Результаты поиска

Routes of administration, reasons for use, and approved indications of medical cannabis in oncology: a scoping review.

INTRODUCTION: Some patients diagnosed with cancer use medical cannabis to self-manage undesirable symptoms, including nausea and pain. To improve patient safety and oncological care quality, the routes of administration for use of medical cannabis, patients' reasons, and prescribed indications must be better understood. METHODS: Based on the Joanna Briggs Institute guidelines, a scoping review was conducted to map the current evidence regarding the use of medical cannabis in oncological settings based on the experiences of patients diagnosed with cancer and their healthcare providers. A searc

Совпадение в полном тексте источника
… Reblin M Sahebjam S Peeri NC Martinez YC Thompson Z Egan KM Medical Cannabis Use in Glioma Patients Treated at a Comprehensive Cancer Center in Florida Journal of Palliative Medicine 2019 22 10 1202 1207 31081711 10.1089/jpm.2018.0528 PMC7364313 48. …

Структурный анализ процесса сбора света с помощью антенн, содержащих родопсины в морской архееи Асгарда.

Акватические бактериальные редопсиновые протонные насосы собирают световую энергию для фотогетертрофного роста и, как известно, содержат гидроксилированные каротеи, расширяющие волны используемого света, но они не характеризуются морской археей. Здесь, комбинируя морскую хромофорную экстракт с очищенными архейскими родопсинами, выявленными в морских метагеномах, мы показываем передачу легкой энергии из различных гидроксилоидных каротеоидных в геймдаллархаэ (HeimdallRs) из некультурных морских планктонных членов «Candidatus Cariarachaeceae» (Candidatus Asgardarchaeota). Эти светообрабатывающие

Совпадение в полном тексте источника
… K. pelagium’) from the estuary of the Apalachicola River, Florida 33 , and HeimdallR3 from ‘ Ca . Kariarchaeum’ scaffold Gs0128817_NODE_76 obtained from metagenomic data from Groves Creek Marsh, Skidaway Island, Georgia (JGI project Gs0128817). …

The influence of telehealth-based cancer rehabilitation interventions on disability: a systematic review.

PurposeTo characterize delivery features and explore effectiveness of telehealth-based cancer rehabilitation interventions that address disability in adult cancer survivors.MethodsA systematic review of electronic databases (CINAHL Plus, Cochrane Library: Database of Systematic Reviews, Embase, National Health Service's Health Technology Assessment, PubMed, Scopus, Web of Science) was conducted in December 2019 and updated in April 2021.ResultsSearches identified 3,499 unique studies. Sixty-eight studies met inclusion criteria. There were 81 unique interventions across included studies. Interv

Совпадение в полном тексте источника
… A telephone-based education and support intervention for rural breast cancer survivors: a randomized controlled trial comparing two implementation strategies in rural Florida. J Cancer Surviv. 2020;14(4):494–503. doi: 10.1007/s11764-020-00866-y. 69. Meneses K, Gisiger-Camata S, Benz R, et al. …

The Application of CAR-T Cells in Haematological Malignancies.

Chimeric antigen receptor (CAR)-T cells (CART) remain one of the most advanced and promising forms of adoptive T-cell immunotherapy. CART represent autologous, genetically engineered T lymphocytes expressing CAR, i.e. fusion proteins that combine components and features of T cells as well as antibodies providing their more effective and direct anti-tumour effect. The technology of CART construction is highly advanced in vitro and every element of their structure influence their mechanism of action in vivo. Patients with haematological malignancies are faced with the possibility of disease rela

Совпадение в полном тексте источника
… Transplantation and cellular therapy meetings, February 19–23, 2020, Orlando, Florida Ali SA, Shi V, Maric I, et al. T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma. Blood. 2016;128:1688–1700. doi: 10.1182/blood-2016-04-711903. …

2026 Приложение к резюме Международного конгресса

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

33rd Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2018) : Washington, D.C., USA. 7-11 November 2018.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Резюме книги: Тема: 13th Международный симпозиум на тему " Ходжкин лимфома " ; октябрь 2024

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Unlocking the Microbial Symphony: The Interplay of Human Microbiota in Cancer Immunotherapy Response.

IntroductionThe emergence of cancer immunotherapy has revolutionized cancer treatment, offering remarkable outcomes for patients across various malignancies. However, the heterogeneous response to immunotherapy underscores the necessity of understanding additional factors influencing treatment efficacy. Among these factors, the human microbiota has garnered significant attention for its potential role in modulating immune response. Body: This review explores the intricate relationship between the human microbiota and cancer immunotherapy, highlighting recent advances and potential mechanisms u

Совпадение в полном тексте источника
… . | Advent Health Cancer Institute, Orlando, Florida, US | NCT04291755 | Development and Analysis of a Sample Bank for Cancer Patients, Enabling the Systematic Study of the Effect of Blood, Urinary Tract, and Gut Microbiomes on Response | Recruiting | Patients undergoing any form of cancer immunotherapy …

Резюме докладов 38th - ежегодное собрание общества общей внутренней медицины.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Corbie-Smith 1, 1 . 1 University of North Carolina, Chapel Hill, NC; 2 University of North Carolina at Chapel Hill, Chapel Hill, NC; 3 University of Arkansas, Fayetteville, AR; 4 University of Pittsburgh, Pittsburgh, PA; 5 University of California, Los Angeles, Los Angeles, CA; 6 University of Florida … METHODS: Across four institutions (University of Arkansas, University of California Los Angeles, University of Florida, and University of North Carolina) with Clinical and Translational Science Awards, we conducted concept mapping sessions with participants from three stakeholder groups. …

Резюме докладов 2017 Ежегодное совещание Общества общей внутренней медицины.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Oral Presentations

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Marine Natural Products as Potent Anticancer Agents (2020-2024): Structural Diversity, SARs and Target Prediction.

In recent years, Marine Natural Products (MNPs) have emerged as a significant source for anticancer drug discovery, as many natural products can offer structural diversity, unique mechanisms of action, and relatively low toxicity. This article provides a systematic review of MNPs with reported anticancer activities from 2020 to 2024. These compounds are classified into seven major categories: terpenoids, alkaloids, sterols, polyketides, peptides and proteins, polysaccharides, and macrolides. For each category, we elaborate on the marine sources, structural identification, in vitro anticancer a

Совпадение в полном тексте источника
… In 2023, Luesch’s research group isolated jezoside ( 85 ) and its novel derivative jezoside B ( 86 ) from the cyanobacterial assemblage collected in Florida ( Figure 41 ) [ 86 ]. Both are polypeptide compounds. …

Monoclonal antibody and protein therapeutic formulations for subcutaneous delivery: high-concentration, low-volume vs. low-concentration, high-volume.

Biologic drugs are used to treat a variety of cancers and chronic diseases. While most of these treatments are administered intravenously by trained healthcare professionals, a noticeable trend has emerged favoring subcutaneous (SC) administration. SC administration of biologics poses several challenges. Biologic drugs often require higher doses for optimal efficacy, surpassing the low volume capacity of traditional SC delivery methods like autoinjectors. Consequently, high concentrations of active ingredients are needed, creating time-consuming formulation obstacles. Alternatives to tradition

Совпадение в полном тексте источника
… Boca Raton, Florida, USA: CRC Press. 56. Wang W. Tolerability of hypertonic injectables. Int J Pharm. 2015;490(1–2):308–15. doi: 10.1016/j.ijpharm.2015.05.069. 57. Tyler-Cross R, Schirch V. …

Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor.

No approved therapy exists for cancer-associated cachexia. The colon-26 mouse model of cancer cachexia mimics recent late-stage clinical failures of anabolic anti-cachexia therapy and was unresponsive to anabolic doses of diverse androgens, including the selective androgen receptor modulator (SARM) GTx-024. The histone deacetylase inhibitor (HDACi) AR-42 exhibited anti-cachectic activity in this model. We explored combined SARM/AR-42 therapy as an improved anti-cachectic treatment paradigm. A reduced dose of AR-42 provided limited anti-cachectic benefits, but, in combination with GTx-024, sign

Совпадение в полном тексте источника
… Following additional washes (TBST), immunoblots were visualized as appropriate by ECL chemiluminescence (Amersham Biosciences, Little Chalfont, United Kingdom) or Duration HRP Chemiluminescence (Alkali Scientific, Florida, United States). …

The Past, Present, and Future of Clinically Applied Chimeric Antigen Receptor-T-Cell Therapy.

Immunotherapy represents the fourth pillar of cancer therapy after surgery, chemotherapy, and radiation. Chimeric antigen receptor (CAR)-T-cell therapy is an artificial immune cell therapy applied in clinical practice and is currently indicated for hematological malignancies, with cluster of differentiation 19 (CD19) as its target molecule. In this review, we discuss the past, present, and future of CAR-T-cell therapy. First, we summarize the various clinical trials that were conducted before the clinical application of CD19-targeted CAR-T-cell therapies began. Second, we discuss the accumulat

Совпадение в полном тексте источника
… Florida-James G.D. Whyte G.P. Pircher H. Guy K. Senescent T-Lymphocytes Are Mobilised into the Peripheral Blood Compartment in Young and Older Humans after Exhaustive Exercise Brain Behav. Immun. 2008 22 544 551 10.1016/j.bbi.2007.11.002 18164586 98. Mooren F.C. Krüger K. …

Oral Presentations

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

The synergistic immunotherapeutic impact of engineered CAR-T cells with PD-1 blockade in lymphomas and solid tumors: a systematic review.

Currently, therapies such as chimeric antigen receptor-T Cell (CAR-T) and immune checkpoint inhibitors like programmed cell death protein-1 (PD-1) blockers are showing promising results for numerous cancer patients. However, significant advancements are required before CAR-T therapies become readily available as off-the-shelf treatments, particularly for solid tumors and lymphomas. In this review, we have systematically analyzed the combination therapy involving engineered CAR-T cells and anti PD-1 agents. This approach aims at overcoming the limitations of current treatments and offers potent

Совпадение в полном тексте источника
… refractory neuroblastoma | GD2 specific CAR-T | Phase 1 | 08-2013 | Undergoing NCT05035407 | National institute of Health Clinical Center, US | Gastric, Cervical, Lung, Breast and other KK-LC-1 positive Cancer | KK-LC-1 Specific CAR-T | Phase 1 | 08-03-2022 | Undergoing NCT02274584 | University of Florida …

Immunotherapies for pediatric cancer: current landscape and future perspectives.

The advent of immunotherapy has revolutionized how we manage and treat cancer. While the majority of immunotherapy-related studies performed to date have focused on adult malignancies, a handful of these therapies have also recently found success within the pediatric space. In this review, we examine the immunotherapeutic agents that have achieved the approval of the US Food and Drug Administration for treating childhood cancers, highlighting their development, mechanisms of action, and the lessons learned from the seminal clinical trials that ultimately led to their approval. We also shine a

Совпадение в полном тексте источника
… Another phase I clinical trial at the University of Florida is currently recruiting pediatric patients with high-grade glioma to evaluate cancer vaccines comprised of dendritic cells “pre-loaded” with allogenic tumor RNA given in combination with GM-CSF ( NCT03334305 ). …

E-Posters

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… P006: Neuronavigation-guided cervical spine osteophytectomy for dysphagia: a case report Luke Pearson 1 , Seung Lee 2 , Jared Weeks 1 , Abdullah Alanazi 1 , Emilio Supsupin 1 , Daryoush Tavanaiepour 1 , Kourosh Tavanaiepour 1 , Dunbar Alcindor 1 , Vashisht Sekar 1 , Aboubakr Amer 1 1 University of Florida …

In vitro расширила человека CD4+CD25+ регуляционные T клетки, подавляющие распространение Т клеток.

Регулирующие Т клетки (Tregs) оказались критически важными в балансе между автоиммунизацией и терпимостью и были связаны с несколькими аутоиммунными заболеваниями человека. Однако небольшое число трегов в периферии крови ограничивает их терапевтический потенциал. Поэтому мы разработали протокол, который позволит расширить "Трегз" при сохранении их подавляющей активности. Мы изолировали клетки CD4+CD25 hi от человеческой периферической крови и расширили их in vitro в присутствии anti-CD3 и anti-CD28 Магнитные кситы и высокие концентрации внешнего интерлейкина (IL) -2. Траги были эффективно расш