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A prospective, open-label trial of clevidipine for controlled hypotension during posterior spinal fusion.

OBJECTIVES: Controlled hypotension is one means to limit or avoid the need for allogeneic blood products. Clevidipine is a short-acting, int … le for inclusion. The study was an open label, observational study. Maintenance anesthesia included desflurane titrated to maintain a bispectral index at 40 to 60 and a remifentanil infusion. Motor and somatosensory evoked potentials were monitored intraoperatively. When the mean arterial pressure (MAP) was ≥ 65 mmHg despite remifentanil at 0.3 mcg/kg/min, c …

Propofol. A pharmacoeconomic appraisal of its use in day case surgery.

Propofol is an intravenous anaesthetic agent that has become widely used in day case surgery. It induces anaesthesia rapidly and 'smoothly', … nce was generally less than 1 hour. However, when compared with volatile anaesthetics (particularly desflurane), the differences in time to discharge were smaller. Propofol is also associated with less PONV than barbiturates, volatile anaesthetics or barbiturate/volatile anaesthetic combinations in the immediate postoperative period. The faster recovery time …

[Clinical use of the ProSeal™ laryngeal mask in infants, children and adolescents : prospective observational survey].

BACKGROUND: In contrast to the adult population scientific data on ProSeal™-LMA (PLMA) usage in infants, children, and adolescents are rathe … ravenous anesthesia (propofol) in 184 patients (36.5%) and by an inhalational agent (sevoflurane or desflurane) in 320 patients (63.7%). Neuromuscular blocking agents were used in 7 patients (1.4%). The patients were anesthetized for an average of 80 min (range 15-270 min) and insertion success rate was 99% with a maximum of 3 attempts. The average initial a …

Economic and Environmental Considerations During Low Fresh Gas Flow Volatile Agent Administration After Change to a Nonreactive Carbon Dioxide Absorbent.

BACKGROUND: Reducing fresh gas flow (FGF) during general anesthesia reduces costs by decreasing the consumption of volatile anesthetics and … nutes) was evaluated. RESULTS: A total of N = 20,235 cases were analyzed (80.2% sevoflurane, 15.1% desflurane, and 4.7% isoflurane). Intraoperative FGF was reduced for cases in which sevoflurane was administered by 435 mL/min (95% confidence interval [CI], 391 to 479 mL/min; P < 10). Hypothesis 1 was accepted. Sevoflurane consumption per minute of administr …

Upper-limb somatosensory evoked potential monitoring in lumbosacral spine surgery: a prognostic marker for position-related ulnar nerve injury.

BACKGROUND CONTEXT: Somatosensory evoked potential (SSEP) is used to monitor integrity of the brain, spinal cord, and nerve roots during spi … e positioned prone on Jackson or Andrews spinal table. Anesthesia was maintained with inhalant gas (desflurane or sevoflurane) and propofol infusion with and without minimal infusion of narcotics (fentanyl, sufentanyl, or remifentanil). Intraoperative neurophysiologic monitoring of upper-limb or ulnar SSEP was achieved by continuously recording cortical and …

Indications for Sleeve Gastrectomy-Is It Worth Waiting for Comorbidities to Develop?

(1) Background and Objectives: Morbid obesity significantly increases the prevalence of comorbidities, such as heart disease, restrictive lung disease, stroke, diabetes mellitus and more. (2) Methods: Patients undergoing gastric sleeve surgery were divided into three groups with BMI between 30-34.9 kg/m2 (Group I), 35-39.9 kg/m2 (Group II), and over 40 kg/m2 (Group III). Preoperative examinations included cardiac ultrasound, respiratory function and laboratory tests, and preoperative comorbidities were also recorded. Following a one-year follow-up, we compared the rate of weight loss in the th

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… Desflurane was used to maintain anesthesia. NSAIDs were administered for postoperative analgesia. Data were analyzed using IBM Statistic software version 20.0, and the Spearman’s correlation analysis and Kruskal-Wallis test were used for statistical analysis. …

Новый тип нарушения почечной функции после радикальной нефрэктомии при почечной карциноме: ретроспективное исследование клинических, интраоперационных и постоперационных факторов риска.

ОБЗОР: Радикальная нефрэктомия является рекомендованным методом лечения локализованного нефрогенного карциномы, когда частичная нефрэктомия не возможна. Этот подход обычно применяется у пациентов с нормальной контрлатеральной нефридой и отсутствием предшествующего хронического почечного заболевания (ХПО). Основная проблема с операцией заключается в потенциальном долгосрочном влиянии на почечную функцию. ЦЕЛИ: Оценить риск развития хронического почечного заболевания после радикальной нефрэктомии. МЕТОДЫ И ПРОЕКТ: Это ретроспективное когортное исследование пациентов с нормальной предоперационн

Совпадение в полном тексте источника
… Studies have shown that propofol anesthesia was associated with a lower risk of AKI and CKD than volatile anesthesia, with no significant differences between sevoflurane and desflurane on renal function. 10 , 31 In this study, all but three patients received maintenance sevoflurane volatile anesthesia …

Radiocopper in BCMA-targeted immunotheranostics of myeloma.

BACKGROUND: The theranostic potential of copper-64 (PET imaging) and copper-67 (SPECT imaging and therapy) is increasingly recognized. This work investigates the performance of this 'true' matched pair in a preclinical radioimmunotheranostic setting that utilizes experimental monoclonal antibodies (mAbs) directed against B cell maturation antigen (BCMA), a transmembrane glycoprotein that has emerged as a critical target for the treatment of multiple myeloma (MM). METHODS: The commercially available BCMA-directed mAbs MAB193 and Vicky-1 were modified with the bispidine N2py4 enabling chelation

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… After the final experiment, anesthetized animals were sacrificed under desflurane anesthetic (Baxter, Deerfield, IL; USA) using CO 2 inhalation and cervical dislocation. …

Abstracts of the ICARE 2024 78th SIAARTI National Congress

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Physiological functions and pharmacological targeting of transient receptor potential channels.

Transient receptor potential (TRP) channels represent an extensive and diverse protein family fulfilling salient roles as versatile cellular sensors and effectors. The pivotal role of TRP and related ion channels in sensory processes has been well documented. Over the last few years, a new concept has emerged that TRP proteins control an exceptionally broad spectrum of homeostatic physiological functions such as maintenance of body temperature, blood pressure, transmitter release from neurons, mineral and energy homeostasis, and reproduction. This notion is further supported by more than 20 he

Резюме МКАРЕ 2023 77th Национальный конгресс &quot; СИААРТИ &quot;

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