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Danggui Buxue decoction regulates the immune function and intestinal microbiota of cyclophosphamide induced immunosuppressed mice.

ETHNOPHARMACOLOGICAL RELEVANCE: Danggui Buxue decoction (DBD) is a traditional Chinese herbal formula. According to the theory of traditional Chinese medicine, the combination of Astragali Radix (AR) and Angelica sinensis (AS) is a classic prescription of tonifying qi and enriching blood. DBD has the functions of hematopoietic, immune enhancement and inflammation inhibition, usually used to treat qi and blood deficiency symptoms. AIM OF THE STUDY: Cyclophosphamide (CY) can inhibit humoral and cellular immunity, leading to the overall immune disorder of the body, resulting in immunosuppressive…

A refined formula derived from Jiawei-Xiaoyao pill exerts rapid antidepressant-like effects in LPS-induced depression by reducing neuroinflammation and restoring neuroplasticity signaling.

ETHNOPHARMACOLOGICAL RELEVANCE: Jiawei-Xiaoyao Pill (JWX), a classic formula in traditional Chinese medicine, is derived from Xiaoyao Pill b … mechanism for both JWX and the refined formula. MATERIALS AND METHODS: Individual herbs (MC; ASR, Angelica Sinensis Radix; Bupleuri Radix; Paeonia Radix Alba) that show antidepressant-like responses were mixed with GF at the proportional dosage in JWX to identify the refined formula. Rapid antidepressant-like effects were assessed by using NSF (Novelty S …

Refractory Periungual Warts Treated with Filiform Fire Needle Combined with Warming-Yang and Collateral-Dredging Chinese Medicine Soak: A Two-Case Report.

RATIONALE: Periungual warts, caused by Human Papillomavirus (HPV) infection, are a therapeutic challenge due to their proximity to the nail … ction (10 g Ramulus Cinnamomi, 6 g Rhizoma Zingiberis, 15 g Poria Cocos, 20 g Coix Seed, 12 g Radix Angelicae Sinensis, 9 g Flos Carthami, 15 g Radix Isatidis, 15 g Folium Isatidis; decocted to 200 mL, soaked at 40-45°C for 20 minutes each time). OUTCOMES: The 38-year-old male patient achieved complete wart shedding after 3 treatments (6 weeks), and the 6 …

[Scientific connotation of Jianpi Huogu Formula in treating steroid-induced ONFH based on lipid metabolism reprogramming and transcriptional regulatory network].

This study systematically elucidated the scientific connotation of Jianpi Huogu Formula in treating phlegm-stasis blocking collaterals syndr … rrected lipid metabolism disorders. The activating blood circulation and dredging collaterals group(Angelicae Sinensis Radix, Chuanxiong Rhizoma, Paeoniae Radix Rubra, Achyranthis Bidentatae Radix, and Cinnamomi Ramulus) exerts effects through 197 chemical components by intervening in the chemokine and NOD-like receptor pathways, inhibiting the formation o …

[Effect of acupoint application of Zhanjin Huoxue formula combined with local cold compress on swelling and pain after knee arthroscopy in patients with knee osteoarthritis].

OBJECTIVE: To compare the effect between acupoint application of Zhanjin Huoxue formula combined with local cold compress and simple local cold compress on swelling and pain after knee arthroscopy in patients with knee osteoarthritis (KOA). METHODS: A total of 62 KOA patients with knee swelling after knee arthroscopy were randomly divided into an observation group and a control group, 31 cases in each group. In the control group, cold compress was adopted after surgery, 3 times a day. On the basis of the treatment as the control group, acupoint application of Zhanjin Huoxue formula (angelicae…

Jiajian Shuyu Pills ameliorates cerebral ischemia-reperfusion injury by regulation hippo signaling and the lipid metabolism-ferroptosis axis.

ETHNOPHARMACOLOGICAL RELEVANCE: Ischemic stroke is a life-threatening cerebrovascular disease characterized by focal injury to the central nervous system. Jiajian Shuyu Pills (JJSYP), a modified traditional Chinese medicine formulation derived from Shuyu Pills, consist of multiple herbs, including Rhizoma Dioscoreae, Polygonum multiflorum Thunb, Rehmannia glutinosa Libosch, Codonopsis pilosula (Franch.) Nannf, Atractylodes macrocephala Koidz, Poria cocos (Schw.) Wolf, Paeonia lactiflora Pall, Angelica sinensis (Oliv.) Diels, Ligusticum chuanxiong Hort, Eucommia ulmoides Oliv, Polygala tenuifol…

Xiaoyaosan ameliorates CUMS-induced depressive-like and anorexia behaviors in mice via necroptosis related cellular senescence in hypothalamus.

ETHNOPHARMACOLOGICAL RELEVANCE: Depression and anorexia often co-occur and share symptoms such as low mood, lack of energy, and weight loss. … mone in licorice root, Glabridin in licorice root regulates ABL1, and β-sitosterol found in Chinese angelica, debark peony root, and fresh ginger regulates MYC. Finally, through in vivo experiments, the expression of necroptosis in the hypothalamus of CUMS mice was verified. The regulatory effects of Xiaoyaosan on key substances RIPK1, RIPK3, MLKL, and p-M …

Immunomodulaton and attenuation of lethal influenza A virus infection by oral administration with KIOM-C.

Herbal medicine is used to treat many conditions such as asthma, eczema, premenstrual syndrome, rheumatoid arthritis, migraine, headaches, menopausal symptoms, chronic fatigue, irritable bowel syndrome, cancer, and viral infections such as influenza. In this study, we investigated the antiviral effect of KIOM-C for the treatment of influenza A virus infection. Our results show that oral administration of KIOM-C conferred a survival benefit to mice infected with the 2009 pandemic H1N1 [A(H1N1)pdm09] virus, and resulted in a 10- to 100-fold attenuation of viral replication in ferrets in a dose-d

[Medication rules and mechanisms of treating chronic renal failure by Jinling medical school based on data mining, network pharmacology, and experimental validation].

This study aims to explore the medication rules and mechanisms of treating chronic renal failure(CRF) by Jinling medical school based on dat … XF)] included "Astragali Radix, Rhei Radix et Rhizoma, Poria, Salviae Miltiorrhizae Radix, and Angelicae Sinensis Radix". The network pharmacology analysis showed that HXF had 91 active compounds and 250 corresponding protein targets including prostaglandin-endoperoxide synthase 2(PTGS2), PTGS1, sodium voltage-gated channel alpha subunit 5(SCN5A) …

The Herba Patriniae (Caprifoliaceae): A review on traditional uses, phytochemistry, pharmacology and quality control.

ETHNOPHARMACOLOGICAL RELEVANCE: Herba Patriniae has been used for thousands of years in China as a traditional Chinese medicine with heat-clearing and detoxicating effects. It is applied widly for the treatment of rheumatoid arthritis, diarrhea, acute hepatitis, pelvic inflammatory disease and ulcerative colitis in clinic. Two species, namely Patrinia scabiosaefolia Fisch. (PS) and Patrinia villosa Juss. (PV) from the Caprifoliaceae family, are considered as Herba Patriniae in the pharmaceutical industry. AIM OF THE REVIEW: This paper aims to comprehensively outline the traditional uses, bota

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… Sinensis Radix, Aurantii Fructus Immaturus, Paeoniae Radix Alba, Tetrapanacis Medulla Qian Jin Fang ⟪千金方⟫ Volume 23 ( Sun, 1998 ) Danggui Xi Tang (当归洗汤) Decoction Angelicae Sinensis Radix, Angelicae Pubescentis Radix, Angelicae Dahuricae Radix, Sanguisorbae Radix, Herba Patriniae, Qian Jin Fang ⟪千金方 … Sinensis Radix, Aurantii Fructus Immaturus, Paeoniae Radix Alba, Tetrapanacis Medulla | Qian Jin Fang ⟪千金方⟫ Volume 23 ( Sun, 1998 ) Danggui Xi Tang (当归洗汤) | Decoction | Angelicae Sinensis Radix, Angelicae Pubescentis Radix, Angelicae Dahuricae Radix, Sanguisorbae Radix, Herba Patriniae, | Qian Jin Fang …

A systems-pharmacology analysis of herbal medicines used in health improvement treatment: predicting potential new drugs and targets.

For thousands of years, tonic herbs have been successfully used all around the world to improve health, energy, and vitality. However, their underlying mechanisms of action in molecular/systems levels are still a mystery. In this work, two sets of tonic herbs, so called Qi-enriching herbs (QEH) and Blood-tonifying herbs (BTH) in TCM, were selected to elucidate why they can restore proper balance and harmony inside body, organ and energy system. Firstly, a pattern recognition model based on artificial neural network and discriminant analysis for assessing the molecular difference between QEH an

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… Disease | TCM | Molecular | Target | Reference* Regulate hemopoietic growth factor | Radix paeoniae alba | Albiflorin | PKC α | Radix paeoniae alba | Paeonioflorin | IL-6, LBP, PKC α , TNF | Angelica sinensis | Ferulic acid | ADRA2A, PTGER4, SHP-2, F2, TUBB1 | Angelica sinensis | ligustilide | SOD1 … Clinical studies demonstrated that Angelica sinensis extract promotes hematopoiesis and thrombopoiesis in the mouse model. This effect results from the anti-apoptosis activity of Angelica sinensis and is likely to involve the PI3K/AKT pathway [ 89 ]. …

[Treatment of diabetic nephropathy by integrative medicine: a multi-center prospective cohort study].

OBJECTIVE: To assess the efficacy and safety of integrative medicine (IM) treatment for diabetic nephropathy (DN), and to explore the medica … gwort root (35.4%), Chinese magnolia-vine fruit (29.5%), safflower (27.9%), peach seed (26.2%), and angelica root (25.3%). There was no abnormal liver function, blood abnormalities, and serious adverse events in two groups during the follow-ups. CONCLUSIONS: CM treatment based on syndrome typing in combination with routine Western medicine for DN could re …

Anhydroicaritin suppresses tumor progression via the PI3K/AKT signaling pathway in hepatocellular carcinoma.

BackgroundHepatocellular carcinoma (HCC) is one of the most malignant tumors. The in vitro experiments on the application of Anhydroicaritin (AHI), the active ingredient of Bushen Huayu Decoction, in HCC treatment remain limited, particularly regarding its molecular mechanism.MethodsThe TCMSP platform was used for drug ingredient screening. The GeneCards database and DisGeNET database are used to collect liver cancer targets. PPI network construction of active component-target intersection target was completed with string database. The GO and KEGG pathway analyses were performed via bioinforma

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… The active ingredients of Bushen Yangxue Huayu Decoction included Radix Rehmanniae, Eucommia ulmoides, Radix Paeoniae Alba, Radix Achyranthis, Radix Astragali, Herba Epimedii, Radix Angelicae Sinensis, Radix Carthamus, Caulis spatholobi, Cistanche deserticola, Rhizoma dogleg, and Radix Aucklandiae. … The active components of Radix Rehmanniae, Eucommia ulmoides, Radix Paeoniae Alba, Achyranthes bidentata, Radix Astragali, Epimedium, Angelica sinensis, safflower, Caulis spatholobi, Cistanche deserticola, Rhizoma dogleg and Radix Aucklandiae were retrieved respectively. …

[Effect of herbal cake-separated moxibustion on behavioral stress reactions and blood lactic acid level and muscular AMPK/PGC-1α signaling in rats with chronic fatigue syndrome].

OBJECTIVE: To observe the effect of herbal cake-separated moxibustion (HCSM) on serum lactic acid (BLA) level and AMPK/PGC-1α signaling path … 1 days. The herbal cake was made of Xiaoyao Powder (Mental Ease Powder, composed of [Danggui (Radix Angelicae Sinensis), Baishao (Radix Paeoniae Alba), Chaihu (Radix Bupleuri), Fuling (Poria), Baizhu (Rhizoma Atractylodis, Macrocephalae), etc.]. The HCSM was applied to "Shenque" (CV8), "Guanyuan "(CV4), bilateral "Zusanli" (ST36) and "Qimen" (LR14), 5 moxa …

Traditional herbal medicine for the prevention of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis with association rule analysis.

IntroductionThis systematic review and meta-analysis evaluated the preventive efficacy and safety of orally-administered traditional herbal medicine (THM) for the management of chemotherapy-induced peripheral neuropathy (CIPN) in patients with cancer.MethodsRandomized controlled trials (RCTs) evaluating the efficacy of orally-administered THM in the prevention of CIPN published up to 30 April 2024 were retrieved from nine databases. The primary outcome was the incidence of CIPN, and the secondary outcomes included changes in neuropathic pain intensity, nerve conduction study parameters, Karnof

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… Kosterm [ Lauraceae ; Cinnamomi Ramulus] , Paeonia lactiflora Pall. [ Paeoniaceae ; Paeoniae Radix Alba] , Ziziphus jujuba Mill. [ Rhamnaceae ; Zizyphi Fructus] , Zingiber officinale Roscoe [ Zingiberaceae ; Zingiberis Rhizoma Recens] , Angelica gigas Nakai [ Apiaceae ; Angelicae Gigantis Radix] , Glycyrrhiza … [Rhamnaceae ; Zizyphi Fructus] | 18 | 5.19 | 25.08 Zingiber officinale Roscoe [Zingiberaceae ; Zingiberis Rhizoma Recens] | 18 | 5.19 | 30.27 Angelica gigas Nakai [Apiaceae ; Angelicae Gigantis Radix] | 17 | 4.90 | 35.17 Glycyrrhiza glabra L. …

A Natural Organic Compound "Decursin" Has Both Antitumor and Renal Protective Effects: Treatment for Osteosarcoma.

Osteosarcoma is a rare malignant tumor that commonly occurs in children. Anticancer drugs, for example, cisplatin, aid in postsurgery recovery but induce side effects such as renal damage, affecting the life prognosis of patients. Decursin which is one of the bioactive components has been reported for its anti-inflammatory, antioxidant, and antitumor effects, but the effect on osteosarcoma is unexplained. In this study, the research theme was to examine the sensitizing effect of decursin and its influence on cisplatin-induced nephrotoxicity. The cell viability and half maximal inhibitory conce

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… Angelica gigas Nakai (AGN) is a natural plant that grows in Southeast Asia and is used as a Chinese herbal medicine [ 13 , 14 ]. It is effective against dysmenorrhea, amenorrhea, and menopausal syndrome [ 13 ]. … Antibacterial coumarins from Angelica gigas roots. Archives of Pharmacal Research . 2003;26(6):449–452. doi: 10.1007/bf02976860. 17. Han J., Jin W., Ho N. A., et al. …

The therapeutic effect of modified Huangqi Guizhi Wuwu Tang for multiple myeloma: An 18-year follow-up case report.

RationaleMultiple myeloma (MM) is a hematologic malignancy characterized by proliferation of clonal plasma cells in the bone marrow. The median survival has increased to 6 years in recent years. But MM remains incurable. Some studies about the effects of Chinese herb medicine on MM have been carried out. Long survival in MM patients through Traditional Chinese Medicine (TCM) therapies has been reported rarely before.Patient concernsWe report a case of a female patient who was diagnosed with MM in 2000 at the age of 49. She received 9 cycles of multiple chemotherapeutic regimens mainly based on

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… Radix Angelicae Sinensis would be added when the patient had blood deficiency. Both HGWT and Wu Ling San are classical Chinese prescriptions first recorded in Jin Kui Yao Lue. Wu Ling San was also recorded in Shanghan Lun. … When Radix Angelicae Sinensis was added, the modified prescription also included another classical Chinese prescription, Danggui Buxue Tang (Radix Astragali and Radix Angelicae Sinensis). Danggui Buxue Tang was recorded in Nei Wai Shang Bian Huo Lun, written in Yuan dynasty. …

Multifunctional Actions of Ninjinyoeito, a Japanese Kampo Medicine: Accumulated Scientific Evidence Based on Experiments With Cells and Animal Models, and Clinical Studies.

Herbal medicines are currently employed for the treatment of several types of diseases, and also employed for the improvement of Quality of Life (QOL) of patients over the world, in particular, in Asian countries. In Japan, a Japanese herbal medicine namely kampo medicine has been prescribed for the improvement of QOL of patients. Ninjinyoeito (NYT), composed of 12 herbal plants, is one of kampo medicines and used for helping recovery of diseases and improving several symptoms that suffer patients such as anemia, anorexia and fatigue. Recent scientific research approaches to kampo medicines wi

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… NYT is composed of 12 crude ingredients, including Rehmannia root, Japanese angelica root, Atractylodes rhizome, Poria sclerotium, Ginseng, Cinnamon bark, Polygala root, Peony root, Citrus unshiu peel, Astragalus root, Glycyrrhiza, and Schisandra fruit. … Japanese angelica root Japanese angelica root contains many of bioactive components. One of main components is ligustilide ( 30 ). Ligustilide has antiinflammatory and antinociceptive effects ( 28 , 29 ). …

Chinese Herbal Medicine Is Helpful for Survival Improvement in Patients With Multiple Myeloma in Taiwan: A Nationwide Retrospective Matched-Cohort Study.

Aim of the studyThe purpose of this study is to demonstrate that Chinese herbal medicine is beneficial for survival improvement in patients with multiple myeloma.Materials and methodsWe performed a 1:1 propensity score-matched cohort study to analyze patients with multiple myeloma diagnosed between January 1, 2002, and December 31, 2012, through the Taiwanese National Health Insurance Research Database. Patients who received Chinese herbal medicine therapy from the initial date of diagnosis of multiple myeloma to December 31, 2012, were included in the Chinese herbal medicine group. Patients w

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… . | 1,162 | 41 | 13 | 0.26 (0.15-0.48) *** | 0.29 (0.16-0.53) *** Multiherb products Shu-Jing-Huo-Xue-Tan | Zhi-Gan-Cao ( Glycyrrhiza glabra L.), Dang-Gui ( Angelica sinensis (Oliv.) … Schischk), Chuan-Qiong ( Ligusticum chuanxiong Hortorum), Ren-Shan ( Panax ginseng C.A.Mey.), Zhi-Gan-Cao ( Glycyrrhiza glabra L.), Dang-Gui ( Angelica sinensis (Oliv.) …

Analgesic Alkaloids Derived From Traditional Chinese Medicine in Pain Management.

Chronic pain is one of the most prevalent health problems. The establishment of chronic pain is complex. Current medication for chronic pain mainly dependent on anticonvulsants, tricyclic antidepressants and opioidergic drugs. However, they have limited therapeutic efficacy, and some even with severe side effects. We turned our interest into alkaloids separated from traditional Chinese medicine (TCM), that usually act on multiple drug targets. In this article, we introduced the best-studied analgesic alkaloids derived from TCM, including tetrahydropalmatine, aloperine, oxysophocarpine, matrine

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… Types of combination | Drug combinations | Effect Alkaloids + Natural Products | Tetrahydropalmatine + Angelica dahurica (Fisch, ex Hoffm.) Benth.et Hook.f. [Apiaceae; angelicae dahuricae radix] | Angelica dahurica (Fisch, ex Hoffm.) Benth.et Hook.f. … [Apiaceae; angelicae dahuricae radix] could be “Zuo” and “Shi” drug (by strengthen overall health and improve drug exposure). In practice, Angelica dahurica (Fisch, ex Hoffm.) Benth. et Hook.f. …