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EQ-5D vision bolt-on in macular degeneration: associations with visual measures and effect on utility differences and cost-effectiveness of stereotactic radiotherapy.

BACKGROUND: The UK STAR trial [Stereotactic Radiotherapy (SRT) for neovascular age-related macular degeneration (nAMD)] compared 16-Gray SRT (n = 274) with double-masked sham SRT (n = 137) in participants with chronic active nAMD. SRT reduced intravitreal anti-vascular endothelial growth factor (VEGF) re-treatments over two years of pro re nata ranibizumab, followed by two years of routine care. However, this resulted in worse best-corrected visual acuity (BCVA) in Years 3 and 4. This paper describes: associations between the EQ-5D vision bolt-on and visual acuity and patient-reported outcome

Balancing diagnostic accuracy and cost in the follow-up of histological low-grade squamous intraepithelial lesions.

INTRODUCTION: Primary cervical screening with testing for human papillomavirus (HPV) brings increased detection of women with low-grade squa … of histological low-grade squamous intraepithelial lesions. The secondary outcome was to perform a cost-effectiveness analysis of these strategies. RESULTS: Using co-testing as the primary follow-up and reserving colposcopy for women who tested positive for HPV or cytology results yielded a sensitivity of 96% for high-grade squamous intraepithelial or more severe lesions. …

Primary HPV-DNA screening in women under 30 years of age: health technology assessment.

BACKGROUND: Primary screening with Human Papilloma Virus (HPV) testing was introduced in Colombia in 2014 for individuals between 30 and 65 years of age. When the result is positive, cytology triage is performed for colposcopy referral. The convenience of initiating HPV-DNA testing for screening at 25 years of age is currently a subject of discussion. Therefore, the objective of this health technology assessment (HTA) is to analyze the available evidence regarding safety, efficacy, cost-effectiveness, values and preferences, ethical dilemmas and considerations pertaining to the implementation

Cost-utility analysis of routine oral anticoagulation for low-risk patients undergoing cardioversion for atrial fibrillation and flutter.

PURPOSE: Canadian guidelines suggest that physicians should consider prescribing four weeks of oral anticoagulation (OAC) for patients undergoing cardioversion for acute atrial fibrillation/flutter (AF/AFL), regardless of stroke risk. While the risk of stroke following cardioversion may be low, the morbidity and cost from a stroke is significant. This study aims to evaluate the cost-effectiveness of routinely providing OAC after cardioversion. METHODS: We conducted a cost-utility analysis comparing no-OAC post-cardioversion to four weeks of OAC, from the perspective of the Canadian public pay

Societal value of newborn screening for severe combined immune deficiency in Arkansas: An economic analysis.

Newborn screening (NBS) is a public health program that detects genetic conditions in neonates enabling treatment before clinical symptoms m … esults in an estimated net cost savings for NBS for SCID in Arkansas of $351,286 per year. Based on cost-effectiveness analysis, NBS for SCID in Arkansas is cost-effective, with higher societal benefit than cost.

Cost-Utility Analysis of Screening Strategies for Diabetic Retinopathy in Korea.

This study involved a cost-utility analysis of early diagnosis and treatment of diabetic retinopathy depending on the screening strategy used. The four screening strategies evaluated were no screening, opportunistic examination, systematic fundus photography, and systematic examination by an ophthalmologists. Each strategy was evaluated in 10,000 adults aged 40 yr with newly diagnosed diabetes mellitus (hypothetical cohort). The cost of each strategy was estimated in the perspective of both payer and health care system. The utility was estimated using quality-adjusted life years (QALY). Increm

Ureteric stenting with magnetic retrieval: an alternative to traditional methods.

INTRODUCTION: Ureteric stents are frequently placed following endo-urological procedures. These stents cause significant morbidity for patients. Standard ureteric stents are removed by flexible cystoscopy. This procedure can be unpleasant for patients and requires additional resources. A newly designed magnetic stent allows removal in an outpatient setting. The aim of our study is to compare the magnetic stent and standard ureteric stents with regard to morbidity, pain on stent removal and cost-effectiveness. METHODS: This study was carried out across two sites between September 2016 and July

The economic costs of jail-based methadone maintenance treatment.

BACKGROUND: The US has the highest incarceration rate in the world and spends $40-$80 billion to house inmates per year. It is well-known that a significant correlation is present between substance use and crime, especially over recent years as opioid use disorder (OUD) has grown exponentially. To mitigate OUD, methadone maintenance treatment (MMT) has demonstrated effectiveness in numerous randomized and quasi-experimental studies. A potentially fruitful environment for MMT is correctional facilities, particularly short-term facilities, such as city and county jails. However, little is known

Cost-Effectiveness of Direct Non-Vitamin K Oral Anticoagulants Versus Vitamin K Antagonists for the Management of Patients with Non-Valvular Atrial Fibrillation Based on Available "Real-World" Evidence: The Italian National Health System Perspective.

BACKGROUND AND OBJECTIVE: The increasing availability of real-world evidence (RWE) about safety and effectiveness of direct non-vitamin K or … of being the most effective for stroke/SE, MB and ACM. Despite their higher acquisition costs, the cost-effectiveness analysis showed all DOACs involved a saving when compared with VKAs, with per-patient savings ranging between €4647 (rivaroxaban) to €6086 (apixaban). Moreover, all DOACs indicated a gain both in quality-adjusted life-years and life-years. According to PSA, …

Effectiveness and cost-effectiveness of the Salut Programme: a universal health promotion intervention for parents and children-protocol of a register-based retrospective observational study.

INTRODUCTION: There is inadequate evidence for the effectiveness and cost-effectiveness of health promotion interventions. The Salut Programme aims to reach all parents and children in the Västerbotten County of Sweden with a combination of health promotion interventions initiated during pregnancy and continued over the childhood period. This study protocol describes an effectiveness study and an economic evaluation study, where the ongoing Salut Programme is compared to care-as-usual over the periods of pregnancy, delivery and the child's first 2 years of life. METHODS: A register-based retr

Genome-Wide Sequencing for Unexplained Developmental Disabilities or Multiple Congenital Anomalies: A Health Technology Assessment.

BACKGROUND: People with unexplained developmental disabilities or multiple congenital anomalies might have had many biochemical, metabolic, and genetic tests for a period of years without receiving a diagnosis. A genetic diagnosis can help these people and their families better understand their condition and may help them to connect with others who have the same condition. Ontario Health (Quality), in collaboration with the Canadian Agency for Drugs and Technologies in Health (CADTH) conducted a health technology assessment about the use of genome-wide sequencing for patients with unexplained

Cocreation of a Digital Psychological Intervention to Improve Mental Health Among Survivors of Breast Cancer (SerenApp): Protocol for a Usability and Pilot Randomized Controlled Trial.

BACKGROUND: Survivors of breast cancer frequently experience anxiety, stress, and depression during the follow-up and survivorship phases, when access to psychosocial support is often limited. Although psychological interventions have demonstrated effectiveness, their implementation in routine clinical practice remains challenging. Digital mental health interventions offer a promising alternative. However, many existing solutions show limited personalization, engagement, and long-term adherence, partly due to insufficient involvement of end users in their design. OBJECTIVE: This study aims to

Cost-effectiveness of targeted COPD case-finding with the PUMA questionnaire followed by spirometry among ever-smokers in Singapore.

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is frequently undiagnosed among ever-smokers. We evaluated the cost-effectiveness of targeted COPD case-finding using the PUMA questionnaire followed by spirometry among ever-smokers aged 50 years and older in Singapore. METHODS: A cohort Markov model compared two strategies: PUMA-based case-finding (PUMA score ≥4) followed by spirometry versus no case-finding, over a lifetime horizon from the healthcare payer perspective, with 3% annual discounting. A willingness-to-pay threshold of SGD75,000/QALY was applied. RESULTS: Case-finding yi

Priority during a meningitis epidemic: vaccination or treatment?

From November 1995 to May 1996, a meningitis epidemic occurred in northern Nigeria. More than 75,000 cases and 8440 deaths (case fatality rate (CFR), 11%) were recorded. Médecins sans Frontières, in cooperation with the Nigerian government, carried out an assistance programme (support to case management, surveillance and mass vaccination) in three states (Bauchi, Kano, Katsina) where 75% of cases occurred. Cost analysis of this assistance in Katsina State reveals that case management and mass vaccination were efficient: US$ 35 per case treated and US$ 0.64 per vaccination. There was, however,

Effect of the national reimbursement drug list negotiation policy on utilization of negotiated anticancer drugs in Chinese public hospital: a quasi-natural experiment.

BackgroundHigh prices have limited access to targeted anticancer drugs in China. In 2017, 18 such drugs were added to the National Reimbursement Drug List (NRDL) through national price negotiation.MethodMonthly hospital procurement data (2015-2019) from 887 public hospitals across 30 provinces were analyzed. Drug utilization was measured by expenditures and defined daily doses (DDDs). A difference-in-differences (DID) model and interrupted time series (ITS) analysis were employed to estimate policy effects.ResultsFollowing policy implementation, total DDDs of negotiated drugs rose 4.03-fold an

Фармакоэкономическая оценка карфилзомиба против ixazomib для лечения повторной и рефрактной множественной миеломы.

ЦЕЛЬ: В настоящем исследовании оценивается рентабельность карфилзомиба плюс линалидомида и дексаметасона (KRd) против ixazomib плюс линалидомида и дексаметазона для повторной и повторной миэломы (RRMM) в Китае. МЕТОДЫ: Модель выживания использовалась для анализа состояния здоровья и затрат на протяжении всей жизни. 4-week цикл. Воздействие обработки на выживаемость без прогрессирования (ПФС) и общее выживаемость (ОС) моделировалось с использованием коэффициентов опасности (РЧ), полученных на основе сетевого метаанализа (НМА). На основе опубликованной литературы были получены данные о стоимости

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… Cost-effectiveness analysis of adding daratumumab to bortezomib, melphalan, and prednisone for untreated multiple myeloma . Front Pharmacol . 2021 ; 12 : 608685 . doi: 10.3389/fphar.2021.608685 33732154 PMC7957051 18 Bian Y , Wang R , Pan W , et al. … 三种微生态制剂治疗急性腹泻的费用——效果分析 [Cost-effectiveness analysis of three microecological preparations for the treatment of acute diarrhoea] . Chin J Microecol . 2002 ;14( 01 ): 38 – 39 . Chinese. doi: 10.3969/j.issn.1005-376X.2002.01.019 . 21 Ma L LID. …

Matching-adjusted indirect comparison and cost-effectiveness of mitoxantrone hydrochloride liposome versus Chidamide in relapsed or refractory peripheral T-cell lymphoma in China.

BACKGROUND: Mitoxantrone hydrochloride liposome (PLM60) is a novel liposome formulation, approved in China for the treatment of patients diagnosed with relapsed or refractory peripheral T-cell lymphoma (R/R PTCL). This study aimed to assess the cost-effectiveness of PLM60 versus chidamide (CS055) in R/R PTCL from the Chinese healthcare perspective. RESEARCH DESIGN AND METHODS: We conducted a cost-utility analysis using a partitioned survival model with a 5-year horizon, applying a 5% discount rate to both costs and health outcomes. Owing to the lack of head-to-head comparison between the two

Preferences for herpes zoster vaccination among adults aged 50 years and older in the United States: results from a discrete choice experiment.

BACKGROUND: Most adults, and disproportionately fewer African-Americans, have not received herpes zoster (HZ) vaccination despite current recommendations. This study (GSK study identifiers: 208677/HO-17-18066) assessed HZ vaccination preferences among adults aged ≥ 50 years. RESEARCH DESIGN AND METHODS: In this discrete choice experiment, respondents chose among a 'no vaccine' option and two HZ vaccine profiles, characterized by seven attributes, in a series of choice questions. Random-parameters logit results were used to predict likely vaccine uptake. Subgroup and latent class analysis of A

Cost-Effectiveness of the Smaller-Incision New Generation Implantable Miniature Telescope for Late-Stage Age-Related Macular Degeneration.

OBJECTIVE: To assess the cost-effectiveness of the smaller-incision new-generation implantable miniature telescope (SING IMT) versus conventional standard care (CSC) from the Italian National Health Service (NHS) and societal perspectives. DESIGN: Model-based cost-utility analysis. SUBJECTS: A simulated cohort of patients with bilateral late-/end-stage age-related macular degeneration (AMD), based on a prospective multicenter study population (mean age, 76 years) eligible for SING IMT, compared with a clinically comparable cohort receiving CSC. METHODS: A cohort Markov model with quarterly

Economic evaluation of therapies for patients suffering from relapsed-refractory multiple myeloma in Greece.

BACKGROUND: Multiple myeloma is a hematologic malignancy that incurs a substantial economic burden in care management. Since most patients with multiple myeloma eventually relapse or become refractory to current therapies (rrMM), the aim of this study was to assess the cost-effectiveness of the combination of lenalidomide-dexamethasone, relative to bortezomib alone, in patients suffering from rrMM in Greece. METHODS: An international discrete event simulation model was locally adapted to estimate differences in overall survival and treatment costs associated with the two alternative treatment

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… It must be highlighted that pharmacoeconomic evaluations comparing different therapeutic options in this group of patients are limited in the literature, and the cost-effectiveness analysis of these agents needs further investigation. 35 However, according to recent evidence, combination therapy with … 000000000-00000 36 Brown RE Stern S Dhanasiri S Schey S Lenalidomide for multiple myeloma: cost-effectiveness in patients with one prior therapy in England and Wales Eur J Health Econ 5 10 2012 [Epub ahead of print.] 10.1007/s10198-012-0395-6 22572968 37 Félix J Almeida J Vandewalle B A comprehensive cost-effectiveness …