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Bortezomib in severe MuSK-antibody positive myasthenia gravis: first clinical experience.

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… Ann Rheum Dis 2015 ; 74 : 1474 – 1478 . 25710470 10.1136/annrheumdis-2014-206016 PMC4484251 14 Khandelwal P Davies SM Grimley MS et al Bortezomib for refractory autoimmunity in pediatrics . … Ann Rheum Dis . 2016 ; 75 : e9 Epub ahead of print 21 7 2015 DOI: 10.1136/annrheumdis-2015-207947. 26199397 16 Thawain SP Tanji K De Sousa EA et al Bortezomib-associated demyelinating neuropathy: clinical and pathological features . …

Dawn of CAR-T cell therapy in autoimmune diseases.

AbstractChimeric antigen receptor (CAR)-T cell therapy has achieved remarkable success in the treatment of hematological malignancies. Based on the immunomodulatory capability of CAR-T cells, efforts have turned toward exploring their potential in treating autoimmune diseases. Bibliometric analysis of 210 records from 128 academic journals published by 372 institutions in 40 countries/regions indicates a growing number of publications on CAR-T therapy for autoimmune diseases, covering a range of subtypes such as systemic lupus erythematosus, multiple sclerosis, among others. CAR-T therapy hold

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… Ann Rheum Dis 2021;80:176–184. doi: 10.1136/annrheumdis-2020-217844. 24. Whittington KB, Prislovsky A, Beaty J, Albritton L, Radic M, Rosloniec EF. … Ann Rheum Dis 2022;81:185. doi: 10.1136/annrheumdis-2022-eular.1120. 68. Lee DW Kochenderfer JN Stetler-Stevenson M Cui YK Delbrook C Feldman SA, et al. …

Clinical role of bisphosphonate therapy.

Bisphosphonates (BPs) are synthetic analogues of pyrophosphate. They inhibit bone resorption and are therefore widely used in disorders where there are increases or disruptions in bone resorption. This includes postmenopausal osteoporosis, glucocorticoid-induced osteoporosis, Paget's disease of bone, and malignancy-related bone loss. To best understand the clinical application of BPs, an understanding of their pharmacokinetics and pharmacodynamics is important. This review describes the structure, pharmacology and mode of action of BPs, focusing on their role in clinical practice. Controversie

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… Arthritis Rheum. 2011;63(2):325–328. doi: 10.1002/art.30135. 30. LoCascio V, Bonucci E, Imbimbo B, et al. Bone loss in response to long-term glucocorticoid therapy. Bone Miner. 1990;8(1):39–51. doi: 10.1016/0169-6009(91)90139-q. 31. van Staa TP. … Arthritis Rheum. 2003;48(11):3224–3229. doi: 10.1002/art.11283. 34. American College of Rheumatology Ad Hoc Committee on Glucocorticoid- induced Osteoporosis. Recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis. …

Экономия и безопасность дотинурада в связи с кислотой и реанимацией у пациентов с гиперперурицемией и повышенными хроническими почечными заболеваниями: единый центр, ретроспективный анализ.

ЦЕЛЬ: мы изучили эффективность и безопасность дотинурада, селективного ингибитора реабсорбции у гиперурисемичных пациентов с продвинутой хронической болезнью почек (CKD) (стадия) G3-5). ВОЗМОЖНОСТИ И МЕТОДЫ: Мы ретроспективно проанализировали случаи 34 больные (средний возраст, 68.6 ± 13.3 годы; 17 мужчин и женщин 17 женщин) после 12 Количество месяцев дотинурадной обработки на основе изменений в мочеисперсной кислоте (UA) и соотношении белков и креатининов мочи (UPCR) плюс ежегодное изменение расчетной гермекулярной фильтрации (eGFR). Гиперурикемия (UA) ≥6.0 мг/дл) и усовершенствованная CKD (

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… Ann Rheum Dis . 2013;72(5):694–700. doi: 10.1136/annrheumdis-2011-201254 14. Matsuo S, Imai E, Horio M, et al. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis . 2009;53(6):982–992. doi: 10.1053/j.ajkd.2008.12.034 15. Vrbin CM. … Int J Rheum Dis . 2019;22(8):1445–1451. doi: 10.1111/1756-185X.13652 24. Heikal MM, Shaaban AA, Elkashef WF, Ibrahim TM. Effect of febuxostat on biochemical parameters of hyperlipidemia induced by a high-fat diet in rabbits. …

Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases.

Bone and joint-related diseases, including osteoarthritis (OA), rheumatoid arthritis (RA), and bone tumors, pose significant health challenges due to their debilitating effects on the musculoskeletal system. 14-3-3 proteins, a family of conserved regulatory molecules, play a critical role in the pathology of these diseases. This review discusses the intricate structure and multifunctionality of 14-3-3 proteins, their regulation of signaling pathways, and their interactions with other proteins. We underscore the significance of 14-3-3 proteins in the regulation of osteoblasts, osteoclasts, chon…

Biosimilars in Oncology: Latest Trends and Regulatory Status.

Biologic-based medicines are used to treat a variety of diseases and account for around one-quarter of the worldwide pharmaceutical market. The use of biologic medications among cancer patients has resulted in substantial advancements in cancer treatment and supportive care. Biosimilar medications (or biosimilars) are very similar to the reference biologic drugs, although they are not identical. As patent protection for some of the most extensively used biologics begins to expire, biosimilars have the potential to enhance access and provide lower-cost options for cancer treatment. Initially, r

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… Semin Arthritis Rheum. 2022;52:151939. doi: 10.1016/j.semarthrit.2021.11.009. 22. IQVIA Institute Biosimilars in the United States 2020–2024. [(accessed on 15 September 2022)]. …

Progress in osteoporosis and fracture prevention: focus on postmenopausal women.

In the past decade, we have witnessed a revolution in osteoporosis diagnosis and therapeutics. This includes enhanced understanding of basic bone biology, recognizing the severe consequences of fractures in terms of morbidity and short-term re-fracture and mortality risk and case finding based on clinical risks, bone mineral density, new imaging approaches, and contributors to secondary osteoporosis. Medical interventions that reduce fracture risk include sufficient calcium and vitamin D together with a wide spectrum of drug therapies (with antiresorptive, anabolic, or mixed effects). Emerging

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… Leufkens HG Cooper C A simple score for estimating the long-term risk of fracture in patients using oral glucocorticoids QJM 2005 98 191 198 10.1093/qjmed/hci029 15728400 van Geel TA van Helden S Geusens PP Winkens B Dinant GJ Clinical subsequent fractures cluster in time after first fractures Ann Rheum … risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women JAMA 2009 301 513 521 10.1001/jama.2009.50 19190316 Sambrook P Cooper C Osteoporosis Lancet 2006 367 2010 2018 10.1016/S0140-6736(06)68891-0 16782492 Lems WF Clinical relevance of vertebral fractures Ann Rheum …

Amyloid Proteins and Peripheral Neuropathy.

Painful peripheral neuropathy affects millions of people worldwide. Peripheral neuropathy develops in patients with various diseases, including rare familial or acquired amyloid polyneuropathies, as well as some common diseases, including type 2 diabetes mellitus and several chronic inflammatory diseases. Intriguingly, these diseases share a histopathological feature-deposits of amyloid-forming proteins in tissues. Amyloid-forming proteins may cause tissue dysregulation and damage, including damage to nerves, and may be a common cause of neuropathy in these, and potentially other, diseases. He

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… Rheum. Dis. 2019 78 1463 1471 10.1136/annrheumdis-2019-215920 31511227 60. Figueroa J.J. Loftus E.V. Jr. Harmsen W.S. Dyck P.J. Klein C.J. … Arthritis Rheum. 2018 48 28 34 10.1016/j.semarthrit.2018.01.003 29398124 70. Ben-Chetrit E. Touitou I. Familial mediterranean Fever in the world Arthritis Rheum. 2009 61 1447 1453 10.1002/art.24458 19790133 71. Ozdogan H. Ugurlu S. …

Soluble Biomarkers of Osteoporosis and Osteoarthritis, from Pathway Mapping to Clinical Trials: An Update.

Serum biomarkers of osteoarticular diseases have been in the limelight of current clinical research trends. Laboratory validation of defined and candidate biomarkers for both osteoarthritis and osteoporosis is of key importance for future decisional algorithms in the diagnosis, monitoring, and prognosis of these diseases. The current guidelines recommend the use of collagen degradation remnants, eg, CTX-I and CTX-II, in the complementary diagnosis of both osteoporosis and osteoarthritis. Besides the collagen degradation markers, enzymes that regulate bone and articular metabolism are useful in

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… Ann Rheum Dis . 2018;77(3):423. doi: 10.1136/annrheumdis-2017-212603 67. Massicotte F, Lajeunesse D, Benderdour M, et al. … Ann Rheum Dis . 2006;65(3):360–365. doi: 10.1136/ard.2005.040642 90. Park YM, Kim SJ, Lee KJ, Yang SS, Min BH, Yoon HC. Detection of CTX-II in serum and urine to diagnose osteoarthritis by using a fluoro-microbeads guiding chip. …

MR and CT angiography in the diagnosis of vasculitides.

Vasculitides represent the wide-ranging series of complex inflammatory diseases that involve inflammation of blood vessel walls. These conditions are characterized according to the caliber of the predominantly involved vessels. The work-up of vasculitides often includes imaging to narrow a differential diagnosis and guide management. Findings from CT and MR angiography in conjunction with a thorough history and physical exam are of utmost importance in making an accurate diagnosis. Further, imaging can be used for follow-up, in order to monitor disease progression and response to treatment. Th

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… Int J Rheum Dis 2014 ; 17 : 355 – 357 . doi: 10.1111/1756-185X.12378 24762121 68. Iliescu DA , Timaru CM , Batras M , De Simone A , Stefan C . Cogan's syndrome . Rom J Ophthalmol 2015 ; 59 : 6 – 13 . 27373108 PMC5729811 69. … Arthritis Rheum 2012 ; 64 : 3452 – 62 . doi: 10.1002/art.34562 23023777 PMC3462364 81. Miloslavsky E , Unizony S . The heart in vasculitis . Rheum Dis Clin North Am 2014 ; 40 : 11 – 26 . doi: 10.1016/j.rdc.2013.10.006 24268007 82. …

Resveratrol downregulates interleukin-6-stimulated sonic hedgehog signaling in human acute myeloid leukemia.

IL-6 and sonic hedgehog (Shh) signaling molecules are considered to maintain the growth of cancer stem cells (CSCs). Resveratrol, an important integrant in traditional Chinese medicine, possesses certain antitumor effects. However, the mechanisms on regulating acute myeloid leukemia (AML) are unclear. This study first used human subjects to demonstrate that the plasma levels of IL-6 and IL-1 β in AML patients were higher and lower, respectively, than healthy donors. The expression of Shh preproproteins, and C- and N-terminal Shh peptides increased in bone marrow and peripheral blood mononuclea

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… Resveratrol (3,5,4′-trans-trihydroxystilbene) is a phytochemical that widely found in plants (such as grape skin, red wine, cranberries, blueberries, and peanuts) and in traditional Chinese medicines (TCMs, such as Rheum officinale Baill. and Polygonum cuspidatum ) [ 18 , 19 ]. … Herbal medicines with resveratrol-containing, such as Rheum officinale Baill. and Polygonum cuspidatum , have been widely used in TCM for eliminating inflammatory response and reducing tumor growth [ 32 , 33 ]. …

Neck swelling in a patient with gout - What is the cause?

We describe the case of a 55-year-old man with underlying tophaceous gout who presented with a 6-month history of multiple joint pains and associated constitutional symptoms. Physical examination revealed firm and non-tender swelling measuring 3x4 cm adjacent to the left clavicular head. This swelling did not move with deglutition. Neck imaging showed bilateral heterogeneous soft tissue lesions at the sternoclavicular, first costochondral and acromioclavicular joints. Multiple lytic lesions with cortical destruction involving the upper manubrium and distal ends of both clavicles were seen. Fin

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… Semin Arthritis Rheum. 2012;42(2):146–154. doi: 10.1016/j.semarthrit.2012.03.007. 4. Gargula S, Poillon G, Daval M, et al. Tophaceous gout of the middle ear. J Otol. 2019;14(4):155–157. doi: 10.1016/j.joto.2019.08.002. 5. Chaoui A, Garcia J, Kurt AM. …

Exploring patient-reported outcomes and morbidity burden of patients with VEXAS syndrome: a scoping review.

BACKGROUND: VEXAS (vacuoles, E1 enzyme, X-linked, auto-inflammatory, somatic) is a recently discovered syndrome of autoinflammatory origin affecting mainly older patients with a clinical picture encompassing a variety of hematological and rheumatological conditions. We aimed to gather current knowledge on patient-reported outcomes (PRO) and morbidity burden of VEXAS patients. METHODS: A scoping review conducted via PubMed (last updated September 2024) identified studies involving VEXAS patients, excluding studies primarily addressing hematologic adverse events or laboratory parameters, with n…

The use of virtual nominal groups in healthcare research: An extended scoping review.

IntroductionThe Nominal Group Technique (NGT) is a consensus group method used to synthesize expert opinions. Given the global shift to virtual meetings, the extent to which researchers leveraged virtual platforms is unclear. This scoping review explores the use of the vNGT in healthcare research during the COVID-19 pandemic.MethodsFollowing the Arksey and O'Malley's framework, eight cross-disciplinary databases were searched (January 2020-July 2022). Research articles that reported all four vNGT stages (idea generation, round robin sharing, clarification, voting) were included. Media Synchron

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… : 27 PCP: 20 | Rheum: 3 PCP: 3 | Rheum: 11, 8, 7 PCP: 7, 4, 9 Occomore-Kent [ 52 ] | 2021 | International Journal of Language and Communication Disorders | Speech and language | Speech-language pathologists’ views of extending their role to work ENT patients | I | 9 | NR | NR Ostbo [ 53 ] | 2021 | ARC … Open Rheumatology | Rheumatology (scleroderma) | Resources for systemic sclerosis patients for nutrition and diet information | IC | 15 | 4 | NR Owensby [ 57 ] | 2020 | Arthritis Care & Research | QI—RA control | Patient- and rheumatologist-perceived barriers to achieving disease control | N | Rheum …

Guselkumab, an inhibitor of the IL-23p19 subunit, provides sustained improvement in signs and symptoms of active psoriatic arthritis: 1 year results of a phase III randomised study of patients who were biologic-naïve or TNFα inhibitor-experienced.

OBJECTIVE: Evaluation of the efficacy and safety of guselkumab, a human monoclonal antibody targeting the interleukin-23p19 subunit, in patients with psoriatic arthritis (PsA) through 1 year. METHODS: Adults who met ClASsification criteria for Psoriatic ARthritis, with active disease (≥3 swollen and ≥3 tender joints; C reactive protein ≥0.3 mg/dL) despite standard treatment (31% previously received ≤2 tumour necrosis factor inhibitors (TNFi)), were randomised (1:1:1) to guselkumab 100 mg every 4 weeks (Q4W); guselkumab 100 mg at Week0, Week4, then Q8W; or placebo with cross-over to guselkumab

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… Ann Rheum Dis 2020;79 (Suppl 1):1148. Correction notice: This article has been corrected since it first published. The provenance and peer review statement has been included. … Ann Rheum Dis 2016 ; 75 : 499 – 510 . 10.1136/annrheumdis-2015-208337 26644232 23 Saad AA , Ashcroft DM , Watson KD , et al . …

Клинические характеристики, диагноз, лечение и прогноз заболевания сывороткой ритуксимаба: ретроспективный анализ 39 Количество зарегистрированных случаев.

Заболевание сывороткой, вызванное ритуксимабом (РИСС), представляет собой необычайно запоздалую гиперчувствительность, характеризующуюся неполной клиническими характеристиками и управлением. Мы намеревались обобщить опубликованные доклады/серии с целью определения клинических моделей, терапевтических стратегий и результатов. МЕТОДЫ: PubMed, EMBASE, Web of Science, WanFang Data и China National Knowledge Infrastructure (CNKI) были найдены отчеты о болезни сыворотки, выпущенные до ноября 31, 2025, используя ключевые слова и свободные текстовые термины (например, "Rituximab", "Serum Bealth", "Ser

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… Int J Rheum Dis. (2012) 15:e6–7. doi: 10.1111/j.1756-185X.2011.01645.x. PMID: 33. Catuogno M, Rezai S, Priori R, Magrini L, Valesini G. Serum sickness associated with rituximab in a patient with hepatitis c virus-related mixed cryoglobulinaemia. … Arthritis Rheum. (2001) 44:1717–8. doi: 10.1002/1529-0131(200107)44:7<1717::Aid-art299>3.0.Co;2-c 38. Goto S, Goto H, Tanoshima R, Kato H, Takahashi H, Sekiguchi O, et al. …

Therapeutic potential of single-nucleotide polymorphism-mediated IL6R inhibitors in ankylosing spondylitis treatment.

OBJECTIVE: Interleukin-6 (IL-6) is a multiple-effect cell factor implicated in the etiopathogenesis of several rheumatologic disorders. The blockade of the IL-6 pathway via IL6R inhibitors effectively treats these disorders. However, the clinical significance of the IL6R blockade for ankylosing spondylitis (AS) therapy remains controversial. With advances in genomics, increasing evidence has revealed the role of heritability in the etiology of disease, and Mendelian randomization (MR) analyses are being used more broadly to infer causation. Therefore, this MR study aims to evaluate the potenti…

Large-scale genome-wide association studies reveal the genetic causal etiology between ankylosing spondylitis and risk of leukemia and lymphocytic malignancies.

BACKGROUND: Evidence from multiple observational studies suggests that ankylosing spondylitis (AS) is associated with leukemia and lymphocytic malignancies. However, the obtained results are inconsistent, and the causal relationship still needs to be determined. In this context, we utilized two-sample Mendelian randomization (MR) to investigate potential causal associations between AS and leukemia and lymphocytic malignancies. METHODS: The analysis was conducted through published genome-wide association studies (GWAS). We obtained genetic data on AS as the exposure and leukemia, including lym

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… Ann rheum Dis. (2006) 65:1184–7. doi: 10.1136/ard.2005.047514 10. Chennamadhavuni A, Lyengar V, Mukkamalla S, et al. Leukemia. In: StatPearls. StatPearls Publishing, Treasure Island (FL: (2023). 11. Zuber V, Grinberg NF, Gill D, Manipur I, Slob EAW, Patel A, et al. … Int J Rheum Dis. (2021) 24:216–22. doi: 10.1111/1756-185X.14036 Associated Data Supplementary Materials Data Availability Statement The original contributions presented in the study are included in the article/ Supplementary Material . …

Prospective and Multicenter Evaluation of Outcomes for Quality of Life and Activities of Daily Living for Balloon Kyphoplasty in the Treatment of Vertebral Compression Fractures: The EVOLVE Trial.

BACKGROUND: Osteoporotic and neoplastic vertebral compression fractures (VCF) are common and painful, threatening quality of life and increasing risk of morbidity and mortality. Balloon kyphoplasty is a percutaneous option for treating painful cancer- and osteoporosis-related VCFs, supported by 2 randomized trials demonstrating efficacy benefits of BKP over nonsurgical care. OBJECTIVE: To investigate 12-mo disability, quality of life, and safety outcomes specifically in a Medicare-eligible population, representing characteristic patients seen in routine clinical practice. METHODS: A total of

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… Rheum Dis Clin North Am . 2001 ; 27 ( 1 ): 255 - 262 . 11285999 10.1016/s0889-857x(05)70197-6 26. … Arthritis Rheum . 2001 ; 44 ( 11 ): 2611 - 2619 . 11710717 10.1002/1529-0131(200111)44:11<2611::aid-art441>3.0.co;2-n 27. …

Exploring neutrophil extracellular traps: mechanisms of immune regulation and future therapeutic potential.

Neutrophil extracellular traps (NETs) are complex, web-like structures consisting of DNA intertwined with antimicrobial proteins, which neutrophils release upon immune activation. These structures play a crucial role in pathogen elimination, particularly in infectious diseases. However, their involvement in various pathological conditions is multifaceted and context-dependent, while NETs contribute to host defense against infections, they can also exacerbate sterile inflammation, autoimmune disorders, and tumor progression. This review provides a comprehensive analysis of the molecular mechani

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… Ann Rheum Dis. 2018;78:238–48. 10.1136/annrheumdis-2018-213181. 84. Angelidou I, et al. REDD1/autophagy pathway is associated with neutrophil-driven IL-1β inflammatory response in active ulcerative colitis. J Immunol. 2018;200:3950–61. 10.4049/jimmunol.1701643. 85. de Andrea CE, et al. … Ann Rheum Dis. 2015;74:2199–206. 10.1136/annrheumdis-2014-205365. 174. Yuzhalin AE, et al. Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix. Nat Commun. 2018;9:4783. 10.1038/s41467-018-07306-7. 175. Antonelou M, et al. …