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Phase 2 Study of Pomalidomide (CC-4047) Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors.

IntroductionTreatment of recurrent primary pediatric brain tumors remains a major challenge, with most children succumbing to their disease. We conducted a prospective phase 2 study investigating the safety and efficacy of pomalidomide (POM) in children and young adults with recurrent and progressive primary brain tumors.MethodsPatients with recurrent and progressive high-grade glioma (HGG), diffuse intrinsic pontine glioma (DIPG), ependymoma, or medulloblastoma received POM 2.6 mg/m2/day (the recommended phase 2 dose [RP2D]) on days 1-21 of a 28-day cycle. A Simon's Optimal 2-stage design was

Effectiveness of bilingual health education on obesity and dietary behaviors in Mongolian adolescents: a six-month intervention study.

BackgroundObesity among adolescents has become a global public health concern. Previous studies have shown that multidimensional interventions, such as school-based programs, health education, and guidance on diet and physical activity, effectively improve obesity in adolescents. However, there is a lack of research on bilingual health education interventions in minority language environments in rural and pastoral areas of China. Based on a 2023 field survey of students from three Mongolian middle schools in Ar Horqin Banner, Chifeng City, Inner Mongolia, this study evaluated the effect of a 6

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… Given that all participants were adolescents aged 11 to 18 years, written informed consent was obtained from their parents or legal guardians prior to their inclusion in the study. … Written informed consent for participation in this study was provided by the participants' legal guardians/next of kin. Author contributions HS: Writing – review & editing, Writing – original draft, Formal analysis. …

Metastatic lung adenocarcinoma causes extensive destruction of the hip and pelvis.

BackgroundLung cancer is the most prevalent tumor and frequently present with distant metastases, with the bone being one of the most common affected sites. However, bone metastases leading to complete resorption of the hip joint and pelvis are extremely rare. This case aimed to report an extensive destruction of the hip and pelvis in metastatic lung adenocarcinoma, and conduct a literature review to explore the factors influencing the diagnosis and treatment decisions of bone metastasis.Case presentationA 56-year-old woman presented with progressive pain in her left hip joint and pelvis accom

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… We confirm that we have obtained the informed consent of all subjects/legal guardians to participate in this study. Consent for publication We confirm that we obtained informed consent from all subjects/legal guardians for publishing information and images in this manuscript. …

Fertility Preservation in Female Patients with Cancer. Part I: Challenges and Future Prospects in Developing Countries; A Narrative Review Study.

While international guidelines on oncofertility practice have been published in developed countries, there is limited information available on oncofertility practice in developing countries, which often face limitations in their cancer health support networks. As survival rates improve in the field of cancer and other diseases, there is a growing need for stronger oncofertility services in developing countries. Given that 50% of cancer patients are under the age of 65, many of these patients are of reproductive age and preserving their fertility health prior to starting treatment is valuable.

Scleredema of Buschke: 2 cases with a remarkable response to treatment of the underlying paraprotein.

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Common haematological malignancies in Northeastern Nigeria: a multi-centre study of their pattern, distribution and treatment challenges.

BackgroundHaematological malignancies (HMs) are primary cancers of the blood and blood-forming organs. They are heterogeneous and of diverse clinical features, treatment protocols and prognoses. They constitute a significant source of cancer-related morbidity and mortality. Northeastern Nigeria, being the region in the country with the worst literacy rate and poverty indices, is also battling with the burden of these diseases with the limited health facilities to adequately diagnose and treat these ailments. There is paucity of a comprehensive data on HMs in the region, so this study aims to r

Polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes syndrome with dilated cardiomyopathy: A case report.

BackgroundPolyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes (POEMS) syndrome is a rare paraneoplastic syndrome that encompass multiple systems. The most common clinical symptoms of POEMS syndrome are progressive sensorimotor polyneuropathy, organ enlargement, endocrine disorders, darkening skin, a monoclonal plasma cell proliferative disorder, and lymph node hyperplasia. The organomegaly consists of hepatosplenomegaly and/or lymphadenopathy; cases of cardiomyopathy are rare. Diagnoses are often delayed because of the atypical nature of the syndrome, exposing patients to pos

Chronic granulomatous disease secondary to a rare compound heterozygote mutation in an adolescent cured by hematopoietic stem cell transplantation: a case report.

BackgroundChronic granulomatous disease (CGD) is a rare inherited primary immunodeficiency characterized by recurrent infections and aberrant inflammation due to defects in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex.Case presentationWe report a case of recurrent pneumonia and significantly elevated IgE levels in an adolescent. Metagenomic next-generation (mNGS) sequencing contributed to the identification of Burkholderia multivorans in bronchoalveolar lavage fluid and the initiation of appropriate treatment. Whole exome sequencing (WES) revealed two point mutations

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… Written informed consent for participation in this study was provided by the participants' legal guardians/next of kin. Written informed consent was obtained from the minor(s)' legal guardian/next of kin for the publication of any potentially identifiable images or data included in this article. …

Analysis of medical malpractice liability disputes related to novel antineoplastic drugs and research on risk prevention and control strategies.

OBJECTIVE: To investigate the general characteristics of litigation cases of medical malpractice liability disputes (MMLDs) related to novel antineoplastic drugs (NADs), the drugs involved, as well as the common types of medical errors related to NADs and their damages in the process of diagnosis and treatment, with the aims of improving the level of rational medication use in the clinical application of NADs and actively prevent medical disputes. METHODS: The China Judgments Online was searched for the cause of action using the key word "MMLDs" along with the name of 77 kinds of NADs. A tota

Изменяющиеся методы лечения и результаты у пациентов с недавно диагностированными множественными миэломами, которые проходят автологическую трансплантацию стволовых клеток: исследование реального мира в Китае.

Это одноцентровое ретроспективное исследование было направлено на оценку тенденций в области клинических характеристик, методов лечения и результатов лечения пациентов с недавно диагностированными множественными миеломами (НДММ), которые прошли первоначальную аутологическую трансплантацию стволовых клеток (ASCT) в период между 2007 и 2023 в Китае. МЕТОДЫ: Всего 390 пациенты с NDMM были сгруппированы в three Временные группы: 2007–2012 (В тыс.79 - пациенты), 2013–2018 (В тыс.143 пациентов), и 2019–2023 (В тыс.168 - пациенты). За эти периоды были проанализированы клинические характеристики, мето

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… Informed consent was obtained from all participants or their legal guardians before inclusion in the study. Consent for publication All the authors consent to the publication of this manuscript in its current form. … Consent for publication was obtained from all patients or legal guardians included in the study. Competing interests The authors declare no competing interests. References 1. …

Efficacy of phosphodiesterase type 5 inhibitors in univentricular congenital heart disease: the SV-INHIBITION study design.

AIMS: In univentricular hearts, selective lung vasodilators such as phosphodiesterase type 5 (PDE5) inhibitors would decrease pulmonary resistance and improve exercise tolerance. However, the level of evidence for the use of PDE5 inhibitors in patients with a single ventricle (SV) remains limited. We present the SV-INHIBITION study rationale, design, and methods. METHODS AND RESULTS: The SV-INHIBITION trial is a nationwide multicentre, randomized, double blind, placebo-controlled, Phase III study, aiming to evaluate the efficacy of sildenafil on the ventilatory efficiency during exercise, in

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… weight over 20 kg • Patients with a single ventricle (e.g. univentricular heart) as defined by the ACC‐CHD classification • Mean pulmonary arterial pressure (mPAP) >15 mmHg and trans‐pulmonary gradient (TPG) >5 mmHg, measured by cardiac catheterization a • Written informed consent for adult patients or legal … Informed consent will be obtained from all patients and their parents or legal guardians for minors. …

Диагностический потенциал биомаркеров на основе крови в множестве склерозов.

Множественный склероз (MS) — хроническое воспалительное заболевание, затрагивающее центральную нервную систему (CNS). Существует значительная задержка с диагностированием MS, поскольку симптомы и тесты пересекаются с другими заболеваниями. Биомаркеры на основе крови, которые дают количественную оценку фрагментам белков, участвующих в патофизиологии MS, обладают потенциалом в качестве диагностических биомаркеров. В этом исследовании мы провели оценку биомаркеров иммуномассами, разрушения тканей, что нашло отражение в крупнокананской деградации матричных металлических протеинов (ММП) (МГМ), кате

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… Written informed consent for participation in this study was provided by the participants’ legal guardians/next of kin. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article. …

Доклад о деле: реактивные Т-клетки большие гранулальные лимфоциты в костном мозге пациента с повторной/охлажденной множественной миеломой, получающего теклистамб.

Лечение Т-клеток для лечения повторной/реактивной (R/R) множественной миеломы (MM) может привести к нейтропенсии с сопутствующими инфекциями или без них, что может ограничить лечение и эффективность. Мы представляем случай пациента с пента-классом R/R MM, который, принимая теклистамб, развивал стойкую или умеренную нейтрализацию с сопутствующими инфекциями. Обзор ее костного мозга подтвердил уничтожение злокачественных плазменных клеток, но цитометрия потока выявила увеличение содержания крупных гранулированных лимфоцитов (T-LGL). После дальнейшего анализа было установлено, что Т-ЛГЛ являются

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… Written informed consent to participate in this study was not required from the participants or the participants’ legal guardians/next of kin in accordance with the national legislation and the institutional requirements. …

Риск злоумышленничества и использование методов лечения болезней при множественном склерозе: изучение роли ДМТ в многоцентровом исследовании.

ЦЕЛЬ: Потенциальная связь между лечением синдрома заболеваний (ДМТ) и злоумышленничеством у пациентов, страдающих множественным склерозом (МС), вызывает серьезную обеспокоенность, особенно с учетом иммунодепрессивного характера этих методов лечения. Противоречивые данные в литературе оставляют этот вопрос нерешенным, что подчеркивает необходимость проведения окончательных исследований для обоснования клинической практики. В этом исследовании этот разрыв устраняется путем изучения случаев заболевания раком среди пациентов, проходящих лечение в двух центрах третичной медицинской помощи в Саудовс

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… The ethics committee/institutional review board waived the requirement of written informed consent for participation from the participants or the participants’ legal guardians/next of kin due to the retrospective nature of the study. …

Cytokine release syndrome was an independent risk factor associated with hypoalbuminemia for patients with relapsed/refractory hematological malignancies after CAR-T cell therapy.

Background & aimsThis study aims to assess the nutritional status of patients during the different phases of the Chimeric Antigen Receptor (CAR)-T cell therapy and to identify prominent risk factors of hypoalbuminemia in patients after CAR-T treatment. The clinical consequences of malnutrition in cancer patients have been highlighted by growing evidence from previous clinical studies. Given CAR-T cell therapy's treatment intensity and possible side effects, it is important to provide patients with sufficient medical attention and support for their nutritional well-being.MethodsThis study was c

Multiple myeloma presenting with amyloid arthropathy as the first manifestation: Two case reports.

BACKGROUND: Multiple myeloma (MM) can be accompanied by amyloidosis, which occurs in a small number of patients and is characterized by deposition of light chains in the joints, leading to multiple myeloma-associated amyloid arthropathy (MAA). As a rare complication of MM, clinical manifestations of MAA are often similar to those of rheumatoid arthritis, and the two are easily confused. CASE SUMMARY: In recent years, our center treated two patients of MM with amyloid arthropathy as the first manifestation, both of whom presented with polyarthritis. After treatment for MM, both patients achiev

Blocking the MIF-CD74 axis augments radiotherapy efficacy for brain metastasis in NSCLC via synergistically promoting microglia M1 polarization.

BackgroundBrain metastasis is one of the main causes of recurrence and death in non-small cell lung cancer (NSCLC). Although radiotherapy is the main local therapy for brain metastasis, it is inevitable that some cancer cells become resistant to radiation. Microglia, as macrophages colonized in the brain, play an important role in the tumor microenvironment. Radiotherapy could activate microglia to polarize into both the M1 and M2 phenotypes. Therefore, searching for crosstalk molecules within the microenvironment that can specifically regulate the polarization of microglia is a potential stra

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… Written informed consent was obtained from legal guardians of the patients. … Written informed consent was obtained from all legal guardians of the patients. All animal experiments were conducted in agreement with the Guide for the Care and Use of Laboratory Animals and were approved by the Committee on Animal Handling of Huazhong University of Science and Technology. …

Quality of life among family caregivers of cancer patients: an investigation of SF-36 domains.

BackgroundWith improving survival rates, cancer has become more of a chronic disease with long-term palliative care requirements. Thus, it is even more than ever necessary to pay careful attention to the well-being of family caregivers of cancer patients, as cancer trajectory is a challenging path for both patients and their caregivers. This study focusses on ascertaining the level of quality of life (QoL) domains and their attributable significant factors among a population of cancer family caregivers.MethodsThis was a cross-sectional study. The study population consist of caregivers of adult

Drug-induced herpes zoster: a pharmacovigilance analysis of FDA adverse event reports from 2004 to 2024.

BACKGROUND: Herpes zoster severely impacts patients' quality of life and therapeutic results. This research utilized data from the FDA Adverse Event Reporting System (FAERS) to examine the prevalence and attributes of drug-induced herpes zoster. METHODS: We analyzed FAERS reports about zoster from Q1 2004 to Q3 2024 and developed a list of possible pathogenic agents. Ranked the 30 medicines with the greatest incidence of reported herpes zoster cases. Statistical disproportionality analysis was employed to identify an elevated reporting frequency of herpes zoster linked to a particular medicat

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… Written informed consent to participate in this study was not required from the participants or the participants’ legal guardians/next of kin in accordance with the national legislation and the institutional requirements. …

Successful Antibiotic Treatment of Phlegmonous Gastritis Following Allogeneic Hematopoietic Stem Cell Transplantation.

Phlegmonous gastritis (PG) is a rare, life-threatening bacterial infection characterized by thickening of the gastric wall. We report a case of PG in a 17-year-old male following allogeneic hematopoietic stem cell transplantation for severe aplastic anemia. Seven months after transplantation, the patient presented with severe abdominal pain, fever, and significant gastric wall thickening on CT. Initial antibiotic therapy was initiated immediately. The patient developed multiple organ failure; however, his condition rapidly improved with intensive care. After two weeks, the patient improved and

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… Informed consent was obtained from the patient for publication of this case report or from their legal guardians or wards. The authors state that they have no Conflict of Interest (COI). References 1. Saito M, Morioka M, Izumiyama K, et al. …