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Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Elderly.

The Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Elderly was elaborated by nutritionists, nutrologists and hematologists physicians from 15 Brazilians reference centers in hematopoietic stem cell transplantation, in order to emphasize the importancy of nutritional status and the body composition during the treatment, as well as the main characteristics related to patient's nutritional assessment. Establishing the consensus, we intended to improve and standardize the nutritional therapy during the hematopoietic stem cell transplantation. The Consensus was approved

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… Hernández-Magro PM, Ruiz Esparza JP, Villanueva Sáenz E, Ramírez JL, Morales Enrique, Hermagnus IF. Colonic complications following human bone marrow transplantation. J Coloproctology. 2015;35(1):46–52. 124. Albertini SM. Neutropenic diets in hematopoietic stem cell transplantation. …

Resveratrol and Cardiovascular Diseases.

The increased incidence of cardiovascular diseases (CVDs) has stimulated research for substances that could improve cardiovascular health. Among them, resveratrol (RES), a polyphenolic compound notably present in grapes and red wine, has been involved in the "French paradox". RES is known for its antioxidant and anti-inflammatory properties and for its ability to upregulate endothelial NO synthase (eNOS). RES was able to scavenge (•)OH/O₂(•-) and peroxyl radicals, which can limit the lipid peroxidation processes. Moreover, in bovine aortic endothelial cells (BAEC) under glucose-induced oxidati

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… Morales J.C. Tomás-Barberán F.A. García-Conesa M.T. Espín J.C. Metabolites and tissue distribution of resveratrol in the pig Mol. Nutr. Food Res. 2011 55 1154 1168 10.1002/mnfr.201100140 21710561 102. Bresciani L. Calani L. Bocchi L. Delucchi F. Savi M. Ray S. Brighenti F. Stilli D. del Rio D. …

Abstract

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Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF-1α Positive Feedback Loop.

Nephroblastoma, also known as Wilms tumor (WT), is the most common pediatric renal malignancy. Current treatment regimens exhibit limited efficacy in high-risk patients and are associated with long-term adverse effects. Through gene set enrichment analysis (GSEA) and validation using clinical specimens, we identified aberrant glycolytic activity in WT, which drives lactate accumulation. Lactate is not merely a metabolic byproduct but also a critical epigenetic regulator that mediates histone lactylation; however, its functional role in WT remains uncharacterized. In this study, we found that t

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… Antonio‐Andres G., Morales‐Martinez M., Jimenez‐Hernandez E., and Huerta‐Yepez S., “The Role of PTEN in Chemoresistance Mediated by the HIF‐1α/YY1 Axis in Pediatric Acute Lymphoblastic Leukemia,” International Journal of Molecular Sciences 25, no. 14 (2024): 7767, 10.3390/ijms25147767. 47. …

Improved oncolytic and immunostimulatory activity of the spontaneous jin-3 reovirus mutant in preclinical bladder cancer models.

Immunotherapy has emerged as a promising strategy for treatment of urothelial carcinoma of the bladder (UCB) but not all patients show clinically desirable responses upon treatment with immune-checkpoint inhibition. Oncolytic viruses may unleash the full potential of immunotherapy. Besides tumor-lysing properties, oncolytic viruses can induce durable and systemic anti-viral and anti-tumor immune responses. Here, we evaluated and compared oncolytic and immunostimulatory properties of wild-type reovirus (R124) and the junction-adhesion molecule-independent mutant reovirus (jin-3) in preclinical

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… Morales-Barrera R. Grande E. Medina A. Gonzalez Graguera M.B. Rubio G. Anido U. Fernandez Calvo O. A randomized phase II/III study of cabazitaxel versus vinflunine in metastatic or locally advanced transitional cell carcinoma of the urothelium (SECAVIN) Ann. …

The Complosome: An Emerging Intracellular Complement Network in Cancer Development and Therapy.

The complement system is traditionally recognized as a major effector of innate immunity, essential for pathogen clearance, inflammation and the maintenance of tissue homeostasis. In recent years, however, its role in cancer has been substantially redefined. Beyond its canonical extracellular activity, complement has emerged as a multifaceted regulator of tumor biology, acting not only within the tumor microenvironment but also intracellularly through the recently described intracellular complement system (complosome). While extracellular complement primarily shapes immune responses and the tu

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… Ortiz-Espinosa S., Morales X., Senent Y., Alignani D., Tavira B., Macaya I., Ruiz B., Moreno H., Remírez A., Sainz C., et al. Complement C5a Induces the Formation of Neutrophil Extracellular Traps by Myeloid-Derived Suppressor Cells to Promote Metastasis. …

Does the B7-H3 Immune Checkpoint Have High Potential as a Therapeutic Target?

B7-H3 (CD276), a member of the B7 family of proteins, is known to play a key role in the progression of a number of cancers. This protein is selectively expressed in both tumor cells and immune cells within the tumor microenvironment. Various investigations, including a number of clinical trials, have reported high levels of expression of this protein in cancerous tissues compared to their healthy counterparts. This difference in expression attracted various research efforts to establish whether such a difference can be linked to the therapeutic potential of this molecule. It is worth noting t

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… Álvarez-Carrasco P., Morales-Villamil F., Maldonado-Bernal C. P-Glycoprotein as a Therapeutic Target in Hematological Malignancies: A Challenge to Overcome. Int. J. Mol. Sci. 2025;26:4701. doi: 10.3390/ijms26104701. 14. Crowley E., McDevitt C.A., Callaghan R. …

Challenges and Potential Solutions to Advance Global Cancer Drug Development.

Despite recent advancements in oncology drug development, patient access to innovative cancer therapies remains inadequate. There is an urgent need for more patient-centric approaches, with meaningful patient input from trial design through to health technology assessment (HTA) consultation. Multi-stakeholder consensus calls for better representation of the diversity of the target population and integration of patients' preferences in clinical cancer research by systematically collecting patient-reported outcomes using standardized methods, and acknowledging trade-offs between survival and lon

Charting the Current Landscape and Future Prospects of Cancer Therapy-Related Cardiovascular Toxicity in Cancer Survivors: From Bench to Bedside.

Cardio-oncology represents an emerging interdisciplinary discipline focusing on optimizing oncologic efficacy while mitigating treatment-related cardiovascular complications. The advent of novel anticancer agents such as targeted therapies, immune checkpoint inhibitors, and endocrine therapies has transformed cancer care, significantly improving survival rates. Nevertheless, prolonged patient survivorship has unmasked clinically significant cardiovascular sequelae, termed cancer therapy-related cardiovascular toxicity (CTR-CVT), which manifests as acute manifestations during therapy and delaye

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… Sola E, Morales-Garcia JA, Lopez-Munoz F, Ramos E, Romero A. In vivo evidence of melatonin’s protective role in alkylating-agent-induced pulmonary toxicity: a systematic review. Antioxidants . 2025;14(6):712. doi: 10.3390/antiox14060712 42. Kurauchi K, Nishikawa T, Miyahara E, Okamoto Y, Kawano Y. …

Dural Lymphomas Unmasked: A Narrative Review of Extra-Axial Mimics and a Pragmatic Diagnostic Decision Algorithm.

Dural-based lymphomas are rare extranodal non-Hodgkin lymphomas that span from indolent primary dural entities, most commonly the extranodal marginal zone (mucosa-associated lymphoid tissue) lymphoma, to aggressive variants that are primary or represent secondary involvement from systemic lymphoma. They overlap radiologically with benign meningiomas, dural metastases, and immune-mediated pachymeningitis, creating a risk of anchoring bias, delayed diagnosis, and unnecessarily extensive resections when limited tissue sampling would be sufficient for diagnosis. We conducted a structured narrative

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… Morales-Martinez A. Chemotherapy is an efficient treatment in primary CNS MALT lymphoma J. Neurooncol. 2022 159 151 161 10.1007/s11060-022-04052-1 35725885 26. Grommes C. Rubenstein J.L. DeAngelis L.M. Ferreri A.J.M. Batchelor T.T. …

Ультрафиолетовое излучение и нейродегенерация: молекулярные механизмы, лежащие в основе двойного нейрозащитного и нейротоксичного воздействия.

Ультрафиолетовое излучение имеет сложную, зачастую противоречивую связь с риском/прогрессом нейродегенерации, охватывающую клинически диагностированные заболевания [Заболевания Паркинсона (PD), болезни Альцгеймера (AD), множественный склероз (MS) и амиотропический боковой склероз (ALS)] или промежуточные фенотипы (уменьшенный нейрогенесис, потеря гиппокампального объема). Цель этого обзора заключается в выявлении двойного воздействия УФ-излучения путем сбора и обобщения экспериментальных (доклинических и переводческих) данных, а также эпидемиологических данных. Нынешняя литература демонстрируе

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… Endocrinol. 347 80–89. 10.1016/j.mce.2011.05.017 Borges-Rodríguez Y., Morales-Cueto R., Rivillas-Acevedo L. (2023). Effect of the ultraviolet radiation on the lens. Curr. Protein Pept. Sci. 24 215–228. 10.2174/1389203724666230106161436 Brar G. A. (2025). …

[XVIII Митинг после ECTRIMS: Обзор новых разработок, представленных на Конгресс ECTRIMS 2025 (Часть I)]

18-е издание совещания Европейского комитета по лечению и исследованию множественной скlerоза (ECTRIMS) прошло 17-18 октября 2025 года в Мадриде, объединив испанских нейрологов, специализирующихся на множественной склерозе (МС), которые представили наиболее значимые достижения, обсуждённые на конгрессе ECTRIMS несколько дней ранее в Барселоне. Целью собрания было обобщить последние достижения в патогенезе, новые критерии диагностики и биомаркеры МС. Эта статья является первой частью двухчастной серии (I и II), которая обзором последних данных о транспортировке клеток в центральную нервную сист

Апиген как потенциальный модулятор нейроинфламмации в многоразовом склерозе: обзор.

Множественный склероз (MS) — хроническое воспалительное заболевание центральной нервной системы (CNS), характеризующееся нейроинфламмацией и обезвоживанием. Несмотря на то, что в течение последнего десятилетия расширились возможности лечения MS, нынешняя терапия направлена главным образом на периферийные иммунные системы и часто связана со значительными побочными эффектами. Кроме того, эта терапия до сих пор не предлагает решений для последующего нейродегенерации, сопровождающего развитие болезни. Результаты исследований, проведенных с использованием клеточных и животных моделей и исследований

Lifestyle and Pharmacological Interventions to Prevent Anthracycline-Related Cardiotoxicity in Cancer Patients.

Anthracyclines remain a cornerstone of cancer therapy but are associated with a significant risk of cardiotoxicity, which can lead to overt heart failure. The risk is modulated by cumulative dose, pre-existing cardiovascular disease, and patient-specific factors. As cancer survival improves, the long-term cardiovascular consequences of anthracycline exposure have become a growing concern, underscoring the need for effective preventive strategies. This narrative review examines lifestyle and pharmacological interventions aimed at mitigating anthracycline-induced cardiotoxicity. Evidence suggest

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… Morales-Ruiz M. Perea R.J. Monzó M. Esteve J. …

Stem cell revolution: bridging the gap between research and clinical application.

Stem cells are characterized by their capacity for self-renewal and their potential for multi-directional differentiation, enabling them to develop into various functional tissues and organs under specific conditions. Their applications hold considerable promise, and the market for stem cell products is progressively expanding. Internationally, several stem cell products have received approval for market release; however, in China, the field remains largely undeveloped, presenting substantial opportunities for growth. Recent years have witnessed significant advancements in stem cell research,

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… Riordan NH, Morales I, Fernandez G, Allen N, Fearnot NE, Leckrone ME, Markovich DJ, Mansfield D, Avila D, Patel AN, et al. Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis. J Transl Med. 2018;16:57. 68. …

Contemporary Perspectives on Chronic Renal Disorders.

The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting progression and providing personalized diagnostics and therapy. This narrative review highlights the improvements in diagnostic applications of kidney disease and briefly discusses a few notable biomarkers emphasizing the high throughput omics technologies, as wel

Technological Resources for Physical Rehabilitation in Cancer Patients Undergoing Chemotherapy: A Scoping Review.

Background/Objectives: Cancer patients undergoing chemotherapy often face challenges that reduce their physical function and quality of life. Technological resources offer innovative solutions for physical rehabilitation, but the extent of their application in this context remains unclear. This scoping review aims to explore and map the various technological tools used to support physical rehabilitation in cancer patients during chemotherapy, focusing on their potential to improve outcomes and enhance patient care. Methods: A scoping review was conducted following the Joanna Briggs Institute (

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… Ariza-Garcia A., Lozano-Lozano M., Galiano-Castillo N., Postigo-Martin P., Arroyo-Morales M., Cantarero-Villanueva I. A Web-Based Exercise System (e-CuidateChemo) to Counter the Side Effects of Chemotherapy in Patients With Breast Cancer: Randomized Controlled Trial. J. Med. …

Взгляды заинтересованных сторон Соединенного Королевства на суррогатные концы рака и потенциальные возможности Соединенного Королевства в области реальных мировых данных для подтверждения их использования в процессе принятия решений.

Продолжительность общего выживаемости пациентов с раком увеличилась благодаря более раннему обнаружению и совершенствованию лечения. Однако эти улучшения породили трудности с оценкой воздействия новых методов лечения, особенно тех, которые используются на раннем этапе лечения. Поскольку общее выживание остается предпочтительным для большинства лиц, принимающих решения, для внедрения в практику клинической практики терапевтических инноваций может потребоваться много времени. Кроме того, трудно экстраполировать полученные результаты на разнородные группы населения и решить проблемы пациентов, же

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… He J, Morales DR, Guthrie B. Exclusion rates in randomized controlled trials of treatments for physical conditions: a systematic review. Trials . 2020;21(1):228. doi: 10.1186/s13063-020-4139-0 5. Capobianco E. High-dimensional role of AI and machine learning in cancer research. …

Barriers to Treg therapy in Europe: From production to regulation.

There has been an increased interest in cell based therapies for a range of medical conditions in the last decade. This explosion in novel therapeutics research has led to the development of legislation specifically focused on cell and gene based therapies. In Europe, the European medicines agency (EMA) designates any medicines for human use which are based on genes, tissues, or cells as advanced therapy medicinal products or advanced therapy medicinal products (ATMPs). In this article we discuss the hurdles to widespread adoption of ATMPs in Europe, with a focus on regulatory T cells (Tregs).

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… Wang D Quan Y Yan Q Morales J Wetsel R . Targeted disruption of the β2-microglobulin gene minimizes the immunogenicity of human embryonic stem cells. Stem Cells Transl Med. ( 2015 ) 4 : 1234 – 45 . 10.5966/sctm.2015-0049 26285657 PMC4572902 28. …

The choice of new treatments in autoimmune hemolytic anemia: how to pick from the basket?

Autoimmune hemolytic anemia (AIHA) is defined by increased erythrocyte turnover mediated by autoimmune mechanisms. While corticosteroids remain first-line therapy in most cases of warm-antibody AIHA, cold agglutinin disease is treated by targeting the underlying clonal B-cell proliferation or the classical complement activation pathway. Several new established or investigational drugs and treatment regimens have appeared during the last 1-2 decades, resulting in an improvement of therapy options but also raising challenges on how to select the best treatment in individual patients. In severe w

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… Kamesaki T, Nishimura JI, Wada H, Yu E, Tsao E, Morales J, et al. Demographic characteristics, thromboembolism risk, and treatment patterns for patients with cold agglutinin disease in Japan. Int J Hematol (2020) 112(3):307–15. doi: 10.1007/s12185-020-02899-6 74. …