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Molecular and physical technologies for monitoring fluid and electrolyte imbalance: A focus on cancer population.

Several clinical examinations have shown the essential impact of monitoring (de)hydration (fluid and electrolyte imbalance) in cancer patients. There are multiple risk factors associated with (de)hydration, including aging, excessive or lack of fluid consumption in sports, alcohol consumption, hot weather, diabetes insipidus, vomiting, diarrhea, cancer, radiation, chemotherapy, and use of diuretics. Fluid and electrolyte imbalance mainly involves alterations in the levels of sodium, potassium, calcium, and magnesium in extracellular fluids. Hyponatremia is a common condition among individuals

Изменения лакта и лактилации в неврологических расстройствах.

Значительное внимание стало уделяться изучению изменений в лактилации различных целевых органов как в области здравоохранения, так и в области болезней. Многие жизненно важные процессы и начало болезней связаны не только с избытком белков, но и в первую очередь регулируются различными посттрансляционными изменениями белков. Лактат, который раньше считался лишь побочным продуктом анаэробного метаболизма, превратился в важнейшую энергетическую субстрату и сигнализирующую молекулу, связанную как с физиологическими, так и патологическими процессами в нервной системе. Кроме того, в недавних исследо

Immunohistochemical expression of CD57 in different histopathological grades of oral squamous cell carcinoma.

Background and aimIn general, the natural killer (NK) cells are considered to represent the innate immune system and act as the vital effector of lymphocytes. Natural killer cells (NK) cells target and destroy tumour-causing cells. The purpose of this study is to analyse the immunohistochemical expression of CD57 in different histopathological grades of Oral Squamous cell Carcinoma (OSCC).Materials and methodsThirty archival blocks were selected from the Department of Oral and Maxillofacial Pathology and Oral Microbiology, Vinayaka Mission's Sankarachariyar Dental College, Salem comprising 10

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… The microenvironment, commonly referred to as the tumour stroma, is needed for nutritional support and for the removal of waste products.[ 8 ] The tumour microenvironment (TME) consists of, endothelial cells, pericytes, mesenchymal cells, adipocytes, and innate and adaptive immune cells.[ 9 ] The tumour …

Nutritional vulnerability, food insecurity, and unmet supportive care needs in multiple myeloma: a cross-sectional study from China.

BACKGROUND: Multiple myeloma patients experience nutritional vulnerability through disease-related factors, treatment toxicity, and systemic inflammation, yet comprehensive assessment integrating validated nutrition screening with health equity dimensions remains limited. This study characterized nutritional vulnerability prevalence, determinants, and supportive-care access barriers among Chinese multiple myeloma patients. METHODS: This single-center, cross-sectional observational study conducted at Shanxi Provincial Key Laboratory, Taiyuan, China (January 2020-December 2024) employed compreh

Piperine: From Green Extraction to Clinical Translation-A Review.

BACKGROUND: Piperine has diverse pharmacological and bioenhancing activities, but poor aqueous solubility, variable exposure, interaction liability, and discontinuity across production, formulation, and clinical evaluation limit translation. This review integrates these frequently separated stages. METHODS: A structured narrative PubMed search covered English-language studies published from 1 January 2021 to 27 April 2026, supplemented by ClinicalTrials.gov records checked through 13 June 2026, backward citation searching, and selected earlier seminal studies. Evidence was synthesized by expe

ИАНКОН 2023 Выдержки из плаката

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Comprehensive Diagnosis and Management of POEMS Syndrome.

Polyneuropathy Organomegaly, Endocrinopathy, Monoclonal protein and Skin changes syndrome is a rare multisystem condition with a range of manifestations which are often overlooked as trivial comorbidities, until their whole triggers the possibility of the diagnosis. The diagnosis is typically delayed by 12-16 months, by which time patients can be severely disabled. There are no established consensus guidelines. We provide clinicians a comprehensive blueprint for managing POEMS from diagnostic suspicion through the work-up, selection of therapy, follow-up, and treatment of relapse based on publ

Trends in patient-reported outcome use in early phase dose-finding oncology trials - an analysis of ClinicalTrials.gov.

BackgroundPatient-reported adverse events (AEs) may be a useful adjunct to clinician-assessed AEs for assessing tolerability in early phase, dose-finding oncology trials (DFOTs). We reviewed DFOTs on ClinicalTrials.gov to describe trends in patient-reported outcome (PRO) use.MethodsDFOTs commencing 01 January 2007 - 20 January 2020 with 'PROs' or 'quality of life' as an outcome were extracted and inclusion criteria confirmed. Study and PRO characteristics were extracted. Completed trials that reported PRO outcomes and published manuscripts on ClinicalTrials.gov were identified, and PRO reporti

Abstracts - IANCON 2024

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Cardiac Amyloidosis in Older Adults With a Focus on Frailty: JACC: Advances Expert Consensus.

Amyloidosis, which is caused by misfolded proteins that form amyloid fibrils, is predominantly diagnosed in older adults. Although previously considered a rare disease, increased awareness and noninvasive diagnostic methods have resulted in a rise in diagnoses. As a multisystem disease that affects multiple organ systems (cardiac, gastrointestinal, renal, and neurological), there is significant overlap with both geriatric conditions and common conditions in heart failure. Frailty is recognized as a distinct biological syndrome of declines across multiple physiological systems, which prevents m

Interleukin-1β - Информация о воспламенении и связанные с миелином изменения в Олигодендроглиа и Шванн Клетках в многоразовом склерозе: модуляторное воздействие ибупрофена и флюрбипрофена.

Нейроинфламмация, рассматриваемая как повышенный уровень Интерлейкина-1β (IL-1β) и его каскада вниз по течению, была продемонстрирована нейропатогенная роль в многочисленных нейродегенеративных болезнях, включая болезнь Альцгеймера и Паркинсона. Западные пятна использовались для определения воздействия IL-1β и его сигнального каскада на клетки человека Олигодендроглиома (HOG) и Шванн, а также для оценки потенциального терапевтического воздействия ибупрофена и флюрбипрофена на патогенез MS in vitro. IL-1β увеличила нейро-воспалительные маркеры, такие, как TNFα, MyD88, βAPP, COX-2 и IL-6, а такж

The role of sarcopenia questionnaires in hospitalized patients with chronic heart failure.

ObjectivesTo compare the diagnostic value of the SARC-F, MRSA-7 and MRSA-5 questionnaires in screening for sarcopenia in inpatients with chronic heart failure (CHF).PatientsA total of 355 CHF patients hospitalized from January 2019 to August 2019 who met the study's selection criteria were included in the analysis.MeasurementsHandgrip strength and gait speed were measured, and bioelectrical impedance analysis (BIA) was used to estimate appendicular skeletal muscle mass. The sensitivity/specificity of the SARC-F, MRSA-7 and MRSA-5 questionnaires was evaluated.ResultsThe diagnostic criteria of t

The Crystalline Nephropathies.

Crystalline nephropathies are a unique form of kidney disease characterized by the histologic finding of intrarenal crystal deposition. The intrinsic nature of some molecules and ions combined with a favorable tubular fluid physiology leads to crystal precipitation and deposition within the tubular lumens. Crystal deposition promotes kidney injury through tubular obstruction and both direct and indirect cytotoxicities. Further kidney injury develops from inflammation triggered by these crystals. From a clinical standpoint, the crystalline nephropathies are associated with abnormal urinalysis a

Evaluation of transfusion pyrexia: a review of differential diagnosis and management.

Background/purpose. Transfusion pyrexia (fever) is an important clinical sign/symptom occurring either as an isolated event or as part of a constellation of signs and symptoms in relation to blood transfusion. It is an important cause of morbidity and may be an important sign of life-threatening complications of blood transfusion. Pyrexia is often a reason for the discontinuation of a blood transfusion episode, and adequate evaluation remains a challenge for clinicians. The decision to stop a blood transfusion episode on account of fever is often a difficult one. This paper reviews the differe

Revolutionizing hematological disorder diagnosis: unraveling the role of artificial intelligence.

The integration of artificial intelligence (AI) into medical diagnostics is transforming the landscape of healthcare, particularly in hematology. AI technologies, leveraging advanced machine learning algorithms and big data analytics, are revolutionizing the diagnosis of hematological disorders such as anemia, leukemia, and lymphoma. This review explores how AI enhances diagnostic accuracy, efficiency, and patient outcomes by processing complex datasets and identifying patterns beyond human capability. AI-driven advancements in hematology include innovations in image analysis, genomic data int

Потенциальные цели микроглии в лечении нейродегенеративных заболеваний: механизм и терапевтические последствия.

В случае различных нейродегенеративных расстройств активируются микроглиальные клетки. Кроме того, дисфункциональная и гиперактивированная микроглия инициирует митохондриальную автофагию, окислительный стресс и патологическое накопление белка, заканчивающееся нейроинфламмацией, которая усугубляет повреждения допаминергических нейронов и вносит значительный вклад в патологию нейродегенеративного расстройства. Микроглиальная чрезмерная активация тесно связана с секрецией провоспалительных цитокинов, фагоцитозом травмированных нейронов и модуляцией нейротоксичной среды. В этом обзоре резюмируется

Талидомид взаимодействует с воспалением в идиопатическом фиброзе легких.

" Трагедия Талидомида " является важной вехой в истории фармацевтической промышленности. Несмотря на ограниченные клинические испытания, прилагаются постоянные усилия по изучению Талидомида в качестве лекарства от рака и подстрекательских заболеваний, таких, как ревматуидный артрит, проказа, и COVID-19. В рамках этого обзора основное внимание уделяется возможностям борьбы с воспалением путем повторного использования талидомида для лечения идиопатического фиброза легких (ИПФ). Статьи были найдены в базе данных Scopus, сортированы и рассмотрены отдельные статьи. Содержание включает в с

Прогрессивная слюнная речь как нетипичное представление GDAP2-относительно Spinocerebellar Ataxia: доклад по делу.

47-летний мужчина с сахарным диабетом и дислипидемией за четыре года развил прогрессивную речь. МРТ не выявила атрофии мозга, и обычные лабораторные и нейрофизиологические исследования были непримечательными. У его брата были похожие, но продвинутые симптомы, включая дисфагию и серьезные походки, что привело к зависимости от инвалидных колясок. Полноэкзомная последовательность выявила вероятную патогенную гомозиговую мутацию в гене GDAP2, подтверждающую диагноз атаксии 27 (SCAR27). В этом докладе подчеркивается важность рассмотрения наследственных атаксий при дифференциальном диагностике прогр

A review of mitochondrial dysfunction in diabetic sarcopenia: Mechanisms, diagnosis, and treatment approaches.

Diabetic sarcopenia is a common complication of diabetes, substantially impacting patients' quality of life and prognosis. Its pathogenesis is closely related to energy metabolism, with mitochondria-often referred to as the cellular "powerhouse"-playing a central role in this process. This review focuses on the role of mitochondrial dysfunction in diabetic sarcopenia, emphasizing mechanisms such as energy metabolism imbalance, oxidative stress-induced damage, and abnormalities in mitochondrial biogenesis and dynamics. Additionally, we discussed current research on diagnostic and therapeutic st

Exercise Interventions to Address Sarcopenia in People with Multiple Myeloma: A Scoping Review.

Background: The clinical characteristics of sarcopenia, including low muscular strength, are commonly seen among people with multiple myeloma. A scoping review was conducted to explore the role of exercise as a potential countermeasure for sarcopenia in this population. Our objectives were to (1) describe the design and findings of the studies and (2) identify the outcomes used in exercise-related studies to characterize sarcopenia. Methods: A systematic search (to March 2025) was conducted for published studies involving exercise or physical activity for individuals with multiple myeloma usin