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Which cancer survivors are at risk for a physically inactive and sedentary lifestyle? Results from pooled accelerometer data of 1447 cancer survivors.

BackgroundPhysical activity has beneficial effects on the health of cancer survivors. We aimed to investigate accelerometer-assessed physical activity and sedentary time in cancer survivors, and describe activity profiles. Additionally, we identify demographic and clinical correlates of physical activity, sedentary time and activity profiles.MethodsAccelerometer, questionnaire and clinical data from eight studies conducted in four countries (n = 1447) were pooled. We calculated sedentary time and time spent in physical activity at various intensities using Freedson cut-points. We used latent p

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… Self-report (socio-demographic variables) and medical records (clinical characteristics) | Actitrainer | MFI Accelerometer data reduction Accelerometer data during waking hours were collected for five [ 25 ] or seven [ 16 , 17 , 23 , 24 , 26 – 28 ] consecutive days with ActiGraph accelerometers (Florida …

A pharmacokinetics and safety phase 1/1b study of oral ixazomib in patients with multiple myeloma and severe renal impairment or end-stage renal disease requiring haemodialysis.

Renal impairment (RI) is a major complication of multiple myeloma (MM). This study aimed to characterize the single-dose pharmacokinetics (PK) of the oral proteasome inhibitor, ixazomib, in cancer patients with normal renal function [creatinine clearance (CrCl) ≥90 ml/min; n = 20), severe RI (CrCl <30 ml/min; n = 14), or end-stage renal disease requiring haemodialysis (ESRD; n = 7). PK and adverse events (AEs) were assessed after a single 3 mg dose of ixazomib. Ixazomib was highly bound to plasma proteins (~99%) in all renal function groups. Unbound and total systemic exposures of ixazomib wer

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… This work has been presented at the following meetings: Poster presented at the 57th American Society of Hematology Annual Meeting, Orlando, Florida, USA, December 5–8, 2015. …

Student Summer Research Awards - SSRAAbstracts of the SSRA September 2022 meeting, UCD School of Medicine.

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… Presenting Author:Muaz Rashid Supervisor:Assoc Prof Bobak Mosadegh QUALITY OF LIFE OUTCOMES OF 400 PATIENTS TREATED WITH STAGE IIIC PROSTATE CANCER Forbes E 1 , Cesaretti J 2 1 UCD School of Medicine, University College Dublin, Ireland 2 Florida Physician Specialists, Jacksonville, Florida USA … Our study cohort consisted of 429 patients (median age: 70) treated at Terk Oncology, Jacksonville, Florida, between 1997-2021 with Gleason grade 5. Patient characteristics such as smoking, age, race, and history were tabulated de-identified. …

Электронные постеры

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… Pasadena, United States 4 The Pain Center, Boise, Idaho, United States, 5 Pain Medicine of the Sounth, Knoxville, United States 6 Desert Interventional Spine Consultants, Gilbert, United States 7 Island Interventional Pain Management, Commack, NY, United States 8 LESS Society, Fort Lauderdale, Florida … Pasadena, United States 4 The Pain Center, Boise, Idaho, United States 5 Pain Medicine of the Sounth, Knoxville, United States 6 Desert Interventional Spine Consultants, Gilbert, United States 7 Island Interventional Pain Management, Commack, NY, United States 8 LESS Society, Fort Lauderdale, Florida …

Efficacy and safety of approved cellular therapies and bispecific antibodies in solid tumors: the current state.

Cancer immunotherapy is a broad term including naked antibodies, bispecific antibodies (BsAbs), immune-checkpoint inhibitors (ICIs), chimeric antigen receptor T-cell (CAR-T) therapy, cancer vaccines, activated immune cells, and allogeneic hematopoietic cell transplantation. Recent advances in immune-engaging T-cell therapies have led to significant progress in novel treatments across various cancer types, resulting in prolonged patient survival, mainly in patients with hematologic malignancies. Several CAR T-cell constructs and BsAbs have been approved by regulatory authorities worldwide for r

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… Abstract 2965: LBL-033, a novel bispecific antibody targeting MUC16 and CD3, for the treatment of tumors over-expressing MUC16. presented at: AACR Annual Meeting; April 4, 2023 2023; Orlando, Florida. Accessed 18 Oct 2024. 88. …

ISEV2021 Abstract Book

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… University Seiko Ikezu, Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine Tsuneya Ikezu, MD, PhD, Department of Pharmacology & Experimental Therapeutics, Center for Systems Neuroscience,Boston University School of Medicine; Department of Neuroscience, Mayo Clinic Florida …

Oral Presentations

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Ось MLKLOPTN регулирует вызванные герпесвирусом неврологические сиквелы.

КОЛИЧЕСТВО: герпес просторексовый вирус-1 (HSV-1) носит пожизненный характер и связан с неврологическими заболеваниями, такими, как множественный склероз (MS), однако основные механизмы в хосте остаются недостаточно понятными. МЕТОДЫ И РЕЗУЛЬТАТЫ: В настоящем исследовании изучается новая молекулярная динамика после заражения HSV-1, выявляется ключевая роль смешанного киназа-домена (MLKL). Помимо известной функции в некроптозе, было установлено, что MLKL контролирует перенос HSV-1 в ядро, жестко регулируемый Оптинёрином (Optineurin). Мы продемонстрировали существенное нормативное взаимодействие

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… David Bloom (University of Florida) and cultured as previously described. 19 The HSV‐1 McKrae strain (HSV‐1) was provided by Dr. Homayon Ghiasi (Cedars Sinai). HSV‐1 KOS and 17 strains were provided by Dr. Patricia Spear (Northwestern University). HSV‐1 K26RFP strain was provided by Dr. …

A global, regional, and national survey on burden and Quality of Care Index (QCI) of hematologic malignancies; global burden of disease systematic analysis 1990-2017.

BackgroundHematologic malignancies (HMs) are a heterogeneous group of cancers that comprise diverse subgroups of neoplasms. So far, despite the major epidemiologic concerns about the quality of care, limited data are available for patients with HMs. Thus, we created a novel measure-Quality of Care Index (QCI)-to appraise the quality of care in different populations.MethodsThe Global Burden of Disease data from 1990 to 2017 applied in our study. We performed a principal component analysis on several secondary indices from the major primary indices, including incidence, prevalence, mortality, ye

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… Gender- and race-specific comparison of tobacco-associated cancer incidence trends in Florida with SEER regional cancer incidence data. Cancer Causes Control. 2008;19(7):711–723. doi: 10.1007/s10552-008-9134-9. 60. Gorini G, Stagnaro E, Fontana V, Miligi L, Ramazzotti V, Nanni O, et al. …

The 4th Global Congress on Sickle Cell Disease Abstract Book 2022

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… shareholder: employee and stock holder of Agios Pharmaceuticals, Inc PI-06: THE NURSE CHAMPION MODEL FOR NEWBORN SCREENING FOR SICKLE CELL DISEASE IN SUB-SAHARAN AFRICA: AN IMPLEMENTATION SCIENCE PROTOCOL JAJA C. 1 , IBEMERE S. 2 , GIBSON R. 3 , EDEM-HOTAH J. 1 , VICK L. 5 1 University of South Florida …

Recognition and management of persistent chylomicronemia: A joint expert clinical consensus by the National Lipid Association and the American Society for Preventive Cardiology.

Extreme hypertriglyceridemia, defined as triglyceride (TG) levels ≥1000 mg/dL, is almost always indicative of chylomicronemia. The current diagnostic approach categorizes individuals with chylomicronemia into familial chylomicronemia syndrome (FCS; prevalence 1-10 per million), caused by the biallelic combination of pathogenic variants that impair the lipolytic action of lipoprotein lipase (LPL), or multifactorial chylomicronemia syndrome (MCS, 1 in 500). A pragmatic framework should emphasize the severity of the phenotype and the risk of complications. Therefore, we endorse the term "persiste

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… In a recent study in 1,294,044 individuals from a large healthcare network across three US states (Minnesota, Florida, and Alabama), 5618 (0.43 %) patients had at least one episode of chylomicronemia [ 11 ]. …

Advances in the application of Raman spectroscopy in haematological tumours.

Hematologic malignancies are a diverse collection of cancers that affect the blood, bone marrow, and organs. They have a very unpredictable prognosis and recur after treatment. Leukemia, lymphoma, and myeloma are the most prevalent symptoms. Despite advancements in chemotherapy and supportive care, the incidence rate and mortality of patients with hematological malignancies remain high. Additionally, there are issues with the clinical diagnosis because several hematological malignancies lack defined, systematic diagnostic criteria. This work provided an overview of the fundamentals, benefits,

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… The RS sequential acquisition for the RESpect probe (EmVision, LLC, Loxahatchee, Florida) employs a unique two-component convergent lens that overlaps the laser excitation and collecting cones. …

Prognostic disclosure in cancer care: a systematic literature review.

BackgroundCollusion in cancer care is the diplomatic concealment of information between a triad of the health care professional (HCP), patient, and caregiver. Free and expressive communication is determined by multiple factors, which establishes a healthy balance between 'patient-centric' and 'family-centric' decision making. The lack of a universal approach to prognostic disclosure techniques emphasizes the need for a systematic review of contemporary practice.MethodsA systematic review of the literature was conducted till June 2020 using themes based on cancer, communication, prognostic disc

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… . | Roscoe et al. 30 | USA, South Florida, Head and neck oncology clinic | Qualitative | 14 | End-stage head and neck cancer | In-person/telephonic interview based University of Washington School of Medicine Quality of Communication Questionnaire (QOC) based structured questionnaire (30 min) | Researcher …

Abstracts From JADPRO Live at APSHO 2015.

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… Lee Moffitt Cancer Center and Research Institute, Tampa, Florida Background: MDS represent a heterogeneous group of myeloid malignancies with variable prognosis. MDS are underdiagnosed, and many lower-risk patients are offered only supportive care (Khan AM. Am J Med. 2012;125[7 suppl]:S15-S7). …

Environmental Predictors of US County Mortality Patterns on a National Basis.

A growing body of evidence has found that mortality rates are positively correlated with social inequalities, air pollution, elevated ambient temperature, availability of medical care and other factors. This study develops a model to predict the mortality rates for different diseases by county across the US. The model is applied to predict changes in mortality caused by changing environmental factors. A total of 3,110 counties in the US, excluding Alaska and Hawaii, were studied. A subset of 519 counties from the 3,110 counties was chosen by using systematic random sampling and these samples w

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… The Northeast, the southern two-thirds of Florida and the southern half of the Rocky Mountain had the lowest cancer mortality rates whereas the highest cancer mortality rates were found primarily in most of the Southeast regions especially the belt including Arkansas, Tennessee, Virginia and the Carolinas …

Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer.

Sleep problems are highly prevalent in cancer patients undergoing chemotherapy. This article reviews existing evidence on etiology, associated symptoms, and management of sleep problems associated with chemotherapy treatment during cancer. It also discusses limitations and methodological issues of current research. The existing literature suggests that subjectively and objectively measured sleep problems are the highest during the chemotherapy phase of cancer treatments. A possibly involved mechanism reviewed here includes the rise in the circulating proinflammatory cytokines and the associate

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… Circadian patterns in integrated wrist temperature, rest-activity, and position (TAP) as a biomarker for personalized cancer chronotherapeutics; SRBR Meeting; 2012 May 19–23; Florida, USA. 44. Ortiz-Tudela EIP, Iurisci I, Karaboué A, et al. …

В центре внимания пользователей находятся проектирование и формальная оценка приборной панели для многомерной оценки ходьбы при множественном склерозе.

Цифровой анализ походов с использованием изношенных датчиков и приборов все чаще проводится в рамках обычного ухода за людьми с множественным склерозом. Однако многоаспектные оценки ходьбы приводят к получению продольных и разнородных результатов, которые часто представляются в разрозненных, трудно интерпретируемых докладах, ограничивая их полезность для клинической коммуникации и совместного принятия решений. Цель этого исследования заключалась в разработке ориентированной на пациента приборной панели, которая включает многоплановые данные о походах в последовательный и интуитивный обзор, в п

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… Footnotes Edited by: Hongwu Wang , University of Florida, United States Reviewed by: Ken Kondo , Gunma Paz University, Japan Adesh Kadambi , Delfina Care Inc, United States Data availability statement The raw data supporting the conclusions of this article will be made available by the authors, …

Pharmacogenomics and Big Data in medical oncology: developments and challenges.

Medical oncology, through conventional chemotherapy as well as targeted drugs, remains an important component of cancer patient management, particularly for systemic disease. Despite advances in all areas of medical oncology, certain challenges persist in the form of drug resistance and severe normal tissue toxicity. These unwanted effects can be counteracted through a patient-tailored treatment approach, which in chemotherapy is translated as pharmacogenomics. This research field investigates the way genetic makeup influences a patient's response to various drugs with the aim to minimize tria

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… clinicians about the implementation of pharmacogenomics into clinics. 71 Some other single institution initiatives towards the implementation of pharmacogenetics/pharmacogenomics include: the customized pharmacogenetics genotyping array for personalized medicine programmes implemented by the University of Florida …

Why do health technology assessment coverage recommendations for the same drugs differ across settings? Applying a mixed methods framework to systematically compare orphan drug decisions in four European countries.

PurposeHealth technology assessment (HTA) coverage recommendations differ across countries for the same drugs. Unlike previous studies, this study adopts a mixed methods research design to investigate, in a systematic manner, these differences.MethodsHTA recommendations for ten orphan drugs appraised in England (NICE), Scotland (SMC), Sweden (TLV) and France (HAS) (N = 35) were compared using a validated methodological framework that breaks down these complex decision processes into stages facilitating their understanding, analysis and comparison, namely: (1) the clinical/cost-effectiveness ev

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… Bartholomew D Steele F Moustaki I Galbraith J Analysis of multivariate social sciences data 2008 2 Florida Taylor & Francis 41. Cohen J Coefficient of agreement for nominal scales Educ. Psychol. Meas. 1960 20 1 37 46 10.1177/001316446002000104 42. …

Emerging advances in drug delivery systems (DDSs) for optimizing cancer complications.

The management and treatment of tumor complications pose continuous challenges due to the inherent complexity. However, the advent of drug delivery systems (DDSs) brings promising opportunities to address the tumor complications using innovative technological approaches. This review focuses on common oncological complications, including cancer thrombosis, malignant serous effusion, tumor-associated infections, cancer pain, and treatment-related complications. Emphasis was placed on the application and potential of DDSs in mitigating and treating these tumor complications, and we delved into th

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… exercise | NA | Luzhou, Sichuan, China | Charles Darwin University NCT05753046 | Enrolling by invitation | Prostate Cancer | TAP Block | IV | Royal Oak, Michigan, United States | William Beaumont Hospitals NCT05842044 | Recruiting | Kidney Cancer | Non-steroidal anti-inflammatory drugs | II | Miami, Florida … Hanna NCT03050060 | Terminated | Malignant Solid Neoplasm | ICIs | PD-L1 Inhibitors/PD-1 Inhibitors | II | Seattle, Washington, United States | University of Washington NCT04562129 | Recruiting | Melanoma | Cytokine therapy/ICIs | Cytokine therapy/PD-1 Inhibitors | II | Tampa, Florida, United States …