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Клинические характеристики и прогностические факторы инфекции Клостридий перфрингенов, осложненные массовым внутриваскулярным гемолизом у пациентов с гематологическими заболеваниями: ретроспективное тематическое исследование.

С пищевым отравлением и газовой гангреной обычно ассоциируются анаэробные бактерии с положительным гравием Clostridium perfringens (CP). В редких случаях он может вызывать смертельный массовый внутриваскулярный гемолиз (MIH) — состояние, связанное с чрезвычайно высокой смертностью, которое создает серьезную клиническую проблему. Ретроспективный анализ был проведен с использованием смертельного случая T-лимфоболической лимфомы/лейкемии, осложненной острым гемолизом, связанным с ХП, который лечился в нашем центре в ноябре 2024 , а также сообщения о связанных с КП MIG пациентах-гематологах с янва

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… The second hit ensues as hemolysis products (e.g., free hemoglobin) and toxins act synergistically to induce a systemic inflammatory response (cytokine storm) and disseminated intravascular coagulation, culminating in irreversible multi-organ failure. … CPA, α-toxin; PFO, θ-toxin; RBC, red blood cell; DIC, disseminated intravascular coagulation; MOF, multi-organ failure; DAMP, damage-associated molecular pattern. …

Fatal septic shock and Waterhouse-Friderichsen syndrome caused by serovar B Capnocytophaga canimorsus in an immunocompetent patient. Case report and review.

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… Septic shock with disseminated intravascular coagulation occurs in 13-30 % of cases and mortality is estimated at 60% [ 15 ]. C. canimorsus infections may have been underestimated because of the difficulty in isolation of the bacteria, due to the slow and unique growth media requirements [ 8 ]. … An Immunocompetent Case of Capnocytophaga canimorsus Infection Complicated by Secondary Thrombotic Microangiopathy and Disseminated Intravascular Coagulation. Intern Med. 2019. Dec 1;58(23):3479-3482. doi: 10.2169/internalmedicine.3110-19. 13. …

Two Случаи протеазонных ингибиторов связаны с тромботическими микроангиопатиями и анализом литературы.

Множественная миелома (ММ) является широко распространенной гематологической халатностью, при этом протеазонные ингибиторы (ИП) играют ключевую роль в ее терапевтическом регулировании. Несмотря на то, что ПИ, как правило, хорошо терпимы и связаны с относительно мягкими побочными эффектами, последние данные все чаще привлекают внимание к протеазной ингибиторной тромботической микроангиопатии (TMA, связанной с ИП). ПРЕДОСТАВЛЕНИЕ СЛЕДУЮЩЕГО ВОПРОСА: two :: случаи с высоким клиническим подозрением в связи с ТМА, связанной с ПИ, с уделением особого внимания диагностическому процессу и последующим

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… Laboratory investigations at the time of neurologic deterioration showed elevated inflammatory markers, anemia, thrombocytopenia, mild schistocytosis (3%), and normal fibrinogen levels, findings that did not support overt disseminated intravascular coagulation (DIC). … Both patients underwent evaluation for alternative causes of TMA, including infection/sepsis, disseminated intravascular coagulation (DIC), antiphospholipid syndrome, disseminated malignancy, and primary thrombotic disorders. …

Septic Hyperinflammation-Is There a Role for Extracorporeal Blood Purification Techniques?

This manuscript investigates the role of extracorporeal blood purification techniques in managing septic hyperinflammation, a critical aspect of sepsis characterized by an uncontrolled immune response leading to multiorgan dysfunction. We provide an overview of sepsis, focusing on the dynamics of immune response, the involvement of neutrophils, and the role of the endothelium in the disease's progression. It evaluates the effectiveness of various blood purification methods, including high-cut-off membranes, high-volume hemofiltration, adsorption techniques, and albumin dialysis, in removing cy

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… Taylor F.B., Jr., Toh C.H., Hoots W.K., Wada H., Levi M., Scientific Subcommittee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemostasis Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. … Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation. Semin. Thromb. Hemost. 2020;46:89–95. doi: 10.1055/s-0039-1694995. 38. Ankawi G., Neri M., Zhang J., Breglia A., Ricci Z., Ronco C. …

Blood hypercoagulability and thrombosis mechanisms in cancer patients -A brief review.

Patients with malignant tumors are prone to present hypercoagulability of blood and form thrombosis, and its pathogenesis is complex involving various factors from clinical and histopathological to genetic influences. Current studies on the potential mechanism of blood hypercoagulability in patients with malignant tumors focus on the following aspects but are not limited: (1) tumor cells release coagulant-promoting substances, (2) tumor cells interact with the fibrinolytic system, (3) tumor cell-mediated platelet activation, (4) tumor-associated complement activation, and (5) genetic factors a

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… In addition, transitional thrombophlebitis, arterial thrombosis, disseminated intravascular coagulation and nonbacterial thrombotic endocarditis (NBTE) are all classified as complications of hypercoagulability in cancer patients [ 33 ]. … A common complication is disseminated intravascular coagulation (DIC). Hematological malignancies such as Hodgkin's lymphoma (HL), Non-hodgkin's lymphoma (NHL), and Multiple myeloma (MM) have much higher risk of thrombosis than non-hematological malignancies [ 117 ]. …

Acquired Factor X Deficiency without Amyloidosis Presenting with Massive Hematuria: A Case Report and Review of the Literature.

Acquired factor X deficiency is a rare diagnosis, especially without the association of other co-existing conditions such as amyloidosis. The authors report the case of a 34-year-old male with severe frank hematuria found to have markedly prolonged prothrombin time and activated partial thromboplastin time. A mixing study showed correction utilizing normal plasma and a coagulation panel testing revealed decreased factor X activity. The patient was treated with multiple blood transfusions, fresh frozen plasma, high-dose pulse steroids, and rituximab. The patient's condition improved during his

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… A fibrin degradation product of 3.1 mg/L (<10 mg/L), and D-dimer of 0.22 mg/L (<0.50 mg/L) indicated that the patient was not in disseminated intravascular coagulation (DIC). The fibrinogen level was increased to 5.6 g/L (2.0–4.0 g/L). … COVID-19 has been associated with thromboembolisms but has rarely been associated with hemorrhagic events, usually explained by disseminated intravascular coagulation and thrombocytopenia. There has only been one other case reported of post-COVID-19-induced AFXD [ 9 ]. …

Delayed gastric emptying in critical illness: is enhanced enterogastric inhibition with cholecystokinin and peptide YY involved?

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… Poor response to platelet transfusions can be seen in patients with other reasons for platelet consumption, including splenomegaly, fever, trauma and crush injury, burns, disseminated intravascular coagulation (DIC), concomitant drugs, or transfusion of platelets of substandard quality. 46 These factors … Even Rh-positive type O RBCs may be used because rates of alloimmunization to Rh 0 (D) are low under the circumstances of emergency transfusion. 128 , 131 Transfusion in Patients with Disseminated Intravascular Coagulation DIC can present the clinician with difficult therapeutic choices. …

Clinical effects of tranexamic acid on bleeding tendency due to fibrinolytic activation of AL amyloidosis.

We report a case where tranexamic acid, which is an antifibrinolytic agent, was used to effectively treat bleeding tendency in a patient with immunoglobulin light chain (AL) amyloidosis. A male patient in his 80s without a history of bleeding disorders was admitted to our hospital for the examination of bleeding tendency and was diagnosed with a bleeding disorder due to AL amyloidosis. Blood tests revealed elevated plasmin-α2-plasmin inhibitor complex levels, suggesting fibrinolytic activation. Managing the bleeding was difficult; however, we suspected fibrinolytic activation associated with A

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… Regarding the evaluation of other differential diseases, since the patient had no history of warfarin or heparin use, the differential diagnosis of bleeding tendency with prolonged PT and aPTT included hepatic failure, vitamin K deficiency, disseminated intravascular coagulation (DIC) and acquired haemophilia … In AL amyloidosis, the administration of tranexamic acid is an effective treatment when disseminated intravascular coagulation is negative, and some findings suggest fibrinolytic activation. …

Mechanism and clinical progression of solid tumors bone marrow metastasis.

The rich blood supply of the bone marrow provides favorable conditions for tumor cell proliferation and growth. In the disease's early stages, circulating tumor cells can escape to the bone marrow and form imperceptible micro metastases. These tumor cells may be reactivated to regain the ability to grow aggressively and eventually develop into visible metastases. Symptomatic bone marrow metastases with abnormal hematopoiesis solid tumor metastases are rare and have poor prognoses. Treatment options are carefully chosen because of the suppression of bone marrow function. In this review, we summ

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… Some patients may also present with life-threatening disseminated intravascular coagulation (DIC) in gastric and colorectal cancers ( Yoshioka et al., 1992 ; Nakashima et al., 2014 ; Hanamura et al., 2016 ; Seki and Wakaki, 2016 ; Zhai et al., 2022 ). … DIC, disseminated intravascular coagulation. mOS, median Overall survival. …

Therapeutic Plasma Exchange Using Membrane Plasma Separation Across a Broad Spectrum of Indications: An Eight-Year Single-Center Retrospective Cohort Study.

BACKGROUND: Therapeutic plasma exchange (TPE) removes pathogenic plasma constituents such as autoantibodies, immune complexes and monoclonal proteins. Plasma can be separated by centrifugation or by membrane plasma separation (MPS); although MPS predominates in many centers because it can be delivered at the bedside on standard renal replacement platforms, most published outcome data derive from centrifugal techniques. OBJECTIVE: To describe the indications, complications, laboratory changes and clinician-assessed treatment response of MPS-based TPE in an unselected single-center cohort. MET

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… The lowest response rates were recorded in fulminant hepatitis with disseminated intravascular coagulation, in which neither of the two patients responded, and in post-transplant glomerulonephritis relapse, in which none of the eight patients with available data achieved a complete response. … intravascular coagulation responded. …

The Dynamic Endothelial Activation and Stress Index (EASIX) as a Predictor of Early Death and Long-Term Survival in Acute Promyelocytic Leukemia (APL): A Multicenter Study.

Background/Objectives: Early death (ED) remains the primary barrier to long-term survival in acute promyelocytic leukemia (APL). Since current risk stratification models rely solely on static baseline parameters, they fail to capture the high biological volatility during the induction phase. We aimed to evaluate the prognostic value of the dynamic evolution of the endothelial activation and stress index (EASIX). Materials and Methods: This multicenter, retrospective study analyzed 131 newly diagnosed adult APL patients treated with the AIDA protocol. EASIX scores were calculated at admission (

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… While intracranial hemorrhage, disseminated intravascular coagulation (DIC), infections and differentiation syndrome (DS) are identified as the leading causes of ED, standard risk stratification models are primarily designed to predict relapse rather than early mortality [ 6 , 12 , 13 ]. … Guidelines for the Diagnosis and Management of Disseminated Intravascular Coagulation Br. J. Haematol. 2009 145 24 33 10.1111/j.1365-2141.2009.07600.x 19222477 31. Sentero D. Hosenpud J. Retinoic Acid Syndrome in Acute Promyelocytic Leukemia Wis. Med. …

Hematology and Hemostasis

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… Update on the treatment of disseminated intravascular coagulation. Hematology. 2004;9:81–5. doi: 10.1080/1024533042000205504. 4. Levi M. Disseminated intravascular coagulation: what’s new? Crit Care Clin. 2005;21:449–67. doi: 10.1016/j.ccc.2005.02.001. 5. Toh CH, Dennis M. … DIC 2002: a review of disseminated intravascular coagulation. Hematology. 2003;8:65–71. doi: 10.1080/1024533031000084213. 6. Warren BL, Reid A, Singer P, et al. High dose antithrombin III in severe sepsis. JAMA. 2001;286:1869–78. doi: 10.1001/jama.286.15.1869. 7. …

Haematological Diseases in the Tropics

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… Thrombotic thrombocytopenia purpura, haemolytic uremic syndrome and disseminated intravascular coagulation can all present with thrombocytopenia. Dysplastic red or white cells should raise the suspicion of myelodysplasia which can be confirmed by bone marrow examination and cytogenetic analysis. …

Therapeutic plasma exchange as rescue therapy in severe sepsis and septic shock: retrospective observational single-centre study of 23 patients.

BackgroundSeveral case series and small randomized controlled trials suggest that therapeutic plasma exchange (TPE) improves coagulation, hemodynamics and possibly survival in severe sepsis. However, the exact role of TPE in modern sepsis therapy remains unclear.MethodsWe performed a retrospective observational single-centre study on the use of TPE as rescue therapy in 23 consecutive patients with severe sepsis or septic shock from 2005 to 2012. Main surrogate markers of multiple organ failure (MOF) before, during and after TPE as well as survival rates are reported.ResultsAt baseline, mean SO

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… Secondary endpoints were dose of vasopressors as a marker of hemodynamic stability, reductions in net fluid balance as a marker of vascular permeability, and platelet count as a marker of disseminated intravascular coagulation (DIC). … Effect of TPE on disseminated intravascular coagulation Since fibrinogen, prothrombin time and activated partial thromboplastin time are highly influenced by TPE, platelet count was chosen as a surrogate marker of possible influences of TPE on DIC. …

UK malaria treatment guidelines 2016.

1.Malaria is the tropical disease most commonly imported into the UK, with 1300-1800 cases reported each year, and 2-11 deaths. 2. Approxima … ment. They may require haemodynamic support and management of: acute respiratory distress syndrome, disseminated intravascular coagulation, acute kidney injury, seizures, and severe intercurrent infections including Gram-negative bacteraemia/septicaemia. 14. Children with severe malaria should also be treated with empirical broad spectrum antibiotics until bacterial infection can be ex …

Antithrombin III for critically ill patients.

BACKGROUND: Critical illness is associated with uncontrolled inflammation and vascular damage which can result in multiple organ failure and … ions specific and not specific to the trial intervention, bleeding events, the effect on sepsis and disseminated intravascular coagulation (DIC) and the length of stay in the intensive care unit (ICU) and in hospital in general. SEARCH METHODS: We searched the following databases from inception to 27 August 2015: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (Ovid …

Endothelial dysfunction and hemostatic imbalance in CAR T-cell-associated toxicities: pathophysiological insights and the role of circulating biomarkers.

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of relapsed or refractory hematologic malignancies. While its clinical efficacy is well established, CAR T-cell therapy is frequently associated with severe immune-mediated toxicities, including cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), coagulopathy, and hemophagocytic lymphohistiocytosis-like syndrome (IEC-HS). Increasing evidence suggests that endothelial dysfunction, hemostatic imbalance, and complement activation are key contributors to the pathogenesis of

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… In severe cases, the coagulopathy may fulfill diagnostic criteria for disseminated intravascular coagulation (DIC) ( 82 ). … Association of endotheliopathy with coagulofibrinolytic reactions and disseminated intravascular coagulation after trauma: a retrospective observational study . …

Endotheliopathy in CAR T-Cell Therapy: Mechanistic Insights into the VWF/ADAMTS13 Axis and the Angiopoietin-Tie2 Pathway.

Chimeric antigen receptor (CAR) T cell therapy has transformed the management of hematologic malignancies, yet its clinical success is tempered by severe immune-mediated toxicities, including cytokine-release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), often accompanied by CAR T cell therapy-related coagulopathy (CARAC). Converging evidence identifies therapy-related endotheliopathy as a central pathophysiological link between cytokine excess, hemostatic dysregulation, capillary leak, and organ injury. Parallel efforts aim to identify circulating biomarke

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… Abbreviations: ADAMTS13, a disintegrin-like and metalloprotease with thrombospondin type 1 repeats; AEs, adverse events; Ang, angiopoietin; aPTT, activated partial thromboplastin time; CLL, chronic lymphocytic leukemia; CRS, cytokine release syndrome; DIC, disseminated intravascular coagulation; DLBCL … intravascular coagulation (DIC), although fulminant DIC remains uncommon. …

Сепсис, вызванный Clostridium Perfringens у женщины пожилого возраста, больной раком груди: доклад по делу.

ЦЕЛЬ: Сообщить о редком случае заболевания раком груди, у которого септический шок и множественные повреждения органов. В нем анализируются клинические характеристики, патогенные факторы и прогноз, связанные с смешанной инфекцией, вызванной Clostridium perfringens и Escherichia coli, в целях обеспечения основы для раннего выявления и вмешательства аналогичных клинических случаев. МЕТОДЫ: Был проведен ретроспективный анализ клинических данных 75-year-old Женщина, больная раком груди, которая также страдала гипертонией и диабетом. Были резюмированы клинические проявления, результаты этиологическ

Development and validation of a novel nomogram to predict overall survival in gastric cancer with lymph node metastasis.

Gastric cancer (GC) with lymph node metastasis (LNM) at diagnosis is associated with a unstable prognosis and indefinite survival times. The aim of the present study was to construct and validate a model for the Overall survival (OS) estimation for patients with LNM. The nomogram was constructed to predict the OS for LNM-positive GC using the primary group of 836 patients and validated using an independent cohort of 411 patients. Factors in the nomogram were identified by multivariate Cox hazard analysis. The predictive capability of nomogram was evaluated by calibration analysis and decision

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… intravascular coagulation (DIC) within 1 month of study onset or during the subsequent treatment); (6) patients who not regularly took procoagulant or anticoagulant therapy or took blood transfusions within 1 month of study onset. … Abbreviations gastric cancer lymph node metastasis Overall Survival systemic immune-inflammation index tumor, lymph node and metastases disseminated intravascular coagulation platelet-lymphocyte ratio rationeutrophil-lymphocyte ratio lymphocyte-mononuclyte ratio lactate dehydrogenas Prothrombin …