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Prognostic factors, long-term survival, and outcome of cancer patients receiving chemotherapy in the intensive care unit.

Prognostic factors and outcomes of cancer patients with acute organ failure receiving chemotherapy (CT) in the intensive care unit (ICU) are still incompletely described. We therefore retrospectively studied all patients who received CT in any ICU of our institution between October 2006 and November 2013. Fifty-six patients with hematologic (n = 49; 87.5 %) or solid (n = 7; 12.5 %) malignancies, of which 20 (36 %) were diagnosed in the ICU, were analyzed [m/f ratio, 33:23; median age, 47 years (IQR 32 to 62); Charlson Comorbidity Index (CCI), 3 (2 to 5); Simplified Acute Physiology Score II (S

Enoxaparin for primary thromboprophylaxis in ambulatory patients with coronavirus disease-2019 (the OVID study): a structured summary of a study protocol for a randomized controlled trial.

OBJECTIVES: The OVID study will demonstrate whether prophylactic-dose enoxaparin improves survival and reduces hospitalizations in symptomat … 90 days of enrolment; (iv) primary efficacy outcome, within 14 days, and 90 days of enrolment; (v) disseminated intravascular coagulation (ISTH criteria, in-hospital diagnosis) within 14 days, 30 days, and 90 days of enrolment. RANDOMISATION: Patients will undergo block stratified randomization (by age: 50-70 vs. >70 years; and by study centre) with a randomization ratio of 1:1 with …

Symptomatic epilepsy in children with poroencephalic cysts secondary to perinatal middle cerebral artery occlusion.

BACKGROUND: Perinatal cerebral artery occlusion is responsible for ischemic cerebral infarction leading to brain cavitation and gliosis; the … for subdural hygroma or cerebrospinal fluid leak. There was one surgery-related death secondary to disseminated intravascular coagulation, following an otherwise uneventful surgical procedure. An elevated systemic blood pressure, secondary to repeated adrenocorticotropic hormone therapy, can represent a possible concurrent factor for this event. No major complications were recorded am …

Screening and diagnosis of coagulation disorders.

After clinical assessment, pertinent history, and family history, the clinician often has a good idea concerning the cause of a patient's bleeding. The most appropriate laboratory tests can then be ordered. Routine screening tests include a complete blood cell count, platelet count, and evaluation of a peripheral blood sample, a prothrombin time, and an activated partial thromboplastin time. Thrombocytopenia may result from idiopathic thrombocytopenic purpura, disseminated intravascular coagulation, or, less commonly, acute leukemia, aplastic anemia, thrombotic thrombocytopenic purpura, or a p…

Review article: angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy.

A body of evidence that vascular-mediated damage occurs in murine tumours after many existing forms of anti-tumour therapy is rapidly accumulating (see Gray Conference Proceedings edited by Moore & West, 1991). Rapid conventional screens of cells in vitro or using leukaemias of lymphomas will not detect this mode of action and such screens will therefore miss effective agents. A change in the approach to experimental cancer therapy is needed to ensure that this important new avenue is fully investigated. Solid tumours will need to be studied and the importance of specific tumour cell biochemis

[Clinical Crrelation and Prognostic Analysis of ALBI Score in Secondary Hemophagocytic Syndrome in Children].

OBJECTIVE: To explore the clinical correlation and prognostic value of the Albumin-Bilirubin (ALBI) score in children with secondary hemopha … is results showed that ALBI score was positively correlated with splenomegaly, respiratory failure, disseminated intravascular coagulation(DIC), pulmonary hemorrhage, gastrointestinal hemorrhage, central nervous system involvement, ALT, AST, TG, LDH, PT, APTT, and SF (the correlation coefficients are: r =0.181, 0.362, 0.332, 0.221, 0.351, 0.347, 0.391, 0.563, 0.180, 0.448, 0.483, 0.37, …

The prognostic values of monitoring changes in coagulative, inflammatory, and blood chemistry markers in COVID-19 patient's before and during admission to ICU: a retrospective cohort study.

INTRODUCTION: The infection caused by the COVID-19 virus is associated with thromboembolic events and severe inflammatory reactions, significantly impacting the prognosis of infected patients. Numerous studies have indicated that COVID-19 patients often exhibit a hypercoagulable state, disseminated intravascular coagulation, and overwhelming inflammation, particularly in critically ill patients with multiple comorbidities requiring admission to the ICU. This study aims to assess the prognostic significance of alterations in coagulation, inflammatory, and blood chemistry markers in COVID-19 pat…

Antifibrinolytics (lysine analogues) for the prevention of bleeding in patients with haematological disorders.

BACKGROUND: Patients with haematological disorders are frequently at risk of severe or life-threatening bleeding as a result of thrombocytop … reported on the following pre-specified outcomes: overall mortality, adverse events of transfusion, disseminated intravascular coagulation (DIC) or quality of life (QoL). AUTHORS' CONCLUSIONS: Our results indicate that the evidence available for the use of antifibrinolytics in haematology patients is very limited. The only available data suggest that TXA and EACA may be useful adjunct …

[Fetal death: Expert consensus from the College of French Gynecologists and Obstetricians].

Fetal death is defined as the spontaneous cessation of cardiac activity after fourteen weeks of amenorrhea. In France, the prevalence of fet … pert opinion). Regarding management, it is suggested that, in the absence of a situation at risk of disseminated intravascular coagulation or maternal vitality, the patient's wishes should be taken into account when determining the time between the diagnosis of fetal death and induction of birth. Returning home is possible if it's the patient wish (Expert opinion). In all situations ex …

Mild anemia as a protective factor against pregnancy loss.

BACKGROUND: Iron deficiency anemia is traditionally considered to be a pathological condition during pregnancy. According to the standards, … onditions, moderate hemodilution is an effective mechanism for preventing the development of severe disseminated intravascular coagulation (DIC) in labor, during surgery, in various forms of obstetric pathology. OBJECTIVE: To study the effect of anemia of varying severity on the pregnancy course and outcomes. METHODS: We conducted a "case-control" study based on cohort. The study inc …

UK malaria treatment guidelines.

Malaria is the tropical disease most commonly imported into the UK, with 1500-2000 cases reported each year, and 10-20 deaths. Approximately … nment. They may require haemodynamic support and management of acute respiratory distress syndrome, disseminated intravascular coagulation, renal impairment/failure, seizures, and severe intercurrent infections including gram-negative bacteraemia/septicaemia. Falciparum malaria in pregnancy is more likely to be severe and complicated: the placenta contains high levels of parasites. Sti …

Antifibrinolytics (lysine analogues) for the prevention of bleeding in people with haematological disorders.

BACKGROUND: People with haematological disorders are frequently at risk of severe or life-threatening bleeding as a result of thrombocytopen … reported on the following pre-specified outcomes: overall mortality, adverse events of transfusion, disseminated intravascular coagulation (DIC) or quality of life (QoL). AUTHORS' CONCLUSIONS: Our results indicate that the evidence available for the use of antifibrinolytics in haematology patients is very limited. The trials were too small to assess whether or not antifibrinolytics de …

Randomized clinical trial to evaluate safety and efficacy of convalescent plasma use among hospitalized patients with COVID-19 (PERUCONPLASMA): a structured summary of a study protocol for a randomized controlled trial.

OBJECTIVES: The general objective of this study is to test the hypothesis that administration of convalescent plasma from donors with previo … vasopressors) 3. Uncontrolled concomitant infections\ 4. Stupor or coma 5. Platelets < 50,000/μL or disseminated intravascular coagulation 6. Serum creatinine > 3.5 mg/dL or dialysis requirement 7. Total bilirubin > 6 mg/dL or jaundice of unknown etiology 8. Myocardial infarction or acute coronary syndrome 9. Active or recent (< 7 days) intracranial hemorrhage 10. Pregnancy Donors: The …

Epidural therapy for the treatment of severe pre-eclampsia in non labouring women.

BACKGROUND: Pre-eclampsia is a pregnancy-specific multi-organ disorder, which is characterised by hypertension and multisystem organ involve … dney failure, liver failure, HELLP syndrome (haemolysis, elevated liver enzymes and low platelets), disseminated intravascular coagulation, pulmonary oedema.For the baby, these were: death: stillbirths (death in utero at or after 20 weeks' gestation), perinatal deaths (stillbirths plus deaths in the first week of life), death before discharge from the hospital, neonatal deaths (death w …

Злоумышленная малярия: результаты вскрытия и морфологические характеристики.

ВАЖНЯЯ малярия, обусловленная инфекцией плазмодия фальципарума, передающейся москитами &lt; &lt; Анофелес &gt; &gt; , представляет собой чрезвычайную ситуацию, угрожающую жизни людей и приводящую к высокому уровню смертности в странах Африки к югу от Сахары. P. falciparum инфицирует красные кровяные клетки, вызывая их агрегацию и сцепление с эндотелиальной облицовкой малых сосудов. Этот микроваскулированный секвестр может препятствовать кровотоку, что приводит к ишемии и кровоизлиянию в организм, вызванному разрывом небольших судов. В случае внезапной смерти диагноз возможен только после вскры

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… In cases of sudden or rapidly fatal disease, autopsy plays a crucial role in establishing the cause of death, revealing characteristic pathological findings of severemalaria such as disseminated intravascular coagulation, ring hemorrhages, and Dürck’s granulomas. … A systematic review and meta-analysis of the proportion estimates of disseminated intravascular coagulation (DIC) in malaria. Trop Med Infect Dis. 2023;8(6):289. 10. Martini M, Angheben A, Riccardi N, Orsini D. Fifty years after the eradication of Malaria in Italy. …

Cancer-associated stroke: Pathophysiology, detection and management (Review).

Numerous types of cancer have been shown to be associated with either ischemic or hemorrhagic stroke. In this review, the epidemiology and pathophysiology of stroke in cancer patients is discussed, while providing vital information on the diagnosis and management of patients with cancer and stroke. Cancer may mediate stroke pathophysiology either directly or via coagulation disorders that establish a state of hypercoagulation, as well as via infections. Cancer treatment options, such as chemotherapy, radiotherapy and surgery have all been shown to aggravate the risk of stroke as well. The clin

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… Table II Management of specific occurrences in patients with cancer-associated stroke. rTPA, recombinant tissue plasminogen activator; IV, intravenous; LMWH, low-molecular-weight heparins; NBTE, non-bacterial thrombotic endocarditis; DIC, disseminated intravascular coagulation. a The treatment can be … Scientific and Standardization Committee of the International Society on Thrombosis and Hemostasis: Management of cancer-associated disseminated intravascular coagulation: Guidance from the SSC of the ISTH. J Thromb Haemost. 2015;13:671–675. doi: 10.1111/jth.12838. 56. Rogers LR. …

7-day longitudinal proteomics of critically ill patients: a pilot study.

An adult's health, indicated by measurable parameters, is stable over time. With the exception of circadian rhythms, variability in these parameters typically does not exceed 20%. In this pilot study, we looked into the stability of proteome in intensive care unit (ICU) patients. This was a single-center, prospective, observational pilot study of blood plasma from adult ICU patients with statistically heterogeneous patterns of clinically observed parameters. Eight week-long batches from seven patients (one patient participated twice) were analyzed by means of bottom-up proteomics. The data wer

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… Popescu NI Lupu C Lupu F Disseminated intravascular coagulation and its immune mechanisms Blood 2022 139 1973 1986 10.1182/blood.2020007208 34428280 PMC8972096 Popescu, N. I., Lupu, C. & Lupu, F. Disseminated intravascular coagulation and its immune mechanisms. … Zaragoza JJ Espinoza-Villafuerte MV Current approach to disseminated intravascular coagulation related to sepsis - organ failure type WJH 2017 6 11 10.5315/wjh.v6.i1.11 Zaragoza, J. J. & Espinoza-Villafuerte, M. V. …

Oncological emergencies associated with gastrointestinal tumors.

Oncological emergencies are defined as acute life-threatening conditions in cancer patients either as a result of the malignancy or as a result of its treatment. In this review, we focus on oncological emergencies associated with gastrointestinal tumors. They can be categorized by their system of origin as hematologic, neurologic or metabolic. Furthermore, we discuss mechanical emergencies such as intestinal obstruction and vena cava superior syndrome as well as acute gastrointestinal bleeding and pulmonary embolism. The patients' performance status as well as prognosis are essential during de

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… Disseminated intravascular coagulation (DIC) DIC is a potentially life-threatening condition, characterized by an abnormal activation of coagulation and fibrinolysis leading to thrombosis and hemorrhage simultaneously [ 13 ]. It occurs in a variety of diseases, including cancer [ 14 ]. … intravascular coagulation result in more insight in the clinical picture and better management strategies Semin Thromb Hemost 2001 27 569 575 11740680 10.1055/s-2001-18862 14 Spero JA Lewis JH Hasiba U Disseminated intravascular coagulation. …

Recent advances in use of fresh frozen plasma, cryoprecipitate, immunoglobulins, and clotting factors for transfusion support in patients with hematologic disease.

Hematologic diseases include a broad range of acquired and congenital disorders, many of which affect plasma proteins that control hemostasis and immune responses. Therapeutic interventions for these disorders include transfusion of plasma, cryoprecipitate, immunoglobulins, or convalescent plasma-containing therapeutic antibodies from patients recovering from infectious diseases, as well as concentrated pro- or anticoagulant factors. This review will focus on recent advances in the uses of plasma and its derivatives for patients with acquired and congenital hematologic disorders.

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… Fresh frozen plasma in patients with disseminated intravascular coagulation or in patients with liver diseases. Thromb Res. 2002;107(Suppl 1):S9–17. doi: 10.1016/s0049-3848(02)00146-9. 4. Rockey DC. Endothelial dysfunction in advanced liver disease. … Endothelial dysfunction is associated with mortality and severity of coagulopathy in patients with sepsis and disseminated intravascular coagulation. Clin Appl Thromb Hemost. 2019;25 doi: 10.1177/1076029619852163. 8. Broze GJ., Jr. Tissue factor pathway inhibitor. …