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[Effects of oliceridine versus sufentanil for anesthesia induction and postoperative analgesia on postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgery: a randomized controlled trial].

Objective: To investigate the effects of oliceridine versus sufentanil for anesthesia induction and postoperative patient-controlled intrave … sthesia induction and PCIA, while Group S received sufentanil; both groups received ondansetron and flurbiprofen axetil in combination. The primary outcome was the incidence of PONV within 48 hours postoperatively. Secondary outcomes included the incidence of nausea and vomiting during 0-<24 h and 24-48 h postoperatively, severity of nausea within 24 hours pos …

Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease.

BackgroundAlzheimer's disease (AD) is the most common form of dementia. The incidence of AD rises exponentially with age and its prevalence … iclofenac sodium OR diflunisal OR diflusinal OR etodolac OR etoricoxib OR fenbufen OR fenoprofen OR flurbiprofen OR hydrocortisone OR ibuprofen OR indometacin OR indomethacin OR ketoprofen OR lumiracoxib OR mefenamic OR meloxicam OR methylprednisolone OR nabumetone OR naproxen OR nimesulide OR "anti-inflammatory" OR prednisone OR piroxicam OR sulindac OR tenox …

The comparison of efficacies of topical corticosteroids and nonsteroidal anti-inflammatory drops on dry eye patients: a clinical and immunocytochemical study.

PURPOSE: To investigate whether conjunctival inflammation represents a primary event in the pathogenesis of keratoconjunctivitis sicca or whether it is a secondary inflammatory reaction caused by enhanced mechanical irritation as a result of surface dryness and whether anti-inflammatory drops (corticosteroids and nonsteroidal anti-inflammatory) have therapeutic effects and are similar. DESIGN: Single-masked, randomized, prospective clinical trial. METHODS: Thirty-two keratoconjuctivitis patients with or without Sjögren syndrome were included in the study. The patients were randomized to thre

Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer.

Prostaglandin endoperoxide H synthase-2 (PGHS-2), also known as cyclooxygenase-2 (COX-2), is a sequence homodimer. However, the enzyme exhibits half-site heme and inhibitor binding and functions as a conformational heterodimer having a catalytic subunit (Ecat) with heme bound and an allosteric subunit (Eallo) lacking heme. Some recombinant heterodimers composed of a COX-deficient mutant subunit and a native subunit (i.e. Mutant/Native PGHS-2) have COX activities similar to native PGHS-2. This suggests that the presence of heme plus substrate leads to the subunits becoming lodged in a semi-stab

Anti-inflammatory agents in the management of alimentary mucositis.

BACKGROUND: Alimentary mucositis is a significant complication of cancer therapy, with important clinical and economic implications. MATERIALS AND METHODS: In June 2005, the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology conducted an evidence-based review of the literature on alimentary mucositis. The goal of this literature review was to update previously published guidelines for the management of mucositis. RESULTS: This article reports the findings of the subgroup charged with reviewing the literature related to

Comparative Effectiveness of Three Prophylactic Strategies to Prevent Clinical Macular Edema after Phacoemulsification Surgery.

PURPOSE: To study the relationship of chemoprophylaxis and other factors with the occurrence of acute, clinical, postoperative macular edema. DESIGN: Retrospective cohort study. The drug regimens consisted of postoperative topical prednisolone acetate (PA) alone or with a nonsteroidal anti-inflammatory drug (NSAID) or intraoperative subconjunctival injection of 2 mg triamcinolone acetonide (TA) alone. PARTICIPANTS: Patients undergoing phacoemulsification at Kaiser Permanente, Diablo Service Area, Northern California, from 2007 through 2013. METHODS: We identified incident macular edema diag

[Effectiveness and safety of multimodal analgesia in open gastrostomy in patients with end-stage head and neck cancer].

Objective: To investigate the effectiveness and safety of multimodal analgesia in patients with end-stage head and neck cancer in open gastr … k and transverse abdominis plane block)+intravenous injection of oxycodone+intravenous injection of flurbiprofen axetil and dexamethasone. In local anesthesia group, local infiltration anesthesia with ropivacaine was adopted. The main outcome measure was the incidence of intraoperative pain numeric rating scale (NRS) score>3 points in the two groups. The secon …

Anti-Aβ agents for mild to moderate Alzheimer's disease: systematic review and meta-analysis.

OBJECTIVE: To assess the efficacy and safety of Aβ-targeting agents for mild to moderate Alzheimer's disease. METHODS: The MEDLINE, Embase, Cochrane Central Register of Controlled Trials, PsycINFO, ClinicalTrials.gov and the WHO's International Clinical Trials Registry Platform search portal were searched from their inception to April 2020. We generated pooled estimates using random effects meta-analyses. RESULTS: Nineteen randomised controlled trials, of which 17 had a low risk of bias, included 12 903 participants. The meta-analysis showed no difference in the cognitive subscale of Alzheim

Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.

BACKGROUND: Alzheimer disease is a multifactorial disorder characterized by the progressive deterioration of neuronal networks. The pathological hallmarks includes extracellular amyloid plaques and intraneuronal neurofibrillary tangles, but the primary cause is only partially understood. Thus, there is growing interest in developing agents that might target multiple mechanisms leading to neuronal degeneration. CHF5074 is a nonsteroidal anti-inflammatory derivative that has been shown to behave as a γ-secretase modulator in vitro and to inhibit plaque deposition and to reverse memory deficit in

Effect of working length measurement by electronic apex locator or digital radiography on postoperative pain: a randomized clinical trial.

INTRODUCTION: The aim of this study was to evaluate the effect of working length determination methods, electronic apex locator and digital radiography, on postoperative pain. METHODS: Two hundred twenty patients with asymptomatic single-rooted vital teeth were randomly assigned to 2 groups according to the method used for working length determination, the radiographic group and the electronic apex locator group. After working length determination, chemomechanical preparation was performed in a crown-down technique with ProTaper instruments. A master cone radiograph was taken. Canals were obt

Migraine prophylactic drugs: proof of efficacy, utilization and cost.

OBJECTIVES: In order to understand the pattern of utilization of migraine prophylactic drugs by US physicians, we reviewed the scientific ri … che frequency when on placebo vs active drug is > 50%. Of the drugs available in the United States, flurbiprofen and metoprolol achieved the best ss (5.00 and 4.33, respectively) but their efficacy over placebo (23% and 14-33%, respectively) and cost ($67.2 and $65.6) were unfavorable. Neurologists and PCPs chose migraine prophylaxis on the basis of scientific …

Low-dose dexmedetomidine improves postoperative sleep and pain in gynecological surgery: a randomized trial.

BACKGROUND: Postoperative sleep disturbances often lead to a vicious cycle with pain, severely hindering the recovery of patients. Women, du … 0 mmHg), postoperative nausea and vomiting (PONV), and the use of rescue analgesia with intravenous flurbiprofen axetil. RESULTS: For the primary outcome, the incidence of sleep disturbance (PSQI ≥ 5) was significantly lower in the DS group compared to the S group (21.5% vs. 47.7%, P = 0.002). Regarding secondary outcomes, PSQI scores on the first and second …

Incidence of mucocutaneous reactions in children treated with niflumic acid, other nonsteroidal antiinflammatory drugs, or nonopioid analgesics.

BACKGROUND AND OBJECTIVE: Results from a relatively small case-control study recently showed that niflumic acid increases the risk of seriou … prescribed drugs were niflumic acid, acetaminophen, and propionic acid derivatives (ketoprofen and flurbiprofen). Users of niflumic acid (n = 32150) were younger and slightly more often had otitis media or upper respiratory tract infections as an indication compared with the other NSAIDs. During use of the various study drugs we identified 1451 mild mucocutan …

Is pomegranate juice a potential perpetrator of clinical drug-drug interactions? Review of the in vitro, preclinical and clinical evidence.

The area of fruit juice-drug interaction has received wide attention with numerous scientific and clinical investigations performed and reported for scores of drugs metabolized by CYP3A4/CYP2C9. While grapefruit juice has been extensively studied with respect to its drug-drug interaction potential, numerous other fruit juices such as cranberry juice, orange juice, grape juice, pineapple juice and pomegranate juice have also been investigated for its potential to show drug-drug interaction of any clinical relevance. This review focuses on establishing any relevance for clinical drug-drug intera

Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase.

We assessed the role of cyclic nucleotides in modulating lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNF-alpha) generation in human peripheral blood monocytes. Exposure of monocytes to LPS (3 ng/ml) evoked a delayed, time-dependent generation of TNF-alpha that reached a maximum level 5-6 hr after LPS challenge and remained constant for up to 24 hr. This effect was concentration dependent and resulted in a 20-40-fold increase in the release of TNF-alpha that was sensitive to actinomycin D and cycloheximide. Treatment of monocytes with agents reputed to activate the cAMP/cAMP-d

Single dose dipyrone (metamizole) for acute postoperative pain in adults.

BACKGROUND: Dipyrone (metamizole) is a nonsteroidal anti-inflammatory drug used in some countries to treat pain (postoperative, colic, cance … ipants). In addition to placebo, all studies used active controls (ibuprofen, paracetamol, aspirin, flurbiprofen, ketoprofen; 338 participants). Seven studies used the oral route of administration, and one study used the intramuscular route. The mean age ranged from 23 to 62 years. Six studies included both men and women, and two studies included only women. A …

Krukenberg's Spindle-Like Corneal Changes in a Patient With Prolonged ICU Admission: A Case Report.

Krukenberg's spindles are vertical, spindle-shaped pigment deposits on the posterior cornea and are primarily associated with pigment dispersion syndrome (PDS). We present a case of Krukenberg's spindle-like corneal changes in a 39-year-old male patient following prolonged ICU management for thyroid storm complicated by infective endocarditis. The patient's complex ICU course included mechanical ventilation, veno-arterial extracorporeal membrane oxygenation (VA-ECMO), and multiple medications. Ophthalmological examination revealed bilateral, brownish, linear changes in the central corneal stro

Совпадение в полном тексте источника
… hydrate sodium | Intravenous injection August 31 | September 15 | Cefazolin sodium | Intravenous injection September 8 | September 8 | Remifentanil hydrochloride | Intravenous injection September 8 | September 12 | Electrolyte solution (IV fluid) | Intravenous injection September 9 | September 9 | Flurbiprofen …

Acute interstitial nephritis - a reappraisal and update.

Acute interstitial nephritis (AIN) is an under recognized and under diagnosed cause of acute kidney injury (AKI). It is estimated to account for 15 - 20% of cases of AKI; it is the reported diagnosis in 2.8% of all kidney biopsies, and 13.5% of biopsies done specifically for acute renal failure. Considerable evidence implicates antigen initiated cell-mediated injury in the pathogenesis of AIN. Drugs account for 70% of all cases, with over 150 different agents incriminated. The remaining cases are due to infections, autoimmune diseases, and rarely idiopathic. The central component of renal inju

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… tetracycline, telithromycin, vancomycin Drug-induced: non-steroidal anti-inflammatory drugs (NSAIDs) Incidence > 30 cases reported Non-selective COX inhibitors: fenoprofen > ibuprofen > naproxen; COX-2 inhibitors: celecoxib > rofecoxib Other agents: aceclofenac, indomethacin, diclofenac, diflusinal, flurbiprofen … tetracycline, telithromycin, vancomycin Drug-induced: non-steroidal anti-inflammatory drugs (NSAIDs) | Incidence > 30 cases reported Non-selective COX inhibitors: fenoprofen > ibuprofen > naproxen; COX-2 inhibitors: celecoxib > rofecoxib Other agents: aceclofenac, indomethacin, diclofenac, diflusinal, flurbiprofen …

Enasidenib in the treatment of relapsed/refractory acute myeloid leukemia: an evidence-based review of its place in therapy.

Introduction: Acute myeloid leukemia (AML) remains a disease with high mortality, especially for older patients and those with relapsed/refractory (R/R) disease. With recent advances in molecular testing, targeting particular leukemogenic mutations such as those occurring in isocitrate dehydrogenase (IDH) became possible. Enasidenib is a new small-molecule inhibitor of mutant isocitrate dehydrogenase-2 (IDH2). Aim: The objective of this article is to review the evidence for the use of enasidenib in R/R AML, as well as to outline future directions of enasidenib therapy. Evidence Review: Enaside

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… I Recruiting NCT03290443 A Phase 1, 2-Part, Multicenter, Open-label, 3-Arm Study to Determine the Effect of Enasidenib (CC-90,007) on the Pharmacokinetics of Single Doses of Caffeine, Dextromethorphan, Flurbiprofen, Midazolam, Omeprazole, Digoxin, Rosuvastatin and Pioglitazone in Subjects With Acute … severe hepatic impairment, and in matched healthy control subjects with normal hepatic function. | I | Recruiting | NCT03290443 A Phase 1, 2-Part, Multicenter, Open-label, 3-Arm Study to Determine the Effect of Enasidenib (CC-90,007) on the Pharmacokinetics of Single Doses of Caffeine, Dextromethorphan, Flurbiprofen …

Выявляется высокий уровень использования медицинских услуг после операции на шейном позвоночнике с использованием комплексных методов прогнозирования.

Расходы на медицинское обслуживание пациентов с хроническими заболеваниями позвоночника и пациентов, проходящих хирургическую операцию, продолжают расти заметными темпами. Таким образом, выявление пациентов, подверженных риску в плане более широкого использования послеоперационного медицинского обслуживания, имеет решающее значение для оптимизации результатов медицинского обслуживания и распределения ресурсов. Цель нашего исследования заключается в использовании целого ряда предоперабельных характеристик пациентов, включая всеобъемлющую медицинскую, хирургическую и социальную историю, для разр

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… leflunomide”, “cyclophosphamide”, “chlorambucil”, “budesonide”, “everolimus”, “abatacept”, “basiliximab”, “daclizumab”, “muromonab”, “vedolizumab”, “ustekinumab”, “tocilizumab”, “secukinumab”, “rituximab”, “ixekizumab”, “golimumab”, “anakinra” | NSAIDs | “celecoxib”, “diclofenac”, “diflunisal”, “etodolac”, “flurbiprofen …