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New hopes and challenges in targeted therapy and immunotherapy for primary central nervous system lymphoma.

Primary central nervous system lymphoma (PCNSL) is non-Hodgkin's lymphoma (NHL) confined to the central nervous system. Most of the patients eventually develop relapsed/refractory (R/R) PCNSL, and the overall prognosis for PCNSL remains dismal. Recently, gene sequencing, transcriptome sequencing, and single-cell sequencing platforms have provided a large amount of data revealing the mechanisms underlying the pathogenesis and drug resistance in PCNSL, including the activation of the NF-κB signaling pathway in tumor cells, tumor heterogeneity, and the immunosuppressive tumor microenvironment. Ad

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… Morales-Martinez A, Lozano-Sanchez F, Duran-Peña A, Hoang-Xuan K, Houillier C. Primary central nervous system lymphoma in elderly patients: management and perspectives. Cancers (Basel). (2021) 13(14):3479. doi: 10.3390/cancers13143479 92. Tsang M, Cleveland J, Rubenstein JL. …

Anti-B Cell Strategy in Nephrotic Syndrome: Beyond Rituximab.

Nephrotic syndrome (NS) is a complex kidney disorder characterized by profound proteinuria, hypoalbuminemia, hyperlipidemia, and edema, significantly impacting patients' quality of life. While corticosteroids and calcineurin inhibitors (CNIs) have traditionally been the primary treatments, B cell-targeted therapies, especially the anti-CD20 monoclonal antibody rituximab, have transformed the management of steroid-dependent and multidrug-resistant NS (MRNS). Rituximab has demonstrated efficacy in reducing relapse rates and steroid dependence by depleting CD20+ B cells, which play a pivotal role

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… Morale W. Obinutuzumab in membranous nephropathy: A potential game-changer in treatment Drugs Context 2025 14 2024-9-1 10.7573/dic.2024-9-1 40017729 PMC11867167 66. Boldrini V.O. Mader S. Kümpfel T. Meinl E. …

The Role of TRL7/8 Agonists in Cancer Therapy, with Special Emphasis on Hematologic Malignancies.

Toll-like receptors (TLR) belong to the pattern recognition receptors (PRR). TLR7 and the closely correlated TLR8 affiliate with toll-like receptors family, are located in endosomes. They recognize single-stranded ribonucleic acid (RNA) molecules and synthetic deoxyribonucleic acid (DNA)/RNA analogs-oligoribonucleotides. TLRs are primarily expressed in hematopoietic cells. There is compiling evidence implying that TLRs also direct the formation of blood cellular components and make a contribution to the pathogenesis of certain hematopoietic malignancies. The latest research shows a positive ef

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… Hart O.M., Athie-Morales V., O’Connor G.M., Gardiner C.M. TLR7/8-Mediated Activation of Human NK Cells Results in Accessory Cell-Dependent IFN-γ Production. J. Immunol. 2005;175:1636–1642. doi: 10.4049/jimmunol.175.3.1636. 79. Salerno F., Heeren J.J.F.-V., Guislain A., Nicolet B.P., Wolkers M.C. …

Pharmaceutical Prevention and Management of Cardiotoxicity in Hematological Malignancies.

Modern treatment modalities in hematology have improved clinical outcomes of patients with hematological malignancies. Nevertheless, many new or conventional anticancer drugs affect the cardiovascular system, resulting in various cardiac disorders, including left ventricular dysfunction, heart failure, arterial hypertension, myocardial ischemia, cardiac rhythm disturbances, and QTc prolongation on electrocardiograms. As these complications may jeopardize the significantly improved outcome of modern anticancer therapies, it is crucial to become familiar with all aspects of cardiotoxicity and pr

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… Bosch X., Rovira M., Sitges M., Domènech A., Ortiz-Pérez J.T., de Caralt T.M., Morales-Ruiz M., Perea R.J., Monzó M., Esteve J. Cardiac Imaging in Heart Failure Enalapril and Carvedilol for Preventing Chemotherapy-Induced Left Ventricular Systolic Dysfunction in Patients with Malignant Hemopathies. …

Fit theory: A cancer experience grounded theory emerging from semi-structured interviews with cancer patients and informal caregivers in Manitoba Canada during the COVID-19 pandemic.

BackgroundIt is not clear how changes to healthcare delivery related to the COVID-19 pandemic, including virtual care and social distancing restrictions, have impacted the experience of living with cancer. This study aimed to discover a theory capable of describing the cancer experience, how the pandemic impacted it, and for guiding predictions about how to improve it.MethodsBetween October 2020 and July 2021 digitally recorded semi-structured one-on-one interviews were conducted virtually with adult cancer patients and informal caregivers in Manitoba, Canada. Transcriptions and field notes fr

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… . […] And that probably made a huge difference in terms of morale and attitude and stuff for both of us. (Participant #29) One important finding was how the pandemic impacted the experience of waiting to access biomedical assets–either prior to appointments with clinicians or in treatment areas. …

Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial.

(1) Background: Chemotherapy-induced peripheral neuropathy (CIPN) decreases the quality of life of patients and can lead to a dose reduction and/or the interruption of chemotherapy treatment, limiting its effectiveness. Potential pathophysiological mechanisms involved in the pathogenesis of CIPN include chronic oxidative stress and subsequent increase in free radicals and proinflammatory cytokines. Approaches for the treatment of CIPN are highly limited in their number and efficacy, although several antioxidant-based therapies have been tried. On the other hand, ozone therapy can induce an ada

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… Clavo B., Ceballos D., Gutierrez D., Rovira G., Suarez G., Lopez L., Pinar B., Cabezon A., Morales V., Oliva E., et al. Long-term control of refractory hemorrhagic radiation proctitis with ozone therapy. J. Pain Symptom. Manag. 2013;46:106–112. doi: 10.1016/j.jpainsymman.2012.06.017. 88. …

Саркоидоз и повышенный риск сопутствующих заболеваний и смертности в Швеции.

ВВЕДЕНИЕ: Саркоидоз — это системное воспалительное заболевание с неясной этиологией, включающее образование гранулом. В большинстве случаев оно затрагивает легкие и лимфоузлы в грудной полости. Саркоидоз может протекать в острой или хронической форме, каждая из которых имеет различные клинические проявления и прогноз. МЕТОДЫ: Кейс-контрольное исследование коморбидности и морбидности у лиц, диагностированных с саркоидозом (код ICD10 D86) в Швеции с 2007 по 2016 год. Контроли были сопоставлены с случаями в соотношении 2:1 по возрасту, полу и району диагностики. Данные собрали из Шведского нацио

Evaluating venetoclax and its potential in treatment-naïve acute myeloid leukemia.

Venetoclax (ABT-199), a BH3-mimetic and selective BCL-2 inhibitor, was recently approved by the US Food and Drug Administration (FDA) for the treatment of acute myeloid leukemia (AML) in adult patients aged 75 years or older, or otherwise unable to tolerate intensive induction chemotherapy, in combination with either hypomethylating agents or low-dose cytarabine. In this review article, we discuss venetoclax's mechanism of action, in relation to both the BCL-2 protein family in general and BH3-mimetic activity in particular. We then outline the pharmacological advances that preceded and facili

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… Morales F , Giordano A . Overview of CDK9 as a target in cancer research . Cell Cycle . 2016 ; 15 ( 4 ): 519 – 527 . doi: 10.1080/15384101.2016.1138186 26766294 PMC5056610 56. Boffo S , Damato A , Alfano L , Giordano A . CDK9 inhibitors in acute myeloid leukemia . …

Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells.

Tumor angiogenesis is widely recognized as one of the "hallmarks of cancer". Consequently, during the last decades the development and testing of commercial angiogenic inhibitors has been a central focus for both basic and clinical cancer research. While antiangiogenic drugs are now incorporated into standard clinical practice, as with all cancer therapies, tumors can eventually become resistant by employing a variety of strategies to receive nutrients and oxygen in the event of therapeutic assault. Herein, we concentrate and review in detail three of the principal mechanisms of antiangiogenic

Gene regulation by non-Coding RNAs in infertility: a mechanistic review.

Infertility is a significant global health issue affecting millions of couples, with noncoding RNAs (ncRNAs) emerging as pivotal regulators in reproductive biology. This review explores the roles of various ncRNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs), long noncoding RNAs (lncRNAs), PIWI-interacting RNAs (piRNAs), and circular RNAs (circRNAs) in male and female infertility. These ncRNAs modulate critical processes such as spermatogenesis, oogenesis, follicular development, and embryo implantation through mechanisms like post-transcriptional regulation, chromatin remode

Left Atrial Appendage Occlusion in Cancer-Associated Atrial Fibrillation: Who, When, and How to Manage Antithrombotic Therapy.

BackgroundCancer-associated atrial fibrillation (AF) is increasingly common, posing dual risks of thrombosis and bleeding. Long-term oral anticoagulation is often limited in these patients due to drug interactions, thrombocytopenia, and treatment-related bleeding. Left atrial appendage occlusion (LAAO) offers a non-pharmacological alternative for stroke prevention, yet its optimal use in cancer remains uncertain.MethodsWe conducted a narrative review of studies from 2009 to October 2025 across PubMed, Embase, and Google Scholar, including randomized trials, observational studies, registries, c

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… J Stroke Cerebrovasc Dis . 2024 ; 33 ( 5 ): 107618 . 38402694 10.1016/j.jstrokecerebrovasdis.2024.107618 32 Tinoco M Echarte-Morales J Guerreiro CE , et al. Short- and long-term outcomes of percutaneous left atrial appendage occlusion in cancer patients . …

Биомаркеры мультимодального МРТ и машинное обучение по расстройству спектра нейромиелита: обзор.

Нейромиелитное расстройство спектра (NMOSD) — воспроизводящееся воспалительное демиелионирующее заболевание центральной нервной системы, которое может привести к значительной кумулятивной неврологической неполноценности. Магнитный резонансный снимок (MRI) играет центральную роль в обнаружении повреждений, дифференциальной диагностике и продольной оценке. Однако обычные МРТ могут не в полной мере улавливать утончённые повреждения тканей и в клинически двусмысленных случаях могут иметь место значительные переплетения со связанными с ними подстрекательскими демиелионирующими расстройствами. Надеж

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… Morales DA Vives-Gilabert Y Gómez-Ansón B Bengoetxea E Larrañaga P Bielza C . Predicting dementia development in Parkinson's disease using Bayesian network classifiers . Psychiatry Res Neuroimaging . ( 2013 ) 213 : 92 – 8 . doi: 10.1016/j.pscychresns.2012.06.001 , 23149030 61. …

Clinical Outcome of Febrile Neutropenia and Associated Factors Among Adult Patients with Cancer Treated at Ethiopian Oncology Centers: A Retrospective Observational Study.

IntroductionFebrile neutropenia (FN) is a major cause of dose-limiting complications in cancer treatment that predisposes patients to serious infections. Despite advancements in therapies, including empirical and definitive antibiotics, FN remains a major morbidity and mortality issue among patients with cancer undergoing cancer treatment. Little is known about the 30-day all-cause mortality rates from FN in Ethiopia, particularly in the Northwest Ethiopia oncology centers.MethodsThis retrospective cross-sectional study was conducted via chart review without direct patient contact at two North

Роль микробиомы в множестве миелом: новые знания и терапевтические возможности.

Множественная миелома — гематологический рак, описываемый распространением плазменных клеток в костном мозге, что вызывает иммунную дисфункцию и другие аномалии. Микробиом кишечника, микробное сообщество в желудочно-кишечном тракте, было обнаружено, что он модифицирует системный иммунитет, воспаление и метаболизм. Хотя взаимосвязь между кишечным микробиомом и множеством миелома была обнаружена в недавних исследованиях, существует пробел в знаниях, связывающий воздействие микробиома на патогенез и лечение множественной миеломы. Несбалансированность в кишечном микробиоме, дисбиозе, может влиять

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… Morales M.L. Gomez-Gordo R. Justo P. Cuellar C. Sanchez-Pina J. Lopez N. Alonso R. Short-Chain Fatty Acid Production by Gut Microbiota Predicts Treatment Response in Multiple Myeloma Clin. Cancer Res. 2024 30 904 917 10.1158/1078-0432.CCR-23-0195 38109212 PMC10870002 41. D’Angelo C.R. Sudakaran S. …

Оптический анализ функционального воздействия демиелинации и ремиэлизации Cuprizone на межсферную нервную коммуникацию в антериорной кортекс через Corpus Callosum.

Cuprizone (CPZ) — широко используемый токсин, который вызывает демиелинизирующие заболевания в моделях животных, производя множественный склероз (MS), похожий на патологию в грызунах. CPZ является одним из немногих токсинов, которые вызывают демиелинацию и последующее воспоминание после прекращения ее применения. В этом исследовании рассматриваются функциональные последствия демиэлизации, вызванной КПЗ, и последующее восстановление нейронной связи в передней коре сингула (АКК) с уделением особого внимания соединению между полушариями через корпус каллосум (CC). Используя широкополосную высокос

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… Front Cell Neurosci 17:1217368. 10.3389/fncel.2023.1217368 Vega-Riquer JM, Mendez-Victoriano G, Morales-Luckie RA, Gonzalez-Perez O (2019) Five decades of cuprizone, an updated model to replicate demyelinating diseases. …

Novel Insights in Venous Thromboembolism Risk Assessment Methods in Ambulatory Cancer Patients: From the Guidelines to Clinical Practice.

Many cancer patients will experience venous thromboembolism (VTE) at some stage, with the highest rate in the initial period following diagnosis. Novel cancer therapies may further enhance the risk. VTE in a cancer setting is associated with poor prognostic, a decreased quality of life, and high healthcare costs. If thromboprophylaxis in hospitalized cancer patients and perioperative settings is widely accepted in clinical practice and supported by the guidelines, it is not the same situation in ambulatory cancer patient settings. The guidelines do not recommend primary thromboprophylaxis, exc

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… Morales Helguera A. Pérez Castillo Y. Cruz Rodríguez J. Guerra Rodríguez J.F. Falanga A. Validation of venous thromboembolism predictive model in hematologic malignancies Ann. Hematol. 2023 102 3613 3620 10.1007/s00277-023-05463-4 37782372 84. Sanfilippo K.M. Luo S. Wang T.F. Fiala M. Schoen M. …

Гематологические болезни у пожилых пациентов: уделение особого внимания потенциальной роли управления гериатрической оценкой.

Управление гериатрической оценкой представляет собой многомерный инструмент, используемый для оценки прогнозов в отношении клинических результатов и целевых показателей в отношении мероприятий для пожилых людей, в которых рак проходит химиотерапию. В ходе этого обзора мы провели оценку возможного применения методов управления гериатрической оценкой (GAM) в гематологических паразитах. У пожилых пациентов с диффузной клеточной лимфомой B GAM может быть полезным как в прогнозировании запланированных госпитализаций, так и в улучшении качества жизни. В хронической миелоидной лейкемии индекс коморби

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… Guillot Morales M., Visa L., Brozos Vázquez E., Feliu Batlle J., Khosravi Shahi P., Laquente Sáez B., de San Vicente Hernández B.L., Macarulla T., Gironés Sarrió R. Update on the management of older patients with pancreatic adenocarcinoma: A perspective from medical oncology. Clin. Transl. …

Quality of Life in Caregivers of Cancer Patients: A Literature Review.

(1) Background: Cancer constitutes one of the principal causes of morbi-mortality in the world and generates an important loss of patients' self-sufficiency. People who are their caregivers usually become the main care providers, which impacts their quality of life; (2) Aim: Analyze the different problems (physical, emotional, social, and financial) faced by people who are caregivers of adults with cancer and describe the strategies required to improve their quality of life; (3) Method: A literature review was conducted on the following database: PubMed, Cinahl, PsycINFO, and Scopus. The follo

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… Bernal-Morales B. Gutiérrez-García A.G. Díaz-Domínguez E. Hernández-Baltazar D. Cibrián-Llanderal T. Evaluación psicoafectiva en pacientes con cáncer avanzado y cuidadores principales Gac. Mex. Oncol. 2018 17 245 252 10.24875/j.gamo.19000131 70. Pino K. Murillo M. Suárez L.F. …

Treatment progress of spinal metastatic cancer: a powerful tool for improving the quality of life of the patients.

Spinal metastasis is a common secondary malignant tumor of the bone, often resulting in spinal cord and nerve root compression, leading to obvious pain and related compression symptoms. This condition has a high incidence and mortality rate. The treatment approach for most patients with spinal metastasis is primarily palliative. Consultation with a multidisciplinary team is widely accepted as a comprehensive treatment approach for patients with spinal metastases. With advancements in research and technology, the evaluation and treatment of spinal metastatic cancer are continuously evolving. Th

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… Greco C Pares O Pimentel N Moser E Louro V Morales X Spinal metastases: from conventional fractionated radiotherapy to single-dose SBRT Rep Pract Oncol Radiother 2015 20 6 454 463 10.1016/j.rpor.2015.03.004 26696786 PMC4661345 80. …

Antidepressant Drug Sertraline against Human Cancer Cells.

The use of FDA-approved drugs for new indications represents a faster and more economical way to find novel therapeutic agents for cancer therapy, compared to the development of new drugs. Repurposing drugs is advantageous in a pharmacological context since these drugs already have extensive data related to their pharmacokinetics, facilitating their approval process for different diseases. Several studies have reported the promising anticancer effects of sertraline, both alone and combined, in different types of cancer cell lines. Here, we performed a literature review on the anticancer potent

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… Morales D.R. Morris A.D. Metformin in Cancer Treatment and Prevention Annu. Rev. Med. 2015 66 17 29 10.1146/annurev-med-062613-093128 25386929 12. Caly L. Druce J.D. Catton M.G. Jans D.A. Wagstaff K.M. The FDA-Approved Drug Ivermectin Inhibits the Replication of SARS-CoV-2 in Vitro Antivir. …