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Case report: A successful second autologous hematopoietic stem cell transplantation in refractory systemic sclerosis, with positive effect on skin involvement, pulmonary function and microcirculation.

BACKGROUND: Systemic sclerosis (SSc) is a complex autoimmune disease characterized by inflammation, vasculopathy and fibrosis of the skin and internal organs. Treatment with autologous hematopoietic cell transplantation (HCT) for progressive SSc has improved overall and event-free survival rates significantly, but unfortunately disease progression after HCT is seen in a subset of patients. Data on the efficacy and safety of second HCT is scarce. CASE: We present a patient with diffuse cutaneous SSc and associated interstitial lung disease (ILD) who successfully underwent a second HCT for prog

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… RP was treated with nifedipine retard 20mg once-daily and for heartburn complaints omeprazole 20mg once-daily was initiated. His arthritis was treated with prednisolone 10mg once-daily. …

Ascites Index - an attempt to objectify the assessment of ascites.

IntroductionAscites is observed in cancer patients as well as in other non-neoplastic processes. In some patients, it may cause severe symptoms that can become directly life-threatening. The assessment of the degree of ascites seems useful in the determination of treatment effects as well as in the monitoring of fluid accumulation and early planning of decompression procedures.AimDetermination of the clinical usefulness of a quantitative method of determining the degree of ascites, so-called Ascites Index.Material and methodsThe Ascites Index is an ultrasonographic way of assessing the grade o

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… Symptoms that follow include appetite loss, difficulty sitting and walking, nausea, vomiting, flatulence, recurring heartburn as well as edema of the lower limbs and reproductive organs. …

Prokinetics for functional dyspepsia.

BACKGROUND: Dyspepsia is a common condition associated with gastrointestinal (GI) disease. Prokinetics are the treatment of choice for funct … other organic and metabolic disorders. Studies only including participants with primarily reflux or heartburn symptoms were excluded. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed study eligibility, study quality and performed data extraction. MAIN RESULTS: From an initial 1388 citations, we identified 43 studies in 40 papers. Of …

Extraluminal amyloidoma of the pelvic cavity causing large bowel obstruction.

AMYLOIDOSIS IS A GROUP OF DIVERSE DISORDERS THAT FALL INTO SEVERAL MAJOR CATEGORIES: primary, secondary, dialysis-associated, and hereditary forms. Clinically, amyloidosis may be categorized as localized or systemic. The gastrointestinal tract is among the most common places for deposition of amyloid, but large, localized amyloid deposits are an uncommon occurrence and rarely cause extraluminal bowel compression resulting in obstruction as was seen in the case presented in this clinical scenario.

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… The esophagus, with symptoms including dysphagia, heartburn, and hematemesis, is involved in 13–22% of patients [ 2 ]. The stomach is involved in 8–12% of patients, but is usually asymptomatic [ 2 , 5 ]. The small bowel is involved in up to 31%. …

The Impact of an Embedded Oncology Pharmacist in an Outpatient Oncology Center in the Treatment of Hematologic Malignancies.

BackgroundThe growing demand for clinicians in the ambulatory oncology setting to reduce fragmentation of care and improve patient outcomes represents a need for oncology pharmacists as advanced practitioners in the provision of direct patient-centered care. These provisions can include supportive care management, drug-drug interaction evaluation, and selection of appropriate chemotherapy regimens to reduce physician workload in a cost-effective manner, while increasing physician and patient satisfaction. However, robust data are currently lacking to support the impact of pharmacists in the am

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… SC = supportive care; OC = order clarification; NV = nausea and vomiting; G-CSF = granulocyte colony-stimulating factor; CA VTE = cancer-associated venous thromboembolism; TLS = tumor lysis syndrome. a diarrhea, constipation, mucositis, heartburn SC: NV | SC: GI a | SC: Anti-infective | SC: G-CSF related …

Acceptability and usefulness of the EORTC 'Write In three Symptoms/Problems' (WISP): a brief open-ended instrument for symptom assessment in cancer patients.

BackgroundThe use of open-ended questions supplementing static questionnaires with closed questions may facilitate the recognition of symptoms and toxicities. The open-ended 'Write In three Symptoms/Problems (WISP)' instrument permits patients to report additional symptoms/problems not covered by selected EORTC questionnaires. We evaluated the acceptability and usefulness of WISP with cancer patients receiving active and palliative care/treatment in Austria, Chile, France, Jordan, the Netherlands, Norway, Spain and the United Kingdom.MethodsWe conducted a literature search on validated instrum

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… 3.8 | 7 | 8.6 Bleeding | 8 | 5.0 | 5 | 6.3 | 3 | 3.7 Edema | 7 | 4.3 | 3 | 3.8 | 4 | 4.9 Dizziness | 7 | 4.3 | 1 | 1.3 | 6 | 7.4 Itching | 7 | 4.3 | 4 | 5.0 | 3 | 3.7 Myoclonus d | 7 | 4.3 | 1 | 1.3 | 6 | 7.4 Sore mouth | 6 | 3.7 | 6 | 7.5 | 0 | 0.0 Other eye symptoms | 6 | 3.7 | 2 | 2.5 | 4 | 4.9 Heartburn … 28.6 | 1 | 14.3 | 4 | 57.1 Dizziness | 7 | 2.4 | 4 | 57.1 | 0 | 0.0 | 3 | 42.9 Itching | 7 | 2.4 | 2 | 28.6 | 1 | 14.3 | 4 | 57.1 Myoclonus d | 7 | 2.4 | 3 | 42.9 | 2 | 28.6 | 2 | 28.6 Sore mouth | 6 | 2.0 | 1 | 16.7 | 0 | 0.0 | 5 | 83.3 Other eye symptoms | 6 | 2.0 | 1 | 16.7 | 3 | 50.0 | 2 | 33.3 Heartburn …

Mapping EORTC QLQ-C30 and QLQ-MY20 to EQ-5D in patients with multiple myeloma.

BACKGROUND: In oncology, health-related quality of life (HRQoL) data are often collected using disease-specific patient questionnaires while generic, patient-level utility data required for health economic modeling are often not collected. METHODS: We developed a mapping algorithm for multiple myeloma that relates HRQoL scores from the European Organization for Research and Treatment of Cancer (EORTC) questionnaires QLQ-C30 and QLQ-MY20 to a utility value from the European QoL-5 Dimensions (EQ-5D) questionnaire. Data were obtained from 154 multiple myeloma patients who had participated in a m

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… Symptoms (includes bone aches or pain, back pain, hip pain, arm or shoulder pain, chest pain, and pain increasing with activity); Side Effects of Treatment (includes drowsiness, thirst, feeling ill, dry mouth, hair loss, upset by hair loss, tingling hands or feet, restlessness/agitation, acid indigestion/heartburn …

Local re-activation of osteoclast differentiation as a novel therapeutic strategy for osteonecrosis of the jaw.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… While bisphosphonates are generally well-tolerated, they can cause side effects in some people, such as gastrointestinal issues (like nausea, heartburn, or stomach pain), flu-like symptoms, and serious complications like osteonecrosis of the jaw (ONJ). …

Реальный опыт использования озанимода у взрослых с множественной скlerозом.

AIM: Ozanimod — фингозин второго поколения. 1-phosphate Модулятор рецептора (S1PR), утвержденный для лечения повторного склероза (MS). Данные об использовании озанимодов в реальной клинической практике отсутствуют. Цель этого исследования состоит в том, чтобы определить характеристики людей, у которых MS (PwMS) предписан озанимод, а также стойкость, терпимость, безопасность и эффективность по отношению к ним. one Год. МЕТОДЫ: Ретроспективно собирались данные по взрослым с синдромом MS или клинически изолированным синдромом, которые получали озанимод two Высшие центры MS. Результаты: Мы определ

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… The most common reason for discontinuation was side effects or AEs, which included worsening hypertension ( n  = 5), gastrointestinal issues such as nausea or heartburn ( n  = 4), heart palpitations ( n  = 3), headache ( n  = 2), fatigue ( n  = 1), dizziness ( n  = 1), mood effects ( n  = 1), heart failure …

Framework for integrating electronic patient-reported data in routine cancer care: an Oncology Intake Questionnaire.

ObjectiveAs part of ongoing implementation of electronic patient-reported outcome tools at the Dana-Farber Cancer Institute, here we describe the development of the electronic New Patient Intake Questionnaire.Materials and methodsThe original New Patient Intake Questionnaire includes a review of symptoms, oncology history, family history, health behaviors, health and social status, health literacy and numeracy, which was modified for integration into the EHR using content determination, build and configuration, implementation, analytics, and interventions. The engagement of key stakeholders, i

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… difficulty breathing | Yes | No | Cough | Yes | No | Wheeze | Yes | No | Headaches | Yes | No | Tremors/shaking | Yes | No | Dizziness | Yes | No | Numbness | Yes | No | Unsteady gait | Yes | No | Confusion | Yes | No | Changes in vision | Yes | No | Nausea | Yes | No | Vomiting | Yes | No | Heartburn …

Wheat flour fortification with iron and other micronutrients for reducing anaemia and improving iron status in populations.

BACKGROUND: Anaemia is a condition where the number of red blood cells (and consequently their oxygen-carrying capacity) is insufficient to … . No trials reported data on adverse effects in children (including constipation, nausea, vomiting, heartburn or diarrhoea), except for risk of infection or inflammation at the individual level. The intervention probably makes little or no difference to the risk of Infection or inflammation at individual level as measured by C-reactive protein (CRP) (mean d …

Myeloma: Patient accounts of their pathways to diagnosis.

BackgroundPathways to myeloma diagnosis can be prolonged, and are often preceded by multiple GP consultations and emergency presentation. This is the first qualitative study to examine events leading to diagnosis by asking patients about their experiences during this time.MethodsSet within a UK population-based cohort, semi-structured interviews were conducted with 20 myeloma patients with varying characteristics and pathways, 12 of whom invited their relatives to take part. Interviews were audio-recorded and qualitative analysis undertaken.ResultsPre-diagnostic awareness of myeloma was minima

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… . | GP Practice nurse (R1) | R1-Respiratory medicine 5 • Haematology | 6 | 1 | 2.5 | Yes P02 * | M | 63 | Heartburn/indigestion, pain (chest, armpits, arms), under-performance, tiredness, poor sleep (due to pain), visible lump (sternum), pale. | GP (R1) | R1-Rheumatology • Haematology • Oncology | 3 …

Development of a Patient Centered Outcome Set for Patients With Multiple Myeloma to be Used in Clinical Practice.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… The EORTC QLQ-MY20 contains items on pain (bone, back, hip, shoulder, chest) increase during activity, other disease symptoms and side effects of treatment (e.g. tingling hands/feet, heartburn, burning/sore eyes), one functional scale on future perspective, and one single item on body image. …

Психометрическая оценка китайской версии вопросника по качеству жизни для пациентов с множественной миеломой.

КОЛИЧЕСТВО: Пациенты с множественной миеломой (ММ) часто страдают от целого ряда связанных с болезнями и лечением симптомов, которые оказывают значительное воздействие на качество их жизни. Множественный модуль " Myeloma " вопросника о качестве жизни 20-item (В тыс.QLQ-MY20) Вопросник, разработанный Европейской организацией исследований и лечения рака (ЕОРТК), предназначался для оценки качества жизни пациентов с миэломой. Однако в Китае оценка не проводилась. Цель этого исследования заключалась в подтверждении китайской версии ЕОРТК QLQ-MY20 Вопросник с точки зрения его надежности, д

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… Have you had acid indigestion or heartburn? | 0.83 | 0.128 | 0.353 18. Have you been thinking about your illness? | 0.83 | 0.128 | 0.353 12. Answer this question only if you lost any hair: Were you upset by the loss of your hair? | 0.82 | 0.122 | 0.29 13. Did you have tingling hands or feet? …

Spontaneous Tumor Lysis Syndrome.

Tumor lysis syndrome (TLS) is a hemato-oncological emergency characterized by metabolic and electrolyte imbalances which are associated with disintegrating tumor cells. The syndrome is frequently observed when starting cytotoxic treatment of hematological malignancies, while the incidence of spontaneous tumor lysis prior to the start of tumor therapy is rare. Here, we present a case of spontaneous TLS in a male patient who was referred with unspecific symptoms and suspected metastatic malignancy. He developed acute renal failure before the diagnosis of a high-grade B-cell lymphoma (double hit

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… During the initial consultation, the patient described a cumulative 4-kg loss of body weight within 3 weeks with a simultaneous increase in abdominal circumference, loss of appetite, and heartburn as well as pronounced night sweats and thirst. …

The Treatment Gap in Osteoporosis.

Worldwide, there are millions of people who have been diagnosed with osteoporosis, a bone disease that increases the risk of fracture due to low bone mineral density and deterioration of bone architecture. In the US alone, there are approximately ten million men and women diagnosed with osteoporosis and this number is still growing. Diagnosis is made by measuring bone mineral density. Medications used for the treatment of osteoporosis are bisphosphonates, denosumab, raloxifene, and teriparatide. Recently, romosozumab has been added as well. In recent years, a number of advances have been made

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… Also, oral forms of bisphosphonates can cause upper gastrointestinal irritation, which may include heartburn, indigestion, esophageal erosion, and esophageal ulcer. …

Development of a multidimensional measure for recurrent abdominal pain in children: population-based studies in three settings.

OBJECTIVE: Recurrent abdominal pain (RAP) is a common problem in children and adolescents. Evaluation and treatment of children with RAP con … The 12 items of the nonpain symptoms scale were classified into 2 components; 1 component included heartburn, burping, passing gas, bloating, problem with ingestion of milk, bad breath, and sour taste (nonpain symptoms I), and the other included nausea/vomiting, diarrhea, and constipation (nonpain symptoms II). The program ordered the 5 components on the b …

Management of bone metastasis with zoledronic acid: A systematic review and Bayesian network meta-analysis.

BACKGROUND: While considered the mainstay of treatment for specific bone metastases, ZA is used predominantly to treat osteolytic lesions. The purpose of this network meta-analysis is to compare ZA to other treatment options in its ability to improve specific clinical outcomes in patients with bone metastases secondary to any primary tumor. METHODS: PubMed, Embase and Web of Science were systematically searched from inception to May 5th, 2022. Keywords used were solid tumor, lung neoplasm, kidney neoplasm, breast neoplasm, prostate neoplasm, ZA and bone metastasis. Every randomized controlled

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… Patients also reported other less serious symptoms including flu-like symptoms, diarrhea, nausea and heartburn [57] . …

A Systematic Review of Sildenafil Mortality Through the Years.

Sildenafil is a medication used for the treatment of erectile dysfunction. It was approved by the U.S. Food and Drug Administration (FDA) in 1998. Several articles have raised concerns regarding the use of sildenafil and the occurrence of serious adverse events, such as myocardial ischemia, stroke, and even death. Our aim is to systematically review the existing literature on mortality associated with sildenafil use. The method used for this systematic review was completed by searching three databases: PubMed, Scopus, and Web of Science. Articles were screened and assessed for eligibility. Thi

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… Commonly reported side effects include headaches, flushed skin, heartburn, dyspepsia, nasal congestion, back pain, and myalgia. …

Pernicious Anemia: The Hematological Presentation of a Multifaceted Disorder Caused by Cobalamin Deficiency.

Pernicious anemia is still a neglected disorder in many medical contexts and is underdiagnosed in many patients. Pernicious anemia is linked to but different from autoimmune gastritis. Pernicious anemia occurs in a later stage of autoimmune atrophic gastritis when gastric intrinsic factor deficiency and consequent vitamin B12 deficiency may occur. The multifaceted nature of pernicious anemia is related to the important role of cobalamin, which, when deficient, may lead to several dysfunctions, and thus, the proteiform clinical presentations of pernicious anemia. Indeed, pernicious anemia may l

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… In a small portion of patients with AAG/PA, reflux-like symptoms may be present, probably due to nonacidic refluxes that may play a role in the heartburn perception [ 66 ]. … Lower pH values of weakly acidic refluxes as determinants of heartburn perception in gastroesophageal reflux disease patients with normal esophageal acid exposure Dis. Esophagus 2016 29 3 9 10.1111/dote.12284 25212408 67. Lahner E. Centanni M. Agnello G. Gargano L. Vannella L. Iannoni C. …