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Molecular Identification and Epidemiological Features of Human Adenoviruses Associated with Acute Respiratory Infections in Hospitalized Children in Southern China, 2012-2013.

BACKGROUND: Acute respiratory infections (ARI) are the major worldwide health problem associated with high morbidity and mortality rates. Hu … thogens (84/495, 17.0%). The most common co-infection pathogens with HAdV were MP (57.1%) and Human Bocavirus (HBoV) (16.7%). The majority of HAdV infected patients were totally recovered (96.9%, 480/495); However, four (0.8%) patients, who were previously healthy and at the age of 2 years or younger died of pneumonia. Seasonal peaks of HAdV infection occur …

Clinical characteristics, pathogen detection, and severity markers among children with acute respiratory infections during the COVID-19 restriction period: a retrospective hospital-based study.

BACKGROUND: The epidemiology of pediatric acute respiratory infections (ARIs) changed substantially during the COVID-19 (coronavirus disease … was documented in 15 children (24.2%). Human rhinovirus was detected in 15 children (24.2%), human bocavirus in 9 (14.5%), and Mycoplasma pneumoniae in 10 (16.1%); co-detection was recorded in 14 children (22.6%). Lower SpO2 and longer symptom duration differed significantly across severity categories (both p < 0.001). In exploratory logistic regression, e …

Epidemiological characteristics of hospitalized pediatric patients with acute respiratory tract infection during and after the COVID-19 period in Ningbo, China: a retrospective single-center study.

BACKGROUND: This study aimed to investigate the changes in the epidemiological characteristics of respiratory pathogens among hospitalized c … uenza A (FluA), influenza B (FluB), human adenovirus (HAdV), and Mp increased, while those of human bocavirus (HBoV), HRV, and HRSV decreased. No significant changes were observed for human parainfluenza virus (HPIV), Chlamydia (Ch), human metapneumovirus (HMPV), and human coronavirus (HCoV). The positivity rate was consistently higher in males than in fema …

[Epidemiological characteristics of respiratory syncytial virus among inpatients in a children's hospital in Shenzhen City from 2020 to 2023].

This study analyzed the epidemiological characteristics and trends of respiratory syncytial virus (RSV) infections among inpatients with acu … of RSV co-infections with other pathogens (mycoplasma pneumoniae, human parainfluenza virus, human bocavirus, human coronavirus, human metapneumovirus, and influenza A) significantly increased (all P trend<0.01). In conclusion, the epidemiological characteristics of RSV infections in Shenzhen Children's Hospital changed from 2020 to 2023. In 2022, there we …

Respiratory infections in the post-COVID-19 era: impact, prevalence, and clinical characteristics of bacterial and viral co-infections.

INTRODUCTION: Humans are affected by respiratory infections globally, originating from both bacterial and viral agents. However, the pathoge … ). Common pathogens causing mono- and co-infections included SARS-CoV-2, rhinovirus, influenza A/B, bocavirus, adenovirus, Streptococcus pneumoniae, and Streptococcus pyogenes. Mixed infections were more common in children aged <5 years (p < 0.05). The disease resulted in a fatal outcome in four patients (1.3%). Notably, one patient with confirmed Streptoco …

Epidemiology and surveillance of influenza, RSV and SARS-CoV-2 in children admitted with severe acute respiratory infection in West bengal, India from 2022 to 2023.

BACKGROUND: Evaluating the burden of respiratory syncytial virus (RSV) and influenza among young children in LMICs is crucial to inform impl … 13.6%), parainfluenza virus group (6.1%), Staphylococcus aureus (8.6%), Moraxella catarrhalis (5%), bocavirus (3.7%), adenovirus (3.7%), Chlamydia pneumoniae (1%), and Bordetella (1%). Viral-bacterial co-detection occurred in 34%, especially in infants < 6 months. Children with RSV had increased risk of having S. pneumoniae [Odds Ratio OR 6.2, 95% CI 1.8-21 …

Factors associated with outcome in a national cohort of rhinovirus hospitalized patients in Brazil in 2022.

The common cold is the primary cause of illness in the community, with over 200 viral strains identified, and rhinovirus infections being th … e factors associated with death were invasive ventilation (p- < 0.001 HR 4.888 CI 95% 3.816-6.262), bocavirus (p- < 0.001 HR 4.204 CI 95% 2.595-6.812), immunodepression/Immunosuppression (p- < 0.001 HR 2.417 CI 95% 1. 544-3, 786), COVID-19 (p- < 0.001 HR 2.167 CI 95% 1.495-3.142), chronic neurological diseases (p-0.007 HR 1.610 CI 95% 1.137-2.280), abdomina …

Contamination by respiratory viruses on outer surface of medical masks used by hospital healthcare workers.

BACKGROUND: Medical masks are commonly used in health care settings to protect healthcare workers (HCWs) from respiratory and other infectio … vity rate was 10.1% (15/148). Commonly isolated viruses from masks samples were adenovirus (n = 7), bocavirus (n = 2), respiratory syncytial virus (n = 2) and influenza virus (n = 2). Virus positivity was significantly higher in masks samples worn for > 6 h (14.1%, 14/99 versus 1.2%, 1/49, OR 7.9, 95% CI 1.01-61.99) and in samples used by participants who e …

[Detection and clinical characterization of WU polyomavirus in acute respiratory tract infection in children].

OBJECTIVE: WU polyomavirus (WUPyV), a new member of the genus Polyomavirus in the family Polyomaviridae, has been found to be associated wit … respiratory syncytial virus (RSV), parainfluenza virus (PIV) 1 and 3, human metapneumovirus, human bocavirus, adenovirus and rhinovirus] by using PCR or RT-PCR. The clinical data of WUPyV infection were collected and analyzed. RESULT: In this study, fifteen of the 771 tested specimens with acute respiratory tract infection were positive for WUPyV, the pos …

Evaluation of Four Commercial Multiplex Molecular Tests for the Diagnosis of Acute Respiratory Infections.

Acute Respiratory Infections (ARIs) are responsible for considerable morbidity and mortality worldwide. Documentation of respiratory specimens can help for an appropriate clinical management with a significant effect on the disease progress in patient, the antimicrobial therapy used and the risk of secondary spread of infection. Here, we compared the performances of four commercial multiplex kits used in French University Hospital diagnostic microbiology laboratories for the detection of ARI pathogens (i.e., the xTAG Respiratory Viral Panel Fast, RespiFinder SMART 22, CLART PneumoVir and Fast

Bronchiolitis: Analysis of 10 consecutive epidemic seasons.

Bronchiolitis is the leading cause of hospitalization in infants under 12 months. Our aims were to analyze epidemiological characteristics of infants with bronchiolitis over 10 consecutive seasons and to evaluate whether there are any clinical differences between infants hospitalized for bronchiolitis during epidemic peak months and infants in non-peak months. We enrolled consecutive enrolled 723 previously healthy term infants hospitalized at the Paediatric Emergency Department, "Sapienza" University of Rome over the period 2004-2014. Fourteen respiratory viruses were detected from nasopharyn

[Clinical characteristics of bronchiolitis obliterans in pediatric patients].

OBJECTIVE: To analyze the clinical characteristics, image findings, laboratory examination, the therapeutic methods and clinical outcomes of … nza virus (2 cases, 8%), influenza virus A (2 cases, 8%) and influenza virus B (2 cases, 8%), human bocavirus (HBoV) (1 case, 4%). There were 8 cases (31%) with combined infection. Chest X-ray in 10 cases indicated changes suggestive of bronchopneumonia (38%), in only 1 case there was an image of interstitial pneumonia disease (4%). All the patients were di …

Viral Respiratory Infections in Hematological Patients.

Viral infections of the respiratory system represent one of the most important complications in hematological patients in terms of both the severity of the clinical picture and its related impact on the duration of hospitalization, and of mortality. The most implicated viruses are those that commonly cause community-based respiratory diseases: respiratory syncytial virus, Influenza virus and rhinovirus. However, in some cases the clinical picture may be triggered by first infection with or reactivation of pathogens normally not responsible for clinically relevant diseases in immunocompetent su

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… Bocavirus (hBoV) has been associated with 2–19% of all URTI and LRTI worldwide. … There is currently no specific recommended treatment for rhinovirus [ 6 , 11 ], bocavirus [ 11 ], metapneumovirus [ 5 ] and coronavirus [ 5 , 6 , 11 ]. …

Genome characteristics of atypical porcine pestivirus from abortion cases in Shandong Province, China.

BACKGROUND: Atypical porcine pestivirus (APPV) is a novel, highly variable porcine pestivirus. Previous reports have suggested that the viru … kobuvirus, porcine sapovirus, Po-Circo-like virus, porcine serum-associated circular virus, porcine bocavirus 1, porcine parvovirus 1, porcine parvovirus 3 and porcine circovirus 3, etc. The first complete genome sequence(11,556 nt) of APPV in Shandong Province of northern China, was obtained using viral metagenomics and designated APPV-SDHY-2022. Compariso …

Multiplex detection and application of MALDI-TOF NAMS for porcine diarrheal pathogens.

UNLABELLED: Porcine diarrheal diseases caused by mixed viral and bacterial infections pose significant challenges to swine health and production. Rapid and accurate identification of key pathogens, including porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), porcine deltacoronavirus (PDCoV), porcine rotavirus (PoRV), swine acute diarrhea syndrome coronavirus (SADS-CoV), porcine bocavirus (PBoV), hepatitis E virus (HEV), and Salmonella, remains a challenge due to overlapping clinical symptoms and co-infections. The zoonotic potential of HEV and PBoV also highlig…

Viral etiology of severe acute respiratory infections in hospitalized patients, Shandong, China.

BACKGROUND: Severe Acute Respiratory Infection (SARI) represents a critical global public health challenge, accounting for substantial sever … human coronaviruses (HCoV), human metapneumovirus (HMPV), rhinovirus (HRV), enterovirus (EV), human bocavirus (HBoV), human adenovirus (HAdV), and SARS-CoV-2 (COVID-19). RESULTS: 501 samples (28.96%) were tested positive for at least one virus. The most frequently detected viruses and their infection rates were as follows: IFA (11.33%), COVID-19 (6.53%), H …

[Analysis of the pathogen composition and epidemiological characteristics of febrile respiratory syndrome cases in the elderly aged 60 years and above in China from 2009 to 2021].

Objective: To understand the pathogenic composition and epidemiological characteristics of febrile respiratory syndrome (FRS) in elderly peo … s (RSV), adenovirus (HAdV), parainfluenza virus (HPIV), metapneumovirus (HMPV), coronavirus (HCoV), bocavirus and rhinovirus (HRV); 7 bacterias, namely Streptococcus pneumoniae (S.pneumoniae), Staphylococcus aureus (S.aureus), Klebsiella pneumoniae (K.pneumoniae), Pseudomonas aeruginosa (P.aeruginosa), Group A Streptococcus (GAS), Haemophilus influenzae (H. …

From actinic keratosis to squamous cell carcinoma.

Chronic stress-responsive signaling has emerged as a modifiable dimension of cancer biology by linking systemic neuroendocrine activation to tumor-cell adaptation, metabolic rewiring, immune suppression, tumor microenvironment remodeling, metastatic dissemination, and therapeutic resistance. Persistent activation of the sympathetic nervous system (SNS) and the hypothalamic pituitary adrenal (HPA) axis elevates catecholamines and glucocorticoids, which act through adrenergic receptors and the glucocorticoid receptor (GR) in tumor, stromal, vascular, and immune compartments. These canonical path

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… These viruses include adenovirus, influenza (A/B) virus, parainfluenza (1-4), human rhinovirus (A/B/C), respiratory syncytial virus (A and B), human bocavirus (1/2/3/4), human metapneumovirus, human coronavirus (229E, NL63, OC43) and human enterovirus. … HRV = human rhinovirus; HEV = human enterovirus; PIV1-3 = para-influenza virus; HboV = human bocavirus; flu = influenza virus A and B. In total, 13 (15.1%) children were admitted to PICU, nine of whom were younger than 1 year of age ( P = 0.40). …

[Epidemiological characteristics of co-infection with drug-resistant Mycoplasma pneumoniae and non-bacterial pathogens in a children's hospital in Ningbo City from 2021 to 2024].

To investigate the epidemiological characteristics of co-infection involving macrolide-resistant Mycoplasma pneumoniae (MRMP) and non-bacter … -old age group. The positive rate for mixed infections involving respiratory syncytial virus, human bocavirus, and parainfluenza virus was notably higher in the 0- to 3-year-old age group. Following the removal of non-pharmaceutical interventions (NPIs) in December 2022, the co-infection rate of other respiratory viruses and MRMP increased in Ningbo City. I …

[Pathogenic agents causing acute respiratory tract infections in pediatric patients in Spring, 2023, in Beijing].

Objective: To explore the pathogenic agents of acute respiratory infection (ARI) in children in Beijing. Methods: In the cross-sectional stu … virus (PIV), and the inpatient ARI group under nucleic acid testing for Flu, RSV, HMPV, ADV, human bocavirus (HBoV), Rhinovirus (Rh), PIV, coronavirus (HCoV), Mycoplasma pneumoniae (Mp) and Chlamydia pneumonia (Cp). Results: There were 320 influenza-like cases enrolled, including 192 males and 128 females, aged 4.7 (3.6, 6.9) years, and 117 cases (36.6%) p …