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The experience of people with multiple sclerosis who receive occupational performance coaching.

OBJECTIVE: To explore how Occupational Performance Coaching (OPC) influences self-management in the daily lives of people with Multiple Sclerosis (PwMS). METHODS: A qualitative study involving 10 PwMS who underwent 6 sessions of telephone OPC over ten weeks. Interpretive description was used as the methodological approach. Participants were interviewed pre- and post-intervention, with thematic analysis performed on transcripts. RESULTS: Pre-intervention themes included resisting MS, living with MS, ongoing challenges, and strategies. Post-intervention, the theme of resisting MS dissipated, w…

Усталость и корреляция с тревогой и депрессией у пациентов с множественным склерозом в Китае.

Множественный склероз (MS) представляет собой хроническое, прогрессивное, иммунизированное заболевание центральной нервной системы. Усталость является распространенным и недействующим симптомом у пациентов с MS (PwMS). Некоторые психологические факторы, такие как депрессия, стресс и беспокойство, также, как представляется, связаны с этими проблемами. ЦЕЛИ: Исследование было направлено на изучение состояния усталости PwMS в Китае и его влияющих факторов, а также на изучение взаимосвязи между усталостью и тревогой и депрессией.МЕТОДЫ: Это исследование является межсекторальным исследованием, пров

Совпадение в аннотации оригинала
BACKGROUND: Multiple Sclerosis (MS) is a chronic, progressive, immune-mediated disease of the central nervous system. Fatigue is a common and disabling symptom in patients with MS (PwMS). Some psychological factors, such as depression, stress, and anxiety, also appear to be related to these issues. OBJECTIVES: The study aimed to investigate the fatigue cond…

Kynurenin Pathway Modulation by Working in Multical Sclerosis: Последствия для защиты от нейро и воспаления.

Множественный склероз (MS) — хроническое, воспалительное и нейродегенеративное заболевание центральной нервной системы (CNS), характеризующееся иммунной диагностикой и нейронным воспалением. Благодаря образованию нейроактивных метаболитов, кинуреньский путь (КП), один из ключевых путей метаболизма триптофана, влияет на патогенез MS, регулируя иммунную реакцию и нейронный гомеостаз. Регулирование КП приводит к перепроизводству таких нейротоксичных метаболитов, как квинолинская кислота (QUIN), для которых характерна потеря гомеостаза между нейрозащитой (например, кинуриновой кислотой, KYNA) и не

Совпадение в аннотации оригинала
Multiple Sclerosis (MS) is a chronic, inflammatory, and neurodegenerative disease of the Central Nervous System (CNS) that is characterized by immune dysregulation and neuroinflammation. Owing to the generation of neuroactive metabolites, the kynurenine pathway (KP), one of the key pathways of tryptophan metabolism, influences the pathogenesis of MS by regul…

HLA-DRB1 and DQB1 Allelic Polymorphism and Multiple Sclerosis in a Moroccan Population.

Introduction: Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS) that leads to inflammation and demyelination, manifesting in either a relapsing-remitting or progressive form. As a multifactorial disease, MS involves both genetic and environmental factors, with a known significant contribution from human leukocyte antigen (HLA) genes, mainly represented by the HLA-DRB1 and HLA-DQB1 loci, which have been linked to either susceptibility or protection, but variably across populations and ethnic groups. We aimed to study the distribution and polymorphi…

Sex-Related Gap in the Use of Disease-Modifying Therapies in Multiple Sclerosis.

BACKGROUND AND OBJECTIVES: In women with multiple sclerosis (MS), the therapeutic strategy may be influenced by the anticipation of future pregnancies, leading to underexposure to disease-modifying therapies (DMTs) and highly effective DMTs (HEDMTs) compared with men. We aimed to evaluate potential therapeutic inertia in women with MS and explore its causes. METHODS: We performed a retrospective cohort study based on data extracted on June 2023 from the Observatoire Français de la Sclérose en Plaques for all patients with a relapsing-remitting MS onset between 18 and 40 years. The primary out…

[Effectiveness of Resistance Training on Multiple Sclerosis-Related Fatigue: A Systematic Review].

BACKGROUND: Patients with multiple sclerosis (MS) often experience impaired muscular fitness and fatigue. Exercise is known to help maintain muscle fitness and alleviate fatigue, with resistance training being recommended as a potential intervention. However, due to the variety of resistance exercises used and inconsistencies in the results obtained, an evidence-based systematic review is needed to synthesize the effectiveness of this intervention. PURPOSE: This study was designed to synthesize the current research on the effectiveness of resistance training in improving muscle fitness and re…

Formulary Restrictions and Relapse Episodes in Persons With Relapsing-Remitting Multiple Sclerosis.

IMPORTANCE: Narrow formularies can be used to increase rebates and manage the use of costly drug therapies in the US. OBJECTIVE: To examine the association between the breadth of formulary coverage for multiple sclerosis (MS) disease-modifying therapies (DMTs) and MS relapse. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study analyzed 100% Medicare administrative data from 2018 to 2022. The data analysis was conducted from August 1, 2024, to January 30, 2025. Beneficiaries with stand-alone prescription drug plans (PDPs) and Medicare Advantage Prescription Drug plans (MA-PDs) …

Physical activity is associated with fatigue in persons newly diagnosed with multiple sclerosis.

BACKGROUND: Fatigue is prevalent, debilitating, and poorly managed in multiple sclerosis (MS), particularly in the early stages. To date, the association between physical activity (PA) and fatigue has not been examined in persons newly diagnosed with MS (PNDwMS), yet this could inform fatigue management in early MS. PURPOSE: This study consists of a secondary data analysis that examined the association between PA and sedentary time and fatigue in PNDwMS. MATERIALS AND METHODS: Participants diagnosed with MS for less than two years (n = 47) wore a waist-worn ActiGraph GT3X+ accelerometer for …

Долгосрочное воздействие перорального кладрибина на юморальный иммунитет при множественном склерозе.

Кладрипин (CLAD), иммунная реконструктивная терапия для активного множественного склероза (MS), может сократить внутритехевое производство антител. ЦЕЛИ: В этом исследовании мы изучили долгосрочное воздействие перорального CLAD на уровень защиты антител, необходимый для профилактики инфекций и иммунной защиты. DESIGN: Долгосрочное исследование наблюдений, включающее группу из 15 пациентов, прошедших курс лечения CLAD.МЕТОДЫ: Мы продольно изучали юморальный иммунитет семи общих патогенов (корь, свинка, вирус варицелла-зостера, дифтерия и токсин столбняка, краснуха, вирус гепатита В (ГББВ)) и аб

Совпадение в аннотации оригинала
BACKGROUND: Cladribine (CLAD), an immune reconstitution therapy for active multiple sclerosis (MS), can reduce intrathecal antibody production. OBJECTIVES: In this study, we investigated the long-term impact of oral CLAD on protective antibody levels, essential for preventing infections and immune defense. DESIGN: Observational long-term study including a …

Ocrelizumab-induced neutropenia in people with multiple sclerosis: a single-centre study.

BACKGROUND: Treatment with CD20 depleting agents can be complicated by the development of neutropenia; its exact prevalence remains poorly understood. The aim of our study was to determine the frequency of neutropenia associated with ocrelizumab (OCR) in people with multiple sclerosis (pwMS). METHODS: Consecutive pwMS receiving OCR treatment were enrolled. Clinical and paraclinical data were collected, with a focus on white blood cells (WBC) and neutrophil counts at baseline and at the 1st, 3rd, and 6th months following infusions. Neutropenia was defined as a decrease in the absolute neutroph…

Боязнь рецидива в множестве склерозов: изучение роли совершенства и нетерпимости к неопределенности.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Повторные выбросы MS (RRMS) характеризуются значительной неопределенностью в силу непредсказуемого характера нападений и их переменного воздействия на функциональность. Такая неопределенность усиливает страх пациентов перед нападениями, что, в свою очередь, отрицательно сказывается на их благополучии и качестве жизни. Однако основополагающие механизмы, лежащие в основе этого страха, по-прежнему недостаточно понятны. Цель настоящего исследования заключалась в изучении взаимосвязи между страхом рецидива, совершенством и нетерпимостью в отношении неопределенности у отдельны

Twenty years of natalizumab in multiple sclerosis: lessons learned and future outlook.

Twenty years on from its initial approval as the first monoclonal antibody for the treatment of multiple sclerosis (MS), natalizumab remains a valuable high-efficacy treatment option for people with relapsing-remitting MS, with robust real-world evidence supporting its long-term efficacy and well-characterized safety profile, provided that the risk of progressive multifocal leukoencephalopathy (PML) is monitored and mitigated. This review explores the long-term clinical impact of natalizumab. It draws on two decades of experience to guide treatment strategies with natalizumab, including its us…

Effects of vascular disease risk factors on brain metabolism in multiple sclerosis.

BACKGROUND: Vascular disease risk factors (VDRF) seemingly contribute to disability progression in people with multiple sclerosis (pwMS). One possible mechanism is impaired brain energy metabolism, quantifiable by measuring adenosine triphosphate (ATP) using magnetic resonance spectroscopic imaging (MRSI). OBJECTIVE: To determine how VDRF affect brain ATP in pwMS. METHODS: We performed a 3-year longitudinal prospective study comparing pwMS with and without VDRF (VDRF+ and VDRF-). We collected 7T MRI and MRSI every 12 months, and clinical data every 6 months. The primary outcome was brain ATP…

Toward a Unified Definition of Progression Independent of Relapse Activity in Multiple Sclerosis.

OBJECTIVES: Progression independent of relapse activity (PIRA) is the main driver of disability accumulation in relapsing multiple sclerosis (MS). We tested various PIRA definitions against the risk of long-term disability. METHODS: Patients with relapsing MS, first visit ≥January 1, 2000, ≥3 visits with Expanded Disability Status Scale (EDSS), and ≥5-year follow-up were extracted from the Italian MS and Related Disorders Register on September 29, 2023. Eighteen PIRA definitions were obtained combining fixed or roving baseline, 24-week, 48-week confirmed or sustained disability accrual, no re…

OPM-MEG в множестве склерозов: Доказательство принципа и эффект натуралистической осанки.

Множественный склероз (MS) — обычное неврологическое расстройство, при котором повреждение миэлина влияет на нейронную сигнализацию. Магнитоэнцефалография (MEG - измерение магнитных полей, генерируемых нейронными течениями) предлагает метрики функции мозга, которые непосредственно связаны с электрофизиологической сигнализацией, что делает ее ценным инструментом для изучения того, как аномальная функция соотносится с симптомами MS. Однако обычное МГЭ требует, чтобы участники сидели или сидели с ограниченным движением головы и тела. Это затрудняет измерение функции мозга, одновременно призывая п

Совпадение в аннотации оригинала
Multiple Sclerosis (MS) is a common neurological disorder in which myelin damage affects neuronal signalling. Magnetoencephalography (MEG - the measurement of magnetic fields generated by neuronal currents) offers metrics of brain function that relate directly to electrophysiological signalling, making it a valuable tool for exploring how abnormal function r…

Intranodal expansion of follicular T helper cells in patients with multiple sclerosis.

Purpose: Care workers at nursing care facilities have a high rate of low back pain (LBP). Although increasing evidence has revealed the important role of psychosocial factors in chronic LBP, factors associated with chronic LBP interfering with work have not been fully investigated in Japanese workers at nursing care facilities. The present study aimed to determine the prevalence of chronic LBP interfering with work and related factors of chronic LBP including psychosocial factors, among workers at nursing care facilities. Material and methods: Eligible participants in the present study were Ja

Clinical characteristics of multiple sclerosis in older adults in a Finnish Tertiary Centre.

OBJECTIVE: Limited data exist on the characteristics of older adults (aged 65 years or older) with multiple sclerosis (OAwMS). This study aimed to investigate the clinical presentation, disease-modifying therapy (DMT) use and neurological disability in OAwMS. We sought to determine how disease activity and disability manifest in this age group and whether early DMT use is associated with reduced disability at an advanced age. METHODS: OAwMS treated at Tampere University Hospital (TUH) were identified from the Finnish MS registry as of 5th December 2023. Demographic and clinical data were extr…

Trends in prevalence and incidence of multiple sclerosis in the Israeli Jewish and Arab populations.

BACKGROUND AND OBJECTIVES: There is a worldwide trend of increasing prevalence and incidence of multiple sclerosis (MS). A previous epidemiological survey conducted a quarter-century ago showed a substantially lower prevalence of MS among Israeli Arabs compared to Israeli Jews. We aimed to explore trends in MS prevalence and incidence among Israel's diverse populations over the past decade. METHODS: This population-based study utilizes the Clalit Health Services (CHS) database. CHS is Israel's largest healthcare organization, providing mandatory and universally funded healthcare to about half…