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The effect of multiple sclerosis on functional status and sexual quality of life in female patients with multiple sclerosis.

BACKGROUND: There is limited data evaluating functional status and quality of sexual life in multiple sclerosis (MS), and there is no data showing the relationship between the two variables. This study aims to investigate the relationship between MS, functional status, and sexual quality of life in female patients with multiple sclerosis. METHODS: This descriptive correlational study was conducted between September 2023 and February 2024 with 236 female patients with MS using the online Google survey tool and snowballing method. Data were collected using the Information Form, Functional Ambula…

Early onset multiple sclerosis and the effect of disease onset age on neurological disability in multiple sclerosis.

OBJECTIVES: The incidence of early onset multiple sclerosis (EOMS) is increasing. We therefore aimed to compare the demographic, clinical, and magnetic resonance imaging features of early onset and adult onset multiple sclerosis patients. Furthermore, the effects of age of onset were evaluated for patients who reached an expanded disability status scale (EDSS) scores of six. PATIENTS AND METHODS: This was a retrospective study of MS patient medical charts between 1977 and 2021, which were registered in the MS database. Only patients with relapsing remitting MS longer than 1 year were included…

Prevalence of Latent Tuberculosis in the Multiple Sclerosis Clinic and Effect of Multiple Sclerosis Treatment on Tuberculosis Testing.

BACKGROUND: Patients with a compromised immune system are at risk for converting from latent tuberculosis infection (LTBI) to active tuberculosis (TB) infection. Multiple sclerosis (MS) therapies may put individuals with LTBI at higher risk of TB. METHODS: Patients at the Beth Israel Deaconess Medical Center MS Clinic were screened for TB as part of routine testing with the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay (Cellestis Ltd) from 2013 to 2017. Patients were tested either before or during immunomodulatory therapy. RESULTS: Four of 222 patients (1.8%; 95% CI, 0.1%-3.6%) had positive QF…

Гены второго класса HLA связаны с множественным склерозом: иммуногенетическое прогнозирование среди многих склерозов иорданских пациентов.

Множественный склероз (MS) — вспыльчивая аутоиммунная болезнь, затрагивающая центральную нервную систему (КНС). Патогенез MS характеризуется нейронной аксонной дегенерацией и демиэлизацией. Среди генов, которые повышают риск склероза, есть гены второго класса HLA. Цель этого исследования заключалась в изучении роли генов HLA-DRB1 и HLA-DQB1 ( впервые) в иорданских пациентах, больных MS, и их связи с заболеваниями MS. Были исследованы связи этих генов с другими клиническими особенностями, такими, как оптический неврит, сенсорное расстройство и симптомы сетчатки головного мозга у пациентов MS, а

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is an inflammatory autoimmune disease affecting the central nervous system (CNS). The pathogenesis of MS is characterized by neuronal axonal degeneration and demyelination. Among the genes that raises MS risk are the HLA-class II genes. The goals of this study were to investigate the role of the HLA-DRB1 and HLA-DQB1 genes (for the fi…

In Vivo Corneal Confocal Microscopy in Multiple Sclerosis: Can it Differentiate Disease Relapse in Multiple Sclerosis?

PURPOSE: This study aims to investigate the role of in vivo corneal confocal microscopy (IVCCM) in the detection of corneal inflammatory activity and subbasal nerve alterations in patients with multiple sclerosis (MS) and to further determine whether IVCCM can be used to detect (acute) disease relapse. DESIGN: Prospective cross-sectional study, with a subgroup follow-up. METHODS: This single-center study included 58 patients with MS (MS-Relapse group [n = 27] and MS-Remission group [n = 31]), and 30 age- and sex-matched healthy control subjects. Patients with a history of optic neuritis or t…

Multiple sclerosis optic neuritis and trans-synaptic pathology on cortical thinning in people with multiple sclerosis.

BACKGROUND: The multi-order visual system represents an excellent testing site regarding the process of trans-synaptic degeneration. The presence and extent of global versus trans-synaptic neurodegeneration in people with multiple sclerosis (pwMS) is not clear. OBJECTIVE: To explore cross-sectional and longitudinal relationships between retinal, thalamic and cortical changes in pwMS with and without MS-related optic neuritis (pwMSON and pwoMSON) using MRI and optical coherence tomography (OCT). METHODS: 162 pwMS and 47 healthy controls (HCs) underwent OCT and brain MRI at baseline and 5.5-ye…

The Multiple Sclerosis Intimacy and Sexuality Questionnaire (MSISQ): Validation of the Turkish version in patient with multiple sclerosis.

This study aimed to psychometrically evaluate the Turkish version of the Multiple Sclerosis Intimacy and Sexuality Questionnaire (MSISQ-15) in women with MS. The study included 130 women with MS. The Turkish linguistic validation process of the original English MSISQ-15 was performed according to standardized guidelines. Reliability analysis was evaluated with test-retest analysis and intra-class correlation (ICC). Internal consistency between the items was analyzed using the Cronbach's alpha coefficient. Item analysis results were used to assess the contribution of the items to the scale. In …

Epidemiologic, clinical and diagnostic characteristics of late-onset multiple sclerosis compared with adult-onset multiple sclerosis.

BACKGROUND: The number of patients with late-onset multiple sclerosis (pwLOMS: initial MS symptoms after 50 years of age) is increasing. Therefore, we investigated pwLOMS compared with patients with adult-onset MS (pwAOMS) using epidemiologic, clinical and diagnostic comparative parameters. METHODS: Using data from the German MS Register, pwLOMS (onset: ≥50 years) were compared with pwAOMS (onset: 18-34 years, 35-49 years). Following outcome measures were considered: time to reach the Expanded Disability Status Scale (EDSS) scores 3.0/6.0/7.0, time to transition from relapsing-remitting to se…

Домашние эксгумы для импровизации когнитивной функции в MUltiple Sclerosis (EXTREMUS).

КОЛИЧЕСТВО: Моторные и когнитивные дисфункции являются распространенными и деформирующими свойствами множественных склерозов (МС), которые по-прежнему трудно лечить. В этой связи мы стремились изучить воздействие экзогам в качестве самостоятельного подхода к людям с НР и ограниченной скоростью обработки. Это был трёхствольный, случайный, скрытный, поддельный суд. Люди, имеющие MS и скорость обработки, были случайно выбраны в соотношении 1:1:1 к 8-недельной учебной подготовке на дому с эксгумами (интервенция интересов), адаптивным комплектом когнитивной подготовки (COWD-TRAK) (обучение памяти в

Совпадение в аннотации оригинала
BACKGROUND: Motor and cognitive dysfunctions are common and disabling features in multiple sclerosis (MS) that remain challenging to treat. Here, we aimed to explore the effect of exergames as a stand-alone approach for people with MS and impaired processing speed. METHODS: This was a three-arm, randomised, rater-blinded, sham-controlled trial. People with …

Amyotrophic lateral sclerosis with multiple sclerosis: a clinical and pathological report.

We report a 62-year-old woman with a past history of painful central visual loss who developed progressive quadriparesis and bulbar palsy. Neurological examination revealed widespread upper and lower motor neuron signs in the bulbar region and extremities. Electromyography demonstrated widespread active and chronic motor axon loss. Magnetic resonance neuroimaging studies revealed enhancing callosal and periventricular white matter lesions and cervical and thoracic cord hyperintensities. Cerebrospinal fluid analysis was consistent with multiple sclerosis. The patient died of respiratory failure…

Multiple Sclerosis and Viruses: « Liaisons Dangereuses ».

Multiple sclerosis (MS) is a complex, multifactorial neurodegenerative disease with an aetiology that is still partially elusive. Several risk factors are associated with MS development including genetic predisposition and various environmental stressors; however, recently, viral infections have gained significant attention as a crucial environmental trigger. Despite the well-established link between Epstein-Barr virus (EBV) and MS susceptibility, a single-pathogen model fails to clearly characterise the molecular cascades driving the disease, suggesting that the transition from infection to a…

Adult-Onset Leukodystrophies Mimicking Multiple Sclerosis.

OBJECTIVE: Genetic white matter disorders may be difficult to distinguish from multiple sclerosis (MS). This article reviews the clinical and radiologic features of leukodystrophies in adults and how to differentiate them from MS. LATEST DEVELOPMENTS: The rapid implementation of next-generation sequencing techniques in clinical practice has led to an increasing number of adult patients diagnosed with leukodystrophies, often with expanded clinical and radiologic phenotypes that include features mimicking MS. Advances in neuroimaging tools allow for the identification of radiologic features tha…

Assessing treatment response in multiple sclerosis.

PURPOSE OF THE REVIEW: The evaluation of treatment response in multiple sclerosis (MS) has become increasingly nuanced as the field shifts from a primarily relapse-oriented perspective toward a more comprehensive understanding of the continuous interaction between inflammatory and neurodegenerative mechanisms. RECENT FINDINGS: Traditional clinical measures, while indispensable, capture only a fraction of the disease process and are insufficient to detect the insidious progression that accounts for a substantial proportion of long-term disability. Enhanced functional assessments provide greate…

Erythrocyte Fragility in Progressive Multiple Sclerosis.

BACKGROUND: Aberrant iron homeostasis is increasingly recognized as a key pathological feature in progressive multiple sclerosis (MS). Although the source of excess brain iron remains unclear, haemoglobin is one possible source. To test this hypothesis, we conducted a case-control study to determine whether erythrocytes are more fragile in people with progressive MS (PwPMS) and examined associations between erythrocyte fragility and brain atrophy. METHODS: PwPMS and control individuals were recruited from two centres. Two measures of erythrocyte fragility were assessed at baseline: the Median…

Investigational approaches to multiple sclerosis therapy.

PURPOSE OF REVIEW: Multiple sclerosis (MS) research is entering a new therapeutic era. Beyond relapse rate reduction, the prevention of disability progression and, ideally, even the avoidance of disease development are now being formulated as new therapeutic goals. This review summarizes emerging treatment strategies spanning next-generation immunomodulation, Epstein-Barr virus (EBV) targeted interventions, remyelination agents, and cell-based therapies. RECENT FINDINGS: Central nervous system (CNS) penetrant Bruton's tyrosine kinase (BTK) inhibitors show early indications of slowing progress…