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Стратегия Монте-Карло по планированию последующей медицинской деятельности: пример множественных данных о миеломе.

Ключевое значение для индивидуального лечения раковых заболеваний имеет разработка стратегий последующей деятельности в интересах конкретных пациентов. Весьма полезными были бы инструменты оказания помощи врачам в принятии решений о лечении и планировании последующих мероприятий на основе предпочтений пациентов и медицинских данных. Эти инструменты должны включать реалистичные модели развития заболеваний в рамках лечения, многоцелевую оптимизацию стратегий лечения и эффективные алгоритмы для индивидуализации последующих мер с учетом истории пациента. Мы предлагаем модель эволюции рака с исполь

COVID-19 Severity and Survival over Time in Patients with Hematologic Malignancies: A Population-Based Registry Study.

Mortality rates for COVID-19 have declined over time in the general population, but data in patients with hematologic malignancies are contradictory. We identified independent prognostic factors for COVID-19 severity and survival in unvaccinated patients with hematologic malignancies, compared mortality rates over time and versus non-cancer inpatients, and investigated post COVID-19 condition. Data were analyzed from 1166 consecutive, eligible patients with hematologic malignancies from the population-based HEMATO-MADRID registry, Spain, with COVID-19 prior to vaccination roll-out, stratified

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… Piñana J.L., Martino R., García-García I., Parody R., Morales M.D., Benzo G., Gómez-Catalan I., Coll R., Fuente I.D.L., Luna A., et al. Risk factors and outcome of COVID-19 in patients with hematological malignancies. Exp. Hematol. Oncol. 2020;9:21. doi: 10.1186/s40164-020-00177-z. 14. …

2022 American Society of Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) Indications for Metabolic and Bariatric Surgery.

MAJOR UPDATES TO 1991 NATIONAL INSTITUTES OF HEALTH GUIDELINES FOR BARIATRIC SURGERY: Metabolic and bariatric surgery (MBS) is recommended for individuals with a body mass index (BMI) >35 kg/m2, regardless of presence, absence, or severity of co-morbidities.MBS should be considered for individuals with metabolic disease and BMI of 30-34.9 kg/m2.BMI thresholds should be adjusted in the Asian population such that a BMI >25 kg/m2 suggests clinical obesity, and individuals with BMI >27.5 kg/m2 should be offered MBS.Long-term results of MBS consistently demonstrate safety and efficacy.Appropriately

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… Morales E Porrini E Martin-Toboada M Renoprotective role of bariatric surgery in patients with established chronic kidney disease Clin Kidney J 2020 14 9 2037 2046 10.1093/ckj/sfaa266 34476090 PMC8406062 126. …

Peripheral neuropathy associated with monomethyl auristatin E-based antibody-drug conjugates.

Since the successful approval of gemtuzumab ozogamicin, antibody-drug conjugates (ADCs) have emerged as a pivotal category of targeted therapies for cancer. Among these ADCs, the use of monomethyl auristatin E (MMAE) as a payload is prevalent in the development of ADC drugs, which has significantly improved overall therapeutic efficacy against various malignancies. However, increasing clinical observations have raised concerns regarding the potential nervous system toxicity associated with MMAE-based ADCs. Specifically, a higher incidence of peripheral neuropathy has been reported in ADCs inco

IgA Nephropathy: Beyond the Half-Century.

In 1968, Jean Berger first introduced the medical world to IgA nephropathy (IgAN). Fifty-five years later, its pathogenesis is still unclear, but treatments such as renin-angiotensin-aldosterone system inhibitors (RAAS-Is), tonsillectomies, and glucocorticoids are currently used worldwide. There have been great strides in the past 20 years since the discoveries of the specific dysregulation of mucosal immunity, galactose-deficient IgA1 (Gd-IgA1), and Gd-IgA1 immune complexes in patients with IgAN. According to these findings, a multi-hit hypothesis was developed, and this multi-hit hypothesis

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… Praga M., Gutiérrez E., González E., Morales E., Hernández E. Treatment of IgAN with ACE inhibitors: A randomized and controlled trial. J. Am. Soc. Nephrol. 2003;14:1578–1583. doi: 10.1097/01.ASN.0000068460.37369.DC. 9. …

Current Advances of Nanomedicines Delivering Arsenic Trioxide for Enhanced Tumor Therapy.

Arsenic trioxide (ATO) is one of the first-line chemotherapeutic drugs for acute promyelocytic leukemia. Its anti-cancer activities against various human neoplastic diseases have been extensively studied. However, the clinical use of ATO for solid tumors is limited, and these limitations are because of severe systemic toxicity, low bioavailability, and quick renal elimination before it reaches the target site. Although without much success, several efforts have been made to boost ATO bioavailability toward solid tumors without raising its dose. It has been found that nanomedicines have various

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… Morales-Marin M.E. Cruz-Colin J.L. Rangel C. Orozco L. Analysis of the dynamic aberrant landscape of DNA methylation and gene expression during arsenic-induced cell transformation Gene 2019 711 143941 10.1016/j.gene.2019.143941 31242453 61. Ngalame N.N.O. Luz A.L. Makia N. Tokar E.J. …

Drug reprofiling history and potential therapies against Parkinson's disease.

Given the high whittling down rates, high costs, and moderate pace of new medication, revelation, and improvement, repurposing "old" drugs to treat typical and uncommon illnesses is progressively becoming an appealing proposition. Drug repurposing is the way toward utilizing existing medications in treating diseases other than the purposes they were initially designed for. Faced with scientific and economic challenges, the prospect of discovering new medication indications is enticing to the pharmaceutical sector. Medication repurposing can be used at various stages of drug development, althou

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… N., Goveas J., Morales K. H., Duda J. E., et al. (2006). Association of dopamine agonist use with impulse control disorders in Parkinson disease. Arch. Neurol. 63 (7), 969–973. 10.1001/archneur.63.7.969 Wen H., Jung H., Li X. (2015). …

Contribution of Population Pharmacokinetics of Glycopeptides and Antifungals to Dosage Adaptation in Paediatric Onco-hematological Malignancies: A Review.

The response to medications in children differs not only in comparison to adults but also between children of the different age groups and according to the disease. This is true for anti-infectives that are widely prescribed in children with malignancy. In the absence of pharmacokinetic/pharmacodynamic paediatric studies, dosage is frequently based on protocols adapted to adults. After a short presentation of the drugs, we reviewed the population pharmacokinetic studies available for glycopeptides (vancomycin and teicoplanin, n = 5) and antifungals (voriconazole, posaconazole, and amphotericin

Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis.

Bone metastasis is a serious and often lethal complication of particularly frequent carcinomas, such as breast and prostate cancers, which not only reduces survival but also worsens the patients' quality of life. Therefore, it is important to find new and/or additional therapeutic possibilities that can counteract the colonization of bone tissue. High adherence to the Mediterranean diet (MD) is effective in the prevention of cancer and improves cancer patients' health, thus, here, we considered its impact on bone metastasis. We highlighted some molecular events relevant for the development of

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… Tarragona M., Pavlovic M., Arnal-Estapé A., Urosevic J., Morales M., Guiu M., Planet E., González-Suárez E., Gomis R.R. Identification of NOG as a Specific Breast Cancer Bone Metastasis-supporting Gene. J. Biol. Chem. 2012;287:21346–21355. doi: 10.1074/jbc.M112.355834. 49. …

Reviewing the Significance of Vitamin D Substitution in Monoclonal Gammopathies.

Vitamin D is a steroid hormone that is essential for bone mineral metabolism and it has several other effects in the body, including anti-cancer actions. Vitamin D causes a reduction in cell growth by interrupting the cell cycle. Moreover, the active form of vitamin D, i.e., 1,25-dihydroxyvitamin D, exerts various effects via its interaction with the vitamin D receptor on the innate and adaptive immune system, which could be relevant in the onset of tumors. Multiple myeloma is a treatable but incurable malignancy characterized by the growth of clonal plasma cells in protective niches in the bo

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… Ferronato M.J., Serrano M.N., Lahuerta E.J.A., Morales C.B., Paolillo G., Aliguer A.M.-S., Santalla H., Mascaró M., Vitale C., Fall Y., et al. Vitamin D analogues exhibit antineoplastic activity in breast cancer patient-derived xenograft cells. J. Steroid Biochem. Mol. …

Effects of the polyunsaturated fatty acids, EPA and DHA, on hematological malignancies: a systematic review.

Omega-3 polyunsaturated fatty acids (PUFAs) have well established anti-cancer properties. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are among this biologically active family of macromolecules for which various anti-cancer effects have been explained. These PUFAs have a high safety profile and can induce apoptosis and inhibit growth of cancer cells both in vitro and in vivo, following a partially selective manner. They also increase the efficacy of chemotherapeutic agents by increasing the sensitivity of different cell lines to specific anti-neoplastic drugs. Various mechanisms

The future of NMR metabolomics in cancer therapy: towards personalizing treatment and developing targeted drugs?

There has been a recent shift in how cancers are defined, where tumors are no longer simply classified by their tissue origin, but also by their molecular characteristics. Furthermore, personalized medicine has become a popular term and it could start to play an important role in future medical care. However, today, a "one size fits all" approach is still the most common form of cancer treatment. In this mini-review paper, we report on the role of nuclear magnetic resonance (NMR) metabolomics in drug development and in personalized medicine. NMR spectroscopy has successfully been used to evalu

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… Monleon D., Morales J.M., Barrasa A., Lopez J.A., Vazquez C., Celda B. Metabolite profiling of fecal water extracts from human colorectal cancer. NMR Biomed. 2009;22:342–348. doi: 10.1002/nbm.1345. 39. …

Intensive care of the cancer patient: recent achievements and remaining challenges.

A few decades have passed since intensive care unit (ICU) beds have been available for critically ill patients with cancer. Although the initial reports showed dismal prognosis, recent data suggest that an increased number of patients with solid and hematological malignancies benefit from intensive care support, with dramatically decreased mortality rates. Advances in the management of the underlying malignancies and support of organ dysfunctions have led to survival gains in patients with life-threatening complications from the malignancy itself, as well as infectious and toxic adverse effect

Инструменты скрининга для раннего выявления потребностей в паллиативном уходе у пациентов с повышенными хроническими условиями: обновленный систематический обзор.

Предыстория/задачи: Более раннее начало паллиативного ухода способствует улучшению клинических результатов, включая повышение эффективности мер по борьбе с симптомами, повышение качества жизни и сокращение использования ресурсов здравоохранения для лечения передовых заболеваний. Цель этого систематического обзора заключалась в выявлении и критической оценке существующих инструментов, разработанных как в обычном порядке, так и на основе искусственного интеллекта, предназначенных для выявления пациентов, имеющих право на раннее паллиативное лечение. Методы: Six Были изучены электронные базы данн

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… Morales-Meyer T. Villarroel L. Pérez-Cruz P. Rojas-Sepúlveda J. Arancibia-García M. Díaz-Pérez A. Moya-Castillo T. Cárdenas-Salazar J. González-González M. Adaptation and validation in Chile of the patient identification instrument needing palliative care: NECPAL-CCOMS-ICO 3.1© Aten. …

Virtual Screening of FDA-Approved Compounds: Exploring New Alternatives for HIV Treatment.

Human immunodeficiency virus (HIV) infection remains a significant public health challenge, particularly because of the emergence of drug-resistant strains against the drugs currently used in highly active antiretroviral therapy (HAART). The ongoing search for new molecules with therapeutic potential remains crucial. In this study, a virtual screening approach was employed to identify novel candidates with therapeutic potential for HIV. High-throughput screening (HTS) data were used to train and validate quantitative structure-activity relationship (QSAR) models, which were subsequently applie

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… Farfan-Morales C. N. Cordero-Rivera C. D. De Jesús-González L. A. Reyes-Ruiz J. M. Hurtado-Monzón A. M. Palacios-Rápalo S. N. Jiménez-Camacho R. Meraz-Ríos M. A. Del Ángel R. M. …

Burning Issues/Hot Topics: The Charcot Foot.

Charcot neuro-osteoarthropathy remains one of the most serious complications of diabetic neuropathy, with the potential for rapid progression to deformity, ulceration and limb-threatening outcomes. The earliest signs and symptoms are often subtle and easily missed, yet early recognition provides a narrow window of opportunity to prevent irreversible structural change. Contemporary diagnostic pathways are underpinned by close clinical observation and correlation of bedside findings with detailed imaging analysis, enabling earlier identification of active disease before collapse occurs. This art

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… Molines-Barroso R.J., Lazaro-Martinez J.L., Beneit-Montesinos J.V., Alvaro-Afonso F.J., Garcia-Morales E., Garcia-Alvarez Y. Early Foot Structural Changes After Lateral Column Exostectomy in Patients with Charcot Foot. Int. J. Low. Extrem. …

DNA Binding, DNA Photocleavage, Molecular Docking Studies and Photo-Induced Effect on Melanoma Cells of 2-Methyl-3-OR Quinazolinone Derivatives.

Thirty 2-methyl-quinazolinone fussed hydroxamic acids (3-OH) and their 3-OEt and 3-OBn derivatives were evaluated for their affinity towards calf-thymus (CT) DNA using UV-vis absorption, viscosity and fluorescence spectroscopy. DNA photocleavage activity was assessed by incubating the compounds with plasmid DNA followed by UV-A and visible light irradiation, which enabled identification of the most potent derivatives active at concentrations of 100 nΜ and 10 μΜ, respectively. Mechanistic studies on the most active compounds indicated the formation of oxygen radical species and a decrease in ef

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… Ramos-Morales F.R. Olivares-Romero J.L. Chiral Hydroxamic Acid Ligands in the Asymmetric Synthesis of Natural Products Chemistry 2023 5 2700 2712 10.3390/chemistry5040174 15. Soares E.V. Perspective on the Biotechnological Production of Bacterial Siderophores and Their Use Appl. Microbiol. …

Exploring CAR-PBMCs: A Novel Strategy Against EGFR-Positive Tumor Cells.

Background: Chimeric antigen receptor (CAR) T cell therapy has shown significant promise in treating hematological malignancies, yet its application in solid tumors, particularly those expressing the epidermal growth factor receptor (EGFR), remains limited. This study investigates the potential of CAR-engineered peripheral blood mononuclear cells (PBMCs) as a novel adoptive cell therapy against EGFR-positive cancers. Methods: Lentiviral transduction at an MOI of 50 was performed to generate specific anti-EGFR second generation CAR-effector cells. The transduced PBMCs were stimulated with cytok

A hierarchical and configurational analysis of Health Technology Assessment outcomes for cell and gene therapies.

BackgroundCell and gene therapies (CGTs) challenge traditional Health Technology Assessment (HTA), creating a fragmented global access landscape. This study identifies the determinants of CGT reimbursement outcomes by quantifying the influence of key variables and identifying the configurations leading to a positive recommendation.MethodsA dual-methodology approach was employed. We constructed a comprehensive dataset of all HTA decisions for CGTs across seven major jurisdictions between January 2017 and July 2025. Hierarchical Linear Modeling (HLM) was used to identify independent predictors o

Systemic therapy and radiotherapy related complications and subsequent hospitalisation rates: a systematic review.

BackgroundHospitalisation resulting from complications of systemic therapy and radiotherapy places a substantial burden on the patient, society, and healthcare system. To formulate preventive strategies and enhance patient care, it is crucial to understand the connection between complications and the need for subsequent hospitalisation. This review aimed to assess the existing literature on complications related to systemic and radiotherapy treatments for cancer, and their impact on hospitalisation rates.MethodsData was obtained via electronic searches of the PubMed, Scopus, Embase and Google

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… Moro-Valdezate D Buch-Villa E Peiró S Morales-Monsalve MD Caballero-Gárate A Martínez-Agulló Á Factors associated with health-related quality of life in a cohort of Spanish breast cancer patients Breast Cancer 2014 21 442 452 10.1007/s12282-012-0402-x 22926507 15. …