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Use of Cannabis and Cannabinoids for Treatment of Cancer.

The endocannabinoid system (ECS) is an ancient homeostasis mechanism operating from embryonic stages to adulthood. It controls the growth and development of many cells and cell lineages. Dysregulation of the components of the ECS may result in uncontrolled proliferation, adhesion, invasion, inhibition of apoptosis and increased vascularization, leading to the development of various malignancies. Cancer is the disease of uncontrolled cell division. In this review, we will discuss whether the changes to the ECS are a cause or a consequence of malignization and whether different tissues react dif

RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS.

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Pathophysiology, evaluation, and management of malnutrition in hematologic malignancies: a comprehensive review.

Hematologic malignancies are frequently complicated by malnutrition, a condition that remains underrecognized yet strongly associated with impaired treatment tolerance, immune recovery, and survival. Unlike solid tumors, hematologic malignancies are characterized by diffuse marrow and immune system involvement, rendering host metabolism highly vulnerable to tumor-driven inflammation and therapy-induced immune stress. Accumulating evidence indicates that nutritional deterioration in hematologic malignancies reflects a state of integrated immunometabolic vulnerability-driven by hyperinflammation

Использование в качестве конечной точки в клинических испытаниях нейродегенеративных заболеваний цепочек освещения нейрофильтрации на основе крови: обзор аналитического исследования.

ВВЕДЕНИЕ: Нейрофильтральная световая цепочка (NfL) представляет собой структурный аксонный белок, измеряемый в CSF и крови, который все чаще изучается в качестве биомаркера нейроаксональных травм в клиническом и исследовательском контекстах. Целью этого обзора является изучение вопроса об использовании в качестве конечной точки при клинических испытаниях нейродегенеративных заболеваний NfL на основе крови. МЕТОД: Был проведен поиск в базе данных MedLINE и EMBASE для выявления вмешательных клинических испытаний и/или соответствующих постспециальных анализов нейродегенеративных заболеваний, опуб

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… Camu W, Mickunas M, Veyrune J-L, Payan C, Garlanda C, Locati M, Juntas-Morales R, Pageot N, Malaspina A, Andreasson U, Kirby J, Suehs C, Saker S, Masseguin C, Vos JD, Zetterberg H, Shaw PJ, Al-Chalabi A, Leigh PN, Tree T, Bensimon G (2020) Repeated 5-day cycles of low dose aldesleukin in amyotrophic …

Последствия злоупотребления наркотиками для путей ферроптоза: потенциальные терапевтические цели для расстройств, связанных с потреблением психоактивных веществ.

Серьезными проблемами в области здравоохранения во всем мире, особенно в развитых странах, по-прежнему являются расстройства, связанные с потреблением психоактивных веществ. Для ОСВ характерна устойчивая нейроинфламмация и синаптическая дисфункция мозга. Несмотря на десятилетия интенсивного расследования, детальные механизмы, лежащие в основе ВСГ, по-прежнему остаются иллюзорными. Ферроптоз — это высокорегулируемый процесс смерти клеток, на который сильно влияют метаболизм железа, пероксидация липидов, производство реактивных видов кислорода (РОС) и антиоксидантные системы. Он был связан с мно

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… Pharmaceuticals 19:ph19040629. doi: 10.3390/ph19040629 Lopez-Pedrajas R., Sanchez-Rodriguez I., Abad-Morales V., Gonzalez-Polo R. A., Fuentes J. M., Jordan J. (2015). Cocaine promotes oxidative stress and microglial-macrophage activation in rat cerebellum. Front. Cell. …

Amyloids and the Heart: An Update.

Amyloids consist of fibrils that can be formed by a large variety of different precursor proteins. In localized amyloidosis, amyloids accumulate at the production site with a single organ being affected, whereas in systemic amyloidosis several organs are affected, with the heart being the most common, followed by the kidneys, liver, and the nervous system. The two most frequent systemic amyloidosis types affecting the heart in the vast majority (>95%) of cases are immunoglobulin light chain (AL) amyloidosis and transthyretin (TTR) amyloidosis (ATTR amyloidosis). Patients with amyloid cardiopat

Регулирование заразительных осложнений в создании химической антигенной приемной клетки (CAR-T)

Химерическая антигенная рецепторная T-клетка (CAR T-клетка) изменила парадигму управления лимфомой не Ходжкина (NHL) и множественной миеломой. Осложнения, связанные с инфекцией, стали предметом озабоченности, которая может возникнуть в процессе лечения и привести к заболеваемости и смертности. В ходе этого обзора мы классифицировали осложнения, связанные с инфекцией, в three Категория, этап предварительного вливания с момента предварительного лимфодерации (LD) до дня zero, ранний этап от дня вливания до дня 30 после введения в эксплуатацию и с запозданием изо дня в день 30 и дальше. Инфекции,

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… Manian Prasad Menon Vidya Morales-Rull Jose Luis O'Mahony D. Shane Overcash J. Scott Ramachandruni Srikant Steingrub Jay S. Taha Hassan S. Waters Michael Young Barnaby E. Phillips Andrew N. Murray Daniel D. Jensen Tomas O. Padilla Maria L. Sahner David Shaw-Saliba Katy Dewar Robin L. …

Allergy in Cancer Care: Antineoplastic Therapy-Induced Hypersensitivity Reactions.

As the backbone of oncological treatments, systemic chemotherapy is still one of the main pawns in cancer care, alone or in combination with newer targeted agents. All chemotherapy agents can be associated with a type of adverse event called an infusion reaction, which can be characterized as unpredictable, non-dose related, and unexplained by the cytotoxic profile of the drug. For some of these events, a certain immunological mechanism can be identified by blood or skin testing. In this case, we can speak of true hypersensitivity reactions that occur as a response to an antigen/allergen. The

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… Morales J. Reacciones de Hipersensibilidad Asociadas al Uso de Asparaginasa En Niños Con Leucemia Linfoblástica Aguda Andes Pediatr. 2021 92 182 192 10.32641/andespediatr.v92i2.2151 34106156 82. Eschalier A. Lavarenne J. Burtin C. Renoux M. Chapuy E. Rodriguez M. …

Targeting super enhancers for liver disease: a review.

BackgroundSuper enhancers (SEs) refer to the ultralong regions of a gene accompanied by multiple transcription factors and cofactors and strongly drive the expression of cell-type-related genes. Recent studies have demonstrated that SEs play crucial roles in regulating gene expression related to cell cycle progression and transcription. Aberrant activation of SEs is closely related to the occurrence and development of liver disease. Liver disease, especially liver failure and hepatocellular carcinoma (HCC), constitutes a major class of diseases that seriously endanger human health. Currently,

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… Singh et al. (2016) Singh AR, Joshi S, Burgoyne AM, Sicklick JK, Ikeda S, Kono Y, Garlich JR, Morales GA, Durden DL. Single agent and synergistic activity of the First-in-Class dual PI3K/BRD4 inhibitor SF1126 with sorafenib in hepatocellular carcinoma. …

Long non-coding RNAs in bone metastasis: progresses and perspectives as potential diagnostic and prognostic biomarkers.

In a precision medicine perspective, among the biomarkers potentially useful for early diagnosis of cancers, as well as to define their prognosis and eventually to identify novel and more effective therapeutic targets, there are the long non-coding RNAs (lncRNAs). The term lncRNA identifies a class of non-coding RNA molecules involved in the regulation of gene expression that intervene at the transcriptional, post-transcriptional, and epigenetic level. Metastasis is a natural evolution of some malignant tumours, frequently encountered in patients with advanced cancers. Onset and development of

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… Cell ( 2010 ) 142 ( 3 ): 409–19 . doi: 10.1016/j.cell.2010.06.040 PMC2956184 20673990 32 Marin-Bejar O Mas AM Gonzalez J Martinez D Athie A Morales X . The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element . …

Frailty in Aging and the Search for the Optimal Biomarker: A Review.

In the context of accelerated aging of the population worldwide, frailty has emerged as one of the main risk factors that can lead to loss of self-sufficiency in older people. This syndrome is defined as a reduced state of physiological reserve and functional capacity. The main diagnostic tools for frailty are based on scales that show deficits compared to their clinical application, such as the Fried frailty phenotype, among others. In this context, it is important to have one or more biomarkers with clinical applicability that can objectively and precisely determine the degree or risk of fra

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… Romero-Morales C. The reliability, validity, and sensitivity of the Edmonton Frail Scale (EFS) in older adults with foot disorders Aging 2020 12 24623 24632 10.18632/aging.202140 33349621 PMC7803512 23. Zupo R. Castellana F. Donghia R. Lampignano L. Guerra V. De Pergola G. Lozupone M. Bortone I. …

A Bibliometric Analysis and Visualization of Decision Support Systems for Healthcare Referral Strategies.

BackgroundThe referral process is an important research focus because of the potential consequences of delays, especially for patients with serious medical conditions that need immediate care, such as those with metastatic cancer. Thus, a systematic literature review of recent and influential manuscripts is critical to understanding the current methods and future directions in order to improve the referral process.MethodsA hybrid bibliometric-structured review was conducted using both quantitative and qualitative methodologies. Searches were conducted of three databases, Web of Science, Scopus

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… Gaytan-Morales F. Alejo-Gonzalez F. Reyes-Lopez A. Palomo M. Rodriguez-Romo L. Villareal-Martínez L. Sandoval-González A. Lopez-Facundo A. Tejocote-Romero I. Cárdenas-Cardos R. …

Improving Biologics' Effectiveness in Clinical Oncology: From the Combination of Two Monoclonal Antibodies to Oligoclonal Antibody Mixtures.

Monoclonal antibodies have revolutionized the treatment of many diseases, but their clinical efficacy remains limited in some other cases. Pre-clinical and clinical trials have shown that combinations of antibodies that bind to the same target (homo-combinations) or to different targets (hetero-combinations) to mimic the polyclonal humoral immune response improve their therapeutic effects in cancer. The approval of the trastuzumab/pertuzumab combination for breast cancer and then of the ipilimumab/nivolumab combination for melanoma opened the way to novel antibody combinations or oligoclonal a

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… Kuemmel S., Tondini C.A., Abraham J., Nowecki Z., Itrych B., Hitre E., Karaszewska B., Juárez-Ramiro A., Morales-Vásquez F., Pérez-García J.M., et al. …

Cellular based treatment modalities for unresectable hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and is unfortunately associated with an overall poor prognosis and high mortality. Early and intermediate stages of HCC allow for treatment with surgical resection, ablation and even liver transplantation, however disease progression warrants conventional systemic therapy. For years treatment options were limited to molecular-targeting medications, of which sorafenib remains the standard of care. The recent development and success of immune checkpoint inhibitors has proven to be a breakthrough in the treatment of

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… T Kruse E He Y Identification of α-fetoprotein-specific T-cell receptors for hepatocellular carcinoma immunotherapy Hepatology 2018 68 574 589 29443377 10.1002/hep.29844 PMC7368991 44 Liu H Xu Y Xiang J Long L Green S Yang Z Zimdahl B Lu J Cheng N Horan LH Liu B Yan S Wang P Diaz J Jin L Nakano Y Morales …

Clinical relevance of extracellular vesicles in hematological neoplasms: from liquid biopsy to cell biopsy.

In the era of precision medicine, liquid biopsy is becoming increasingly important in oncology. It consists in the isolation and analysis of tumor-derived biomarkers, including extracellular vesicles (EVs), in body fluids. EVs are lipid bilayer-enclosed particles, heterogeneous in size and molecular composition, released from both normal and neoplastic cells. In tumor context, EVs are valuable carriers of cancer information; in fact, their amount, phenotype and molecular cargo, including proteins, lipids, metabolites and nucleic acids, mirror nature and origin of parental cells rendering EVs a

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… Morales-Kastresana A, Musich TA, Welsh JA, Telford W, Demberg T, Wood JCS, et al. High-fidelity detection and sorting of nanoscale vesicles in viral disease and cancer. J Extracell Vesicles. 2019;8:1597603. doi: 10.1080/20013078.2019.1597603. 41. …

Molecular and physical technologies for monitoring fluid and electrolyte imbalance: A focus on cancer population.

Several clinical examinations have shown the essential impact of monitoring (de)hydration (fluid and electrolyte imbalance) in cancer patients. There are multiple risk factors associated with (de)hydration, including aging, excessive or lack of fluid consumption in sports, alcohol consumption, hot weather, diabetes insipidus, vomiting, diarrhea, cancer, radiation, chemotherapy, and use of diuretics. Fluid and electrolyte imbalance mainly involves alterations in the levels of sodium, potassium, calcium, and magnesium in extracellular fluids. Hyponatremia is a common condition among individuals

N-3 Long-Chain Polyunsaturated Fatty Acids, Eicosapentaenoic and Docosahexaenoic Acid, and the Role of Supplementation during Cancer Treatment: A Scoping Review of Current Clinical Evidence.

This scoping review examines the evidence for n-3 long-chain polyunsaturated fatty acid [LCPUFA, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] supplementation in clinical cancer therapy. A comprehensive literature search was performed to identify relevant clinical intervention studies conducted through August 2020. Fifty-seven unique cancer trials, assessing EPA and/or DHA supplementation pre- or post-treatment, concomitant with neoadjuvant chemotherapy, radiation or surgery, or in palliative therapy were included. Breast, head and neck, gastrointestinal, gastric, colorectal/rect

MYC inhibitors in multiple myeloma.

The importance of MYC function in cancer was discovered in the late 1970s when the sequence of the avian retrovirus that causes myelocytic leukemia was identified. Since then, over 40 years of unceasing research have highlighted the significance of this protein in malignant transformation, especially in hematologic diseases. Indeed, some of the earliest connections among the higher expression of proto-oncogenes (such as MYC), genetic rearrangements and their relation to cancer development were made in Burkitt lymphoma, chronic myeloid leukemia and mouse plasmacytomas. Multiple myeloma (MM), in

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… Cancers (Basel) 2020 12 2743 10.3390/cancers12102743 32987735 PMC7598606 88 Raab MS Thomas SK Ocio EM The first-in-human study of the pan-PIM kinase inhibitor PIM447 in patients with relapsed and/or refractory multiple myeloma Leukemia 2019 33 2924 33 10.1038/s41375-019-0482-0 31092894 89 Buettner R Morales …

Natural and semisynthetic candidate molecules for COVID-19 prophylaxis and treatment.

Coronaviruses (CoVs) represent a family of viruses that have numerous animal hosts, and they cause severe respiratory, as well as systemic and enteric infections, in humans. Currently, there are limited antiviral strategies for treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The lack of specific antiviral medicines and SARS-CoV-2 vaccines continues to aggravate the situation. Natural product-based antiviral drugs have been used in the two previous CoV outbreaks: Middle East respiratory syndrome coronavirus (MERS-CoV) and the first SARS-CoV. This re

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… Alghoul H, Alser O, Alshammari TM, Biedermann P, Burn E, Casajust P, Conover M, Culhane AC, Davydov A, DuVall SL, Dymshyts D, Fernández Bertolín S, Fišter K, Hardin J, Hester L, Hripcsak G, Kent S, Khosla S, Kolovos S, Lambert CG, ver der Lei J, Lynch KE, Makadia R, Margulis AV, Matheny ME, Mehta P, Morales …

The Mediterranean Diet, a Rich Source of Angiopreventive Compounds in Cancer.

Diet-based chemoprevention of cancer has emerged as an interesting approach to evade the disease or even target its early phases, reducing its incidence or slowing down tumor progression. In its basis in the essential role of angiogenesis for tumor growth and metastasis, angioprevention proposes the use of inhibitors of angiogenesis in cancer prevention. The anti-angiogenic potential exhibited by many natural compounds contained in many Mediterranean diet constituents makes this dietary pattern especially interesting as a source of chemopreventive agents, defined within the angioprevention str

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… Valdés K., Morales J., Rodríguez L., Günther G. Potential use of nanocarriers with pentacyclic triterpenes in cancer treatments. Nanomedicine. 2016;12:3139–3156. doi: 10.2217/nnm-2016-0251. 83. Haque W., Pattanayak S.P., Sinha B.N. …