-related morbidity in individuals with cancer. Commissioned by the Spanish Society of Medical Oncology (SEOM), in this review, we sought to distill the most recent evidence on this topic, focusing on the mechanisms that underpin the effects of PA on cancer, the role of PA in cancer prevention and in the prognosis of cancer and practical recommendations for clinicians regarding PA counseling

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… 0.39–0.86) BC recurrence HR 0.67 (95% CI 0.46–0.96) Schmidt et al. [ 102 ] Germany 3393 Women with early BC 50–74 year Pre-diagnosis ≥ 42 MET-h/week All-cause mortality HR 0.66 (95% CI 0.47–0.92) BC mortality HR 0.80 (95% CI 0.53–1.21) Cancer recurrence HR 0.65 (95% CI 0.44–0.97) Holick et al. [ 103 ] Florida-Boston … recurrence | HR 0.67 (95% CI 0.46–0.96) Schmidt et al. [ 102 ] Germany | 3393 Women with early BC 50–74 year | Pre-diagnosis ≥ 42 MET-h/week | All-cause mortality | HR 0.66 (95% CI 0.47–0.92) BC mortality | HR 0.80 (95% CI 0.53–1.21) Cancer recurrence | HR 0.65 (95% CI 0.44–0.97) Holick et al. [ 103 ] Florida-Boston …

Abstracts From JADPRO Live 2019: Washington State Convention Center • Seattle • October 24-27.

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… JL708 Complementary Therapy and Quality of Life for Oncology Patients Receiving Outpatient Chemotherapy Michelle Manias, MSN, APRN, NP-C, OCN®, Florida Cancer Specialists; Kara Armbruster, MSN, FNP-C, UPMC Magee Womens Hospital; Bettina I. … LeFebvre, MSN, RN, RN-BC, AOCN®, Oncology Nursing Society; David DeRemer, PharmD, BCOP, FCCP, FHOPA, University of Florida College of Pharmacy; Joshua Nubla, PharmD, National Community Oncology Dispensing Association; Julianne Orr, PharmD, BCOP, Indiana University Health; Michael Reff, RPh, MBA, National …

Clinical Determinants of Functional Independence at Discharge in Patients With Spinal Cord Dysfunction Due to Metastatic Spinal Tumors.

ObjectivesTo identify the clinical factors associated with independence in activities of daily living (ADL) at discharge in patients with spinal cord dysfunction resulting from metastatic spinal tumors.DesignRetrospective cohort study.SettingA single university hospital in Japan.ParticipantsA total of 153 patients (N=153) (median age 69 [interquartile range: 58.5-75.5]; 67% men) with spinal cord dysfunction caused by metastatic spinal tumors received inpatient rehabilitation during hospitalization between 2012 and 2022. The inclusion criteria were age ≥18 years, a diagnosis of spinal cord dysf

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… Annual Meeting of the Florida Association of Institutional Research Cocoa Beach, FL 2006 February 1-3 32 Cohen J. Statistical power analysis for the behavioral sciences 2nd ed. 1988 Lawrence Erlbaum Associates Hillsdale, NJ 33 Chen H. Cohen P. Chen S. How big is a big odds ratio? …

Расовые различия в выживании нескольких миелом: ассоциации с трансплантацией стволовых клеток, страхованием и расширением сети медицинских учреждений.

На уровне населения чернокожие пациенты с множественной миеломой (ММ) могут выжить хуже, чем белые. Авторы изучили вопрос о том, как автологическая трансплантация стволовых клеток (ASCT), страхование и расширение сети " Медикэйд " связаны с расовыми различиями в общем уровне выживания (rwOS) в реальном мире. МЕТОДЫ: Данные, полученные 4932 больные MM (MM)24% Блэк) в Флатиронской базе данных исследований в области здравоохранения анализировался с использованием моделей " Кокс регрессиал " (rwOS), " Файн энд срей " (ASCT) и " политомная регрессия " (страхо

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… Kentucky, Louisiana, Massachusetts, Maryland, Maine, Michigan, Minnesota, Missouri, New Hampshire, New Jersey, New Mexico, New York, Ohio, Oklahoma, Oregon, Pennsylvania, Virginia, Washington, and West Virginia. b States in the study that did not expand Medicaid in the 2011–2021 study period: Alabama, Florida …

Trends and Disparities in Cancer-Related Mortality Among Adults With Diabetes in the United States: 1999-2019.

AimCancer and diabetes are major public health concerns, with diabetes linked to increased cancer-related mortality. However, national trends and disparities remain underexplored.MethodsUsing CDC WONDER data, we analysed deaths where both diabetes and cancer were listed as causes. Age-adjusted mortality rates (AAMRs) were calculated for diabetic cancer patients aged ≥ 25 years and stratified by demographics and geography. Joinpoint regression estimated annual percent changes (APCs) and average annual percent changes (AAPCs).ResultsFrom 1999 to 2019, 699,007 cancer-related deaths occurred among

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… These states had AAMRs that were more than twice those in the lower 10th percentile, which included Nevada, Arizona, Florida, Utah, and Massachusetts (Table S4 ). …

Acute exercise mobilizes NKT-like cells with a cytotoxic transcriptomic profile but does not augment the potency of cytokine-induced killer (CIK) cells.

CD3+/CD56+ Natural killer (NK) cell-like T-cells (NKT-like cells) represent ex vivo into cytokine-induced killer (CIK) cells, however this therapeutic cell product has had mixed results against hematological malignancies in clinical trials. The aim of this study was to determine if NKT-like cells mobilized during acute cycling exercise could be used to generate more potent anti-tumor CIK cells from healthy donors. An acute exercise bout increased NKT-like cell numbers in blood 2-fold. Single cell RNA sequencing revealed that exercise mobilized NKT-like cells have an upregulation of genes and t

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… Front Immunol ( 2019 ) 10 : 3082 . doi: 10.3389/fimmu.2019.03082 32038628 PMC6993603 17 Campbell JP Guy K Cosgrove C Florida-James GD Simpson RJ . …

Gram-Negative Taxa and Antimicrobial Susceptibility after Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection.

Fecal microbiota transplantation (FMT) has promising applications in reducing multidrug-resistant organism (MDRO) colonization and antibiotic resistance (AR) gene abundance. However, data on clinical microbiology results after FMT are limited. We examined the changes in antimicrobial susceptibility profiles in patients with Gram-negative infections in the year before and the year after treatment with FMT for recurrent Clostridioides difficile infection (RCDI). We also examined whether a history of FMT changed health care provider behavior with respect to culture ordering and antibiotic prescri

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… —denoted as multiple | Multiple oral vancomycin tapers | Nasogastric tube/1 | Friend | Remission | | Until 17 mo post-FMT, patient subsequently moved to Florida | | | | | | | | | | | | 2 | 73 | F | African American | Churg-Strauss syndrome, pulmonary fibrosis, Zenker’s diverticulum, right …

Prognostic significance of FDG-PET/CT based radiomics analysis in newly-diagnosed multiple myeloma: a comparative study with clinical assessment.

ObjectiveThis study aimed to construct and validate a fusion diagnostic model based on Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography(FDG-PET/CT) radiomics for predicting overall survival of multiple myeloma (MM) patients.MethodsA total of 199 patients newly diagnosed with MM were included from two centers. All patients underwent whole-body PET/CT scans within one month before the initiation of treatment and were followed up for over five years. Radiomic features of MM were extracted from CT images and dimensionality reduction was performed by LASSO regression analysis. Co

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… It includes scales for points, radscore, gender, age, FL (Florida), SUVmax, total points, and a linear predictor. The bottom scales show survival probabilities for one, three, and five years. …

Gene expression signatures that predict radiation exposure in mice and humans.

BackgroundThe capacity to assess environmental inputs to biological phenotypes is limited by methods that can accurately and quantitatively measure these contributions. One such example can be seen in the context of exposure to ionizing radiation.Methods and findingsWe have made use of gene expression analysis of peripheral blood (PB) mononuclear cells to develop expression profiles that accurately reflect prior radiation exposure. We demonstrate that expression profiles can be developed that not only predict radiation exposure in mice but also distinguish the level of radiation exposure, rang

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… genome-wide expression patterns Proc Natl Acad Sci U S A 95 14863 14868 9843981 10.1073/pnas.95.25.14863 PMC24541 Saldanha AJ 2004 Java Treeview-extensible visualization of microarray data Bioinformatics 20 3246 3248 15180930 10.1093/bioinformatics/bth349 Gelman, A 2004 Bayesian data analysis Boca Raton (Florida …

Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)

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2018 ACVIM Forum Research Report Program. Seattle, Washington, June 14 - 16, 2018.

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… Troedsson 5 1 Hagyard Equine Medical Insititute, Paris, KY, USA, 2 Equine Internal Medicine NC State Veterinary School, Raleigh, NC, USA, 3 Department of Large Animal Medicine, University of Georgia College of Veterinary Medicine, Athens, GA, USA, 4 Department of Large Animal Science University of Florida … Columbia, MO, USA, 11 Georgia Equine Veterinary Hospital and Services, Canton, GA, USA, 12 Purdue University College of Veterinary Medicine, West Lafayette, IN, USA, 13 Oregon State University, Corvallis, OR, USA, 14 Tryon Equine Hospital P.L.L.C, Columbus, NC, USA, 15 Equine Medicine Specialists of South Florida …