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Adaptive microevolution in CC17 Streptococcus agalactiae from a mother-neonate infection.

BACKGROUND: The hypervirulent CC17 GBS is a major cause of neonatal invasive disease. Although this lineage can acquire mutations during hos … GBS strains were collected and identified, and all were susceptible to penicillin, but resistant to clindamycin and erythromycin. The strains could be classified into ST17 and ST2247. The two types of strains showed no significant differences in growth curve, hemolysis activity, or serum inhibition. In hyaluronic acid solution, the ST2247 strain exhibited hig …

Short-course antimicrobial prophylaxis after emergency caesarean section.

BACKGROUND: The role of short-course antimicrobial prophylaxis (ScAP) after emergency caesarean section is unclear, particularly in low-midd … ther oral amoxicillin/clavulanate, oral sultamicillin (a pro-drug of ampicillin/sulbactam), or oral clindamycin (for suspected or confirmed penicillin allergy). The primary outcome was a composite of any infection related to emergency caesarean section, surgical site infections (SSI), endometritis, and persistent fever of unknown aetiology within 30 days of s …

Phenotypic Detection of Antimicrobial Resistance Patterns in Microorganisms Isolated From the Primary Molars of Pediatric Dental Patients Undergoing Pulp Therapy.

Background Pulp necrosis is a prevalent complication following dental caries in primary dentition. Certain bacteria exhibit increased adapta … ancomycin, teicoplanin, linezolid, amikacin, and imipenem, while variable resistance to macrolides, clindamycin, fluoroquinolones, and β-lactams was observed. No extended-spectrum β-lactamase (ESBL) or carbapenem-resistant strains were identified. Conclusion Enterococcus faecalis remains the predominant pathogen in pediatric endodontic infections, with its in …

[Epidemiology of Clostridioides difficile carriage in maternal and infant populations: underlying determinants, molecular types, and drug resistance].

Objective: To understand the molecular types and drug resistance characteristics of Clostridioides (C.) difficile detected in the maternal a … ive to metronidazole, rifampicin, and vancomycin, but highly resistant to erythromycin (81.18%) and clindamycin (91.76%). The differences in C. difficile carriage rate in infants with different feeding patterns were significant (P=0.019). The lowest carriage rate was found in breastfeeding infants (25.00%, 18/72), followed by those with mixed feeding (40.00%, …

Epidemiology and antimicrobial resistance analysis of staphylococcus aureus isolated from women, children and neonates in a maternal and child specialty hospital in Southeast China.

BACKGROUND: Staphylococcus aureus (S. aureus) is a common bacterium posing a significant global health threat, with methicillin-resistant S. … .0122, P = 0.0491). Significant differences in susceptibility rates to penicillin, erythromycin and clindamycin were observed among the three subgroups. CONCLUSIONS: S. aureus isolates were predominantly obtained from neonates and lactating mothers, mainly from the lower respiratory tract and skin/soft tissue sites. The high proportion of genital tract and i …

Molecular epidemiology and environmental persistence of methicillin-resistant coagulase-positive Staphylococci in a Veterinary Teaching Hospital in Thailand: Evidence for nosocomial transmission and One Health implications.

BACKGROUND AND AIM: Methicillin-resistant coagulase-positive Staphylococci (MRCoPS), including methicillin-resistant Staphylococcus pseudint … RSC isolates carried SCCmec type V and displayed a consistent triple resistance pattern (gentamicin-clindamycin-erythromycin), while MRSP isolates exhibited diverse antibiograms and untypeable SCCmec elements. PFGE revealed clonal similarity (pattern A) between canine and environmental isolates, confirming the potential for nosocomial transmission. CONCLUSIO …

Staphylococcical scalded skin syndrome: a case series description of a rare and critical disease in a tertiary pediatric center.

BACKGROUND: Staphylococcal-scalded skin syndrome (SSSS) is a potentially life-threatening disorder characterized by superficial skin blister … children received intravenous (IV) antibiotics: oxacillin in 76% of patients, while teicoplanin and clindamycin in 19%. The median duration of IV and oral antibiotic therapy was 12.8 days (IQR 10-14). Only one patient was treated with IV immunoglobulin. The median hospitalization length was 7.8 days (IQR 5-9). All our cases had a favorable outcome. CONCLUSIO …

Australian Group on Antimicrobial Resistance (AGAR) Australian Staphylococcus aureus Surveillance Outcome Program (ASSOP) Bloodstream Infection Annual Report 2024.

From 1 January to 31 December 2024, fifty-five institutions across Australia participated in the Australian Staphylococcus aureus Surveillan … e ST45-V [5C2&5], which has acquired resistance to multiple antimicrobials including ciprofloxacin, clindamycin, erythromycin, gentamicin, and tetracycline. Overall, 89.6% of methicillin-resistant SAB episodes were caused by CA-MRSA clones. Although polyclonal, approximately 72% of CA-MRSA clones were characterised as ST93-IV [2B] (Queensland clone), ST5-IV [ …

Инвазивная группа А Стрептококковые инфекции 10 США.

ВАЖНОСТЬ: Инвазивная группа А инфекция Стрептококка (ГАС) связана со значительной заболеваемостью, смертностью и экономическим бременем. ЦЕЛЬ: Обновление тенденций в области заболеваемости инвазивным газом 10 США между 2013 и 2022. DESIGN, SETTING И УЧАСТНИКИ: Клинические, демографические и лабораторные данные по случаям применения инвазивного газа были собраны в рамках осуществляемого населением наблюдения в сети активной бактериальной базы наблюдения, охватывающей 34.9 million людей по всему миру 10 США. Один случай определяется как изоляция ГАЗ от обычного стерильного участка или от раны па

Совпадение в аннотации оригинала
IMPORTANCE: Invasive group A Streptococcus (GAS) infections are associated with substantial morbidity, mortality, and economic burden. OBJE … ntially elevated GAS incidence rates. Among tested isolates, those nonsusceptible to macrolides and clindamycin increased from 12.7% in 2013 to 33.1% in 2022. CONCLUSIONS: Invasive GAS infections increased substantially in 10 US states during a surveillance period from 2013 to 2022. Accelerated efforts to prevent and control GAS are needed, especially among …

Identification of bacteria on Thai banknotes and coins using MALDI-TOF mass spectrometry and their phenotypic antimicrobial susceptibility profiles.

BACKGROUND: The existence and transmission of pathogenic and antibiotic-resistant bacteria through currency banknotes and coins poses a glob … ant (MDR). It is notable that none of the staphylococci and macrococci isolates exhibited inducible clindamycin resistance (D-test negative). Escherichia coli and Pseudomonas putida isolates were carbapenem-resistant, and Acinetobacter baumannii isolates were MDR with showing carbapenem resistance. CONCLUSION: Our data demonstrated a high prevalence of medic …

What role does antibiotic resistance play in secondary endodontic infections?

DATA SOURCES: The systematic review utilised multiple electronic databases to gather relevant literature, including PubMed, Scopus, EMBASE, … levels. The antibiotics demonstrating the highest resistance patterns against E. faecalis included clindamycin, gentamicin, metronidazole, and rifampicin, which are contraindicated in SPEI cases. CONCLUSIONS: Ongoing monitoring of antibiotic resistance patterns is crucial for effective endodontic treatment protocols. The emergence of resistance among Entero …

Mismatch Rate of Empirical Antimicrobial Treatment in Fracture-Related Infections.

OBJECTIVES: To evaluate the current standard of care regarding empirical antimicrobial therapy in fracture-related infections (FRIs). DESIG … /75) and Staphylococcus epidermidis (41%, 31/75). The most frequently used empirical antibiotic was clindamycin (59%, 44/75), followed by combinations of gram-positive and gram-negative covering antibiotics (15%, 11/75). The overall mismatch rate was 51% (38/75) [95% confidence interval (CI), 0.39-0.62] and did not differ between extremities [upper: 31% (4/13 …

Methicillin-Resistant Staphylococcus aureus among Students: Nasal Carriage Rate, Contributing Factors, and Antimicrobial Susceptibility.

Background and Objectives: Staphylococcus aureus is a prominent component of the human flora; however, it can cause various pathological con … of S. aureus isolates displayed resistance to erythromycin followed by fluoroquinolones (47.6%) and clindamycin (42.2%). All the S. aureus isolates, including MR-SA, remained susceptible to vancomycin and linezolid. PCR results revealed that 95.5% (63) of MR-SA isolates carried the mecA gene. Conclusions: The high prevalence of multi-drug-resistant (MDR) S. a …

Comparison of bacteriological culture method and multiplex real-time PCR for detection of mastitis.

This study includes the evaluation of multiplex real-time PCR (rPCR) kit, which was developed to provide rapid diagnosis of mastitis infecti … nce of the isolates was evaluated, 78 (31.96%) tetracycline, 72 (29.5%) penicillin, and 60 (24.59%) clindamycin resistance were observed predominantly in Gram-positive isolates, while 6 (23.07%) tigecycline, 6 (23.07%) netilmicin, 6 (23.07%) pipercillin resistance was found in gram-negative isolates. While a bacteria and/or yeast gene was found by rPCR in 187 …

Evaluation of commercial, customized microdilution plates for Ureaplasma parvum, Ureaplasma urealyticum, and Mycoplasma hominis antimicrobial susceptibility testing and determination of antimicrobial resistance prevalence in France.

UNLABELLED: Antimicrobial susceptibility testing (AST) of human mycoplasmas using microdilution is time-consuming. In this study, we compare … , levofloxacin, and moxifloxacin resistance rates were 11.1%, 2.2%, and 2.2%, respectively, with no clindamycin resistance. For 248 U. parvum isolates, the levofloxacin and moxifloxacin resistance rates were 5.2% and 0.8%, respectively; they were 2.9% and 1.5% in 68 U. urealyticum isolates. Tetracycline resistance in U. urealyticum (11.8%) was significantly ( …

Use of trimethoprim- sulfamethoxazole for treating Pneumocystis jirovecii pneumonia in a patient with glucose-6-phosphate dehydrogenase deficiency: a case report.

BACKGROUND: Pneumocystis jirovecii pneumonia (PJP) is an opportunistic infection caused by the yeast-like fungus P. jirovecii. As recommended by some guidelines, the first-line treatment for this infection is trimethoprim-sulfamethoxazole (TMP-SMX), and the second-line treatment includes drugs such as dapsone, pentamidine, primaquine, Atovaquone, clindamycin, and caspofungin. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked gene disorder in which treatment with oxidizing drugs, such as sulfonamides, dapsone, primaquine, can directly destroy hemoglobin present in red blood cel…

Comparative efficacy and safety of treatment regimens for Pneumocystis jirovecii pneumonia in people living with HIV: a systematic review and network meta-analysis of randomized controlled trials.

BACKGROUND: Pneumocystis jirovecii pneumonia (PCP) is a serious opportunistic infection in people living with HIV (PWH) who have low CD4 cou … tistically significant superiority over TMP-SMX in direct comparison. In the network meta-analysis, clindamycin/primaquine was ranked the best (surface under the cumulative ranking curve, 0.8), followed by intravenous pentamidine (0.8) and TMP-SMX (0.8) regarding treatment failure. Regarding all-cause mortality, TMP-SMX was superior to atovaquone in direct co …

Magnitude and antimicrobial susceptibility profile of bacteria isolated from pediatric sepsis cases at University of Gondar Hospital, Northwest Ethiopia.

BACKGROUND: Sepsis is one of the major causes of morbidity and mortality among pediatric patients throughout the world. The varying microbio … eading bacteria was Klebsiella pneumoniae (n = 20; 25%) followed by Escherichia coli (n = 7; 8.8%). Clindamycin, Chloramphenicol, Gentamicin and Ciprofloxacin were the most effective antibiotics against Gram-positive bacterial isolates while Amikacin, Meropenem and Chloramphenicol were effective against Gram-negative pathogens. Methicillin resistance was dete …

Isolation, identification and antimicrobial susceptibility of the bacteria isolated from Hyalomma dromedarii infesting camels in Al-Jouf province, Saudi Arabia.

Ticks are important ectoparasites that transmit various pathogens causing morbidity and mortality in humans and animals. Saudi Arabia faces … t to benzylpenicillin; 90.3% (n = 28) were resistant to oxacillin; 58.1% (n = 18) were resistant to clindamycin; 48.4% (n = 15) were resistant to vancomycin. In addition, 32.3% (n = 10) were resistant to trimethoprim/sulfamethoxazole and rifampicin; 25.8% (n = 8) were resistant to erythromycin; 16.1% (n = 5) were resistant to teicoplanin; 6.5% (n = 2) were re …

Occurrence and Antimicrobial Resistance among Staphylococci Isolated from the Skin Microbiota of Healthy Goats and Sheep.

Staphylococci colonize the skin and mucous membranes of different animals. The purpose of this study was to determine the staphylococcal com … ne antimicrobial agent, with the highest frequency of resistance to penicillin (16.8%), followed by clindamycin (9.6%), erythromycin (8.4%), moxifloxacin (8.4%), and tetracycline (7.2%). All isolates were susceptible to eight antibiotics (amikacin, gentamycin, ciprofloxacin, levofloxacin, rifampicin, chloramphenicol, trimethoprim-sulfamethoxazole, and tigecyc …