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Exposure to total and methylmercury among pregnant women in Suriname: sources and public health implications.

Previous research has found that women and children living in rural, interior communities in Suriname have high concentrations of mercury in hair. Freshwater fish from these areas also have high concentrations of mercury. Artisanal and small-scale gold mining operations in parts of the country use elemental mercury to extract gold from soils and sediments. Total mercury and methylmercury concentrations have been determined in hair and blood from pregnant women across the country. Pregnant women from interior communities have significantly higher concentrations of both total and methylmercury i…

Describing the toxicity and sources and the remediation technologies for mercury-contaminated soil.

Mercury (Hg) is a natural element and its compounds are found as inorganic and organic forms in the environment. The different Hg forms (e.g., methylmercury (MeHg)), are responsible for many adverse health effects, such as neurological and cardiovascular effects. The main source of Hg is from natural release. Nevertheless, with the development of industrialization and urbanization, Hg-contaminated soil mainly influenced by human activities (especially near mercury mining areas) has become a problem. Therefore, much more attention has been paid to the development and selection of various treatm…

Malignant mesothelioma in Sub-Saharan Africa: A case report from Lubumbashi, DR Congo.

Although asbestos has been used throughout Africa in the past decades, no reports of asbestos-related malignant mesothelioma are available from sub-Saharan Africa, except from South Africa and Zimbabwe. We present a case of a 39-year-old man who died from a histologically proven malignant mesothelioma of the peritoneum in Lubumbashi, DR Congo. No occupational exposure to asbestos could be found in his history. In view of his young age, we speculated that he had been exposed to asbestos as a child, which was highly plausible because he had grown up in one of the numerous mining estates of the r…

Dual-Functional Titanium(IV) Immobilized Metal Affinity Chromatography Approach for Enabling Large-Scale Profiling of Protein Mannose-6-Phosphate Glycosylation and Revealing Its Predominant Substrates.

Mannose-6-phosphate (M6P) glycosylation is an important post-translational modification (PTM) and plays a crucial role in transferring lysos … tial M6P glycoproteins that possessed different subcellular locations and molecular functions. Deep mining of their roles implicated in lysosomal and nonlysosomal function can provide new insights into functional roles of this important yet poorly studied modification.

Exploring the dark genome: implications for precision medicine.

The increase in the number of both patients and healthcare practitioners who grew up using the Internet and computers (so-called "digital natives") is likely to impact the practice of precision medicine, and requires novel platforms for data integration and mining, as well as contextualized information retrieval. The "Illuminating the Druggable Genome Knowledge Management Center" (IDG KMC) quantifies data availability from a wide range of chemical, biological, and clinical resources, and has developed platforms that can be used to navigate understudied proteins (the "dark genome"), and their p…

Hidradenitis suppurativa and schizophrenia: a nationwide cohort study.

BACKGROUND: Hidradenitis suppurativa (HS) is a chronic, debilitating, dermatological disease that causes substantial psychosocial impediments with increased suicidal risk. Yet data on psychiatric comorbidity in HS have not been sufficiently elucidated in population-based studies. The current study sought to investigate the association between HS and schizophrenia, a major psychiatric disease, in a nationwide population-based study in Israel. METHODS: Data mining was performed on the database of Clalit Health Services (CHS), the largest managed healthcare company in Israel. Patients diagnosed …

Spatial epidemiology of cutaneous leishmaniasis in Colombia: socioeconomic and demographic factors associated with a growing epidemic.

BACKGROUND: Despite the identification of some environmental factors linked to the cutaneous leishmaniasis (CL) epidemic, little is known ab … y found that human activities such as deforestation linked to agriculture, livestock production and mining activities are key drivers of the spatial distribution of the CL epidemic. The intensity of these human activities, which are projected to increase because of social and economic transformations in progress in Colombia, will potentially exacerbate t …

Microbial communities are sensitive indicators for freshwater sediment copper contamination.

Anthropogenic activities, such as mining and agriculture, have resulted in many freshwater systems having elevated concentrations of copper. Despite the prevalence of this contamination, and the vital ecological function of prokaryotes, just three studies have investigated prokaryote community responses to copper concentration in freshwater sediments. To address this, the current study investigated these communities in outdoor mesocosms spiked with varying copper concentrations. We profiled the prokaryotic communities at the taxonomic level, using next-generation high-throughput sequencing tec…

Business Modeling of Orthopaedic Trauma in the Emergency Department: An Untapped Revenue Stream.

INTRODUCTION: Emergency departments (EDs) and emergency medicine and orthopaedic residencies can be faced with financial challenges while caring for patients. Procedures performed by residents are a potentially viable source of revenue that may make orthopaedic coverage of the ED a financially viable service line. METHODS: A custom text-mining program was created and validated, which allowed evaluation of all orthopaedic resident notes. Procedures performed in the ED were quantified, allowing for the calculation of professional fee billing data. The patients with distal radius fractures were …

A hybrid computational approach for efficient Alzheimer's disease classification based on heterogeneous data.

There is currently a lack of an efficient, objective and systemic approach towards the classification of Alzheimer's disease (AD), due to it … voxels from PiB-PET brain scans, ApoE, and age) can be automatically identified from parallel data mining algorithms. In this work, Bayesian network modelling across different time points is used to identify and visualize time-varying relationships among the significant features, and importantly, in an efficient way using only coarse-grained data. Cruci …

Bugs in the program: can pregnancy drugs and smoking disturb molecular reprogramming of the fetal germline, increasing heritable risk for autism and neurodevelopmental disorders?

In a seeming paradox, the prevalence of autism spectrum disorder (ASD) has surged, while at the same time research has pointed to the strong heritability of this neurodevelopmental pathology. Here an autism research philanthropist suggests a biological phenomenon of exogenously induced 'gamete disruption' that could reconcile these seemingly contradictory observations. Mining information from her own family history and that of her fellow autism parents, while also engaging with the scientific community, she proposes that a subset of the autisms may be rooted in a variety of molecular glitches …

Occupational Patterns in Unintentional and Undetermined Drug-Involved and Opioid-Involved Overdose Deaths - United States, 2007-2012.

The opioid epidemic affects multiple segments of the U.S. population (1). Occupational patterns might be critical to understanding the epide … isynthetic opioids, and synthetic opioids other than methadone were construction, extraction (e.g., mining, oil and gas extraction), and health care practitioners. The workplace is an integral part of life for the majority of the adult U.S. population; incorporating workplace research and interventions likely will benefit the opioid epidemic response.

Birth weights of newborns and pregnancy outcomes of environmentally boron-exposed females in Turkey.

Boric acid and sodium borates are currently classified as being toxic to reproduction under "Category 1B" with the hazard statement of "H360 FD" in the European CLP regulation. This has prompted studies on boron-mediated reprotoxic effects in male workers in boron mining areas and boric acid production plants. By contrast, studies on boron-mediated developmental effects in females are scarce. The present study was designed to fill this gap. Hundred and ninety nine females residing in Bandirma and Bigadic participated in this study investigating pregnancy outcomes. The participants constituted …

Global Interactomics Uncovers Extensive Organellar Targeting by Zika Virus.

Zika virus (ZIKV) is a membrane enveloped Flavivirus with a positive strand RNA genome, transmitted by Aedes mosquitoes. The geographical ra … l infections; the remaining interactors comprise hundreds of new putative ZIKV functional partners. Mining this rich data set, we highlight several examples of how ZIKV may usurp or disrupt the function of host cell organelles, and uncover an important role for peroxisomes in ZIKV infection.

Multiple sclerosis as an adverse drug reaction: clues from the FDA Adverse Event Reporting System.

BACKGROUND: Possible relationship between drug exposure and multiple sclerosis (MS) development is insufficiently investigated, and further … rieved with a lower limit of the 95% confidence interval (CI) >1. RESULTS: After a customized data-mining process, 3,226 reports of MS were retrieved. 'Antineoplastic and immunomodulating drugs' (33% of total reports) were the most frequently reported, with 10 disproportionality signals, including etanercept (445 cases; ROR: 2.48; 95% Cl: 2.24-2.74), ad …

Asbestos Ban in Italy: A Major Milestone, Not the Final Cut.

Background and history: Italy was the main asbestos producer and one of the greatest consumers in 20th century Europe until the asbestos ban was introduced in 1992. Asbestos exposure affected the population in a wide range of working environments, namely mining and marketing of asbestos, asbestos cement production, shipyards and textile industries. This also determined a widespread environmental asbestos exposure affecting the surrounding communities. Methods: To investigate the drivers and difficulties of the process leading to the asbestos ban and its subsequent implementation, we focused on…

Экологические ниши, моделирующие бешенство в меняющейся Арктике Аляски.

Раби является заболеванием глобального значения, в том числе в приполярной Арктике. На Аляске энзоотические бешенства сохраняются в северных и западных прибрежных районах. Лишь спорадические случаи имели место в районах за пределами районов, считающихся энзоотичными для вируса, таких, как внутренние районы штата и городские районы. РЕЗУЛЬТАТЫ: Здесь мы исследуем распределение диагностированных бешенств на Аляске, явно в пространстве и во времени. Мы используем геоинформационную систему (ГИС) — 20 слоев экологических данных и представляем количественную непартийную оценку прогнозируемой экологи

Совпадение в аннотации оригинала
BACKGROUND: Rabies is a disease of global significance including in the circumpolar Arctic. In Alaska enzootic rabies persist in northern an … d provide a quantitative non-parsimonious estimate of the predicted ecological niche, based on data mining, machine learning and open access data. We identify ecological correlates and possible drivers that determine the ecological niche of rabies virus in Alaska. More specifically, our models show that rabies cases are closely associated with human infr …

Mouse genotypes drive the liver and adrenal gland clocks.

Circadian rhythms regulate a plethora of physiological processes. Perturbations of the rhythm can result in pathologies which are frequently studied in inbred mouse strains. We show that the genotype of mouse lines defines the circadian gene expression patterns. Expression of majority of core clock and output metabolic genes are phase delayed in the C56BL/6J line compared to 129S2 in the adrenal glands and the liver. Circadian amplitudes are generally higher in the 129S2 line. Experiments in dark - dark (DD) and light - dark conditions (LD), exome sequencing and data mining proposed that mouse…

Prediction of time dependent survival in HF patients after VAD implantation using pre- and post-operative data.

Heart failure is one of the most common diseases worldwide. In recent years, Ventricular Assist Devices (VADs) have become a valuable option for patients with advanced HF. Although it has been shown that VADs improve patient survival rates, several complications persist during left VAD (LVAD) support. The stratification scores currently employed are mostly generic, i.e. not specifically built for LVAD patients, and are based on pre-implantation patient data. In this work we apply data mining approaches for the prediction of time dependent survival in patients after LVAD implantation. Moreover,…

Safety in ready mixed concrete industry: descriptive analysis of injuries and development of preventive measures.

Ready mixed concrete (RMC) industry, one of the barebones of construction sector, has its distinctive occupational safety and health (OSH) r … search in this sector exacerbates this problem. This study aims to fill this gap by conducting data mining in Turkish Social Security Institution archives and performing univariate frequency and cross tabulation analysis on 71 incidents that RMC truck drivers were involved. Also, investigations and interviews were conducted in seven RMC plants in Turkey …