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Innovative Biomaterials for the Treatment of Bone Cancer.

Bone cancer is a demanding challenge for contemporary medicine due to its high frequency of presentation and significant heterogeneity of malignant lesions developing within the bone. To date, available treatments are rarely curative and are primarily aimed at prolonging patients' survival and ameliorating their quality of life. Furthermore, both pharmacological and surgical therapies are aggravated by a consistent burden of adverse events and subsequent disability due to the loss of healthy bone structural and functional properties. Therefore, great research efforts are being made to develop

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… Europium-doped amorphous calcium phosphate porous nanospheres: Preparation and application as luminescent drug carriers Nanoscale Res. Lett. 2011 6 67 10.1186/1556-276X-6-67 21711603 PMC3212214 78. Zhou Z.F. Sun T.W. Chen F. Zuo D.Q. Wang H.S. Hua Y.Q. Cai Z.D. Tan J. …

Nanohydroxyapatite (nHAp) Doped with Iron Oxide Nanoparticles (IO), miR-21 and miR-124 Under Magnetic Field Conditions Modulates Osteoblast Viability, Reduces Inflammation and Inhibits the Growth of Osteoclast - A Novel Concept for Osteoporosis Treatment: Part 1.

PURPOSE: Osteoporosis results in a severe decrease in the life quality of many people worldwide. The latest data shows that the number of osteoporotic fractures is becoming an increasing international health service problem. Therefore, a new kind of controllable treatment methods for osteoporotic fractures is extensively desired. For that reason, we have manufactured and evaluated nanohydroxyapatite (nHAp)-based composite co-doped with iron oxide (IO) nanoparticles. The biomaterial was used as a matrix for the controlled delivery of miR-21-5p and miR-124-3p, which have a proven impact on bone

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… The Potential Selective Cytotoxicity of Poly (L- Lactic Acid)-Based Scaffolds Functionalized with Nanohydroxyapatite and Europium (III) Ions toward Osteosarcoma Cells . Materials . 2019 ; 12 ( 22 ): 3779 . doi: 10.3390/ma12223779 PMC6888250 31752084 36. …

TSP-1 interaction with RANK and OPG: implications for bone remodeling and osteolytic bone metastasis.

Excessive bone disruption, driven by upregulation of bone-degrading osteoclasts, occurs in several pathologies, including breast cancer osteolytic bone metastasis, a condition associated with poor prognosis and diminished quality of life for patients. The matricellular protein thrombospondin-1 (TSP-1) plays pleiotropic roles in physiological and pathological remodeling of several tissues, including bone, and in shaping the microenvironment of primary tumors and metastasis. This study aimed to explore the role of TSP-1 in bone remodeling associated with osteolytic bone metastasis. We have ident

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… Moreover, E123CaG did not prevent the binding of Europium-labeled RANKL to RAW 264.7 cells (Supplementary Fig. 2B ), confirming the lack of binding competition also in a more physiological setting that preserves the receptor plasticity and the physiological movements in the cell membrane required for …

In Vivo Bone Tissue Engineering Strategies: Advances and Prospects.

Reconstruction of critical-sized bone defects remains a tremendous challenge for surgeons worldwide. Despite the variety of surgical techniques, current clinical strategies for bone defect repair demonstrate significant limitations and drawbacks, including donor-site morbidity, poor anatomical match, insufficient bone volume, bone graft resorption, and rejection. Bone tissue engineering (BTE) has emerged as a novel approach to guided bone tissue regeneration. BTE focuses on in vitro manipulations with seed cells, growth factors and bioactive scaffolds using bioreactors. The successful clinical

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… Natarajan et al. presented the group of rare earth metal-based nanoparticles (cerium, gold, europium, gadolinium and others) as emerging perspective biomaterials for BTE. …

Гибридные композитные соединения с оксидами металлов: всеобъемлющий обзор синтеза и многофункциональных видов применения.

В ряде передовых технологий может использоваться разнообразное семейство композитных полимерных (CP) составов с особыми физико-химическими свойствами (MO x). В настоящем исследовании представлен всеобъемлющий обзор комплексных подходов к этим гибридным композитным материалам с уделением особого внимания синергической интеграции оксидов металлов с ХП в целях укрепления их структурной основы, а также их электрических и каталитических свойств. Изучается многофункциональное применение этих материалов, в частности в таких областях, как биомедицинское зондирование, энергосберегающие модули и техноло

Chest and Mediastinum

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… The detector plates often contain Barium fluoro bromide crystals doped with Europium. Energy from X-ray photons falling on the detector plate is absorbed and thereby electrons are raised to higher energy levels. …

Organelle-oriented nanomedicines in tumor therapy: Targeting, escaping, or collaborating?

Precise tumor therapy is essential for improving treatment specificity, enhancing efficacy, and minimizing side effects. Targeting organelles is a key strategy for achieving this goal and is a frontier research area attracting a considerable amount of attention. The concept of organelle targeting has a significant effect on the structural design of the nanodrugs employed. Most notably, the intricate interactions among different organelles in a tumor cell essentially create a unified system. Unfortunately, this aspect might have been somewhat overlooked when existing organelle-targeting nanodru

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… According to recent studies, metal complexes containing easily-modified coordination ligands and various transition metals, including iridium( iii ), gold( iii ), copper, europium, manganese, platinum, cobalt, nickel, zinc, rhodium, antimony, and osmium, exhibit the ability to target mitochondria [ 61 …

ISEV2020 Резюме

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Всемирный конгресс молекулярного воображения 2022.

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The Fifth International Meeting of ISEV, ISEV2016, Rotterdam, The Netherlands, 4 - 7 May, 2016.

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The 46th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Poster Session (P001-P706).

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Абстрактный сборник ISEV2022.

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ISEV2018 абстрактная книга

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The 48th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Poster Session (P001 - P578).

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:: 45th Ежегодное совещание Европейского общества по трансплантации крови и костного мозга: Врачи - сессия плаката.

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ISEV2025 Резюме книги.

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Резюме книги для 27th Конгресс Европейской ассоциации гематологии

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