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Oviduct-derived C-type natriuretic peptide improves bovine preimplantation embryo development in vitro by attenuating oxidative damage.

It is widely accepted that the poor quality of in vitro-produced (IVP) embryos becomes one of the most intractable issues currently limiting … d genes. Notably, we show that CNP alleviates the elevated reactive oxygen species (ROS) levels and lipid peroxidation in in vitro embryos. These findings demonstrate that CNP supplementation is a feasible and effective approach to prevent deterioration in embryo quality and improve developmental potential by inhibiting excessive lipid droplet accumulation and eleva …

Effects of acute hypoxia on nutrient metabolism and physiological function in turbot, Scophthalmus maximus.

Acute hypoxia is a common stress in aquaculture, and causes energy deficiency, oxidative damage and death in fish. Many studies have confirm … asphyxiation point is about 1.5 mg/L. Acute hypoxia induced perk-mediated ER stress, and increased lipid peroxidation and liver injury in turbot. The blood HB level and liver vegfab expression were increased under hypoxia, which enhances oxygen transport. At hypoxia stress, hif3α, anaerobic glycolysis-related genes expression, and lactate content were increased in …

Lipid oxidation is inhibited by isoeugenol exposure in chinook Salmon (Oncorhynchus Tshawytscha) fillets during storage at 15 degrees C.

The method of harvest for farmed fish and the postharvest tissue metabolism can have a significant effect on the quality and storage stabili … air at 15 degrees C for 96 h. Exposure to isoeugenol resulted in significantly decreased late-stage lipid peroxidation (TBARS) levels in the fillets during storage regardless of the harvest method. Protein carbonyl concentrations increased 73% in the fillets during storage (from 406 to 703 nmol/g wet weight) and were not affected by the harvest method. Fillet vitami …

[Influence of standard treatment on changes in the structural and functional properties of circulation red blood cells in obstructive and non-obstructive acute pyelonephritis].

AIM: To determine the effect of standard treatment on changes in the structural and functional properties of erythrocytes in obstructive and … pomyosin) are insignificant, alike from acute obstructive pyelonephritis. In addition, processes of lipid peroxidation inside red blood cells are intensified, and oxidative stress develops with a decrease in the sorption capacity of erythrocytes, as well as the content and ratio of lipid fractions in the plasma membrane, which form the basis of the lipid components …

Neuroinvasive virus facilitates viral replication by employing lipid droplets to reduce arachidonic acid-induced ferroptosis.

Lipids have been previously implicated in the lifecycle of neuroinvasive viruses. However, the role of lipids in programmed cell death and t … as further demonstrated to induce ferroptosis to inhibit neuroinvasive virus replication. Moreover, lipid peroxidation and viral replication inhibition could be significantly alleviated by a ferroptosis inhibitor, ferrostatin-1, indicating that AA affected neuroinvasive virus replication mainly through inducing ferroptosis. Furthermore, AA was demonstrated to activa …

Docosahexaenoic acid impairs the maturation of very low density lipoproteins in rat hepatic cells.

One mechanism of the lipid-lowering effects of the fish oil n-3 fatty acids [e.g., docosahexaenoic acid (DHA)] in cell and animal models is … rticles failed to quantitatively assemble into fully lipidated (mature) VLDL. This failure required lipid peroxidation and was accompanied by the formation of apoB aggregates (known to be degraded by autophagy). Preventing the exit of proteins from the Golgi blocked the aggregation of apoB but did not restore VLDL maturation, indicating that failure to fully lipidat …

Hydrogen Sulfide Alleviates Oxidative Damage under Chilling Stress through Mitogen-Activated Protein Kinase in Tomato.

Tomato is the vegetable with the largest greenhouse area in China, and low temperature is one of the main factors affecting tomato growth, y … , indicating that NaHS improved the seedlings' cold tolerance by alleviating the degree of membrane lipid peroxidation and oxidative damage. However, H2S scavenger hypotaurine (HT) treatment showed the opposite effect. We found that H2S content, L-cysteine desulfhydrase (LCD) activity, and mRNA expression were increased by chilling stress but reduced by MPK inhibito …

Enzymatic and non-enzymatic pathways of kynurenines' dimerization: the molecular factors for oxidative stress development.

Kynurenines, the products of tryptophan oxidative degradation, are involved in multiple neuropathologies, such as Huntington's chorea, Parki … decreases in Drosophila mutant cardinal with L-3HOK excess relative to the wild type Canton-S, and lipid peroxidation decreases in aged cardinal. Taken together, our data supports the conception of hydroxykynurenines' dual role in neurotoxicity: serving as antioxidants themselves, blocking lipid peroxidation by H-atom donation, they also can easily generate ROS upo …

Assessment of cellular and plasma oxidative stress in SAHS patients before and after continuous positive airway pressure treatment.

BACKGROUND: Several indirect techniques have been used for measuring oxidative stress in sleep apnoea-hypopnoea syndrome (SAHS) patients. The purpose of this study was to find out if both, cellular or plasma oxidative stress evaluations, are good estimators to assess oxidative stress in SAHS patients before and after one month's CPAP treatment. METHODS: The study included 28 SAHS patients requiring CPAP treatment and 15 healthy control subjects. Plasma and serum oxidative stress biomarkers (lipid peroxidation, total antioxidant capacity, and the activities of glutathione peroxidase, glutathio…

Synergistic remediation of oil-contaminated soil using sorghum and oil sludge-derived biochar.

Oil sludge contamination poses a significant threat to agricultural soil health and productivity. While biochar is a promising soil amendmen … r than the sum of their individual effects. In plants, biochar mitigated oxidative stress, reducing lipid peroxidation (MDA) by 73% while boosting the antioxidant system. Consequently, biochar restored sorghum growth under high contamination, increasing shoot and root biomass by 43% and 72%, respectively, and maintained nutrient uptake. Our findings demonstrate that …

Advances in molecular, biochemical mechanisms and innovative technologies for browning regulation and quality preservation of fresh-cut lotus (Nelumbo nucifera Gaertn.) rhizome.

Fresh-cut lotus (Nelumbo nucifera Gaertn.) rhizome (FCLR) is highly susceptible to enzymatic browning and non-enzymatic blue/black staining … ion of FCLR, dissecting physiological wound responses including reactive oxygen species metabolism, lipid peroxidation, and transcriptional networks governing phenolic metabolism, while clearly differentiating enzymatic browning from iron-polyphenol-mediated non-enzymatic discoloration. Three innovative technology clusters are critically evaluated: chemical signalin …

MicroRNA-mediated regulation of ferroptosis via GPX4: mechanisms and therapeutic opportunities.

Ferroptosis is a type of regulated cell death that depends on iron and lipid peroxidation and is considered a key pathological mechanism in a continuum of pathologies, including oncogenic, neurodegenerative, cardiovascular, and metabolic diseases. GPX4 serves as the regulator of ferroptosis, reducing the toxic lipid hydroperoxides to non-toxic lipid alcohols using the glutathione-dependent reaction and maintaining membrane integrity and cellular viability. MicroRNAs, short non-coding RNAs that regulate gene expression in a post-transcriptional manner, have been reported to play an important ro…

Oxidation-Dependent Behavior of Saturated and Unsaturated Phosphatidylcholine Model Membranes: Insights from Langmuir Monolayers and TBARS Analysis.

Lipid oxidation plays an important role in modifying membrane organization and interfacial behavior, particularly in phospholipids containing unsaturated acyl chains. In this study, Langmuir monolayer measurements and thiobarbituric acid reactive substances (TBARS) analysis were used to investigate the oxidative behavior of saturated and unsaturated phosphatidylcholine model systems. Surface pressure-mean molecular area (π-Mma) isotherms and constant-pressure stability measurements were obtained for DMPC, DPPC, POPC, and PAPC monolayers under ambient and controlled oxidative conditions. Differ

Co-Exposure of N-Methyl-N-Nitrosourea and Benzo[A]Pyrene Elicits Toxicity in Drosophila Melanogaster.

Human exposure to environmental pollutants is multi-variant with resultant interactive effects such as oxidative stress, and it's associated … ased. NMU and BaP caused a reduction in mitochondrial metabolic rate, and levels of total H2O2, NO, lipid peroxidation, and protein carbonyl content were observed to increase significantly; however, the total sulfhydryl and Non-protein thiols, as well as the activities of catalase, glutathione-s-transferase, and acetylcholinesterase, were decreased relative to contr …

The anti-cancer effects and mechanisms of conjugated fatty acids.

In the past 20 years, there is sufficient evidence to emphasize the anticancer potential of conjugated fatty acids (CFA), including conjugated linoleic acid (CLA) and conjugated linolenic acid (CLNA). This article reviewed the in vivo experimental studies on the anticancer effect of CFA, in which colon cancer and breast cancer have been reported most frequently. The antitumor mechanisms are primarily mediated by the activation of peroxisome proliferator-activated receptor γ (PPARγ) and ferroptosis, which is driven by lipid peroxidation. This propensity for oxidation is inherent to the conjugat…

Research progress on ferroptosis in drug resistance and therapy of gastric cancer.

AIM: The clinical management of gastric cancer (GC) is frequently challenged by the development of drug resistance, leading to poor patient outcomes. This review aims to explore the role of ferroptosis, an iron-dependent form of programmed cell death driven by lipid peroxidation, in overcoming this therapeutic hurdle. Our objective is to provide a theoretical foundation for developing novel strategies to reverse drug resistance in GC by targeting the ferroptosis pathway. METHODS: This review systematically elucidates the core regulatory mechanisms of ferroptosis and analyzes its key role in m…

Role of Ferroptosis in the Redox Biology of Mycotoxins.

Ferroptosis, an iron-dependent regulated cell death process driven by lipid peroxidation, has emerged as a pivotal mechanism in mycotoxin-induced redox pathology. This review synthesizes the molecular interplay between fungal secondary metabolites (e.g., aflatoxin B1, deoxynivalenol) and ferroptotic pathways, revealing how mycotoxins subvert cellular iron homeostasis through transferrin receptor 1 (TfR1) upregulation and ferritinophagy-mediated iron release, while concurrently inactivating glutathione peroxidase 4 (GPX4) and depleting reduced glutathione. Through integrative analysis of tissue…

Oxidative stress, mitochondrial dysfunction, and ferroptosis in the placenta of gestational diabetes mellitus.

Gestational diabetes mellitus (GDM) has become a significant concern in the domain of women's health. The pathophysiology of GDM is complica … oxidative damage leads to mitochondrial dysfunction and further induces ferroptosis by facilitating lipid peroxidation. The objective of this review is to predominantly assess recent research, published within the last five years, that investigates the roles of placental oxidative stress, mitochondrial dysfunction, and ferroptosis as pathological mechanisms influenc …

Ferroptosis: a novel pathway in the pathogenesis and treatment of endometriosis.

As a common chronic disease, endometriosis (EMs) affects nearly 10% of women of childbearing age, may cause other complications such as infertility, and has a tendency to develop malignant tumors. Ferroptosis is a newly discovered apoptotic process characterized by intracellular free iron excess, which mediates Fenton reaction and eventually leads to lipid peroxidation in the cell membrane leading to cell death. The abnormal changes of intracellular iron concentration may lead to the accumulation of reactive oxygen species (ROS) and the imbalance of redox homeostasis, thus leading to the occur…

Ферроптоз: Новый Путь в взаимодействии между Гутом Микробиотой и множественным склерозом.

Множественный склероз (MS) — хроническое аутоиммунное расстройство, отмеченное нейроинфламмацией, обезвоживанием и нервными повреждениями. Последние достижения указывают на новое взаимодействие между железозависимой клеточной смертностью, известной как ферроптоз, и кишечной микробиотой, которая может оказать значительное влияние на патофизиологию MS. Ферроптоз, движущийся липидным пероксидацией и тесно связанный с метаболизмом железа, является одним из основных факторов, вызывающих окислительный стресс, наблюдаемый в MS. В то же время кишечная микробиота, которая, как известно, влияет на систе

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune disorder marked by neuroinflammation, demyelination, and neuronal damage. Recent advancements highlight a novel interaction between iron-dependent cell death, known as ferroptosis, and gut microbiota, which may significantly influences the pathophysiology of MS. Ferroptosis, driven by lipid peroxidation and tig…