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Mindfulness-Based Group Medical Visits: Strategies to Improve Equitable Access and Inclusion for Diverse Patients in Cancer Treatment.

BackgroundMindfulness-based interventions (MBIs) are supported by clinical practice guidelines as effective non-pharmacologic interventions for common symptoms experienced by cancer patients, including anxiety, depression, and fatigue. However, the evidence predominately derives from White breast cancer survivors. Racial and ethnic minority patients have less access to integrative oncology care and worse cancer outcomes. To address these gaps, we designed and piloted a series of mindfulness-based group medical visits (MB-GMVs), embedded into comprehensive cancer care, for racially and ethnical

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… Accessed September 27, 2023. 4 Costas-Muniz R Hunter-Hernandez M Garduno-Ortega O Morales-Cruz J Gany F . Ethnic differences in psychosocial service use among non-Latina white and Latina breast cancer survivors . …

Роль фитохимикатов в борьбе с нейропотической болью: сколько успехов мы добились?

Нетрофическая боль — это сложное и изнурительное состояние, вызванное повреждением нерва, которое характеризуется такими ощущениями, как горение, покалывание и стрельба. Она часто связана с такими условиями, как множественный склероз (MS), синдром Гильен-Барре (GBS) и диабетическая полиномропата. Лечение обычной боли часто обеспечивает ограниченное облегчение и сопровождается существенными побочными эффектами, подчеркивая необходимость изучения альтернативных вариантов лечения. Фитохимические вещества, являющиеся биоактивными соединениями, полученными от растений, привлекли внимание к их потен

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… Agüera-Morales E. Impact of Cognitive Impairment on Quality of Life in Multiple Sclerosis Patients: A Comprehensive Review J. Clin. Med. 2024 13 3321 10.3390/jcm13113321 38893032 PMC11172944 54. Racke M.K. Frohman E.M. Frohman T. …

Risk factors and current state of therapy for anemia after kidney transplantation.

Post-transplant anemia is one of the most common complications in kidney transplant recipients, severely affecting patient prognosis and quality of life, and is an independent predictor of graft kidney loss and patient mortality. However, our clinical understanding and the attention given to post-transplant anemia are currently insufficient. This paper reviews the current status, risk factors, and therapeutic progress in anemia after transplantation in kidney transplant recipients. We recommend that clinical staff pay attention to anemia and its complications in kidney transplant recipients an

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… Vanrenterghem Y, Ponticelli C, Morales JM, Abramowicz D, Baboolal K, Eklund B, et al. (2003). Prevalence and management of anemia in renal transplant recipients: a European survey. Am J Transplant 3:835–45. doi: 10.1034/j.1600-6143.2003.00133.x, PMID: 13. …

Trichloroethylene: An Invisible Cause of Parkinson's Disease?

The etiologies of Parkinson's disease (PD) remain unclear. Some, such as certain genetic mutations and head trauma, are widely known or easily identified. However, these causes or risk factors do not account for the majority of cases. Other, less visible factors must be at play. Among these is a widely used industrial solvent and common environmental contaminant little recognized for its likely role in PD: trichloroethylene (TCE). TCE is a simple, six-atom molecule that can decaffeinate coffee, degrease metal parts, and dry clean clothes. The colorless chemical was first linked to parkinsonism

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… [58] Laouali N , Pilorget C , Cyr D , Neri M , Kaerlev L , Sabroe S , Gorini G , Richiardi L , Morales-Suárez-Varela M , Llopis-Gonzalez A , Ahrens W , Jöckel K-H , Afonso N , Eriksson M , Merletti F , Olsen J , Lynge E , Guénel P ( 2018 ) Occupational exposure to organic solvents andrisk of male breast …

Challenges in Treating Cancer Patients With Unstable Psychiatric Disorder.

In this review, we first present a case of chronic myeloid leukemia with acute psychosis, and then we will discuss the incidence of cancer in patients with psychotic disorders, the manifestations of new-onset psychosis, and the prevalence of preexisting psychosis in cancer patients, coupled with their impact on the treatment, diagnosis, and prognosis of cancer. This was a case that presented with acute psychosis and was found to have an elevated white blood cell count upon admission to an inpatient psychiatric unit. He was diagnosed with chronic myeloid leukemia and successfully managed with i

Integrating imaging and biomarker assessment to better define psoriatic arthritis and predict response to biologic therapy.

The treatment options for PsA have substantially expanded over the last decade. Approximately 40% of patients will not respond to first-line anti-TNF-α therapies. There is limited data to help clinicians select the most appropriate biologic therapy for PsA patients, including guidance for decisions on biologic therapy switching. In this review we will examine the current understanding of predictors of response to treatment. Imaging technology has evolved to allow us to better study psoriatic disease and define disease activity, including synovitis and enthesitis. Enthesitis is implicated in th

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… Morales-Lara MJ, Cañete JD, Torres-Moreno D. et al. Effects of polymorphisms in TRAILR1 and TNFR1A on the response to anti-TNF therapies in patients with rheumatoid and psoriatic arthritis. Joint Bone Spine 2012;79:591–6. 103. Ramírez J, Fernández-Sueiro JL, López-Mejías R. et al. …

Metformin and Its Benefits for Various Diseases.

Metformin is a widely used biguanide drug due to its safety and low cost. It has been used for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability to decrease plasma glucose levels. Over time, different uses of metformin were discovered, and the benefits of metformin for various diseases and even aging were verified. These diseases include cancers (e.g., breast cancer, endometrial cancer, bone cancer, colorectal cancer, and melanoma), obesity, liver diseases, cardiovascular disease, and renal diseases. Metformin exerts different effects through differe

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… Morales DR, Morris AD. Metformin in cancer treatment and prevention. Annu Rev Med. (2015) 66:17–29. 10.1146/annurev-med-062613-093128 8. Lamanna C, Monami M, Marchionni N, Mannucci E. Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials. …

National burden of cancer in Italy, 1990-2017: a systematic analysis for the global burden of disease study 2017.

We monitored the burden of cancer in Italy and its trends over the last three decades, providing estimates of cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs), for cancer overall and 30 cancer sites using data from the Global Burden of Disease study 2017. An overview of mortality trends between 1990 and 2017 was also provided. In 2017, there were 254,336 new cancer cases in men and 214,994 in women, corresponding to an age-standardized incidence rate (ASIR) of 438 and 330/100,000, respectively. Between 1990 and 2017, incid

Research Communications of the 26th ECVIM‐CA Congress

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… canine spontaneous hyperadrenocorticism: a retrospective study of 73 cases ESVE‐P‐3 | Mclean | Prevalence of and risk factors for feline hyperthyroidism in South Africa ESVE‐P‐4 | Rochel | Clinical and biological evaluation of 66 hyperthyroid cats treated with iodine‐deficient diet ESVE‐P‐5 | Clares Moral … Morales 1 , P. Garcia 1 , S. Belinchon‐Lorenzo 2 , L.C. Gomez‐Nieto 2 , E. Aguilera‐Tejero 1 , I. Lopez 1 . 1 Department of Medicina y Cirugia Animal, University of Cordoba, Cordoba, Spain, 2 LeishmanCeres Laboratory,. …

The Gut Microbiota in Hematologic Malignancies: Mechanisms, Clinical Associations, and Translational Opportunities.

Hematologic malignancies arise and progress within a systemic ecosystem in which the gut microbiota is an increasingly recognized, partially modifiable component. Across acute leukemias, chronic lymphocytic leukemia, plasma cell disorders, lymphomas, and clonal myeloid neoplasms, human studies consistently report reduced microbial diversity, depletion of barrier-supportive, short-chain fatty acid-producing commensals, and enrichment of Gram-negative, pro-inflammatory, or hospital-adapted taxa. These alterations are associated with pre-leukemic clonal expansion, adverse genetic and immunologica

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… Morales M.L. Guevara-Ramirez P. Justo P. López-Muñoz N. Microbiota-derived urolithin A in monoclonal gammopathies and multiple myeloma therapy Microbiome 2025 13 56 10.1186/s40168-025-02045-6 40022244 PMC11869585 49. Young L.S. Rickinson A.B. Epstein–Barr virus: 40 years on Nat. Rev. …

Toxicities associated with CAR-T therapy compared with standard treatments in hematologic malignancies: a systematic review and meta-analysis.

BACKGROUND: Chimeric antigen receptor T-cell (CAR-T) treatment has revolutionized the therapeutic approach for relapsed or refractory hematologic malignancies. But its unique toxicity profile, particularly immune-mediated adverse events, is a significant question in comparison with other high-intensity therapy strategies. Systematic, comparative, specific assessment of CAR-T–associated toxicities are essential to guide clinical practice and institutional preparedness. METHODS: We conducted a systematic review and meta-analysis comparing the incidence and management of significant toxicities as

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… Alexandra Porras-Ramírez (APR), Alejandro Rico-Mendoza (ARM), Liliana Encinales (LE), Oscar Madiedo (OM), Marianna Carrillo-Encinales (MCE), Juan Pablo Duque-Bolívar (JPDB), Juan Fernando Ramón-Cuellar (JFRC), Jorge Andrés Urquijo-Méndez (JAUM), Lucía Mora-Quiñones (LMQ), Alexandra Marín-Morales (AMM …

Обзор гута дисбиоза и недоедания в неврологических расстройствах: последствия, признаки и перспективные терапевтические подходы.

Предыстория/цели: Неврологические заболевания растут во всем мире, однако биологические процессы, лежащие в основе этих заболеваний, по-прежнему плохо понимаются, а существующие методы лечения неэффективны при прекращении развития заболеваний. Появляющиеся данные свидетельствуют о том, что дисбиоз оси микробиота-гут-мозгов и недоедание являются сопутствующими факторами неврологической дисфункции. Методы: Была разработана расширенная стратегия поиска с использованием многопланового подхода в различных базах данных для выявления приемлемых исследований, опубликованных в период с января 2010 года

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… Holmes A., Finger C., Morales-Scheihing D., Lee J., McCullough L.D. Gut dysbiosis and age-related neurological diseases: An innovative approach for therapeutic interventions. Transl. Res. 2020;226:39–56. doi: 10.1016/j.trsl.2020.07.012. 3. …

Immune effector cell-associated hematotoxicity: mechanisms, clinical manifestations, and management strategies.

Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment landscape for hematologic malignancies. However, it is frequently complicated by immune effector cell-associated hematotoxicity (ICAHT), a potentially life-threatening adverse event encompassing neutropenia, anemia, and thrombocytopenia. These cytopenias elevate the risk of severe infections, transfusion dependence, and prolonged hospital stays, contributing substantially to morbidity and non-relapse mortality. This review delineates the incidence, mechanisms, and risk factors for ICAHT, highlighting the complex inter

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… Morales-Mantilla DE, King KY. The role of interferon-gamma in hematopoietic stem cell development, homeostasis, and disease. Curr Stem Cell Rep. 2018;4(3):264-271. 64. Giudice V, Feng X, Lin Z, et al. …

NLRP3 inflammasome: a key driver of neuroinflammation and a novel therapeutic target for neuropathic pain.

Neuropathic pain represents a serious complication arising from a spectrum of disorders that precipitate lesions within the central and peripheral nervous systems. This disabling pain can persist for years, severely diminishing the quality of life of the affected individuals. The treatment options available for neuropathic pain at present have limited efficacy. Moreover, the adverse effects associated with these options restrict their application. The exact etiological mechanisms underlying the pathogenesis of neuropathic pain remain unclear. However, neuroinflammatory processes mediated by th

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… Carranza-Aguilar CJ, Hernández-Mendoza A, Mejias-Aponte C, Rice KC, Morales M, González-Espinosa C, et al. …

Advances in the research on myokine-driven regulation of bone metabolism.

The traditional view posits that bones and muscles interact primarily through mechanical coupling. However, recent studies have revealed that myokines, proteins secreted by skeletal muscle cells, play a crucial role in the regulation of bone metabolism. Myokines are widely involved in bone metabolism, influencing bone resorption and formation by interacting with factors related to bone cell secretion or influencing bone metabolic pathways. Here, we review the research progress on the myokine regulation of bone metabolism, discuss the mechanism of myokine regulation of bone metabolism, explore

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… Celis-Morales C. Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis J Cachexia Sarcopenia Muscle 13 1 2022 86 99 10.1002/jcsm.12783 34816624 PMC8818604 8 Kirk B. Zanker J. Duque G. …

Herpes Zoster and Cardiovascular Disease: Exploring Associations and Preventive Measures through Vaccination.

Herpes zoster, induced by the reactivation of the varicella-zoster virus (VZV), is a unilaterally distributed vesicular rash that can cause multiple complications. VZV not only causes neurological problems, including postherpetic neuralgia and ocular zoster, but also causes inflammatory vasculopathy and increases the incidence of hemorrhagic or ischemic complications. Therefore, understanding the association between the development of herpes zoster and the subsequent occurrence of acute stroke or cardiovascular diseases, including myocardial infarction and heart failure, is of great interest.

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… Morales A.R., Adelman S., Fine G. Varicella myocarditis. A case of sudden death. Arch. Pathol. 1971;91:29–31. 109. Elikowski W., Marszalek A., Malek-Elikowska M., Ganowicz-Kaatz T., Mozer-Lisewska I. Myopericarditis in a 23-year-old male with herpes zoster. Pol. Merkur. …

New PET Radiotracers for the Imaging of Neuroendocrine Neoplasms.

Opinion statementNeuroendocrine neoplasms (NEN) are a heterogeneous group of tumours derived from cells of neuroendocrine origin and can potentially arise everywhere in the human body. The diagnostic assessment of NEN can be performed using a variety of PET radiopharmaceuticals. Well-differentiated NEN (NET) present a high expression of SSTR (somatostatin receptors) and can therefore be studied with 68Ga-DOTA-peptides ([68Ga]Ga-DOTANOC, [68Ga]Ga-DOTATOC, [68Ga]Ga-DOTATATE). Current guidelines recommend the use of SSTR imaging to assess disease extension at staging/restaging, follow-up, assessm

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… Morales MI, Erhard A, Lozano MD, Quincoces G, Richter JA, Rodríguez-Fraile M. Incidental diagnosis of neuroendocrine tumour with 68Ga-PSMA PET/CT: report of clinical case. Diagnóstico incidental de tumor neuroendocrino con 68Ga-PSMA PET/TC: a propósito de un caso. …

Pseudomonas aeruginosa Infections in Cancer Patients.

Pseudomonas aeruginosa (P. aeruginosa) is one of the most frequent opportunistic microorganisms causing infections in oncological patients, especially those with neutropenia. Through its ability to adapt to difficult environmental conditions and high intrinsic resistance to antibiotics, it successfully adapts and survives in the hospital environment, causing sporadic infections and outbreaks. It produces a variety of virulence factors that damage host cells, evade host immune responses, and permit colonization and infections of hospitalized patients, who usually develop blood stream, respirato

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… Lima-Morales D. Barth A. Plasmid-mediated Colistin Resistance: What Do We Know? J. Infect. 2018 1 16 22 10.29245/2689-9981/2018/2.1109 15. Abd El-Baky R.M. Masoud S.M. Mohamed D.S. Waly N.G. Shafik E.A. Mohareb D.A. Elkady A. Elbadr M.M. Hetta H.F. …

Double Repositioning: Veterinary Antiparasitic to Human Anticancer.

Drug repositioning, the approach of discovering different uses for existing drugs, has gained enormous popularity in recent years in the anticancer drug discovery field due to the increasing demand for anticancer drugs. Additionally, the repurposing of veterinary antiparasitic drugs for the treatment of cancer is gaining traction, as supported by existing literature. A prominent example is the proposal to implement the use of veterinary antiparasitics such as benzimidazole carbamates and halogenated salicylanilides as novel anticancer drugs. These agents have revealed pronounced anti-tumor act

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… Morales L.D. Zhang Y. Mito S. Tsin A. Niclosamide induces protein ubiquitination and inhibits multiple pro-survival signaling pathways in the human glioblastoma U-87 MG cell line PLoS ONE 2017 12 e0184324 28877265 10.1371/journal.pone.0184324 PMC5587337 87. Oh H.-C. Shim J.-K. Park J. Lee J.-H. …

The Controversial Role of IL-33 in Lung Cancer.

Interleukin-33 (IL-33) belongs to the interleukin-1 (IL-1) family, and its structure is similar to IL-18. When cells are damaged or undergo necrosis, mature form of IL-33 is secreted as a cytokine, which can activate the immune system and provide danger signals. The IL-33/ST2 signaling pathway is composed of IL-33, suppression of tumorigenicity 2 (ST2), and IL-1 receptor accessory protein (IL-1RAcP). IL-33 has been reported to be strongly associated with lung cancer progression, and can exhibit opposite effects on lung cancer under different conditions. In this review, we have summarized the s